公开(公告)号：US20020102555A1

公开(公告)日：2002-08-01

申请号：US09773804

申请日：2001-02-01

Applicant: XEROX CORPORATION

Inventor： Richard H. Bruce ,  Scott A. Elrod ,  Babur B. Hadimioglu ,  David A. Horine ,  Jaan Noolandi ,  Joy Roy ,  Robert A. Sprague

IPC: C12Q001/68 ,  G06F019/00 ,  G01N033/48 ,  G01N033/50 ,  B05D003/00

CPC classification number: G01N35/10 ,  G01N35/00712 ,  G01N35/1009 ,  G01N2035/1037 ,  G06F19/00

Abstract: A method and mechanism for ensuring quality control in printed biological assays is provided. A multi-ejector system having a plurality of individual drop ejectors is loaded with a variety of biofluids. Biofluids include at least a carrier fluid, a biological material to be used in the testing, and markers, such as fluorescent dyes. Data regarding the biofluid loaded in each of the drop ejectors is stored along with an expected signature output of the biofluid. Particularly, the signature output represents signals from individual ones of the fluorescent markers included within the biofluid. Once a biological assay consisting of the biofluid drops has been printed, a scanner capable of detecting the markers scans the biological assay and obtains signature output signals for each of the drops of the biological assay. A comparing operation is undertaken to compare the obtained signature output through the scanning operation, with the expected signature output signals for the biofluid loaded in the corresponding drop ejector. The biological material itself may also be tagged with a marker to ensure its inclusion in the biofluid. By the comparing operation, it is possible to verify the biofluids were loaded in the proper drop ejector, including the proper biological material, and that the drop ejectors are functioning properly.

Abstract translation: 提供了一种用于确保印刷生物测定中的质量控制的方法和机制。 具有多个单独的液滴喷射器的多喷射器系统装载有各种生物流体。 生物流体至少包括载体流体，用于测试的生物材料和标记物，例如荧光染料。 关于装载在每个液滴喷射器中的生物流体的数据与生物流体的预期签名输出一起存储。 特别地，签名输出表示来自生物流体内包含的荧光标记的各个信号。 一旦已经印刷了由生物流体液滴组成的生物测定法，能够检测标记物的扫描仪扫描生物测定并获得生物测定中每一滴的签名输出信号。 进行比较操作以将获得的通过扫描操作的签名输出与加载在相应的滴液喷射器中的生物流体的预期签名输出信号进行比较。 生物材料本身也可以用标记来标记，以确保其包含在生物流体中。 通过比较操作，可以验证生物流体是否装载在适当的滴液喷射器中，包括适当的生物材料，并且液滴喷射器正常工作。

公开(公告)号：US20030124549A1

公开(公告)日：2003-07-03

申请号：US10121264

申请日：2002-04-12

Applicant: Xerox Corporation ,  The Scripps Research Institute

Inventor： Emest Beutler ,  Richard Bruce ,  Scott A. Elrod ,  John Stuart Fitch ,  Huangpin Ben Hsieh ,  Eric Peeters ,  Richard A. Lerner

IPC: C12Q001/68 ,  C12M001/34

CPC classification number: B01L3/50853 ,  B01L2300/047 ,  B01L2300/0829 ,  B01L2400/0406 ,  B01L2400/0683 ,  G01N35/1074 ,  G01N2035/1037

Abstract: The invention provides devices for analyzing genetic material comprising a substrate and a first genetic material position and a second genetic material position on the substrate that each comprise genetic material attached to the substrate. The invention also provides methods of distributing genetic material comprising distributing at least one device.

Abstract translation: 本发明提供了用于分析遗传物质的装置，其包括基底和第一遗传物质位置以及基底上的第二遗传物质位置，每个遗传物质包含连接到基底的遗传物质。 本发明还提供分布遗传物质的方法，包括分配至少一种装置。

公开(公告)号：US20020015074A1

公开(公告)日：2002-02-07

申请号：US09957710

申请日：2001-09-20

Applicant: Xerox Corporation

Inventor： Scott A. Elrod ,  Babur B. Hadimioglu ,  David Steinmetz ,  Kaiser H. Wong

IPC: B41J002/135

CPC classification number: B41J2/14008 ,  B41J2002/14322

Abstract: Low acoustic solid wave attenuation structures are formed with an electroformed nickel mold, and are incorporated within acoustic ink emitters, between the focusing lens and surface of an ink layer. The structures have characteristics of low attenuation of acoustic waves to increase the efficiency of acoustic wave transmission within the acoustic ink emitter. Using the described structures, acoustic ink printers can accurately emit materials having high viscosity, including hot melt inks.

Abstract translation: 低声波固体波衰减结构由电铸镍模形成，并且被结合在声学油墨发射器之间，在聚焦透镜和油墨层的表面之间。 该结构具有声波衰减低的特性，以增加声波发射器内声波传播的效率。 使用所述结构，声墨打印机可以精确地发射具有高粘度的材料，包括热熔油墨。

公开(公告)号：US20030186453A1

公开(公告)日：2003-10-02

申请号：US10114611

申请日：2002-04-01

Applicant: Xerox Corporation

Inventor： Alan G. Bell ,  Richard H. Bruce ,  Scott A. Elrod ,  Eric Peeters ,  Francisco E. Torres

IPC: G01N025/20

CPC classification number: B82Y15/00 ,  G01N25/4846 ,  G01N25/4866 ,  Y10S977/957 ,  Y10T436/25 ,  Y10T436/25625 ,  Y10T436/2575

Abstract: A nanocalorimeter array for detecting chemical reactions includes at least one thermal isolation region residing on a substrate. Each thermal isolation region includes at least one thermal equilibration region, within which resides a thermal measurement device connected to detection electronics.

Abstract translation: 用于检测化学反应的纳米尺度计阵列包括驻留在基底上的至少一个热隔离区域。 每个热隔离区域包括至少一个热平衡区域，其中存在连接到检测电子器件的热测量装置。

公开(公告)号：US20030183525A1

公开(公告)日：2003-10-02

申请号：US10115336

申请日：2002-04-01

Applicant: Xerox Corporation

Inventor： Scott A. Elrod ,  Eric Peeters ,  Francisco E. Torres ,  David K. Biegelsen ,  John L. Dunec ,  Alan G. Bell

IPC: G01N027/26 ,  G01N027/447

CPC classification number: B01F13/0071 ,  B01F5/0085 ,  B01F13/0076 ,  B01J2219/0036 ,  B01J2219/00527 ,  B01J2219/00653 ,  B01L3/502792 ,  B01L2300/089 ,  B01L2400/0415 ,  B01L2400/0427 ,  C40B60/14 ,  G02B26/005

Abstract: A device for effecting motion of liquid droplets on a surface through the use of electrostatic field force includes a single substrate on which are disposed a plurality of spaced-apart electrodes. A dielectric material surrounds the electrodes on the substrate. The surface on which the liquid droplets are deposited is fabricated from a material that facilitates motion of the liquid droplets.

Abstract translation: 用于通过使用静电场力来实现液滴在表面上的运动的装置包括单个基板，多个间隔开的电极在其上设置单个基板。 电介质材料围绕衬底上的电极。 液滴沉积在其上的表面由促进液滴运动的材料制成。

公开(公告)号：US20040235036A1

公开(公告)日：2004-11-25

申请号：US10856167

申请日：2004-05-28

Applicant: Xerox Corporation ,  The Scripps Research Institute

Inventor： Ernest Beutler ,  Richard Bruce ,  Scott A. Elrod ,  John Stuart Fitch ,  Huangpin Ben Hsieh ,  Eric Peeters ,  Richard A. Lerner

IPC: C12Q001/68 ,  C12M001/34

CPC classification number: B01L3/50853 ,  B01L2300/047 ,  B01L2300/0829 ,  B01L2400/0406 ,  B01L2400/0683 ,  G01N35/1074 ,  G01N2035/1037

Abstract: The invention provides devices for analyzing genetic material comprising a substrate and a first genetic material position and a second genetic material position on the substrate that each comprise genetic material attached to the substrate. The invention also provides methods of distributing genetic material comprising distributing at least one device.

Abstract translation: 本发明提供了用于分析遗传物质的装置，其包括基底和第一遗传物质位置以及基底上的第二遗传物质位置，每个遗传物质包含连接到基底的遗传物质。 本发明还提供分布遗传物质的方法，包括分配至少一种装置。

公开(公告)号：US20020101478A1

公开(公告)日：2002-08-01

申请号：US09773350

申请日：2001-01-31

Applicant: XEROX CORPORATION

Inventor： Joy Roy ,  Scott A. Elrod ,  Donald L. Smith ,  Jerry Elkin ,  John S. Fitch

IPC: B41J002/135

CPC classification number: B41J2/04 ,  B41J2/14008 ,  B41J2202/08

Abstract: This invention relates to a method and apparatus for acoustic ink printing using a bilayer configuration. More particularly, the invention concerns an acoustically actuated droplet emitter which is provided with a continuous, high velocity, laminar flow of cooling liquid in addition to a stagnant pool of liquid to be emitted as droplets.

Abstract translation: 本发明涉及使用双层结构的声学油墨印刷的方法和装置。 更具体地说，本发明涉及一种声学致动的液滴发射器，除了要作为液滴喷射的液体的滞留池之外，还提供了连续的，高速的冷却液层流。