公开(公告)号：US20090030088A1

公开(公告)日：2009-01-29

申请号：US12148574

申请日：2008-04-21

申请人： Xi Wang ,  James C. Morris ,  Feng Chen ,  Thomas Beckham

发明人： Xi Wang ,  James C. Morris ,  Feng Chen ,  Thomas Beckham

IPC分类号： A61K31/11 ,  A61P31/00 ,  A61P35/00

CPC分类号： A61K31/11 ,  Y02A50/415

摘要： 6-methoxy gossypol and 6,6′-dimethoxy gossypol were isolated from cottonseeds. Bioactivities of these two gossypol derivatives and gossypol were investigated regarding their antioxidant activities, DNA damage prevention ability, anti-cancer, and anti-trypanosomal activities. Both methoxy compounds had nearly equivalent bioactivities, but gossypol showed greater bioactivities than either methoxy derivative on free radical scavenging activity, reducing power, and DNA damage prevention ability. Gossypol and its methoxy derivatives inhibited growth of three cancer cell lines, i.e., SiHa (cervical cancer), MCF-7 (breast cancer) and Caco-2 (colon cancer) cells, in a dose dependent manner. These three compounds also significantly inhibited growth of trypanosome T. brucei, the cause of African Sleeping Sickness, which affects thousands in western and central Africa.

摘要翻译： 从棉籽中分离出6-甲氧基棉酚和6,6'-二甲氧基棉酚。 研究了这两种棉酚衍生物和棉酚的抗氧化活性，DNA损伤预防能力，抗癌和抗锥虫活性的生物活性。 两种甲氧基化合物具有几乎相同的生物活性，但是棉酚显示出比甲氧基衍生物对自由基清除活性，降低功率和DNA损伤预防能力更大的生物活性。 棉酚及其甲氧基衍生物以剂量依赖性方式抑制三种癌细胞系（即SiHa（宫颈癌）），MCF-7（乳腺癌）和Caco-2（结肠癌）细胞）的生长。 这三种化合物也显着抑制了锥虫T.布鲁斯的生长，这是非洲睡眠病的原因，影响了西非和中非数千人。

公开(公告)号：US20130149723A1

公开(公告)日：2013-06-13

申请号：US13507238

申请日：2012-06-14

申请人： Xi Wang ,  Feng Chen

发明人： Xi Wang ,  Feng Chen

IPC分类号： C07K17/10 ,  G01N33/68

CPC分类号： C07K17/10 ,  G01N33/5097 ,  G01N33/56966 ,  G01N33/6803 ,  G01N2333/415 ,  G01N2333/43552 ,  G01N2430/10 ,  Y10T428/2982

摘要： An assay system is provided in which gossypol is used as a biological marker to detect evolved resistance of insects to Bt cotton. Detection of gossypol using a monoclonal antibody ELISA-based protocol enables at risk populations of insects to be evaluated for evolved resistance to Bt present in a genetically modified cotton.The specificity of the monoclonal antibody to gossypol also enables the production of nanoparticles having a conjugated monoclonal antibody which retains the ability to selectively bind gossypol. Accordingly, nanoparticles can be provided with additional target ligands, such as antibodies, so as to specifically attach to tumors or cancer cells thereby delivering the gossypol to the target cells.

摘要翻译： 提供了一种测定系统，其中使用棉酚作为生物标志物来检测昆虫对Bt棉的演变抗性。 使用单克隆抗体检测棉酚基于ELISA的方案可使危险的昆虫种群被评估为在转基因棉花中存在的Bt的进化抗性。 单克隆抗体对棉酚的特异性还能够生产具有共轭单克隆抗体的纳米颗粒，其保留选择性结合棉酚的能力。 因此，可以向纳米颗粒提供额外的靶配体，例如抗体，以便特异性地附着于肿瘤或癌细胞，从而将棉酚递送至靶细胞。

公开(公告)号：US20080241967A1

公开(公告)日：2008-10-02

申请号：US12069136

申请日：2008-02-06

申请人： Feng Chen ,  A. B. Bodine ,  Paul L. Dawson ,  Thomas R. Scott ,  Xi Wang

发明人： Feng Chen ,  A. B. Bodine ,  Paul L. Dawson ,  Thomas R. Scott ,  Xi Wang

IPC分类号： G01N33/536

CPC分类号： G01N33/54346

摘要： A radioimmunoassay method for determining the quantity of an analyte of interest in a sample is disclosed. The analyte of interest may be an antigen or other chemical entity. A known antibody to the antigen or other entity is employed and is conjugated to a functionalized nanoparticle. Because of the high surface area presented by the present nanoparticle—antibody conjugates, the present radioimmunoassay method is particularly suited for the qualitative and quantitative analysis of low molecular weight chemicals.

摘要翻译： 公开了一种用于确定样品中感兴趣分析物的量的放射免疫测定方法。 感兴趣的分析物可以是抗原或其他化学实体。 使用抗原或其他实体的已知抗体并与功能化的纳米颗粒缀合。 由于本发明纳米颗粒 - 抗体缀合物表现出高表面积，本发明的放射免疫测定方法特别适用于低分子量化学品的定性和定量分析。

公开(公告)号：US20090175885A1

公开(公告)日：2009-07-09

申请号：US12225940

申请日：2007-04-05

申请人： Xi Wang ,  Feng Chen

发明人： Xi Wang ,  Feng Chen

IPC分类号： A61K39/395 ,  G01N33/566 ,  A61P35/00

CPC分类号： C07K17/10 ,  G01N33/5097 ,  G01N33/56966 ,  G01N33/6803 ,  G01N2333/415 ,  G01N2333/43552 ,  G01N2430/10 ,  Y10T428/2982

摘要： An assay system is provided in which gossypol is used as a biological marker to detect evolved resistance of insects to Bt cotton. Detection of gossypol using a monoclonal antibody ELISA-based protocol enables at risk populations of insects to be evaluated for evolved resistance to Bt present in a genetically modified cotton.The specificity of the monoclonal antibody to gossypol also enables the production of nanoparticles having a conjugated monoclonal antibody which retains the ability to selectively bind gossypol. Accordingly, nanoparticles can be provided with additional target ligands, such as antibodies, so as to specifically attach to tumors or cancer cells thereby delivering the gossypol to the target cells.

摘要翻译： 提供了一种测定系统，其中使用棉酚作为生物标志物来检测昆虫对Bt棉的演变抗性。 使用单克隆抗体检测棉酚基于ELISA的方案可使危险的昆虫种群被评估为在转基因棉花中存在的Bt的进化抗性。 单克隆抗体对棉酚的特异性还能够生产具有共轭单克隆抗体的纳米颗粒，其保留选择性结合棉酚的能力。 因此，可以向纳米颗粒提供额外的靶配体，例如抗体，以便特异性地附着于肿瘤或癌细胞，从而将棉酚递送至靶细胞。

公开(公告)号：US20060099721A1

公开(公告)日：2006-05-11

申请号：US11244567

申请日：2005-10-06

申请人： Feng Chen ,  Ashby Bodine ,  Paul Dawson ,  Thomas Scott ,  Ya-Ping Sun ,  Xi Wang

发明人： Feng Chen ,  Ashby Bodine ,  Paul Dawson ,  Thomas Scott ,  Ya-Ping Sun ,  Xi Wang

IPC分类号： G01N33/551

CPC分类号： G01N33/54346

摘要： A radioimmunoassay method for determining the quantity of an analyte of interest in a sample is disclosed. The analyte of interest may be an antigen or other chemical entity. A known antibody to the antigen or other entity is employed and is conjugated to a functionalized nanoparticle. Because of the high surface area presented by the present nanoparticle-antibody conjugates, the present radioimmunoassay method is particularly suited for the qualitative and quantitative analysis of low molecular weight chemicals.

摘要翻译： 公开了一种用于确定样品中感兴趣分析物的量的放射免疫测定方法。 感兴趣的分析物可以是抗原或其他化学实体。 使用抗原或其他实体的已知抗体并与功能化的纳米颗粒缀合。 由于本发明纳米颗粒 - 抗体缀合物表现出高表面积，本发明的放射免疫测定方法特别适用于低分子量化学品的定性和定量分析。

公开(公告)号：US20220245984A1

公开(公告)日：2022-08-04

申请号：US17164813

申请日：2021-02-01

申请人： Xi Wang

发明人： Xi Wang

IPC分类号： G07F7/10 ,  G06Q20/40 ,  G06K19/07

摘要： A contactless PIN card includes an orientation reference feature, a plurality of tactile sensors, an arrangement of a plurality of tactile sensors along the edge, an arrangement of a plurality of tactile sensors on the surface or surfaces, an arrangement of a plurality tactile of sensors along the edge and on the surface or surfaces. A plurality of tactile sensors allowed the user to input a binary PIN according to the way how the finger is interacting with the tactile sensors. In addition to the validation of the identifying information embedded within the memory of any existing contactless credit card, debit cards, prepaid electronic cash card, loyalty card and access card, the user's identification is also validated through the binary PIN. An irreversible mathematical equation can be used to compute the identifying information and user's binary PIN to generate the validation Radio Frequency Identification signal.

公开(公告)号：US08965198B2

公开(公告)日：2015-02-24

申请号：US13658587

申请日：2012-10-23

申请人： Qiong Zhang ,  Paparao Palacharla ,  Xi Wang ,  Motoyoshi Sekiya

发明人： Qiong Zhang ,  Paparao Palacharla ,  Xi Wang ,  Motoyoshi Sekiya

IPC分类号： H04B10/00

CPC分类号： H04J14/0284 ,  H04J14/0212 ,  H04J14/0217 ,  H04J14/0268

摘要： A method for shared mesh restoration includes configuring a switch to allow sharing of a plurality of backup line cards across a plurality of node degrees associated with a reconfigurable optical add/drop multiplexer (ROADM). The switch is communicatively coupled to the ROADM. The method further includes configuring a number of backup line cards coupled to the switch. The number of backup line cards is based on determining a number of active backup lightpaths for each of a plurality of network failures associated with each of the plurality of node degrees of the ROADM, identifying which node degree and failure has the largest number of active backup lightpaths for all of the plurality of node degrees of the ROADM and for each of the plurality of network failures, and determining the number of backup line cards to configure based on the identified largest number of active backup lightpaths.

摘要翻译： 一种用于共享网格恢复的方法包括配置交换机以允许在与可重配置光分插复用器（ROADM）相关联的多个节点度上共享多个备用线卡。 交换机通信耦合到ROADM。 该方法还包括配置耦合到交换机的多个备用线路卡。 备用线路卡的数量基于确定与ROADM的多个节点度中的每一个相关联的多个网络故障中的每一个的主动备用光路的数量，识别哪个节点度和故障具有最大数量的主动备份 用于ROADM的所有多个节点度数和多个网络故障中的每一个的光路，以及基于所识别的最大数量的主动备用光路确定要配置的备用线路卡的数量。

公开(公告)号：US08942114B2

公开(公告)日：2015-01-27

申请号：US13165352

申请日：2011-06-21

申请人： Xi Wang ,  Inwoong Kim ,  Qiong Zhang ,  Paparao Palacharla ,  Motoyoshi Sekiya

发明人： Xi Wang ,  Inwoong Kim ,  Qiong Zhang ,  Paparao Palacharla ,  Motoyoshi Sekiya

IPC分类号： H04L12/26 ,  H04L12/28

CPC分类号： H04L43/0882

摘要： A system and method are provided for monitoring traffic in a network comprising a plurality of links, wherein each of the plurality of links comprises a plurality of neighboring pairs of slots. The system and method may include identifying a first usage status and a second usage status, calculating a utilization entropy value based at least on the difference between the first and second usage status, iteratively calculating a set of utilization entropy values for a portion of the network, and calculating an overall utilization entropy value for the portion of the network under analysis based at least on a statistical analysis of the set of utilization entropy values.

摘要翻译： 提供了一种用于监视包括多个链路的网络中的业务的系统和方法，其中所述多个链路中的每一个包括多个相邻的时隙对。 系统和方法可以包括识别第一使用状态和第二使用状态，至少基于第一和第二使用状态之间的差异来计算使用熵值，迭代地计算网络的一部分的一组利用熵值 以及至少基于所述利用熵值集合的统计分析来计算所分析的网络的部分的总利用熵值。

公开(公告)号：US08606846B2

公开(公告)日：2013-12-10

申请号：US11955463

申请日：2007-12-13

申请人： Joseph Czechowski, III ,  William David Smith, II ,  Xi Wang ,  Christopher Duane Carothers

发明人： Joseph Czechowski, III ,  William David Smith, II ,  Xi Wang ,  Christopher Duane Carothers

IPC分类号： G06F15/16

CPC分类号： H04L67/104 ,  H04L63/08 ,  H04L67/06 ,  H04L67/1002 ,  H04L67/1008 ,  H04L67/1012 ,  H04L67/1021 ,  H04L67/1023 ,  H04L67/1025 ,  H04L67/1031 ,  H04L67/1072 ,  H04L67/1076

摘要： The acceleration of peer-to-peer downloads of content files wherein a tracker performs a condition based peer selection that is dynamically adjustable. A further feature relates to the use of enhanced message scheme for communications. One embodiment is a system in a swarm having at least one origin seed capable of at least initially storing the content files with at least one tracker maintaining a list of peers wherein the tracker uses at least one dynamically adjusting peer selection algorithm to generate a condition based peer-list and provides the condition based peer-list to a requesting peer.

摘要翻译： 内容文件的对等下载的加速，其中跟踪器执行可动态调整的基于条件的对等选择。 另一个特征涉及使用增强的消息方案进行通信。 一个实施例是具有至少一个起始种子的群体中的系统，其能够至少初始地存储具有维护对等体列表的至少一个跟踪器的内容文件，其中跟踪器使用至少一个动态调整对等体选择算法来生成基于条件 对等体列表，并向请求对等体提供基于条件的对等体列表。

公开(公告)号：US08501593B2

公开(公告)日：2013-08-06

申请号：US13260757

申请日：2011-07-25

申请人： Miao Zhang ,  Bo Zhang ,  Zhongying Xue ,  Xi Wang

发明人： Miao Zhang ,  Bo Zhang ,  Zhongying Xue ,  Xi Wang

IPC分类号： H01L27/092

CPC分类号： C30B29/52 ,  C30B1/00 ,  H01L21/28518 ,  H01L29/165 ,  H01L29/456

摘要： The present invention discloses a method of NiSiGe epitaxial growth by introducing Al interlayer, comprising the deposition of an Al thin film on the surface of SiGe layer, subsequent deposition of a Ni layer on Al thin film and then the annealing process for the reaction between Ni layer and SiGe material of SiGe layer to form NiSiGe material. Due to the barrier effect of Al interlayer, NiSiGe layer features a single crystal structure, a flat interface with SiGe substrate and a thickness of up to 0.3 nm, significantly enhancing interface performance.

摘要翻译： 本发明公开了一种通过引入Al中间层的NiSiGe外延生长方法，包括在SiGe层的表面上沉积Al薄膜，随后在Al薄膜上沉积Ni层，然后在Ni之间进行退火处理 SiGe层的SiGe材料，形成NiSiGe材料。 由于Al中间层的阻挡效应，NiSiGe层具有单晶结构，与SiGe衬底的平坦界面，厚度可达0.3nm，显着提高了界面性能。