公开(公告)号：US20090030088A1

公开(公告)日：2009-01-29

申请号：US12148574

申请日：2008-04-21

申请人： Xi Wang ,  James C. Morris ,  Feng Chen ,  Thomas Beckham

发明人： Xi Wang ,  James C. Morris ,  Feng Chen ,  Thomas Beckham

IPC分类号： A61K31/11 ,  A61P31/00 ,  A61P35/00

CPC分类号： A61K31/11 ,  Y02A50/415

摘要： 6-methoxy gossypol and 6,6′-dimethoxy gossypol were isolated from cottonseeds. Bioactivities of these two gossypol derivatives and gossypol were investigated regarding their antioxidant activities, DNA damage prevention ability, anti-cancer, and anti-trypanosomal activities. Both methoxy compounds had nearly equivalent bioactivities, but gossypol showed greater bioactivities than either methoxy derivative on free radical scavenging activity, reducing power, and DNA damage prevention ability. Gossypol and its methoxy derivatives inhibited growth of three cancer cell lines, i.e., SiHa (cervical cancer), MCF-7 (breast cancer) and Caco-2 (colon cancer) cells, in a dose dependent manner. These three compounds also significantly inhibited growth of trypanosome T. brucei, the cause of African Sleeping Sickness, which affects thousands in western and central Africa.

摘要翻译： 从棉籽中分离出6-甲氧基棉酚和6,6'-二甲氧基棉酚。 研究了这两种棉酚衍生物和棉酚的抗氧化活性，DNA损伤预防能力，抗癌和抗锥虫活性的生物活性。 两种甲氧基化合物具有几乎相同的生物活性，但是棉酚显示出比甲氧基衍生物对自由基清除活性，降低功率和DNA损伤预防能力更大的生物活性。 棉酚及其甲氧基衍生物以剂量依赖性方式抑制三种癌细胞系（即SiHa（宫颈癌）），MCF-7（乳腺癌）和Caco-2（结肠癌）细胞）的生长。 这三种化合物也显着抑制了锥虫T.布鲁斯的生长，这是非洲睡眠病的原因，影响了西非和中非数千人。

公开(公告)号：US20130149723A1

公开(公告)日：2013-06-13

申请号：US13507238

申请日：2012-06-14

申请人： Xi Wang ,  Feng Chen

发明人： Xi Wang ,  Feng Chen

IPC分类号： C07K17/10 ,  G01N33/68

CPC分类号： C07K17/10 ,  G01N33/5097 ,  G01N33/56966 ,  G01N33/6803 ,  G01N2333/415 ,  G01N2333/43552 ,  G01N2430/10 ,  Y10T428/2982

摘要： An assay system is provided in which gossypol is used as a biological marker to detect evolved resistance of insects to Bt cotton. Detection of gossypol using a monoclonal antibody ELISA-based protocol enables at risk populations of insects to be evaluated for evolved resistance to Bt present in a genetically modified cotton.The specificity of the monoclonal antibody to gossypol also enables the production of nanoparticles having a conjugated monoclonal antibody which retains the ability to selectively bind gossypol. Accordingly, nanoparticles can be provided with additional target ligands, such as antibodies, so as to specifically attach to tumors or cancer cells thereby delivering the gossypol to the target cells.

摘要翻译： 提供了一种测定系统，其中使用棉酚作为生物标志物来检测昆虫对Bt棉的演变抗性。 使用单克隆抗体检测棉酚基于ELISA的方案可使危险的昆虫种群被评估为在转基因棉花中存在的Bt的进化抗性。 单克隆抗体对棉酚的特异性还能够生产具有共轭单克隆抗体的纳米颗粒，其保留选择性结合棉酚的能力。 因此，可以向纳米颗粒提供额外的靶配体，例如抗体，以便特异性地附着于肿瘤或癌细胞，从而将棉酚递送至靶细胞。

公开(公告)号：US20080241967A1

公开(公告)日：2008-10-02

申请号：US12069136

申请日：2008-02-06

申请人： Feng Chen ,  A. B. Bodine ,  Paul L. Dawson ,  Thomas R. Scott ,  Xi Wang

发明人： Feng Chen ,  A. B. Bodine ,  Paul L. Dawson ,  Thomas R. Scott ,  Xi Wang

IPC分类号： G01N33/536

CPC分类号： G01N33/54346

摘要： A radioimmunoassay method for determining the quantity of an analyte of interest in a sample is disclosed. The analyte of interest may be an antigen or other chemical entity. A known antibody to the antigen or other entity is employed and is conjugated to a functionalized nanoparticle. Because of the high surface area presented by the present nanoparticle—antibody conjugates, the present radioimmunoassay method is particularly suited for the qualitative and quantitative analysis of low molecular weight chemicals.

摘要翻译： 公开了一种用于确定样品中感兴趣分析物的量的放射免疫测定方法。 感兴趣的分析物可以是抗原或其他化学实体。 使用抗原或其他实体的已知抗体并与功能化的纳米颗粒缀合。 由于本发明纳米颗粒 - 抗体缀合物表现出高表面积，本发明的放射免疫测定方法特别适用于低分子量化学品的定性和定量分析。

公开(公告)号：US20090175885A1

公开(公告)日：2009-07-09

申请号：US12225940

申请日：2007-04-05

申请人： Xi Wang ,  Feng Chen

发明人： Xi Wang ,  Feng Chen

IPC分类号： A61K39/395 ,  G01N33/566 ,  A61P35/00

CPC分类号： C07K17/10 ,  G01N33/5097 ,  G01N33/56966 ,  G01N33/6803 ,  G01N2333/415 ,  G01N2333/43552 ,  G01N2430/10 ,  Y10T428/2982

摘要： An assay system is provided in which gossypol is used as a biological marker to detect evolved resistance of insects to Bt cotton. Detection of gossypol using a monoclonal antibody ELISA-based protocol enables at risk populations of insects to be evaluated for evolved resistance to Bt present in a genetically modified cotton.The specificity of the monoclonal antibody to gossypol also enables the production of nanoparticles having a conjugated monoclonal antibody which retains the ability to selectively bind gossypol. Accordingly, nanoparticles can be provided with additional target ligands, such as antibodies, so as to specifically attach to tumors or cancer cells thereby delivering the gossypol to the target cells.

摘要翻译： 提供了一种测定系统，其中使用棉酚作为生物标志物来检测昆虫对Bt棉的演变抗性。 使用单克隆抗体检测棉酚基于ELISA的方案可使危险的昆虫种群被评估为在转基因棉花中存在的Bt的进化抗性。 单克隆抗体对棉酚的特异性还能够生产具有共轭单克隆抗体的纳米颗粒，其保留选择性结合棉酚的能力。 因此，可以向纳米颗粒提供额外的靶配体，例如抗体，以便特异性地附着于肿瘤或癌细胞，从而将棉酚递送至靶细胞。

公开(公告)号：US20060099721A1

公开(公告)日：2006-05-11

申请号：US11244567

申请日：2005-10-06

申请人： Feng Chen ,  Ashby Bodine ,  Paul Dawson ,  Thomas Scott ,  Ya-Ping Sun ,  Xi Wang

发明人： Feng Chen ,  Ashby Bodine ,  Paul Dawson ,  Thomas Scott ,  Ya-Ping Sun ,  Xi Wang

IPC分类号： G01N33/551

CPC分类号： G01N33/54346

摘要： A radioimmunoassay method for determining the quantity of an analyte of interest in a sample is disclosed. The analyte of interest may be an antigen or other chemical entity. A known antibody to the antigen or other entity is employed and is conjugated to a functionalized nanoparticle. Because of the high surface area presented by the present nanoparticle-antibody conjugates, the present radioimmunoassay method is particularly suited for the qualitative and quantitative analysis of low molecular weight chemicals.

摘要翻译： 公开了一种用于确定样品中感兴趣分析物的量的放射免疫测定方法。 感兴趣的分析物可以是抗原或其他化学实体。 使用抗原或其他实体的已知抗体并与功能化的纳米颗粒缀合。 由于本发明纳米颗粒 - 抗体缀合物表现出高表面积，本发明的放射免疫测定方法特别适用于低分子量化学品的定性和定量分析。

公开(公告)号：USD998609S1

公开(公告)日：2023-09-12

申请号：US29887604

申请日：2023-03-22

申请人： Feng Chen

设计人： Feng Chen

摘要： FIG. 1 is a front, top perspective view of a switch portable dock showing my new design.
FIG. 2 is a front view thereof;
FIG. 3 is a rear view thereof;
FIG. 4 is a left side view thereof;
FIG. 5 is a right side view thereof;
FIG. 6 is a top view thereof;
FIG. 7 is a bottom view thereof;
FIG. 8 is a rear, bottom perspective view; and,
FIG. 9 is a front perspective view thereof, showing the switch portable dock in an open state of use.
The broken lines in the drawings depict portions of the switch portable dock that form no part of the claimed design.

公开(公告)号：US11265438B2

公开(公告)日：2022-03-01

申请号：US16978593

申请日：2018-04-26

申请人： Hewlett-Packard Development Company, L.P. ,  Da Peng Li ,  Zhi Wen Xing ,  Feng Chen

发明人： Da Peng Li ,  Zhi Wen Xing ,  Feng Chen

IPC分类号： H04N1/00 ,  H04N1/10 ,  G06F3/12

摘要： An example device includes a U-shaped body to be placed around a guide on which a scanner carriage is to be guided. A fixed leg of the U-shaped body is attached to a linearly translatable scanner carriage. A free leg of the U-shaped body is not attached to the scanner carriage and has inward facing ribs. The ribs on the free leg of the U-shaped body are positioned to come into contact with the guide to align the scanner carriage with the guide.

公开(公告)号：US10819535B2

公开(公告)日：2020-10-27

申请号：US16217556

申请日：2018-12-12

申请人： Feng Chen ,  Franz-Josef Götz ,  Marcel Kießling ,  An Ninh Nguyen ,  Jürgen Schmitt

发明人： Feng Chen ,  Franz-Josef Götz ,  Marcel Kießling ,  An Ninh Nguyen ,  Jürgen Schmitt

IPC分类号： G06F15/173 ,  H04L12/40 ,  H04L12/46 ,  H04L12/721 ,  H04L12/891 ,  H04L12/841 ,  H04L12/801 ,  H04L12/931

摘要： Methods and systems are provided for improved data packet transmission in a network bridge. Separate data packets received from a plurality of automation components are aggregated into a single data packet stream. The data packet stream is transmitted to another network node, for example, another network bridge.

公开(公告)号：US08934591B2

公开(公告)日：2015-01-13

申请号：US13727849

申请日：2012-12-27

申请人： Lianliang Tai ,  Guangren Li ,  Feng Chen

发明人： Lianliang Tai ,  Guangren Li ,  Feng Chen

IPC分类号： H04L7/00 ,  H04L7/033

CPC分类号： H04L7/0012 ,  H04L7/0338

摘要： The present invention provides a clock and data recovery circuit, including an n-phase clock, a sampling and edge detection unit, an edge determination unit, a clock picking unit and a data picking unit. The sampling and edge detection unit performs spaced sampling on the input serial data using the n-phase clock, and performs edge detection and resampling on the sampled data. The edge determination unit filters the resampled data by the counting units, and obtains the positions of the edges of the serial data according to the counting result of the counting units. The clock picking unit selects a clock from the n clocks that is the farthest away from the edges as the recovered clock. The data picking unit obtains the recovered data according to the recovered clock. The present invention also provides a parallel output circuit.

摘要翻译： 本发明提供一种包括n相时钟，采样和边缘检测单元，边缘确定单元，时钟采集单元和数据采集单元的时钟和数据恢复电路。 采样和边沿检测单元使用n相时钟对输入串行数据执行间隔采样，并对采样数据执行边沿检测和重采样。 边缘确定单元通过计数单元对重采样数据进行滤波，并根据计数单元的计数结果获得串行数据的边沿的位置。 时钟采集单元从距离边缘最远的n个时钟选择时钟作为恢复时钟。 数据采集​​单元根据恢复的时钟获得恢复的数据。 本发明还提供一种并行输出电路。

公开(公告)号：US20140006686A1

公开(公告)日：2014-01-02

申请号：US13992809

申请日：2011-12-30

申请人： Feng Chen ,  Michael P. Mesnier

发明人： Feng Chen ,  Michael P. Mesnier

IPC分类号： G06F3/06

CPC分类号： G06F3/0656 ,  G06F3/0611 ,  G06F3/0679 ,  G06F12/0238 ,  G06F12/0246 ,  G06F12/1009 ,  G06F12/14 ,  G06F12/1433 ,  G06F2212/7205

摘要： Storage class memory may be used in an architecture to achieve high performance, high reliability, high compatibility. In some embodiments, reads may be handled in a conventional way used in a memory based model. However writes do not use a memory based model but instead correspond to a storage based model. The hybrid nature can be achieved by setting the storage class memory to be write protected so that all writes must go through a software based block device interface. In some embodiments, the software based block device interface prevents erroneous writes to the storage class memory.

摘要翻译： 存储类内存可用于架构，以实现高性能，高可靠性，高兼容性。 在一些实施例中，读取可以以基于存储器的模型中使用的常规方式来处理。 但是，写入不使用基于内存的模型，而是对应于基于存储的模型。 可以通过将存储类存储器设置为写保护来实现混合性质，以便所有写操作都必须通过基于软件的块设备接口。 在一些实施例中，基于软件的块设备接口防止对存储类存储器的错误写入。