公开(公告)号：US20070156056A1

公开(公告)日：2007-07-05

申请号：US11686784

申请日：2007-03-15

申请人： Xiaoyi Min ,  Yougandh Chitre ,  Jeffery Snell ,  Gene Bornzin ,  Jong Kil

发明人： Xiaoyi Min ,  Yougandh Chitre ,  Jeffery Snell ,  Gene Bornzin ,  Jong Kil

IPC分类号： A61B5/04

CPC分类号： A61B5/0452 ,  A61B5/0456 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/7242 ,  A61N1/3627 ,  A61N1/3702

摘要： A technique is provided for detecting episodes of cardiac ischemia based on an examination of the total energy of T-waves. Since cardiac ischemia is often a precursor to acute myocardial infarction (AMI) or ventricular fibrillation (VF), the technique thereby provides a method for predicting the possible onset of AMI or VF. Briefly, the technique integrates internal electrical cardiac signals occurring during T-waves and then compares the result against a running average. If the result exceeds the average by some predetermined amount, ischemia is thereby detected and a warning signal is provided to the patient. The maximum slope of the T-wave is also exploited. Techniques are also set forth herein for reliably detecting T-waves, which help prevent P-waves from being misinterpreted as T-waves on unipolar sensing channels. The T-wave detection technique may be used in conjunction with ischemia detection or for other purposes.

摘要翻译： 提供了一种基于对T波总能量的检查来检测心脏缺血发作的技术。 由于心脏缺血通常是急性心肌梗死（AMI）或心室颤动（VF）的前兆，因此该技术提供了一种预测AMI或VF可能发病的方法。 简而言之，该技术集成了T波期间发生的内部电心脏信号，然后将结果与运行平均值进行比较。 如果结果超过平均预定量，则由此检测到缺血，并向患者提供警告信号。 T波的最大斜率也被利用。 本文还阐述了可靠地检测T波的技术，这有助于防止P波被单解为单极感测通道上的T波。 T波检测技术可以与缺血检测或其他目的结合使用。

公开(公告)号：US07218960B1

公开(公告)日：2007-05-15

申请号：US10606299

申请日：2003-06-24

申请人： Xiaoyi Min ,  Yougandh Chitre ,  Jeffery D. Snell ,  Gene A. Bornzin ,  Jong Kil

发明人： Xiaoyi Min ,  Yougandh Chitre ,  Jeffery D. Snell ,  Gene A. Bornzin ,  Jong Kil

IPC分类号： A61B5/0452

CPC分类号： A61B5/0452 ,  A61B5/0031 ,  A61B5/7242 ,  A61N1/3702

摘要： A technique is provided for detecting episodes of cardiac ischemia based on an examination of the total energy of T-waves. Since cardiac ischemia is often a precursor to acute myocardial infarction (AMI) or ventricular fibrillation (VF), the technique thereby provides a method for predicting the possible onset of AMI or VF. Briefly, the technique integrates internal electrical cardiac signals occurring during T-waves and then compares the result against a running average. If the result exceeds the average by some predetermined amount, ischemia is thereby detected and a warning signal is provided to the patient. The maximum slope of the T-wave is also exploited. Techniques are also set forth herein for reliably detecting T-waves, which help prevent P-waves from being misinterpreted as T-waves on unipolar sensing channels. The T-wave detection technique may be used in conjunction with ischemia detection or for other purposes.

摘要翻译： 提供了一种基于对T波总能量的检查来检测心脏缺血发作的技术。 由于心脏缺血通常是急性心肌梗死（AMI）或心室颤动（VF）的前兆，因此该技术提供了一种预测AMI或VF可能发病的方法。 简而言之，该技术集成了T波期间发生的内部电心脏信号，然后将结果与运行平均值进行比较。 如果结果超过平均预定量，则由此检测到缺血，并向患者提供警告信号。 T波的最大斜率也被利用。 本文还阐述了可靠地检测T波的技术，这有助于防止P波被单解为单极感测通道上的T波。 T波检测技术可以与缺血检测或其他目的结合使用。

公开(公告)号：US07643872B2

公开(公告)日：2010-01-05

申请号：US11686784

申请日：2007-03-15

申请人： Xiaoyi Min ,  Yougandh Chitre ,  Jeffery D. Snell ,  Gene A. Bornzin ,  Jong Kil

发明人： Xiaoyi Min ,  Yougandh Chitre ,  Jeffery D. Snell ,  Gene A. Bornzin ,  Jong Kil

IPC分类号： A61B5/0452 ,  A61N1/36

CPC分类号： A61B5/0452 ,  A61B5/0456 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/7242 ,  A61N1/3627 ,  A61N1/3702

摘要： A technique is provided for detecting episodes of cardiac ischemia based on an examination of the total energy of T-waves. Since cardiac ischemia is often a precursor to acute myocardial infarction (AMI) or ventricular fibrillation (VF), the technique thereby provides a method for predicting the possible onset of AMI or VF. Briefly, the technique integrates internal electrical cardiac signals occurring during T-waves and then compares the result against a running average. If the result exceeds the average by some predetermined amount, ischemia is thereby detected and a warning signal is provided to the patient. The maximum slope of the T-wave is also exploited. Techniques are also set forth herein for reliably detecting T-waves, which help prevent P-waves from being misinterpreted as T-waves on unipolar sensing channels. The T-wave detection technique may be used in conjunction with ischemia detection or for other purposes.

摘要翻译： 提供了一种基于对T波总能量的检查来检测心脏缺血发作的技术。 由于心脏缺血通常是急性心肌梗死（AMI）或心室颤动（VF）的前兆，因此该技术提供了一种预测AMI或VF可能发作的方法。 简而言之，该技术集成了T波期间发生的内部电心脏信号，然后将结果与运行平均值进行比较。 如果结果超过平均预定量，则由此检测到缺血，并向患者提供警告信号。 T波的最大斜率也被利用。 本文还阐述了可靠地检测T波的技术，这有助于防止P波被单解为单极感测通道上的T波。 T波检测技术可以与缺血检测或其他目的结合使用。

公开(公告)号：US07225015B1

公开(公告)日：2007-05-29

申请号：US10603398

申请日：2003-06-24

申请人： Xiaoyi Min ,  Yougandh Chitre ,  Jeffery D. Snell ,  Gene A. Bornzin ,  Jong Kil

发明人： Xiaoyi Min ,  Yougandh Chitre ,  Jeffery D. Snell ,  Gene A. Bornzin ,  Jong Kil

IPC分类号： A61B5/0468

CPC分类号： A61B5/0452 ,  A61B5/0456 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/7242 ,  A61N1/3627 ,  A61N1/3702

摘要： A technique is provided for detecting episodes of cardiac ischemia based on an examination of the total energy of T-waves. Since cardiac ischemia is often a precursor to acute myocardial infarction (AMI) or ventricular fibrillation (VF), the technique thereby provides a method for predicting the possible onset of AMI or VF. Briefly, the technique integrates internal electrical cardiac signals occurring during T-waves and then compares the result against a running average. If the result exceeds the average by some predetermined amount, ischemia is thereby detected and a warning signal is provided to the patient. The maximum slope of the T-wave is also exploited. Techniques are also set forth herein for reliably detecting T-waves, which help prevent P-waves from being misinterpreted as T-waves on unipolar sensing channels. The T-wave detection technique may be used in conjunction with ischemia detection or for other purposes.

公开(公告)号：US20050080471A1

公开(公告)日：2005-04-14

申请号：US10652996

申请日：2003-08-28

申请人： Yougandh Chitre ,  Gene Bornzin ,  Sheldon Williams

发明人： Yougandh Chitre ,  Gene Bornzin ,  Sheldon Williams

IPC分类号： A61N1/05

CPC分类号： A61N1/056

摘要： An implantable cardiac stimulation lead system for use with a stimulation device includes a lead body preferably having an outer diameter of less than 4 French and formed of a biocompatible material having a Young's modulus of at least 20,000 pounds per square inch. In the lead body, an inner insulator is composed of a suitable polymer such as PTFE or ETFE with an outer peripheral surface formed with a helical groove containing a conductor extending between a proximal connector and a distal tip electrode, and an outer insulator composed of polyurethane or silicone rubber or a combination thereof is positioned around the inner insulator. The lead system may be formed with a lumen for receiving a guidewire longitudinally through the lead body. A pair of insulated conductors may be received in the helical groove, one extending to the distal tip electrode, the other extending to a ring electrode proximally spaced from the distal tip electrode.

摘要翻译： 用于刺激装置的可植入心脏刺激引导系统包括优选具有小于4 French的外径的引线体，并且由具有至少20,000磅/平方英寸的杨氏模量的生物相容性材料形成。 在引线体中，内绝缘体由诸如PTFE或ETFE的合适的聚合物构成，外周表面形成有包含在近端连接器和远端末端电极之间延伸的导体的螺旋槽，以及由聚氨酯 或硅橡胶或其组合位于内绝缘体周围。 引导系统可以形成有用于纵向地通过引线主体接收导丝的内腔。 一对绝缘导体可以容纳在螺旋槽中，一个延伸到远端尖端电极，另一对延伸到与远侧末端电极间隔开的环状电极。

公开(公告)号：US07925343B1

公开(公告)日：2011-04-12

申请号：US11539576

申请日：2006-10-06

申请人： Xiaoyi Min ,  Scott Salys ,  Yougandh Chitre ,  Eric Falkenberg ,  Gene A. Bornzin

发明人： Xiaoyi Min ,  Scott Salys ,  Yougandh Chitre ,  Eric Falkenberg ,  Gene A. Bornzin

IPC分类号： A61N1/39

CPC分类号： A61N1/3956 ,  A61B5/04014 ,  A61B5/046 ,  A61B5/7203 ,  A61N1/0563 ,  A61N1/37288

摘要： A subcutaneous implantable cardiac device system applies defibrillation currents in pathways aligned with the heart's own electrical system to decrease defibrillation thresholds. In one implementation, one or more subcutaneous sensors detect ventricular fibrillation. Positioning of subcutaneous sensors and filtering result in improved sensing with reduced noise. A subcutaneous patch component of the system that is in communication with a subcutaneous pacemaker or cardioverter-defibrillator may perform the sensing and apply the defibrillation. The subcutaneous patch may include one or more electrodes that perform both sensing and defibrillation. Variations of the subcutaneous patch may include battery and capacitor for generating onboard defibrillation current and may also include a microprocessor for advanced programmable operation.

摘要翻译： 皮下植入式心脏装置系统在与心脏自身的电气系统对准的途径中应用除颤电流以降低除颤阈值。 在一个实施方案中，一个或多个皮下传感器检测心室颤动。 皮下传感器的定位和过滤导致改进的感测，噪音降低。 与皮下起搏器或心律转复除颤器连通的系统的皮下补片部件可以执行感测并施加除颤。 皮下补片可以包括执行感测和除颤的一个或多个电极。 皮下贴片的变化可以包括用于产生板上除颤电流的电池和电容器，并且还可以包括用于高级可编程操作的微处理器。

公开(公告)号：US20080215127A1

公开(公告)日：2008-09-04

申请号：US12122458

申请日：2008-05-16

申请人： Yougandh Chitre ,  Xiaoyi Min ,  Gene A. Bornzin

发明人： Yougandh Chitre ,  Xiaoyi Min ,  Gene A. Bornzin

IPC分类号： A61N1/05

CPC分类号： A61N1/056 ,  A61N1/0573

摘要： A bipolar pacing and sensing lead incorporates a range of active surface areas for each of the anode and cathode electrodes, and a range of inter-electrode spacings between the anode and cathode electrodes which, in combination, provide acceptable near-field signal amplitudes and attenuate the amplitudes of unwanted signals, such as far-field R-waves, far-field P-waves, and T-waves.

摘要翻译： 双极起搏和感测引线包括用于阳极和阴极电极中的每一个的一系列活性表面积，以及阳极和阴极电极之间的一系列电极间间隔，其组合提供可接受的近场信号幅度并衰减 不想要的信号的幅度，例如远场R波，远场P波和T波。

公开(公告)号：US07383091B1

公开(公告)日：2008-06-03

申请号：US10656649

申请日：2003-09-04

申请人： Yougandh Chitre ,  Xiaoyi Min ,  Gene A. Bornzin

发明人： Yougandh Chitre ,  Xiaoyi Min ,  Gene A. Bornzin

IPC分类号： A61N1/05

CPC分类号： A61N1/056 ,  A61N1/0573

摘要： A bipolar pacing and sensing lead incorporates a range of active surface areas for each of the anode and cathode electrodes, and a range of inter-electrode spacings between the anode and cathode electrodes which, in combination, provide acceptable near-field signal amplitudes and attenuate the amplitudes of unwanted signals, such as far-field R-waves, far-field P-waves, and T-waves.

摘要翻译： 双极起搏和感测引线包括用于阳极和阴极电极中的每一个的一系列活性表面积，以及阳极和阴极电极之间的一系列电极间间隔，其组合提供可接受的近场信号幅度并衰减 不想要的信号的幅度，例如远场R波，远场P波和T波。

公开(公告)号：US08965482B2

公开(公告)日：2015-02-24

申请号：US12895403

申请日：2010-09-30

申请人： James R. Thacker ,  Jon Parker ,  Yougandh Chitre

发明人： James R. Thacker ,  Jon Parker ,  Yougandh Chitre

IPC分类号： A61B5/06 ,  A61N1/36 ,  A61B19/00 ,  A61B5/00 ,  A61N1/372

CPC分类号： A61B5/065 ,  A61B5/063 ,  A61B5/066 ,  A61B5/407 ,  A61B34/20 ,  A61B90/06 ,  A61B2034/2051 ,  A61B2034/2072 ,  A61B2090/062 ,  A61B2560/045 ,  A61N1/36071 ,  A61N1/36128 ,  A61N1/36185 ,  A61N1/37217 ,  A61N1/37241

摘要： Systems and methods for positioning implanted devices in a patient are disclosed. A method in accordance with a particular embodiment includes, for each of a plurality of patients, receiving a target location from which to deliver a modulation signal to the patient's spinal cord. The method further includes implanting a signal delivery device within a vertebral foramen of each patient, and positioning an electrical contact carried by the signal delivery device to be within ±5 mm. of the target location, without the use of fluoroscopy. The method can still further include, for each of the plurality of patients, activating the electrical contact to modulate neural activity at the spinal cord. In further particular embodiments, RF signals, ultrasound, magnetic fields, and/or other techniques are used to locate the signal delivery device.

摘要翻译： 公开了将植入装置定位在患者体内的系统和方法。 根据特定实施例的方法包括对于多个患者中的每一个，接收目​​标位置，从所述目标位置向所述患者的脊髓传送调制信号。 该方法还包括将信号传送装置植入每个患者的椎骨孔内，并将由信号传送装置承载的电接触定位在±5mm以内。 的目标位置，无需使用荧光透视。 该方法还可以包括对于多个患者中的每一个，激活电接触以调节脊髓的神经活动。 在另外的特定实施例中，使用RF信号，超声波，磁场和/或其它技术来定位信号传递装置。

公开(公告)号：US08428748B2

公开(公告)日：2013-04-23

申请号：US13447050

申请日：2012-04-13

申请人： Konstantinos Alataris ,  Andre B. Walker ,  Jon Parker ,  Yougandh Chitre ,  Sangsoo Wesley Park ,  James R. Thacker

发明人： Konstantinos Alataris ,  Andre B. Walker ,  Jon Parker ,  Yougandh Chitre ,  Sangsoo Wesley Park ,  James R. Thacker

IPC分类号： A61N1/18

CPC分类号： A61N1/36071 ,  A61N1/0551 ,  A61N1/0553 ,  A61N1/06 ,  A61N1/36021 ,  A61N1/3605 ,  A61N1/36157 ,  A61N1/36164 ,  A61N1/36167 ,  A61N1/36171 ,  A61N1/36175 ,  A61N1/36182 ,  A61N1/37235 ,  A61N1/37241 ,  A61N1/37247 ,  A61N1/37264 ,  A61N1/3787

摘要： Selective high-frequency spinal chord modulation for inhibiting pain with reduced side affects and associated systems and methods are disclosed. In particular embodiments, high-frequency modulation in the range of from about 1.5 KHz to about 50 KHz may be applied to the patient's spinal chord region to address low back pain without creating unwanted sensory and/or motor side affects. In other embodiments, modulation in accordance with similar parameters can be applied to other spinal or peripheral locations to address other indications.

摘要翻译： 公开了选择性高频脊髓调制，用于抑制疼痛，减少副作用和相关系统和方法。 在特定实施例中，可以将大约1.5KHz至大约50KHz范围内的高频调制施加到患者的脊弦区域以解决腰背痛而不产生不想要的感觉和/或运动副作用。 在其他实施例中，根据类似参数的调制可以应用于其他脊柱或周边位置以解决其他指示。