Heart sounds-based pacing optimization
    2.
    发明授权
    Heart sounds-based pacing optimization 有权
    基于心音的起搏优化

    公开(公告)号:US08617082B2

    公开(公告)日:2013-12-31

    申请号:US13111260

    申请日:2011-05-19

    IPC分类号: A61B5/02

    摘要: An implantable medical device receives both heart sound and electrogram signals. A processor within the implantable medical device extracts physiologically relevant information from both the heart sound signal and the electrogram signal. Based on the extracted physiologically relevant information a set of pacing parameters is evaluated. In certain examples, the values of the pacing parameters may be changed by the implantable medical device in response to the physiologically relevant information extracted from the heart sound signal and the electrogram signal.

    摘要翻译: 可植入医疗设备接收心音和电描记信号。 可植入医疗装置内的处理器从心音信号和电描记图信号中提取生理相关信息。 基于提取的生理相关信息,评估一组起搏参数。 在某些示例中,响应于从心脏声音信号和电描记图信号提取的生理学相关信息,可由可植入医疗装置改变起搏参数的值。

    Apparatus and method for selecting a preferred pacing vector in a cardiac resynchronization device
    3.
    发明授权
    Apparatus and method for selecting a preferred pacing vector in a cardiac resynchronization device 有权
    用于在心脏再同步装置中选择优选起搏载体的装置和方法

    公开(公告)号:US09199087B2

    公开(公告)日:2015-12-01

    申请号:US13301043

    申请日:2011-11-21

    IPC分类号: A61N1/368

    CPC分类号: A61N1/3684 A61N1/3686

    摘要: A medical device and associated method control the delivery of a cardiac pacing therapy including selecting left ventricular pacing sites for delivering the therapy. The left ventricular pacing sites are selected by delivering pacing pulses to a patient's left ventricle at multiple pacing sites one at a time and determining right ventricular activation times in response to the pacing pulses being delivered at each of the pacing sites. A left ventricular pacing site is selected in response to the determined right ventricular activation times.

    摘要翻译: 医疗设备和相关方法控制心脏起搏疗法的递送,包括选择用于递送治疗的左心室起搏部位。 通过在多个起搏部位一次一个地向患者的左心室递送起搏脉冲来选择左心室起搏部位,并且响应于在每个起搏部位递送的起搏脉冲来确定右心室激活时间。 响应于确定的右心室激活时间来选择左心室起搏部位。

    Method and apparatus to deliver mechanically fused pacing therapy
    4.
    发明授权
    Method and apparatus to deliver mechanically fused pacing therapy 有权
    递送机械融合起搏治疗的方法和装置

    公开(公告)号:US07930027B2

    公开(公告)日:2011-04-19

    申请号:US11742085

    申请日:2007-04-30

    IPC分类号: A61N1/365

    摘要: A medical device system and method for delivering mechanically fused left ventricular cardiac stimulation. A sensor monitors left ventricular acceleration while left ventricular cardiac stimulation is provided at an AV interval. The left ventricular acceleration is used to calculate a mechanical response interval and the mechanical response interval is compared to a desired mechanical response interval. The AV interval is adjusted until the mechanical response interval is equal to the desired mechanical response interval.

    摘要翻译: 用于输送机械融合的左心室心脏刺激的医疗装置系统和方法。 传感器监测左心室加速度,而AV间期提供左心室心脏刺激。 使用左心室加速度来计算机械响应间隔,并将机械响应间隔与期望的机械响应间隔进行比较。 调整AV间隔直到机械响应间隔等于所需的机械响应间隔。

    DETECTING ELECTRICAL CONDUCTION ABNORMALITIES IN A HEART
    5.
    发明申请
    DETECTING ELECTRICAL CONDUCTION ABNORMALITIES IN A HEART 有权
    检测心脏电导率异常

    公开(公告)号:US20100286541A1

    公开(公告)日:2010-11-11

    申请号:US12463470

    申请日:2009-05-11

    IPC分类号: A61B5/0452

    摘要: Techniques are described for detecting conduction abnormalities in a heart of a patient. In particular, an IMD may be configured to obtain electrical signals corresponding to cardiac activity of the heart of the patient and periodically analyze a most recent electrical signal of the obtained electrical signals to detect an electrical conduction abnormality of the heart. The IMD adjusts a frequency at which the most recent electrical signal is analyzed based on at least one physiological parameter of the patient. For example, the IMD may increase the frequency at which the most recent electrical signal is analyzed when a heart rate parameter has significantly changed and the number of detected premature ventricular contractions (PVCs) is greater than or equal to a threshold number. In this manner, the most recent electrical signal is analyzed at a higher frequency in situations in which conduction abnormalities are more likely.

    摘要翻译: 描述了用于检测患者心脏中的传导异常的技术。 特别地,可以将IMD配置为获得对应于患者心脏的心脏活动的电信号,并且周期性地分析所获得的电信号的最新电信号以检测心脏的电传导异常。 IMD基于患者的至少一个生理参数来调整分析最近的电信号的频率。 例如,当心率参数已经显着改变并且检测到的早产性心室收缩(PVC)的数量大于或等于阈值数量时,IMD可以增加最近的电信号被分析的频率。 以这种方式,在导电异常更可能的情况下,以更高的频率分析最新的电信号。

    APPARATUS AND METHODS OF OPTIMIZING ATRIOVENTRICULAR PACING DELAY INTERVALS
    6.
    发明申请
    APPARATUS AND METHODS OF OPTIMIZING ATRIOVENTRICULAR PACING DELAY INTERVALS 有权
    优化ATRIOVENTRICULAR PACING DELAY INTERVALS的装置和方法

    公开(公告)号:US20110190841A1

    公开(公告)日:2011-08-04

    申请号:US13084244

    申请日:2011-04-11

    IPC分类号: A61N1/365

    摘要: Provided herewith are methods and apparatus for optimizing an atrioventricular (AV) pacing delay interval based upon ECG-based optimization is calculated as a linear function of P-wave duration, sensed PR (intrinsic) interval, sensed or paced QRS duration and heart rate. Since the relationship among these parameters is linear, once the coefficients are solved (which can be any value, including null) with reference to a known optimized AV interval (AVopt) such as from an echocardiographic study, an AVopt value can be dynamically adjusted in an ambulatory subject. The various combinations of values can be loaded into a look up table or calculated automatically. And, since some of the parameters do not typically change much over time they can be determined acutely and fed into the equation while the other values can be measured frequently. The parameter values can be measured by an implantable medical device such as a dual- or triple-chamber pacemaker.

    摘要翻译: 提供了用于优化基于ECG的优化的房室(AV)起搏延迟间隔的方法和装置,其被计算为P波持续时间,感测的PR(固有)间隔,感测或节奏QRS持续时间和心率的线性函数。 由于这些参数之间的关系是线性的,所以参考已知的优化AV间隔(AVopt)(例如来自超声心动图研究),一旦系数被解决(其可以是包括空值的任何值)可以动态调整AVopt值 一个流动的主题。 值的各种组合可以加载到查找表中或自动计算。 并且,由于一些参数通常不会随着时间而变化很大,因此它们可以被急剧地确定并且被馈送到方程式中,而可以频繁地测量其它值。 参数值可以通过诸如双室或三室起搏器的可植入医疗装置来测量。

    APPARATUS AND METHODS FOR AUTOMATIC ADJUSTMENT OF AV INTERVAL TO ENSURE DELIVERY OF CARDIAC RESYNCHRONIZATION THERAPY
    7.
    发明申请
    APPARATUS AND METHODS FOR AUTOMATIC ADJUSTMENT OF AV INTERVAL TO ENSURE DELIVERY OF CARDIAC RESYNCHRONIZATION THERAPY 有权
    用于自动调整AV间隔以确保进行心脏再生治疗的装置和方法

    公开(公告)号:US20100016914A1

    公开(公告)日:2010-01-21

    申请号:US12505925

    申请日:2009-07-20

    IPC分类号: A61N1/365 A61N1/08

    摘要: The disclosure provides methods and apparatus of left ventricular pacing including automated adjustment of a atrio-ventricular (AV) pacing delay interval and intrinsic AV nodal conduction testing. It includes—upon expiration or reset of a programmable AV Evaluation Interval (AVEI)—performing the following: temporarily increasing a paced AV interval and a sensed AV interval and testing for adequate AV conduction and measuring an intrinsic atrio-ventricular (PR) interval for a right ventricular (RV) chamber. Thus, in the event that the AV conduction test reveals a physiologically acceptable intrinsic PR interval then storing the physiologically acceptable PR interval in a memory structure (e.g., a median P-R from one or more cardiac cycles). In the event that the AV conduction test reveals an AV conduction block condition or if unacceptably long PR intervals are revealed then a pacing mode-switch to a bi-ventricular (Bi-V) pacing mode occurs and the magnitude of the AVEI is increased.

    摘要翻译: 本公开提供了左心室起搏的方法和装置,包括自动调节心房(AV)起搏延迟间隔和内部AV节点传导测试。 它包括 - 可编程AV评估间隔(AVEI)的到期或复位 - 执行以下操作:临时增加节奏的AV间隔和感测到的AV间隔,并测试足够的AV传导并测量内在的心房(PR)间隔 右心室(RV)室。 因此,在AV传导测试揭示生理上可接受的固有PR间隔的情况下,然后将生理上可接受的PR间期存储在存储器结构中(例如,来自一个或多个心动周期的中值P-R)。 在AV传导测试显示AV传导阻滞状态或者如果不能接受的长PR间隔被揭示的情况下,则起搏模式切换到双心室(Bi-V)起搏模式并且增加AVEI的幅度。

    Method and Apparatus to Deliver Mechanically Fused Pacing Therapy
    8.
    发明申请
    Method and Apparatus to Deliver Mechanically Fused Pacing Therapy 有权
    提供机械融合起搏治疗的方法和装置

    公开(公告)号:US20080269816A1

    公开(公告)日:2008-10-30

    申请号:US11742085

    申请日:2007-04-30

    IPC分类号: A61N1/362

    摘要: A medical device system and method for delivering mechanically fused left ventricular cardiac stimulation. A sensor monitors left ventricular acceleration while left ventricular cardiac stimulation is provided at an AV interval. The left ventricular acceleration is used to calculate a mechanical response interval and the mechanical response interval is compared to a desired mechanical response interval. The AV interval is adjusted until the mechanical response interval is equal to the desired mechanical response interval.

    摘要翻译: 用于输送机械融合的左心室心脏刺激的医疗装置系统和方法。 传感器监测左心室加速度,而AV间期提供左心室心脏刺激。 使用左心室加速度来计算机械响应间隔,并将机械响应间隔与期望的机械响应间隔进行比较。 调整AV间隔直到机械响应间隔等于所需的机械响应间隔。

    Method and apparatus to deliver mechanically fused pacing therapy
    9.
    发明授权
    Method and apparatus to deliver mechanically fused pacing therapy 有权
    递送机械融合起搏治疗的方法和装置

    公开(公告)号:US09272147B2

    公开(公告)日:2016-03-01

    申请号:US13088581

    申请日:2011-04-18

    摘要: A medical device system and method for delivering mechanically fused left ventricular cardiac stimulation. A sensor monitors left ventricular acceleration while left ventricular cardiac stimulation is provided at an AV interval. The left ventricular acceleration is used to calculate a mechanical response interval and the mechanical response interval is compared to a desired mechanical response interval. The AV interval is adjusted until the mechanical response interval is equal to the desired mechanical response interval.

    摘要翻译: 用于输送机械融合的左心室心脏刺激的医疗装置系统和方法。 传感器监测左心室加速度,而AV间期提供左心室心脏刺激。 使用左心室加速度来计算机械响应间隔,并将机械响应间隔与期望的机械响应间隔进行比较。 调整AV间隔直到机械响应间隔等于所需的机械响应间隔。

    Method and apparatus for adaptive cardiac resynchronization therapy employing a multipolar left ventricular lead
    10.
    发明授权
    Method and apparatus for adaptive cardiac resynchronization therapy employing a multipolar left ventricular lead 有权
    使用多极左心室导联的自适应心脏再同步治疗的方法和装置

    公开(公告)号:US08639333B2

    公开(公告)日:2014-01-28

    申请号:US13301012

    申请日:2011-11-21

    IPC分类号: A61N1/365

    摘要: A medical device and associated method control the delivery of a cardiac pacing therapy by selecting first and second pacing sites along a first ventricle of a patient's heart and delivering the pacing therapy by pacing the first ventricle using the first pacing site during the periods of a first ventricular pacing mode and using the second pacing site during periods of a second ventricular pacing mode. In one embodiment, the device determines activation times at multiple sites along a ventricle in response to pacing pulses being delivered to the opposite ventricle. A first pacing site is selected in response to the activation time determination. The device delivers the pacing therapy by pacing the first ventricle using the first pacing site during periods of the first ventricular pacing mode.

    摘要翻译: 医疗装置和相关联的方法通过沿着患者心脏的第一脑室选择第一和第二起搏部位来控制心脏起搏治疗的递送,并且通过在第一时间段期间使用第一起搏部位起搏第一心室来递送起搏治疗 心室起搏模式,并且在第二心室起搏模式期间使用第二起搏部位。 在一个实施例中,该装置响应于递送到相对心室的起搏脉冲,沿着心室确定多个部位的激活时间。 响应于激活时间确定选择第一起搏站点。 该装置通过在第一次心室起搏模式期间使用第一起搏部位起搏第一脑室来进行起搏治疗。