利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

26 条记录 (耗时 0.039 秒)

    Parallel polymorphism scoring by amplification and error correction
    2.
    发明申请
    Parallel polymorphism scoring by amplification and error correction 审中-公开
    平行多态性通过放大和纠错得分

    公开(公告)号：US20070009954A1

    公开(公告)日：2007-01-11

    申请号：US11521754

    申请日：2006-09-15

    申请人： Yan Wang ,  Michael Finney ,  Fan Chen

    发明人： Yan Wang ,  Michael Finney ,  Fan Chen

    IPC分类号： C12Q1/68 ,  C12P19/34 ,  C07H21/04

    CPC分类号： C12Q1/6858 ,  C07K2319/80 ,  C12Q1/6823 ,  C12Q1/6869 ,  C12Q2535/125 ,  C12Q2521/319 ,  C12Q2521/101 ,  C12Q2565/537

    摘要： This invention provides a method of detecting polymorphisms, e.g., single nucleotide polymorphisms (SNPs), by amplification and error correction. The invention encompasses methods of performing amplification and error correction using an improved generation of nucleic acid polymerases, and methods of multiplexing the assay. The improvement to the polymerases is the joining of a sequence-non-specific nucleic-acid-binding domain to the enzyme in a manner that enhances the ability of the enzyme to bind and catalytically modify the nucleic acid.

    摘要翻译： 本发明提供了通过扩增和错误校正来检测多态性（例如单核苷酸多态性（SNP））的方法。 本发明包括使用改进的核酸聚合酶的产生来进行扩增和纠错的方法，以及多重测定的方法。 对聚合酶的改进是以提高酶结合和催化修饰核酸的能力的方式连接序列非特异性核酸结合结构域与酶。

    System and methods for improved linguistic pattern matching
    4.
    发明授权
    System and methods for improved linguistic pattern matching 有权
    改进语言模式匹配的系统和方法

    公开(公告)号：US07328211B2

    公开(公告)日：2008-02-05

    申请号：US09957465

    申请日：2001-09-21

    申请人： Ty Bordner ,  Derrick Cobey ,  Michael Finney

    发明人： Ty Bordner ,  Derrick Cobey ,  Michael Finney

    IPC分类号： G06F17/30

    CPC分类号： G06F17/277 ,  Y10S707/99936

    摘要： A system and method for reducing the number of false negatives with minimal impact on false positive search results while allowing searches to return phonetic equivalents, misspellings, common short names, and other such applicable information. New, N-Gram based indexing and search systems and methods facilitate searching of data containing non-Arabic letters, such as numbers, symbols, and foreign language characters. Ability to customize indexing and other features further enhance search results. Linguistic pattern matching search results are improved based on dynamically modified search attributes.

    摘要翻译： 一种用于减少假阴性数量的系统和方法，对假阳性搜索结果的影响最小，同时允许搜索返回语音等效物，拼写错误，常用短名称和其他此类适用信息。 新的基于N-gram的索引和搜索系统和方法便于搜索包含非阿拉伯字母的数据，例如数字，符号和外语字符。 能够自定义索引和其他功能进一步增强搜索结果。 基于动态修改的搜索属性，语言模式匹配搜索结果得到改进。

    Annuloplasty device having a helical anchor and methods for its use
    5.
    发明授权
    Annuloplasty device having a helical anchor and methods for its use 有权
    具有螺旋锚的瓣膜成形术装置及其使用方法

    公开(公告)号：US08454683B2

    公开(公告)日：2013-06-04

    申请号：US11734536

    申请日：2007-04-12

    申请人： Nasser Rafiee ,  Nareak Douk ,  Eliot Bloom ,  Michael Finney ,  Morgan House ,  Rany Huynh ,  Stuart Mac Donald ,  Juan-Pablo Mas ,  David Barone

    发明人： Nasser Rafiee ,  Nareak Douk ,  Eliot Bloom ,  Michael Finney ,  Morgan House ,  Rany Huynh ,  Stuart Mac Donald ,  Juan-Pablo Mas ,  David Barone

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2451 ,  A61F2/2466

    摘要： A system for modifying a heart valve annulus includes a helically helical anchored annuloplasty device delivered to the annulus via an elongated delivery member. The helical anchors of the devices disclosed herein are rotated into the valve annulus along an anchor guide by using a driver that is movably disposed in the delivery member. A tether is disposed within an inner channel of the helical anchor and a locking device is used to secure the annuloplasty device after the valve annulus has been modified. The annuloplasty device can be delivered to the annulus using, traditional surgical approach or a minimally invasive or catheter based methods.

    摘要翻译： 用于修改心脏瓣膜环的系统包括经由细长递送构件递送至环带的螺旋状螺旋锚定瓣环成形术装置。 本文公开的装置的螺旋锚通过使用可移动地设置在输送构件中的驱动器沿着锚定引导件旋转到阀环中。 系绳设置在螺旋锚固件的内部通道内，并且锁定装置用于在瓣膜环已被修改之后固定瓣环成形术装置。 瓣膜成形术装置可以使用传统的手术方法或基于微创或基于导管的方法递送至环带。

    Multifunctional Electrophoresis Cassette
    7.
    发明申请
    Multifunctional Electrophoresis Cassette 审中-公开
    多功能电泳盒

    公开(公告)号：US20070284250A1

    公开(公告)日：2007-12-13

    申请号：US11685634

    申请日：2007-03-13

    申请人： Gary Magnant ,  Michael Finney ,  Todd Barbera ,  William Bowers ,  Diane Kozwich ,  Samuel Seymour ,  Robert Nelson ,  T. Boles

    发明人： Gary Magnant ,  Michael Finney ,  Todd Barbera ,  William Bowers ,  Diane Kozwich ,  Samuel Seymour ,  Robert Nelson ,  T. Boles

    IPC分类号： C07K1/26 ,  C07K1/28 ,  C25B9/08

    CPC分类号： G01N27/44739 ,  G01N27/44795

    摘要： Devices and methods are provided for more efficiently performing electrophoresis and electroblotting. A sandwich structure includes an electrophoresis gel affixed to a blotting membrane. A gel casting and/or running frame is used to hold the sandwich. A method and composition that allows separation of the gel and membrane after performing a combined electrophoresis and electroblotting operation so as to allow further operations to be performed individually upon the membrane, gel or both. A uniform electrophoretic field may be created by surrounding the sandwich structure using an insulating fluid; the insulating fluid is then swapped for a conducting fluid to allow application of an electroblotting field. An apparatus automatically manages fluid exchange and actuation of electrophoresis and electroblotting electrodes. A plurality of parallel cavities may be used to hold multiple gels or gel membrane sandwiches.

    摘要翻译： 提供了更有效地进行电泳和电印迹的装置和方法。 夹心结构包括贴在印迹膜上的电泳凝胶。 凝胶浇注和/或运行框架用于夹持夹心物。 在进行组合电泳和电印迹操作之后允许分离凝胶和膜的方法和组合物，以允许在膜，凝胶或两者上分别进行进一步的操作。 可以通过使用绝缘流体围绕夹层结构来产生均匀的电泳场; 然后将绝缘流体交换用于导电流体以允许施加电印迹场。 一种装置自动地管理电泳和电印迹电极的流体交换和致动。 可以使用多个平行的空腔来容纳多个凝胶或凝胶膜三明治。

    Device for Treating Mitral Valve Regurgitation
    9.
    发明申请
    Device for Treating Mitral Valve Regurgitation 审中-公开
    二尖瓣反流治疗装置

    公开(公告)号：US20070078297A1

    公开(公告)日：2007-04-05

    申请号：US11468604

    申请日：2006-08-30

    申请人： Nasser Rafiee ,  Eliot Bloom ,  Raymond Godaire ,  Michael Finney

    发明人： Nasser Rafiee ,  Eliot Bloom ,  Raymond Godaire ,  Michael Finney

    IPC分类号： A61F2/00 ,  A61F2/24

    CPC分类号： A61F2/2487 ,  A61B17/00234 ,  A61B17/0401 ,  A61B17/0482 ,  A61B2017/00243 ,  A61B2017/00867 ,  A61B2017/0443 ,  A61B2017/06052

    摘要： A system for treating mitral valve regurgitation comprises tensioning device that can be deployed using a delivery catheter. The device includes tension member linking a proximal anchor and distal anchor. The device is constructed from a material having suitable elastic properties such that the device applies a constant tension force between the anchors, while stretching or flexing in response to a heartbeat when positioned across a chamber of a heart. The anchors may include a plurality of arms. In some embodiments, the arms may also flex in response to a heart beat. When positioned across the left ventricle of a heart, the device can reduce the lateral distance between the walls of the ventricle and thus allow better coaption of the mitral valve leaflets thereby reducing mitral regurgitation.

    摘要翻译： 用于治疗二尖瓣回流的系统包括可以使用输送导管部署的张紧装置。 该装置包括连接近端锚和远端锚的张力构件。 该装置由具有合适的弹性特性的材料构成，使得该装置在锚定器之间施加恒定的张力，同时当穿过心脏腔室定位时响应于心跳而伸展或弯曲。 锚固件可以包括多个臂。 在一些实施例中，臂也可以响应于心跳而弯曲。 当位于心脏的左心室时，该装置可以减小心室壁之间的横向距离，从而允许二尖瓣小叶更好地分离，从而减少二尖瓣反流。