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公开(公告)号：US20110300104A1
公开(公告)日：2011-12-08
申请号：US13152377
申请日：2011-06-03
申请人： Yao-Ling Qiu , Ce Wang , Hui Cao , Xiaowen Peng , Datong Tang , Yat Sun Or
发明人： Yao-Ling Qiu , Ce Wang , Hui Cao , Xiaowen Peng , Datong Tang , Yat Sun Or
IPC分类号： A61K31/4178 , A61K31/4439 , A61K31/5377 , A61K31/496 , A61K31/427 , C12N7/06 , A61P31/14 , A61K39/00 , A61K38/21 , A61K38/19 , A61K31/7056 , C07D491/107 , A61K31/422
CPC分类号： A61K31/4178 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/496 , A61K31/5377 , A61K31/7056 , A61K38/21 , A61K45/06 , C12N2770/24211 , A61K2300/00
摘要： The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit RNA-containing virus, particularly the Hepatitis C Virus (HCV). Consequently, the compounds of the present invention interfere with the life cycle of the Hepatitis C Virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
摘要翻译： 本发明公开了式（I）化合物或其药学上可接受的盐，酯或前药：其抑制含RNA病毒，特别是丙型肝炎病毒（HCV）。 因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。 本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。
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公开(公告)号：US08778938B2
公开(公告)日：2014-07-15
申请号：US13152377
申请日：2011-06-03
申请人： Yao-Ling Qiu , Ce Wang , Hui Cao , Xiaowen Peng , Datong Tang , Yat Sun Or
发明人： Yao-Ling Qiu , Ce Wang , Hui Cao , Xiaowen Peng , Datong Tang , Yat Sun Or
IPC分类号： A61K31/397 , A61K31/5377 , A61K31/495 , A61K31/506 , A61K31/443 , A61K31/4525 , A61K31/47 , A61K31/41 , A61K31/4178 , A61K31/4196 , A61K31/422 , A61K31/42 , A61K31/4245 , A61K31/427 , A61K31/428 , C07D273/01 , C07D239/24 , C07D241/04 , C07D221/20 , C07D277/60 , C07D277/20 , C07D263/02 , C07D263/30 , C07D261/20 , C07D257/02 , C07D233/54
CPC分类号： A61K31/4178 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/496 , A61K31/5377 , A61K31/7056 , A61K38/21 , A61K45/06 , C12N2770/24211 , A61K2300/00
摘要： The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit RNA-containing virus, particularly the Hepatitis C Virus (HCV). Consequently, the compounds of the present invention interfere with the life cycle of the Hepatitis C Virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
摘要翻译： 本发明公开了式（I）化合物或其药学上可接受的盐，酯或前药：其抑制含RNA病毒，特别是丙型肝炎病毒（HCV）。 因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。 本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。
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公开(公告)号：US20100226882A1
公开(公告)日：2010-09-09
申请号：US12707190
申请日：2010-02-17
申请人： Yat Sun Or , Xiaowen Peng , Ce Wang , Lu Ying , Datong Tang , Yao-Ling Qiu
发明人： Yat Sun Or , Xiaowen Peng , Ce Wang , Lu Ying , Datong Tang , Yao-Ling Qiu
IPC分类号： A61K38/21 , C07D233/64 , A61K31/4178 , C07D401/14 , A61K31/444 , A61K31/4545 , C07D413/14 , A61K31/5377 , C07D241/04 , A61K31/497 , C07D277/593 , A61K31/427 , C07D263/38 , A61K31/422 , C07D257/04 , A61K31/41 , C07D215/12 , A61K31/4709 , C07D277/64 , A61K31/428 , C07D239/42 , A61K31/506 , C07D221/06 , A61K31/473 , A61K39/29 , A61P31/18 , A61P31/22 , C12N7/00
CPC分类号： C07D403/14 , A61K31/41 , A61K31/4178 , A61K31/422 , A61K31/427 , A61K31/428 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/473 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K38/21 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D495/04 , C07D498/04 , C07F9/65583 , C12N2770/24211 , A61K2300/00
摘要： The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit RNA-containing virus, particularly the hepatitis C virus (HCV). Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
摘要翻译： 本发明公开了式（I）化合物或其药学上可接受的盐，酯或前药：其抑制含RNA病毒，特别是丙型肝炎病毒（HCV）。 因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。 本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。
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公开(公告)号：US08420686B2
公开(公告)日：2013-04-16
申请号：US12707190
申请日：2010-02-17
申请人： Yat Sun Or , Xiaowen Peng , Ce Wang , Lu Ying , Datong Tang , Yao-Ling Qiu
发明人： Yat Sun Or , Xiaowen Peng , Ce Wang , Lu Ying , Datong Tang , Yao-Ling Qiu
IPC分类号： A61K31/4178 , C07D403/10 , C07D403/12
CPC分类号： C07D403/14 , A61K31/41 , A61K31/4178 , A61K31/422 , A61K31/427 , A61K31/428 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/473 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K38/21 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D495/04 , C07D498/04 , C07F9/65583 , C12N2770/24211 , A61K2300/00
摘要： The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit RNA-containing virus, particularly the hepatitis C virus (HCV). Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
摘要翻译： 本发明公开了式（I）化合物或其药学上可接受的盐，酯或前药：其抑制含RNA病毒，特别是丙型肝炎病毒（HCV）。 因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。 本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。
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公开(公告)号：US08609648B2
公开(公告)日：2013-12-17
申请号：US12816171
申请日：2010-06-15
申请人： Yat Sun Or , Lu Ying , Xiaowen Peng , Datong Tang , Ce Wang , Yao-Ling Qiu
发明人： Yat Sun Or , Lu Ying , Xiaowen Peng , Datong Tang , Ce Wang , Yao-Ling Qiu
IPC分类号： A01N43/42 , A01N43/00 , A61K31/00 , A61K31/535 , C07D513/02 , C07D515/02 , C07D267/02 , C07D281/02 , C07D291/08 , C07D413/00
CPC分类号： C07F9/6561 , A61K31/437 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/675 , A61K31/7056 , A61K38/00 , A61K45/06 , C07D471/04 , C07D487/04 , C07D513/04 , C07D519/00 , A61K2300/00
摘要： The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit RNA-containing virus, particularly the hepatitis C virus (HCV). Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
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公开(公告)号：US20110008288A1
公开(公告)日：2011-01-13
申请号：US12816171
申请日：2010-06-15
申请人： Yat Sun Or , Lu Ying , Xiaowen Peng , Datong Tang , Ce Wang , Yao-Ling Qiu
发明人： Yat Sun Or , Lu Ying , Xiaowen Peng , Datong Tang , Ce Wang , Yao-Ling Qiu
IPC分类号： A61K31/437 , C07D471/04 , C07F9/6561 , C07D498/04 , C07D513/04 , A61K31/5377 , A61K31/496 , A61K31/675 , A61K31/4709 , A61K31/506 , A61K39/00 , A61K38/21 , A61K31/7056 , A61P31/14 , C12N7/04
CPC分类号： C07F9/6561 , A61K31/437 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/675 , A61K31/7056 , A61K38/00 , A61K45/06 , C07D471/04 , C07D487/04 , C07D513/04 , C07D519/00 , A61K2300/00
摘要： The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit RNA-containing virus, particularly the hepatitis C virus (HCV). Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
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公开(公告)号：US20120076755A1
公开(公告)日：2012-03-29
申请号：US13252818
申请日：2011-10-04
申请人： Yao-Ling Qiu , Ce Wang , Xiaowen Peng , Lu Ying , Hui Cao , Yat Sun Or
发明人： Yao-Ling Qiu , Ce Wang , Xiaowen Peng , Lu Ying , Hui Cao , Yat Sun Or
IPC分类号： A61K31/4188 , A61K31/424 , A61K31/4439 , A61K31/454 , A61K31/5377 , A61P31/14 , A61P37/02 , A61K38/21 , A61K39/12 , A61K31/4196 , A61K31/427 , A61P1/16 , A61P29/00 , A61P31/18 , C12N7/06 , C07D487/16
CPC分类号： A61K31/415 , A61K31/4188 , A61K31/4196 , A61K31/424 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/5377 , A61K45/06 , C07D471/22 , C07D487/18 , C07D487/22 , C07D498/18 , C07D498/22 , C07D513/18 , Y02A50/463 , A61K2300/00
摘要： The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts, esters, or prodrugs thereof: Q-G-A-L-B-W (I), which inhibit RNA-containing virus, particularly the hepatitis C virus (HCV). Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
摘要翻译： 本发明公开了式（I）化合物及其药学上可接受的盐，酯或前药：抑制含RNA病毒，特别是丙型肝炎病毒（HCV）的Q-G-A-L-B-W（I） 因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。 本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。
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公开(公告)号：US20110189129A1
公开(公告)日：2011-08-04
申请号：US13013212
申请日：2011-01-25
申请人： Yao-Ling Qiu , Ce Wang , Xiaowen Peng , Lu Ying , Hui Cao , Yat Sun Or
发明人： Yao-Ling Qiu , Ce Wang , Xiaowen Peng , Lu Ying , Hui Cao , Yat Sun Or
IPC分类号： A61K38/21 , C07D487/14 , A61K31/4188 , A61K31/7056 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/41 , A61K31/427 , A61K31/675 , A61K31/422 , A61K31/439 , A61K31/4196 , A61K31/4245 , A61K31/506 , A61P31/12 , C12N7/04 , A61K39/12 , A61P37/04 , A61P1/16 , A61P31/18 , A61K38/19
CPC分类号： C07D498/18 , C07D519/00 , C07F9/6561
摘要： The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts, esters, or prodrugs thereof: Q-G-A-L-B—W (I), which inhibit RNA-containing virus, particularly the hepatitis C virus (HCV). Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
摘要翻译： 本发明公开了式（I）的化合物及其药学上可接受的盐，酯或前药：抑制含RNA病毒，特别是丙型肝炎病毒（HCV）的Q-G-A-L-B-W（I） 因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。 本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。
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公开(公告)号：US08653070B2
公开(公告)日：2014-02-18
申请号：US12967486
申请日：2010-12-14
申请人： Yao-Ling Qiu , Ce Wang , Xiaowen Peng , Hui Cao , Lu Ying , Yat Sun Or
发明人： Yao-Ling Qiu , Ce Wang , Xiaowen Peng , Hui Cao , Lu Ying , Yat Sun Or
IPC分类号： A61K31/4184 , A61K31/4439 , A61K31/454 , A61K31/5377 , A61K31/496 , A61K31/439 , C07D403/14 , C07D401/14 , C07D413/14
CPC分类号： C07D401/14 , A61K38/00 , C07D403/14 , C07D413/14
摘要： The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit RNA-containing virus, particularly the hepatitis C virus (HCV). Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
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公开(公告)号：US08933110B2
公开(公告)日：2015-01-13
申请号：US13252818
申请日：2011-10-04
申请人： Yao-Ling Qiu , Ce Wang , Xiaowen Peng , Lu Ying , Hui Cao , Yat Sun Or
发明人： Yao-Ling Qiu , Ce Wang , Xiaowen Peng , Lu Ying , Hui Cao , Yat Sun Or
IPC分类号： C07D207/16 , C07D209/44 , A61K38/00 , A61P31/14 , A61K31/415 , A61K31/4188 , A61K31/4196 , A61K31/424 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/5377 , A61K45/06 , C07D471/22 , C07D487/18 , C07D487/22 , C07D498/18 , C07D498/22 , C07D513/18
CPC分类号： A61K31/415 , A61K31/4188 , A61K31/4196 , A61K31/424 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/5377 , A61K45/06 , C07D471/22 , C07D487/18 , C07D487/22 , C07D498/18 , C07D498/22 , C07D513/18 , Y02A50/463 , A61K2300/00
摘要： The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts, esters, or prodrugs thereof: Q-G-A-L-B—W (I), which inhibit RNA-containing virus, particularly the hepatitis C virus (HCV). Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
摘要翻译： 本发明公开了式（I）的化合物及其药学上可接受的盐，酯或前药：抑制含RNA病毒，特别是丙型肝炎病毒（HCV）的Q-G-A-L-B-W（I） 因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。 本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。
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