公开(公告)号：US4469685A

公开(公告)日：1984-09-04

申请号：US491844

申请日：1983-05-05

申请人： Yasuhiko Kojima ,  Seishi Konno ,  Sadao Tamamura ,  Takashi Hashimoto

发明人： Yasuhiko Kojima ,  Seishi Konno ,  Sadao Tamamura ,  Takashi Hashimoto

IPC分类号： A61K36/00 ,  A61K36/233 ,  A61K36/489 ,  A61K36/754 ,  A61K36/8888 ,  A61K36/8965 ,  A61K35/78

CPC分类号： A61K36/00 ,  A61K36/233 ,  A61K36/489 ,  A61K36/754 ,  A61K36/8888 ,  A61K36/8965

摘要： A process for producing interferon inducers from the plants, comprising extracting a water-soluble interferon inducer with water from the tissue of a plant selected from the genera Atractylodes, Lonicera, Plantago, Lithospermum, Ligusticum, Cnidium, Bupleurum, Notopeterygium, Heracleum, Aralia, Panax, Polygala, Sophora, Euchresta, Astragalus, Sinomenium, Stephania, Cocculus, Cimicifuga, Rheum, Gastroida, Asparagus, Pinellia, Evoida and variants thereof capable of producing said interferon inducer at a temperature of from ambient to the boiling point of the extraction mixture for a period sufficient to extract the major portion of said interferon inducer present in the plant tissue, forming a supernatant, fractionating the supernatant to yield fractions containing the major portion of said interferon inducer in the supernatant and recovering said interferon inducer therefrom. Preferably, the fractionation may be effected by ultrafiltration. The interferon inducers thus obtained have a molecular weight of from about 30,000 to about 3,000,000 and are of potential interest for preventing and treating various diseases of humans and animals caused by viral infection.

摘要翻译： 一种从植物中产生干扰素诱导物的方法，包括用水从植物组织中提取水溶性干扰素诱导物，所述植物选自白术，金银花，车前子，紫草，Ligusticum，Cnidium，柴胡，Notopetellgium，Heracleum，Aralia， 番茄，Polygala，Sophora，Euchresta，黄芪，Sinomenium，Stephania，Cocculus，Cimicifuga，Rheum，Gastroida，芦笋，Pinellia，Evoida及其能够在提取混合物的环境温度至沸点温度下产生所述干扰素诱导剂的变异体 足以提取存在于植物组织中的所述干扰素诱导剂的主要部分的时间，形成上清液，分离上清液以产生含有上清液中所述干扰素诱导物主要部分的级分并从其中回收所述干扰素诱导剂。 优选地，分级可以通过超滤来实现。 由此获得的干扰素诱导物具有约30,000至约3,000,000的分子量，并且对于预防和治疗由病毒感染引起的人和动物的各种疾病具有潜在的兴趣。

公开(公告)号：US4419349A

公开(公告)日：1983-12-06

申请号：US266038

申请日：1981-05-22

申请人： Yasuhiko Kojima ,  Seishi Konno ,  Sadao Tamamura ,  Yoshimoto Sano ,  Nobuyuki Shibukawa ,  Takashi Hashimoto

发明人： Yasuhiko Kojima ,  Seishi Konno ,  Sadao Tamamura ,  Yoshimoto Sano ,  Nobuyuki Shibukawa ,  Takashi Hashimoto

IPC分类号： A61K36/535 ,  C07C7/00 ,  C07G99/00 ,  A61K35/78

CPC分类号： A61K36/535

摘要： An interferon inducer isolated from the plant tissue, having an elemental analysis of H: 8.5-8.7 %, C: 48.8-49 %, N: 6.3-6.5 % and P: 1.0-1.1 % and a molecular weight of from about 100,000 to about 3,000,000 (mainly about 200,000 to about 1,000,000) and containing as main constituents amino acids, sugars and phosphoric acid. This substance is believed to be a homogeneous polymer of protein and sugars, containing phosphoric acid. This substance has an excellent interferon inducing activity and low toxicity and is significantly active against various viruses. The interferon inducer may be produced by extracting a substance having interferon inducing activity from the tissue of a plant of the genus Perilla of the family Labiatae or a variant thereof containing said active substance and recovering the active substance from the extract thereby obtained. Preferably, the extraction may be effected with water and the recovery may be effected by ultrafiltration. Pharmaceutical composition of this invention comprises as active ingredient the interferon inducer of this invention in association with a pharmaceutical carrier or excipient.

摘要翻译： 从植物组织分离的干扰素诱导物，其H分析为8.5-8.7％，C：48.8-49％，N：6.3-6.5％，P：1.0-1.1％，分子量为约100,000至 约300万（主要为约20万至约100万），主要成分为氨基酸，糖和磷酸。 该物质被认为是含有磷酸的蛋白质和糖的均匀聚合物。 该物质具有优异的干扰素诱导活性和低毒性，对各种病毒具有显着的活性。 干扰素诱导剂可以通过从Labiatae家族的紫苏属植物的组织或其含有所述活性物质的变体的组织提取具有干扰素诱导活性的物质，并从由此获得的提取物中回收活性物质来制备。 优选地，提取可以用水进行，并且可以通过超滤实现回收。 本发明的药物组合物与药物载体或赋形剂一起包含本发明的干扰素诱导剂作为活性成分。

公开(公告)号：US4442087A

公开(公告)日：1984-04-10

申请号：US282468

申请日：1981-07-13

申请人： Yasuhiko Kojima ,  Seishi Konno ,  Sadao Tamamura ,  Takashi Hashimoto ,  Nobuyuki Shibukawa

发明人： Yasuhiko Kojima ,  Seishi Konno ,  Sadao Tamamura ,  Takashi Hashimoto ,  Nobuyuki Shibukawa

IPC分类号： C07G99/00 ,  A61K36/28 ,  A61K36/282 ,  A61P43/00 ,  C07K14/415 ,  A61K31/69 ,  A61K39/00 ,  A61K45/02

CPC分类号： C07K14/415 ,  Y10S514/889

摘要： An interferon inducer isolated from the plant tissue, having an elemental analysis of H:7.4.+-.0.4%, C: 45.6.+-.0.4%, N: 13.5.+-.0.4%, P: 2.8.+-.0.3% and a molecular weight of from about 100,000 to about 3,000,000 (mainly about 200,000 to about 1,000,000) and containing as main chemical constituents amino acids and phosporic acid. This substance is believed to be a homogeneous polymer of protein and phosphoric acid.This substance has an excellent interferon inducing activity and low toxicity and is significantly active upon various viruses. This interferon inducer may be produced by extracting a substance having interferon inducing activity from the tissue of a plant of the genus Artemisia of the family Compositae or a variant thereof containing the said active substance with water and recovering the active substance from the extracted solution. The recovery may preferably be effected by ultrafiltration. Pharmaceutical composition of this invention comprises as active ingredient the said active substance in association with a pharmaceutical carrier or excipient.

摘要翻译： 从植物组织分离的干扰素诱导物，具有H：7.4 +/- 0.4％，C：45.6 +/- 0.4％，N：13.5 +/- 0.4％，P：2.8 +/- 0.3％的元素分析和 分子量为约100,000至约3,000,000（主要为约200,000至约1,000,000），并含有主要化学成分的氨基酸和磷酸。 该物质被认为是蛋白质和磷酸的均匀聚合物。 该物质具有优异的干扰素诱导活性和低毒性，对各种病毒具有显着的活性。 这种干扰素诱导剂可以通过从菊科的蒿属植物的组织或其含有所述活性物质的变体的组织中提取具有干扰素诱导活性的物质，并从提取的溶液中回收活性物质来制备。 回收率优选通过超滤来实现。 本发明的药物组合物与药物载体或赋形剂一起包含作为活性成分的所述活性物质。

公开(公告)号：US4421746A

公开(公告)日：1983-12-20

申请号：US392994

申请日：1982-06-28

申请人： Yasuhiko Kojima ,  Sadao Tamamura ,  Seishi Konno ,  Takashi Hashimoto

发明人： Yasuhiko Kojima ,  Sadao Tamamura ,  Seishi Konno ,  Takashi Hashimoto

IPC分类号： A61K36/42 ,  A61K36/428 ,  A61K35/78

CPC分类号： A61K36/42 ,  A61K36/428 ,  Y10S514/889

摘要： An interferon inducer is produced by extracting a tissue of a plant belonging to the Gound family selected from the group consisting of Benincasa, Cucurbita, Citrullus, Cucumia, Lagenaria, Luffa, Mormordica, Tricsanthes and their variants by water extraction at a temperature of from ambient to the boiling point of the extraction mixture, forming a supernatant from the extracted solution, fractionating the supernatant to yield fractions containing the interferon inducer and recovering same.

摘要翻译： 干扰素诱导剂是通过在环境温度下通过水提取提取属于野生型家族的植物的组织，所述植物组织选自Benincasa，Cucurbita，Citrullus，Cucumia，Lagenaria，Luffa，Mormordica，Tricsanthes及其变体 到提取混合物的沸点，从提取的溶液形成上清液，分馏上清液以产生含有干扰素诱导物的级分并回收。

公开(公告)号：US4456597A

公开(公告)日：1984-06-26

申请号：US290284

申请日：1981-08-06

申请人： Yasuhiko Kojima ,  Seishi Konno ,  Takashi Hashimoto

发明人： Yasuhiko Kojima ,  Seishi Konno ,  Takashi Hashimoto

IPC分类号： A61K38/00 ,  A61K31/69 ,  A61K36/28 ,  A61K36/286 ,  A61K38/21 ,  A61P35/00 ,  A61P43/00 ,  C07K14/555

CPC分类号： A61K36/286

摘要： An interferon inducer isolated from the plant tissue, having an elemental analysis of H: 6.54.+-.0.3% C: 41.9.+-.0.3%, N: 2.39.+-.0.3% and P: 0.28.+-.0.03% and a molecular weight of from about 100,000 to about 3,000,000 (mainly about 200,000 to about 1,000,000) and containing as main constituents amino acids, sugars and phosphoric acid. This substance is believed to be a homogeneous polymer of protein and sugars, containing phosphoric acid. This substance has an excellent interferon inducing activity and low toxicity and is significantly active against various viruses. The interferon inducer may be produced by extracting a substance having interferon inducing activity from the tissue of a plant of the genus Carthamus of the family Compositae or a variant thereof containing said active substance and recovering the active substance from the extract thereby obtained. Preferably, the active substance may be extracted from the flower of this plant with water and the recovery may be effected by ultrafiltration using a membrane capable of fractionating substances having a molecular weight of from 200,000 to 1,000,000. Pharmaceutical composition of this invention comprises as active ingredient the interferon inducer of this invention in association with a pharmaceutical carrier or excipient.

摘要翻译： 从植物组织分离的干扰素诱导物，具有H：6.54 +/- 0.3％C：41.9 +/- 0.3％，N：2.39 +/- 0.3％和P：0.28 +/- 0.03％的元素分析，以及 分子量为约100,000至约3,000,000（主要为约200,000至约1,000,000），并以主要成分为主要成分氨基酸，糖和磷酸。 该物质被认为是含有磷酸的蛋白质和糖的均匀聚合物。 该物质具有优异的干扰素诱导活性和低毒性，对各种病毒具有显着的活性。 干扰素诱导剂可以通过从菊科菊属植物的组织或其含有所述活性物质的变体的组织提取具有干扰素诱导活性的物质并从由此获得的提取物中回收活性物质来制备。 优选地，活性物质可以用水从该植物的花中提取，并且回收可以通过使用能够分馏分子量为200,000至1,000,000的物质的膜进行超滤来进行。 本发明的药物组合物与药物载体或赋形剂一起包含本发明的干扰素诱导剂作为活性成分。

公开(公告)号：US4440761A

公开(公告)日：1984-04-03

申请号：US290283

申请日：1981-08-06

申请人： Yasuhiko Kojima ,  Seishi Konno ,  Takashi Hashimoto

发明人： Yasuhiko Kojima ,  Seishi Konno ,  Takashi Hashimoto

IPC分类号： A61K38/00 ,  A61K36/00 ,  A61K36/28 ,  A61K36/286 ,  A61K38/21 ,  A61P43/00 ,  C07K14/415 ,  C07K14/555 ,  A61K35/78

CPC分类号： A61K36/286 ,  Y10S514/889

摘要： A process for producing an interferon inducer by extracting a substance having interferon inducing activity with water from the tissue of a plant selected from the genus Carthamus and variants thereof containing the said active substance to give an extracted solution, forming a supernatant from the extracted solution, fractionating the supernatant to yield fractions containing a major portion of the said active substance present in the supernatant and recovering the said active substance therefrom, characterized by fractionating the supernatant to yield fractions containing the said active substance having a molecular weight of from about 10,000 to about 200,000. Preferably the seed may be used as the tissue and the fractionation may be effected by ultrafiltration using a membrane capable of fractionating substances having the above-mentioned molecular weight.

摘要翻译： 一种通过从含有所述活性物质的植物的组织提取具有干扰素诱导活性的物质的干扰素诱导剂的制造方法，得到提取液，从所提取的溶液中形成上清液， 分离上清液以产生含有上清液中存在的主要部分所述活性物质的级分并从其中回收所述活性物质，其特征在于将上清液分馏以产生含有分子量为约10,000至约 20万。 优选地，种子可以用作组织，并且分级可以通过使用能够分馏具有上述分子量的物质的膜进行超滤来进行。

公开(公告)号：US4871540A

公开(公告)日：1989-10-03

申请号：US887168

申请日：1986-07-17

申请人： Yasuhiko Kojima ,  Sadao Tamamura

发明人： Yasuhiko Kojima ,  Sadao Tamamura

IPC分类号： A61K38/00 ,  A61K31/715 ,  A61K36/00 ,  A61K36/899 ,  A61P37/00 ,  A61P43/00

CPC分类号： A61K31/715 ,  A61K36/899 ,  Y10S514/885

摘要： A biologically active substance comprising a kind of glycolipid having an elemental analysis (%) of H: 5.20-5.40, C: 42.55-44.17 and N: 3.94-4.08 and a molecular weight of about 30,000-10.sup.6 is obtained by extracting the tissue of a plant of maize (Zea mays Linne) or a variant thereof by extracting the tissue with water and recovering the desired active substance from the resultant extract. This substance is capable of inhibiting the formation of IgE antibodies and promoting the formation of IgG and IgM antibodies, and moreover exhibits various biological activities such as interferon-inducing activity, polyclonal B lymphocite activating activity, mitrogenic activity, adjuvant activity and anti-tumour activity. Thus, this substance is expected to be useful for preventing and treating, for example, aesthema, rhintitis, B-type hepatitis, AIDS and other allergic diseases and immunological insufficiency.

摘要翻译： 包含一种具有H：5.20-5.40，C：42.55-44.17和N：3.94-4.08的元素分析（％）和分子量约30,000-106的一种糖脂的生物活性物质是通过提取组织 玉米植物（Zea mays Linne）或其变体，通过用水提取组织并从所得提取物中回收所需的活性物质。 该物质能够抑制IgE抗体的形成并促进IgG和IgM抗体的形成，此外还表现出各种生物学活性，例如干扰素诱导活性，多克隆B淋巴细胞活化活性，有丝分裂活性，佐剂活性和抗肿瘤活性 。 因此，预期该物质可用于预防和治疗例如美学，鼻炎，B型肝炎，AIDS和其他过敏性疾病和免疫功能不全。

公开(公告)号：US20140023656A1

公开(公告)日：2014-01-23

申请号：US13824672

申请日：2011-09-26

申请人： Masato Kuwabara ,  Yasuhiko Kojima ,  Takashi Oyamada ,  Michio Honjo ,  Kazuko Uno ,  Yukio Yajima ,  Akina Kuwabara

发明人： Masato Kuwabara ,  Yasuhiko Kojima ,  Takashi Oyamada ,  Michio Honjo ,  Kazuko Uno ,  Yukio Yajima ,  Akina Kuwabara

IPC分类号： A61K33/30 ,  G01N33/68

CPC分类号： A61K33/30 ,  A61K33/06 ,  A61K33/42 ,  A61K36/42 ,  A61K36/899 ,  A61K45/06 ,  G01N33/6893 ,  A61K2300/00

摘要： The present invention provides a medicinal agent and a method for each of various testing or the like, which enable the treatment and prevention, particularly preventive treatment, of Th3 march-related diseases. The present invention also provides a pharmaceutical composition for treating and/or preventing Th3 march-related diseases, which comprises zinc, calcium and phosphorus and additionally comprises pumpkin seeds and corn silk, and which preferably can activate the DNA repairing ability of a zinc finger, particularly the ability of repairing defect or mutation of DNA for a filaggrin gene, of a zinc finger.

摘要翻译： 本发明提供能够对Th3游行相关疾病进行治疗和预防，特别是预防治疗的各种试验等的药剂和方法。 本发明还提供了用于治疗和/或预防Th3游行相关疾病的药物组合物，其包含锌，钙和磷，并且还包括南瓜籽和玉米丝，并且其优选可以激活锌指的DNA修复能力， 特别是修复锌指的丝聚蛋白基因的DNA的缺陷或突变的能力。

公开(公告)号：US07815874B2

公开(公告)日：2010-10-19

申请号：US12125339

申请日：2008-05-22

申请人： Kenji Sakai ,  Yasuhiko Kojima

发明人： Kenji Sakai ,  Yasuhiko Kojima

IPC分类号： F28D7/00

CPC分类号： B01J19/02 ,  B01J19/0013 ,  B01J19/0053 ,  B01J19/2425 ,  B01J2219/00092 ,  B01J2219/00256 ,  B01J2219/0286 ,  F28D7/06 ,  F28F9/0219 ,  F28F9/0229 ,  F28F9/18 ,  F28F19/06 ,  F28F2275/20

摘要： A reactor including a reactor vessel and heat exchange tubes provided in the reactor vessel. The reactor vessel includes a tubesheet and is configured to receive a reaction fluid. The tubesheet has a first plate member configured to contact the reaction fluid and a second plate member configured to not contact the reaction fluid. Heat exchange tubes are provided in the reactor vessel and fixed to the first plate member. The heat exchange tubes are configured to receive a heat exchange medium. At least a portion of the first plate member configured to contact the reaction fluid is made of a metal that has a high corrosion-resistance against the reaction liquid, and the second plate member is made of a metal that has a low corrosion-resistance against the reaction liquid. The second plate member is detachably fixed to a remainder of the reactor vessel.

摘要翻译： 包括反应器容器和设置在反应器容器中的热交换管的反应器。 反应器容器包括管板，并且构造成容纳反应流体。 管板具有构造成接触反应流体的第一板构件和构造成不接触反应流体的第二板构件。 热交换管设置在反应器容器中并固定到第一板构件。 热交换管被构造成接收热交换介质。 构成为接触反应流体的第一板状构件的至少一部分由对反应液体具有高耐腐蚀性的金属制成，第二板构件由耐腐蚀性低的金属制成 反应液体。 第二板构件可拆卸地固定到反应器容器的其余部分。

公开(公告)号：US20100099254A1

公开(公告)日：2010-04-22

申请号：US12443983

申请日：2007-10-01

申请人： Masaki Narushima ,  Yasuhiko Kojima

发明人： Masaki Narushima ,  Yasuhiko Kojima

IPC分类号： H01L21/768 ,  H01L21/00

CPC分类号： H01L21/76843 ,  C23C16/44 ,  H01L21/67207 ,  H01L21/68742 ,  H01L21/76831 ,  H01L21/76861 ,  H01L21/76864 ,  H01L23/53238 ,  H01L23/53295 ,  H01L2924/0002 ,  H01L2924/09701 ,  H01L2924/12044 ,  H01L2924/00

摘要： A semiconductor manufacturing apparatus, when a barrier film and a copper film are formed along a recess in an insulating film by using an alloy layer of copper and addictive metal, e.g., Mn, and copper wiring is embedded therein, reduces Mn in the copper film to suppress an increase in wiring resistance. A vacuum transfer module is connected, through a load lock chamber, to a loader module for transferring a wafer with respect to a carrier. A formic acid treatment module supplying formic acid vapor as an organic acid to the wafer and a module forming a film of Cu, e.g., by CVD are connected to the vacuum transfer module to configure an apparatus manufacturing a semiconductor. The wafer W subjected to alloy layer formation and then, e.g., to annealing is transferred into the apparatus, and treatment with formic acid is performed followed by Cu film formation.

摘要翻译： 半导体制造装置，通过使用例如Mn的铜和上釉金属的合金层，在绝缘膜中的凹部形成阻挡膜和铜膜，并且嵌入铜布线，从而减少铜膜中的Mn 以抑制布线电阻的增加。 真空传递模块通过负载锁定室连接到用于相对于载体传送晶片的加载器模块。 向晶片供给作为有机酸的甲酸蒸气的甲酸处理组件和例如通过CVD形成Cu膜的模块连接到真空转印模块以构造制造半导体的装置。 进行合金层形成然后例如退火的晶片W被转移到装置中，然后用甲酸处理，然后进行Cu膜形成。