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    Stable polymer emulsion composition capable of giving a thromboresistant surface, and process for production thereof
    1.
    发明授权
    Stable polymer emulsion composition capable of giving a thromboresistant surface, and process for production thereof 失效
    能够产生抗血栓表面的稳定的聚合物乳液组合物及其生产方法

    公开(公告)号：US4604412A

    公开(公告)日：1986-08-05

    申请号：US475499

    申请日：1983-03-15

    申请人： Yasushi Joh ,  Toshio Nagase ,  Noriaki Kaneko

    发明人： Yasushi Joh ,  Toshio Nagase ,  Noriaki Kaneko

    IPC分类号： C08G18/00 ,  A61L33/00 ,  A61L33/06 ,  C08L75/00 ,  C08L75/04 ,  C08L83/04 ,  C08L83/06 ,  C09D5/00 ,  C09K3/00

    CPC分类号： A61L33/062 ,  C08L75/04 ,  Y10S525/903

    摘要： A stable polymer emulsion composition capable of giving a thromboresistant surface, said composition comprising polyurethane, a polydiorganosiloxane, and a cyclic ether, said polydiorganosiloxane being dispersed as particles having an average particle diameter of 0.1 to 50 microns in a solution of the polyurethane in the cyclic ether, and at least a part of the surfaces of said particles being crosslinked. The said composition can be prepared by dispersing a polydiorganosiloxane having a hydroxyl or acetate end group as fine particles in a solution of polyurethane in a cyclic ether to form an emulsion, and reacting the polydiorganosiloxane with a crosslinking agent to crosslink at least a part of the surfaces of the particles in the presence of 10 to 500 ppm of water.

    摘要翻译： 所述组合物包含聚氨酯，聚二有机硅氧烷和环醚，所述聚二有机硅氧烷在平均粒径为0.1-50微米的颗粒中分散在聚氨酯在环状 醚，并且所述颗粒的至少一部分表面是交联的。 所述组合物可以通过将具有羟基或乙酸酯端基的聚二有机硅氧烷作为细颗粒分散在聚氨酯在环醚中的溶液中以形成乳液，并使聚二有机硅氧烷与交联剂反应以使至少一部分 在10至500ppm水存在下颗粒的表面。

    Cannula
    2.
    发明授权
    Cannula 失效
    插管

    公开(公告)号：US4508535A

    公开(公告)日：1985-04-02

    申请号：US483138

    申请日：1983-04-08

    申请人： Yasushi Joh ,  Noriaki Kaneko ,  Toshio Nagase

    发明人： Yasushi Joh ,  Noriaki Kaneko ,  Toshio Nagase

    IPC分类号： A61M1/10 ,  A61M1/12 ,  A61M1/36 ,  A61M25/00 ,  A61M39/10

    CPC分类号： A61M1/10 ,  A61M1/1008 ,  A61M1/122 ,  A61M1/3659 ,  A61M1/106 ,  A61M25/0041

    摘要： The invention relates to a tubular cannula for use with an artificial heart in open heart surgery.The cannula has a tubular portion with an axis having a three-dimensional configuration by being bent at least twice in different directions between an insertion distal end tip for insertion into a heart and a connection proximal end tip for connection with the artificial heart.

    摘要翻译： 本发明涉及一种用于心脏开放心脏手术中人造心脏的管状插管。 插管具有管状部分，其轴线具有三维构型，通过在用于插入心脏的插入远端末端和用于与人造心脏连接的连接近端尖端之间沿不同方向弯曲至少两次。

    Method of manufacturing hollow fiber
    3.
    发明授权
    Method of manufacturing hollow fiber 失效
    制造中空纤维的方法

    公开(公告)号：US4385017A

    公开(公告)日：1983-05-24

    申请号：US273306

    申请日：1981-06-15

    申请人： Yasushi Joh ,  Masahiro Yamazaki ,  Noriaki Kaneko ,  Shigehiko Oikawa ,  Yoshihiro Makuta ,  Chizuko Hayashi

    发明人： Yasushi Joh ,  Masahiro Yamazaki ,  Noriaki Kaneko ,  Shigehiko Oikawa ,  Yoshihiro Makuta ,  Chizuko Hayashi

    IPC分类号： D01D5/24 ,  D01F1/08 ,  D01F8/08 ,  B29D27/00

    CPC分类号： B01D71/42 ,  B01D63/021 ,  B01D71/12 ,  B01D71/30 ,  D01D5/24 ,  Y10T428/2975

    摘要： A method of manufacturing a microporous hollow fiber having a high permeability to water characterized in that a spinning solution of (A) polyacrylonitrile, (B) an acrylonitrile copolymer, or (C) an admixture of (A) and (B) in an organic solvent is extruded from an annular slit, while simultaneously extruding an organic core liquid which is a solvent for (A), (B) and (C) or a swelling agent capable of swelling them from an orifice encircled by the annular slit and introducing the extruded spinning solution with the core liquid into an aqueous coagulating bath to coagulate the spinning solution to form the hollow fiber.

    摘要翻译： 一种具有高渗透性的微孔中空纤维的制造方法，其特征在于：（A）聚丙烯腈，（B）丙烯腈共聚物或（C）（A）和（B）的混合物的有机溶剂 溶剂从环形狭缝挤出，同时挤出作为（A），（B）和（C）的溶剂的有机芯液或能够从由环形狭缝包围的孔中膨胀的溶胀剂，并引入 将具有核心液体的挤出纺丝溶液加入到水性凝固浴中以使纺丝溶液凝结以形成中空纤维。

    Medical tubes with porous textured walls
    6.
    发明授权
    Medical tubes with porous textured walls 失效
    医疗管与多孔纹理的墙壁

    公开(公告)号：US4822352A

    公开(公告)日：1989-04-18

    申请号：US66849

    申请日：1987-06-25

    申请人： Yasushi Joh ,  Noriaki Kaneko

    发明人： Yasushi Joh ,  Noriaki Kaneko

    IPC分类号： A61F2/06 ,  A61L27/18 ,  A61L27/56 ,  B29C47/00 ,  B29C67/24 ,  C08G18/10 ,  C08G18/48

    CPC分类号： C08G18/4854 ,  A61F2/06 ,  A61L27/18 ,  A61L27/56 ,  B29C67/24 ,  C08G18/10 ,  B29C47/00 ,  B29C47/0023 ,  B29K2075/00 ,  B29K2995/0088 ,  B29L2031/7534

    摘要： Disclosed is a medical tube comprising a mono-layer medical tube comprising a high molecular weight compound, wherein the inner texture of a tube wall constituting the tube is porous and no skin layer is present on the inner face of the tube wall.The porous inner texture of the tube is microscopically spongy and contains cells or voids interconnected by pores. The inner wall of the tube contains concavities which open into the cells or voids and communicates them with any fluid flowing through the tube.Disclosed is also a process for producing a medical tube, comprising thrusting forward a core rod having a round cross-section and made of a rigid body from a circular orifice to extrude a solution of a high molecular weight compound from a gap slit defined between the orifice and the core rod in such a manner that the solution is spread over the whole surface of the core rod, and leading the core rod in a solidifying medium to solidify the high molecular weight compound around the core rod, followed by taking out the core rod.The medical tubes of this invention or the medical tubes produced by the present process has excellent compatibility with blood, particularly is suitable for an artificial blood vessel which is required to have excellent long term patency.

    Method and apparatus for removing gas from interior of hollow-fiber permeability apparatus
    7.
    发明授权
    Method and apparatus for removing gas from interior of hollow-fiber permeability apparatus 失效
    从中空纤维透气装置内部除去气体的方法和装置

    公开(公告)号：US4108764A

    公开(公告)日：1978-08-22

    申请号：US797765

    申请日：1977-05-17

    申请人： Noriaki Kaneko ,  Yasushi Joh

    发明人： Noriaki Kaneko ,  Yasushi Joh

    IPC分类号： A61M1/14 ,  A61M1/36 ,  B01D63/02 ,  B01D65/00 ,  B01D13/00

    CPC分类号： B01D63/021 ,  A61M1/3643 ,  B01D65/00

    摘要： In a method and apparatus for removing gas from the interior of a hollow-fiber permeability apparatus in which a permeating region of a housing contains a bundle of hollow fibers, and materials can selectively permeate through the membranes formed by the permeable walls of the hollow fibers, between first and second fluids flowing through the housing inside and outside the fibers respectively, at least one of first and second materials to produce carbonic acid gas by mutual chemical reaction is contained in a flow path for the first fluid and/or another flow path for the second fluid, and the first and second materials react with each other in at least one part of the apparatus to produce carbonic acid gas, whereby the gas previously existing in the interior of the housing is substituted with the produced carbonic acid gas.

    摘要翻译： 在用于从中空纤维透气装置的内部除去气体的方法和装置中，其中壳体的渗透区域包含一束中空纤维，并且材料可以选择地渗透通过中空纤维的可渗透壁形成的膜 在分别在纤维内部和外部流过第一和第二流体之间，通过相互化学反应产生碳酸气体的第一和第二材料中的至少一种被包含在用于第一流体和/或另一个流动路径的流动路径中 对于第二流体，并且第一和第二材料在装置的至少一部分中彼此反应以产生碳酸气体，由此先前存在于壳体内部的气体被产生的碳酸气体代替。

    Hollow fiber permeability apparatus
    10.
    发明授权
    Hollow fiber permeability apparatus 失效
    中空纤维透气装置

    公开(公告)号：US4237013A

    公开(公告)日：1980-12-02

    申请号：US21885

    申请日：1979-03-19

    申请人： Masahiro Yamazaki ,  Yoshihiro Makuta ,  Yasushi Joh ,  Noriaki Kaneko

    发明人： Masahiro Yamazaki ,  Yoshihiro Makuta ,  Yasushi Joh ,  Noriaki Kaneko

    IPC分类号： A61M1/18 ,  B01D63/02 ,  B01D31/00

    CPC分类号： B01D63/02

    摘要： A hollow-fiber permeability apparatus includes a housing having a permeating region, a bundle of permeable-wall hollow fibers in the permeating region, means for supplying a first fluid flowing between the exteriors of the fibers, another means for passing a second fluid through the interiors of fibers such that materials selectively permeate through the walls of the fibers, and an enlarged cross-section portion to define at least one compartment between the bundle and a wall of the housing and having an inlet opening for introducing the first fluid into the housing, the permeating region having a flattened cross-section in the direction substantially perpendicular to the lengthwise direction of the fibers, and the enlarged cross-section portion being formed at least along substantially the whole lengths of the longer side of the cross section of the permeating region.

    摘要翻译： 中空纤维透气装置包括具有渗透区域的壳体，渗透区域中的一层可渗透壁中空纤维，用于供应在纤维外部之间流动的第一流体的装置，用于使第二流体通过 纤维的内部，使得材料选择性地渗透通过纤维的壁，以及扩大的横截面部分，以在束和壳体的壁之间限定至少一个隔室，并具有用于将第一流体引入壳体 所述渗透区域在与所述纤维的长度方向大致垂直的方向上具有扁平的横截面，并且所述扩大的横截面部分至少沿着渗透层的横截面的长边的大致整个长度形成 地区。