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    GTPase inhibitors and methods of use
    2.
    发明授权
    GTPase inhibitors and methods of use 有权
    GTPase抑制剂和使用方法

    公开(公告)号：US07517890B2

    公开(公告)日：2009-04-14

    申请号：US10994165

    申请日：2004-11-19

    申请人： Yi Zheng ,  Jie Zheng ,  Yuan Gao ,  John B. Dickerson

    发明人： Yi Zheng ,  Jie Zheng ,  Yuan Gao ,  John B. Dickerson

    IPC分类号： A61K31/506

    CPC分类号： A61K31/506 ,  A61K31/47 ,  A61K31/505 ,  Y02A50/409

    摘要： The preferred embodiments generally relate to methods and compositions that affect the GTP-binding activity of members of the Rho family GTPases, preferably Rac (Rac1, Rac2 and/or Rac3), such compositions include compounds that modulate the GTP/GDP exchange activity, along with uses for the compounds including screening for compounds which recognize Rac GTPase, and methods of treating pathological conditions associated or related to a Rho family GTPase, including Rac. The preferred embodiments also relate to methods of using such compounds, or derivatives thereof, e.g., in therapeutics, diagnostics, and as research tools.

    摘要翻译： 优选的实施方案通常涉及影响Rho家族GTP酶，优选Rac（Rac1，Rac2和/或Rac3）成员的GTP-结合活性的方法和组合物，所述组合物包括调节GTP / GDP交换活性的化合物 用于化合物的用途，包括筛选识别Rac GTP酶的化合物，以及治疗与Rho家族GTP酶（包括Rac）相关或相关的病理状况的方法。 优选实施方案还涉及使用这些化合物或其衍生物的方法，例如在治疗学，诊断学和研究工具中。

    One-pot synthesis of highly mechanical and recoverable double-network hydrogels
    3.
    发明授权
    One-pot synthesis of highly mechanical and recoverable double-network hydrogels 有权

    公开(公告)号：US10336896B2

    公开(公告)日：2019-07-02

    申请号：US14787041

    申请日：2014-04-23

    申请人： Jie Zheng ,  Qiang Chen ,  Chao Zhao

    发明人： Jie Zheng ,  Qiang Chen ,  Chao Zhao

    IPC分类号： C12C11/02 ,  C08L33/26 ,  C08B37/00 ,  C08L5/12 ,  C08J3/075 ,  C08L5/00

    摘要： A method of forming a hybrid physically and chemically cross-linked double-network hydrogel with highly recoverable and mechanical properties in a single-pot synthesis is provided. The method comprises the steps of combining the hydrogel precursor reactants into a single pot. The hydrogel precursor reactants include water; a polysaccharide; a methacrylate monomer; an ultraviolet initiator; and a chemical crosslinker. Next the hydrogel precursor reactants are heated to a temperature higher than the melting point of the polysaccharide and this temperature is retained until the polysaccharide is in a sol state. Then the single-pot is cooled to a temperature lower than the gelation point of the polysaccharide and this temperature is retained to form a first network. Thereafter, photo-initiated polymerization of the methacrylate monomer occurs via the ultraviolet initiator to form the second network.

    ONE-POT SYNTHESIS OF HIGHLY MECHANICAL AND RECOVERABLE DOUBLE-NETWORK HYDROGELS
    4.
    发明申请
    ONE-POT SYNTHESIS OF HIGHLY MECHANICAL AND RECOVERABLE DOUBLE-NETWORK HYDROGELS 审中-公开
    高效机械和可恢复的双网络水合物的一步法合成

    公开(公告)号：US20160083574A1

    公开(公告)日：2016-03-24

    申请号：US14787041

    申请日：2014-04-23

    申请人： Jie Zheng ,  Qiang Chen ,  Chao Zhao

    发明人： Jie Zheng ,  Qiang Chen ,  Chao Zhao

    IPC分类号： C08L33/26 ,  C08L5/12

    CPC分类号： C08L33/26 ,  C08B37/0039 ,  C08J3/075 ,  C08J2305/12 ,  C08J2333/26 ,  C08J2405/12 ,  C08J2433/26 ,  C08L5/00 ,  C08L5/12 ,  C08L33/10

    摘要： A method of forming a hybrid physically and chemically cross-linked double-network hydrogel with highly recoverable and mechanical properties in a single-pot synthesis is provided. The method comprises the steps of combining the hydrogel precursor reactants into a single pot. The hydrogel precursor reactants include water; a polysaccharide; a methacrylate monomer; an ultraviolet initiator; and a chemical crosslinker. Next the hydrogel precursor reactants are heated to a temperature higher than the melting point of the polysaccharide and this temperature is retained until the polysaccharide is in a sol state. Then the single-pot is cooled to a temperature lower than the gelation point of the polysaccharide and this temperature is retained to form a first network. Thereafter, photo-initiated polymerization of the methacrylate monomer occurs via the ultraviolet initiator to form the second network.

    摘要翻译： 提供了在单锅合成中形成具有高可回收和机械性质的杂化物理和化学交联双网络水凝胶的方法。 该方法包括以下步骤：将水凝胶前体反应物合并成单个罐。 水凝胶前体反应物包括水; 多糖; 甲基丙烯酸酯单体; 紫外线引发剂; 和化学交联剂。 接下来将水凝胶前体反应物加热到高于多糖的熔点的温度，并保持该温度，直到多糖处于溶胶状态。 然后将单釜冷却至低于多糖的凝胶化点的温度，并保持该温度以形成第一网络。 此后，通过紫外线引发剂发生甲基丙烯酸酯单体的光引发聚合以形成第二网络。

    Diamond metal composite
    5.
    发明授权
    Diamond metal composite 有权
    钻石金属复合材料

    公开(公告)号：US08936665B2

    公开(公告)日：2015-01-20

    申请号：US12741318

    申请日：2008-10-30

    申请人： Jie Zheng

    发明人： Jie Zheng

    IPC分类号： C22C26/00 ,  B01J3/06 ,  C09K3/14 ,  C22C47/08

    CPC分类号： B22F3/1007 ,  B01J3/065 ,  B01J2203/062 ,  B01J2203/0655 ,  B22F3/1035 ,  B22F2999/00 ,  C09K3/1436 ,  C22C47/08 ,  Y10T428/12049 ,  B22F2201/10 ,  B22F2201/20

    摘要： The present invention relates to a method for producing diamond-metal composites comprising mixing diamond particles with metal-filler particles forming a diamond/metal-filler mixture, forming a green body of the diamond/metal-filler mixture, optionally green machining the green body to a work piece before or after pre-sintering by heating the green body to a temperature ≦500° C., infiltrating the green body or the work piece with one or more wetting elements or infiltrating the green body or the work piece with one or more wetting alloys, which infiltration step being carried out under vacuum or in an inert gas atmosphere at a pressure ≦200 Bar. The invention relates further to a green body, a diamond metal composite, and use of the diamond metal composite.

    摘要翻译： 本发明涉及一种生产金刚石 - 金属复合材料的方法，包括将金刚石颗粒与形成金刚石/金属 - 填料混合物的金属 - 填料颗粒混合，形成金刚石/金属 - 填料混合物的生坯，任选地绿色加工生坯 通过将生坯体加热至温度<500℃而在预烧结之前或之后的工件; 500℃，用一种或多种润湿元件渗透生坯或工件，或者用一个或多个润湿元件浸入生坯或工件 或更多润湿合金，该渗透步骤在真空下或在惰性气体气氛中在压力为200巴下进行。 本发明进一步涉及生坯，金刚石金属复合材料和金刚石金属复合材料的用途。

    Sensor Device Having Plural Resistance Change Type Sensors and Method of Using the Same
    6.
    发明申请
    Sensor Device Having Plural Resistance Change Type Sensors and Method of Using the Same 有权
    具有多个电阻变化型传感器的传感器装置及其使用方法

    公开(公告)号：US20140283597A1

    公开(公告)日：2014-09-25

    申请号：US14224223

    申请日：2014-03-25

    申请人： Jie Zheng ,  Ryo Ito ,  Kenji Kanazawa ,  Osamu Takahashi

    发明人： Jie Zheng ,  Ryo Ito ,  Kenji Kanazawa ,  Osamu Takahashi

    IPC分类号： G01N27/12 ,  G03G15/00

    CPC分类号： G03G21/203 ,  G01N27/121 ,  G03G2215/00084

    摘要： To detect humidity, used are a first series connection circuit connecting a thermistor and a fixed resistor via a node, a second series connection circuit connecting a resistance change type humidity sensor and the thermistor via the node, and a third series connection circuit connecting the humidity sensor and the fixed resistor via the node. A predetermined voltage is applied across the first circuit to detect a first voltage indicating temperature through the node, and secondly across the second circuit to detect a second voltage indicating a first humidity through the node, and finally across the third circuit to detect a third voltage indicating a second humidity through the node. Then, the first voltage is compared with a reference voltage and judgment is made, based on a comparison result, to determine which of the second voltage and the third voltage is relevant to use as a basis for outputting the humidity as detected.

    摘要翻译： 为了检测湿度，使用的是通过节点连接热敏电阻和固定电阻器的第一串联连接电路，经由节点连接电阻变化型湿度传感器和热敏电阻的第二串联连接电路和连接湿度的第三串联连接电路 传感器和固定电阻通过节点。 在第一电路两端施加预定电压以检测通过该节点的指示温度的第一电压，其次跨越第二电路检测指示通过节点的第一湿度的第二电压，最后跨越第三电路检测第三电压 表示通过节点的第二湿度。 然后，将第一电压与参考电压进行比较，并且基于比较结果进行判断，以确定第二电压和第三电压中的哪一个与用作输出检测到的湿度的基础相关。

    METHOD AND APPARATUS FOR DETERMINING TREATMENT MARGIN OF TARGET AREA
    7.
    发明申请
    METHOD AND APPARATUS FOR DETERMINING TREATMENT MARGIN OF TARGET AREA 有权
    用于确定目标区域治疗标准的方法和装置

    公开(公告)号：US20140064449A1

    公开(公告)日：2014-03-06

    申请号：US14013188

    申请日：2013-08-29

    申请人： Xiang Deng ,  Jie Zheng

    发明人： Xiang Deng ,  Jie Zheng

    IPC分类号： A61B6/00

    CPC分类号： A61B6/504 ,  A61B6/032 ,  A61B6/4441 ,  A61B6/463 ,  A61B6/5217 ,  A61B6/5235

    摘要： Disclosed is a method and apparatus for determining a tumor ablation margin. The method includes acquiring an angiography image before tumor ablation and an angiography image after tumor ablation when tumor ablation is performed, registering the angiography image before tumor ablation and the angiography image after tumor ablation, and determining the tumor ablation margin according to the relative positions of the tumor area in the angiography image before tumor ablation and the ablation area in the angiography image after tumor ablation after registration. Using an embodiment, one directly determines the tumor ablation margin during tumor ablation, thus improving the efficiency and success rate of tumor ablation.

    摘要翻译： 公开了一种用于确定肿瘤消融边缘的方法和装置。 该方法包括在进行肿瘤消融术前获取肿瘤消融前的血管造影图像和肿瘤消融后的血管造影图像，在肿瘤消融前记录血管造影图像和肿瘤消融后的血管造影图像，并根据相对位置确定肿瘤消融边缘 肿瘤消融前血管造影图像中的肿瘤区域和注射后肿瘤消融后血管造影图像中的消融区域。 使用一个实施例，在肿瘤消融期间直接确定肿瘤消融边缘，从而提高肿瘤消融的效率和成功率。

    Nano-sized optical fluorescence labels and uses thereof
    9.
    发明授权
    Nano-sized optical fluorescence labels and uses thereof 失效
    纳米尺寸的光学荧光标记及其用途

    公开(公告)号：US07611907B2

    公开(公告)日：2009-11-03

    申请号：US10519267

    申请日：2003-06-27

    申请人： Robert Martin Dickson ,  Jie Zheng

    发明人： Robert Martin Dickson ,  Jie Zheng

    IPC分类号： G01N33/553

    CPC分类号： B82Y15/00 ,  G01N33/582 ,  G01N33/588 ,  Y10S436/805

    摘要： A composition is disclosed which is capable of being used for detection, comprising an encapsulated noble metal nanocluster. Methods for preparing the encapsulated noble metal nanoclusters, and methods of using the encapsulated noble metal nanoclusters are also disclosed. The noble metal nanoclusters are preferably encapsulated by a dendrimer or a peptide. The encapsulated noble metal nanoclusters have a characteristic spectral emission, wherein said spectral emission is varied by controlling the nature of the encapsulating material, such as by controlling the size of the nanocluster and/or the generation of the dendrimer, and wherein said emission is used to provide information about a biological state.

    摘要翻译： 公开了能够用于检测的组合物，其包含包封的贵金属纳米簇。 还公开了制备包封的贵金属纳米簇的方法，以及使用包封的贵金属纳米团簇的方法。 贵金属纳米团簇优选被树枝状聚合物或肽包封。 封装的贵金属纳米团簇具有特征光谱发射，其中所述光谱发射通过控制封装材料的性质而变化，例如通过控制纳米簇的尺寸和/或树枝状聚合物的产生，并且其中使用所述发射 提供有关生物状态的信息。

    Raman-Enhancing, and Non-Linear Optically Active Nano-Sized Optical Labels and Uses Thereof
    10.
    发明申请
    Raman-Enhancing, and Non-Linear Optically Active Nano-Sized Optical Labels and Uses Thereof 审中-公开
    拉曼增强和非线性光学活性纳米尺寸光学标签及其用途

    公开(公告)号：US20080118912A1

    公开(公告)日：2008-05-22

    申请号：US10598722

    申请日：2005-03-10

    申请人： Robert Martin Dickson ,  Jie Zheng ,  Lynn Anne Capadona ,  Jeffrey Thomas Petty ,  Sandeep Ajit Patel ,  Marcus Weck

    发明人： Robert Martin Dickson ,  Jie Zheng ,  Lynn Anne Capadona ,  Jeffrey Thomas Petty ,  Sandeep Ajit Patel ,  Marcus Weck

    IPC分类号： G01N33/543 ,  G01N33/53 ,  C12Q1/68

    CPC分类号： G01N33/588 ,  A61K49/0065 ,  A61K49/0067 ,  A61K49/0093 ,  B82Y15/00 ,  G01N33/532 ,  G01N33/54346 ,  G01N33/5436 ,  G01N33/582 ,  Y10T436/107497

    摘要： A composition is disclosed which is capable of being used for detection, comprising an encapsulated noble metal nanocluster. Methods for preparing the encapsulated noble metal nanoclusters, and methods of using the encapsulated noble metal nanoclusters are also disclosed. In certain embodiments, the noble metal nanoclusters are encapsulated by a dendrimer, a peptide, a small organic or inorganic molecule, or an oligonucleotide. The encapsulated noble metal nanoclusters have a characteristic spectral emission, wherein said spectral emission is varied by controlling the nature of the encapsulating material, such as by controlling the size of the nanocluster, the generation of a dendrimer, the incorporation of a functional group, and wherein said emission is used to provide information about a biological state. The emission is selected from the group consisting of nanocluster fluorescence, multiphoton excited nanocluster fluorescence, Stokes or Anti-Stokes Raman emission from the encapsulating material, and second harmonic generation.

    摘要翻译： 公开了能够用于检测的组合物，其包含包封的贵金属纳米簇。 还公开了制备包封的贵金属纳米簇的方法，以及使用包封的贵金属纳米团簇的方法。 在某些实施方案中，贵金属纳米簇被树枝状聚合物，肽，小有机或无机分子或寡核苷酸包封。 封装的贵金属纳米团簇具有特征光谱发射，其中通过控制封装材料的性质来改变所述光谱发射，例如通过控制纳米簇的尺寸，树枝状聚合物的产生，官能团的结合，和 其中所述发射用于提供关于生物学状态的信息。 发射选自纳米团簇荧光，多光子激发纳米团簇荧光，来自封装材料的斯托克斯或反斯托克斯拉曼发射以及二次谐波产生。