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公开(公告)号：US20050222117A1
公开(公告)日：2005-10-06
申请号：US11007325
申请日：2004-12-09
申请人： Yih-Chih Hsu , Wen-Tyng Li , Jeffrey Lin , Bor-Iuan Jan , Tzu-I Wu , Jih-Shen Wen , Chi-Ming Yang
发明人： Yih-Chih Hsu , Wen-Tyng Li , Jeffrey Lin , Bor-Iuan Jan , Tzu-I Wu , Jih-Shen Wen , Chi-Ming Yang
IPC分类号： A61K31/409 , A61K31/555
CPC分类号： A61K31/409 , A61K41/0071 , A61K49/0036
摘要： The present invention relates to a method for treating liver cancer or oral cancer through photodynamic therapy, comprising administrating a subject in need thereof an effective amount of formula I, formula □, formula III or formula IV, which could release reactive oxygen species to inhibit the growth of cancer cells, which comprise with formulas as described in the specification, wherein R1 is an alkyl or an aldehyde with carbon atoms no more than 2; the cancer is liver cancer or oral cancer.
摘要翻译： 本发明涉及通过光动力疗法治疗肝癌或口腔癌的方法，包括给予有需要的受试者有效量的式I，式□，式III或式IV，其可释放活性氧以抑制 由说明书中所述的式所组成的癌细胞的生长，其中R1是碳原子数不超过2的烷基或醛; 癌症是肝癌或口腔癌。
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2.发明申请Cell culture and method for screening for a compound useful in the treatment or prevention of hepatic cirrhosis 有权用于筛选用于治疗或预防肝硬化的化合物的细胞培养和方法公开(公告)号：US20060172416A1
公开(公告)日：2006-08-03
申请号：US11298586
申请日：2005-12-12
申请人： Wen-Tyng Li , Rung-Jiun Gau , Yu-Shih Weng , Cheng-Ta Hsieh , Pei-Shan Li
发明人： Wen-Tyng Li , Rung-Jiun Gau , Yu-Shih Weng , Cheng-Ta Hsieh , Pei-Shan Li
IPC分类号： C12N5/08
CPC分类号： G01N33/5067 , G01N33/5023 , G01N2800/085
摘要： The present invention provides a cell-culturing model and a method for screening compounds which can be applied in treating or preventing hepatic cirrhosis. The cell culturing model comprises a population of hepatocytes and hepatic stellate cells (HSCs) derived from co-culturing, and at least one population of the cells comprises a nucleotide sequence fragment of a reporter gene and a cell specific regulatory sequence. The cell-culturing model of the present invention can be applied in high throughput screening for effective compounds of medication, and also in understanding the functional mechanism of the effective compounds.
摘要翻译： 本发明提供了可用于治疗或预防肝硬化的化合物的细胞培养模型和筛选方法。 细胞培养模型包括源自共培养的肝细胞群和肝星状细胞（HSC），至少一个细胞群包含报告基因的核苷酸序列片段和细胞特异性调节序列。 本发明的细胞培养模型可以用于高通量筛选有效的药物化合物，也可用于理解有效化合物的功能机制。
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公开(公告)号：US20130149789A1
公开(公告)日：2013-06-13
申请号：US13490171
申请日：2012-06-06
申请人： Ging-Ho Hsiue , Shia-Chung Chen , Yaw-Jen Chang , Yi-Hua Fan , Wen-Tyng Li , Yung Chang , Ming-Fa Hsieh , Ching-Wei Huang , Ying-Ming Liang
发明人： Ging-Ho Hsiue , Shia-Chung Chen , Yaw-Jen Chang , Yi-Hua Fan , Wen-Tyng Li , Yung Chang , Ming-Fa Hsieh , Ching-Wei Huang , Ying-Ming Liang
IPC分类号： G01N21/75
CPC分类号： G01N35/10 , B01L3/50273 , B01L7/52 , G01N33/80 , G01N2035/00158 , G01N2035/00495
摘要： A liquid testing system is provided, which includes a distribution module, a testing chip, a driving module and an image analyzing module. The distribution module is for providing a liquid. The testing chip receives the liquid from the distribution module. The driving module is connected to the testing chip and drives the testing chip to rotate, wherein the liquid flowing in the testing chip is actuated by centrifugal force. The image analyzing module produces and analyzes an image of the liquid in the testing chip.
摘要翻译： 提供了一种液体检测系统，它包括分配模块，测试芯片，驱动模块和图像分析模块。 分配模块用于提供液体。 测试芯片从分配模块接收液体。 驱动模块连接到测试芯片并驱动测试芯片旋转，其中在测试芯片中流动的液体由离心力驱动。 图像分析模块生成和分析测试芯片中液体的图像。
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公开(公告)号：US20050142656A1
公开(公告)日：2005-06-30
申请号：US11019380
申请日：2004-12-23
申请人： Wen-Tyng Li , Yu-Shi Weng , Ming-Zheng Shiu
发明人： Wen-Tyng Li , Yu-Shi Weng , Ming-Zheng Shiu
摘要： A cell incubating apparatus and a method of culturing a cell in vitro are disclosed, which relates to a medical cell proliferation, pharmaceutical screening and automatic cell analysis in tissue engineering technology. The apparatus establishes an imitating three-dimensional transportation microenvironment by assembling a top plate, a bottom plate and at least one culture plate apparatus for incubating a cell. The apparatus is not only for incubating the tissue specific cell with biological function but also for lowering the cost of culturing personal medical cells.
摘要翻译： 公开了细胞培养装置和体外培养细胞的方法，其涉及组织工程技术中的医学细胞增殖，药物筛选和自动细胞分析。 该装置通过组装顶板，底板和用于孵育细胞的至少一个培养板装置来建立模仿的三维运输微环境。 该装置不仅用于培养具有生物功能的组织特异性细胞，而且用于降低培养个人医疗细胞的成本。
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5.发明授权Cell culture and method for screening for a compound useful in the treatment or prevention of hepatic cirrhosis 有权用于筛选用于治疗或预防肝硬化的化合物的细胞培养和方法公开(公告)号：US07745120B2
公开(公告)日：2010-06-29
申请号：US11298586
申请日：2005-12-12
申请人： Wen-Tyng Li , Rung-Jiun Gau , Yu-Shih Weng , Cheng-Ta Hsieh , Pei-Shan Li
发明人： Wen-Tyng Li , Rung-Jiun Gau , Yu-Shih Weng , Cheng-Ta Hsieh , Pei-Shan Li
CPC分类号： G01N33/5067 , G01N33/5023 , G01N2800/085
摘要： The present invention provides a cell-culturing model and a method for screening compounds which can be applied in treating or preventing hepatic cirrhosis. The cell culturing model comprises a population of hepatocytes and hepatic stellate cells (HSCs) derived from co-culturing, and at least one population of the cells comprises a nucleotide sequence fragment of a reporter gene and a cell specific regulatory sequence. The cell-culturing model of the present invention can be applied in high throughput screening for effective compounds of medication, and also in understanding the functional mechanism of the effective compounds.
摘要翻译： 本发明提供了可用于治疗或预防肝硬化的化合物的细胞培养模型和筛选方法。 细胞培养模型包括源自共培养的肝细胞群和肝星状细胞（HSC），至少一个细胞群包含报告基因的核苷酸序列片段和细胞特异性调节序列。 本发明的细胞培养模型可以用于高通量筛选有效的药物化合物，也可用于理解有效化合物的功能机制。
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公开(公告)号：US07029907B2
公开(公告)日：2006-04-18
申请号：US11019380
申请日：2004-12-23
申请人： Wen-Tyng Li , Yu-Shi Weng , Ming-Zheng Shiu
发明人： Wen-Tyng Li , Yu-Shi Weng , Ming-Zheng Shiu
IPC分类号： C12M1/12
摘要： A cell incubating apparatus and a method of culturing cells in vitro are disclosed, which relates to medical cell proliferation, pharmaceutical chemical screening and automatic cell analysis in tissue engineering technology. The apparatus establishes an imitating three-dimensional transportation microenvironment by assembling a top plate, a bottom plate and at least one culture plate apparatus for incubating cells. The apparatus is not only for incubating the tissue specific cells with biological function but also for lowering the cost of culturing cells for personal medical use.
摘要翻译： 公开了细胞培养装置和体外培养细胞的方法，其涉及组织工程技术中的医学细胞增殖，药物化学筛选和自动细胞分析。 该装置通过组装顶板，底板和用于孵育细胞的至少一个培养板装置来建立模仿的三维运输微环境。 该装置不仅用于培养具有生物功能的组织特异性细胞，而且用于降低培养用于个人医疗用途的细胞的成本。
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