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1.发明申请公开(公告)号：US20070010459A1
公开(公告)日：2007-01-11
申请号：US11333030
申请日：2006-01-17
申请人： Ying Liu , Xingchu Gu , Quanhai Liu , Longhai Shen , Jingzhi Dai , Minyu Liu
发明人： Ying Liu , Xingchu Gu , Quanhai Liu , Longhai Shen , Jingzhi Dai , Minyu Liu
IPC分类号： A61K31/704 , A61K31/20
CPC分类号： A61K31/20 , A61K31/704
摘要： Compositions comprising asiatic acid and its derivatives and asiaticoside and the methods of use there of to treat pulmonary fibrosis are provided.
摘要翻译： 提供了包含积雪草酸及其衍生物和积雪草苷的组合物及其用于治疗肺纤维化的方法。
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公开(公告)号：US20140128463A1
公开(公告)日：2014-05-08
申请号：US14129000
申请日：2012-06-25
申请人： Zhenpeng Yu , Gouping Wang , Zhen Zhang , Minyu Liu , Xiaoling Huang , Ying Liu , Lin Xiao , Li Cai , Xuejun Wu , Yifang Deng , Mianli Pan , Renhai Chen , Shenrong Tang , Quanhai Liu
发明人： Zhenpeng Yu , Gouping Wang , Zhen Zhang , Minyu Liu , Xiaoling Huang , Ying Liu , Lin Xiao , Li Cai , Xuejun Wu , Yifang Deng , Mianli Pan , Renhai Chen , Shenrong Tang , Quanhai Liu
IPC分类号： C07C235/84 , C07C231/02
CPC分类号： C07C235/84 , A61K31/165 , A61K31/166 , A61K31/222 , C07C231/02 , C07C235/20 , C07C235/26 , C07C251/24 , C07C325/02 , C07C2601/02 , C07C2601/14
摘要： Disclosed are amide compounds, preparation method and uses thereof, specifically, the compounds represented by formula I or pharmaceutically acceptable salts, wherein R1, R2, R3, R4, R5, Q, X and n are defined as in the description. Also disclosed are a method for preparing the compounds of formula I, a composition containing the compounds, and the uses of the same in the preparation of medicaments for regulating blood lipid and/or preventing gallstone. The compounds of formula I disclosed in the present invention have stability in vitro, good solubility in the pharmaceutical organic solvents and favorable bioavailability in animals.
摘要翻译： 公开了酰胺化合物，其制备方法和用途，具体地，由式I表示的化合物或其药学上可接受的盐，其中R 1，R 2，R 3，R 4，R 5，Q，X和n如描述中所定义。 还公开了制备式I化合物的方法，含有该化合物的组合物及其在制备用于调节血脂和/或预防胆结石的药物中的用途。 本发明公开的式I化合物在体外具有稳定性，在药用有机溶剂中的溶解性好，动物中具有良好的生物利用度。
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公开(公告)号：US08962880B2
公开(公告)日：2015-02-24
申请号：US14006198
申请日：2012-03-21
申请人： Guobin Ren , Ying Liu , Jinyao Chen , Xiaoling Huang , Lin Xiao , Li Cai , Zhen Zhang , Xuejun Wu , Haiyan Sun , Quanhai Liu , Liling Jin , Minyu Liu , Yifang Deng , Zhiru Xu , Renhai Chen , Chungang Li , Xiangduan Tan , Yan Qin
发明人： Guobin Ren , Ying Liu , Jinyao Chen , Xiaoling Huang , Lin Xiao , Li Cai , Zhen Zhang , Xuejun Wu , Haiyan Sun , Quanhai Liu , Liling Jin , Minyu Liu , Yifang Deng , Zhiru Xu , Renhai Chen , Chungang Li , Xiangduan Tan , Yan Qin
IPC分类号： C07C227/14 , C07C215/10 , C07C229/38 , C07J63/00
CPC分类号： C07C227/14 , C07C215/10 , C07C229/38 , C07J63/008
摘要： An amorphous asiatic tromethamine salt and the preparation method thereof. The method includes the steps of: (1) dissolving asiatic acid in an organic solvent; step (2) mixing with tromethamine; step (3) stirring and salifying the same, and then removing the organic solvent. The method for preparing the amorphous asiatic tromethamine salt is easy and effective, and the water solubility and bioavailability of the asiatic tromethamine salt thus obtained are greatly compared with the prior art.
摘要翻译： 一种无定形亚洲氨丁三醇盐及其制备方法。 该方法包括以下步骤：（1）将积雪草酸溶解在有机溶剂中; 步骤（2）与氨丁三醇混合; 步骤（3）搅拌并使其成盐，然后除去有机溶剂。 无定形亚洲氨基丁三醇盐的制备方法容易有效，与现有技术相比，所得到的亚稳氨基甲基胺盐的水溶性和生物利用度大大降低。
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公开(公告)号：US10428013B2
公开(公告)日：2019-10-01
申请号：US14129000
申请日：2012-06-25
申请人： Zhenpeng Yu , Gouping Wang , Zhen Zhang , Minyu Liu , Xiaoling Huang , Ying Liu , Lin Xiao , Li Cai , Xuejun Wu , Yifang Deng , Mianli Pan , Renhai Chen , Shenrong Tang , Quanhai Liu
发明人： Zhenpeng Yu , Gouping Wang , Zhen Zhang , Minyu Liu , Xiaoling Huang , Ying Liu , Lin Xiao , Li Cai , Xuejun Wu , Yifang Deng , Mianli Pan , Renhai Chen , Shenrong Tang , Quanhai Liu
IPC分类号： C07C235/84 , A61K31/165 , A61K31/166 , A61K31/222 , C07C325/02 , C07C235/20 , C07C235/26 , C07C251/24 , C07C231/02
摘要： Disclosed are amide compounds, preparation method and uses thereof, specifically, the compounds represented by formula I or pharmaceutically acceptable salts, wherein R1, R2, R3, R4, R5, Q, X and n are defined as in the description. Also disclosed are a method for preparing the compounds of formula I, a composition containing the compounds, and the uses of the same in the preparation of medicaments for regulating blood lipid and/or preventing gallstone. The compounds of formula I disclosed in the present invention have stability in vitro, good solubility in the pharmaceutical organic solvents and favorable bioavailability in animals.
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公开(公告)号：US20140243553A1
公开(公告)日：2014-08-28
申请号：US14006198
申请日：2012-03-21
申请人： Guobin Ren , Ying Liu , Jinyao Chen , Xiaoling Huang , Lin Xiao , Li Cai , Zhen Zhang , Xuejun Wu , Haiyan Sun , Quanhai Liu , Liling Jin , Minyu Liu , Yifang Deng , Zhiru Xu , Renhai Chen , Chungang Li , Xiangduan Tan , Yan Qin
发明人： Guobin Ren , Ying Liu , Jinyao Chen , Xiaoling Huang , Lin Xiao , Li Cai , Zhen Zhang , Xuejun Wu , Haiyan Sun , Quanhai Liu , Liling Jin , Minyu Liu , Yifang Deng , Zhiru Xu , Renhai Chen , Chungang Li , Xiangduan Tan , Yan Qin
IPC分类号： C07C227/14 , C07C229/38
CPC分类号： C07C227/14 , C07C215/10 , C07C229/38 , C07J63/008
摘要： An amorphous asiatic tromethamine salt and the preparation method thereof. The method includes the steps of: (1) dissolving asiatic acid in an organic solvent; step (2) mixing with tromethamine; step (3) stirring and salifying the same, and then removing the organic solvent. The method for preparing the amorphous asiatic tromethamine salt is easy and effective, and the water solubility and bioavailability of the asiatic tromethamine salt thus obtained are greatly compared with the prior art.
摘要翻译： 一种无定形亚洲氨丁三醇盐及其制备方法。 该方法包括以下步骤：（1）将积雪草酸溶解在有机溶剂中; 步骤（2）与氨丁三醇混合; 步骤（3）搅拌并使其成盐，然后除去有机溶剂。 无定形亚洲氨基丁三醇盐的制备方法容易有效，与现有技术相比，所得到的亚稳氨基甲基胺盐的水溶性和生物利用度大大降低。
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公开(公告)号：US08258176B2
公开(公告)日：2012-09-04
申请号：US12676470
申请日：2008-08-29
申请人： Guoping Wang , Quanhai Liu , Haiyan Sun , Wei Wu , Jian Hou , Lin Yao , Chungang Li , Minyu Liu , Fei Li , Xuejun Wu , Shuai Zhao
发明人： Guoping Wang , Quanhai Liu , Haiyan Sun , Wei Wu , Jian Hou , Lin Yao , Chungang Li , Minyu Liu , Fei Li , Xuejun Wu , Shuai Zhao
IPC分类号： A61K31/407 , C07D487/04 , C07D487/02
CPC分类号： C07D495/04
摘要： The invention discloses a dithiolopyrrolone compound represented by formula I or its pharmaceutically acceptable salts, wherein X1, R1, R2, R3, R4 are defined as in the description. The invention also discloses the preparation of such compounds, and the use of such compounds in preparation of medicaments for increasing peripheral white blood cells and in preparation of ancillary medicaments for inhibiting the decrease of peripheral white blood cells in radiotherapy or chemotherapy.
摘要翻译： 本发明公开了由式I表示的二硫代环吡咯酮化合物或其药学上可接受的盐，其中X1，R1，R2，R3，R4如描述中所定义。 本发明还公开了这样的化合物的制备，以及这些化合物在制备用于增加外周白细胞的药物中的用途以及用于抑制放射治疗或化学疗法中外周白细胞减少的辅助药物。
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公开(公告)号：US20100210856A1
公开(公告)日：2010-08-19
申请号：US12676470
申请日：2008-08-29
申请人： Guoping Wang , Quanhai Liu , Haiyan Sun , Wei Wu , Jian Hou , Lin Yao , Chungang Li , Minyu Liu , Fei Li , Xuejun Wu , Shuai Zhao
发明人： Guoping Wang , Quanhai Liu , Haiyan Sun , Wei Wu , Jian Hou , Lin Yao , Chungang Li , Minyu Liu , Fei Li , Xuejun Wu , Shuai Zhao
IPC分类号： C07D495/04
CPC分类号： C07D495/04
摘要： The invention discloses a dithiolopyrrolone compound represented by formula I or its pharmaceutically acceptable salts, wherein X1, R1, R2, R3, R4 are defined as in the description. The invention also discloses the preparation of such compounds, and the use of such compounds in preparation of medicaments for increasing peripheral white blood cells and in preparation of ancillary medicaments for inhibiting the decrease of peripheral white blood cells in radiotherapy or chemotherapy.
摘要翻译： 本发明公开了由式I表示的二硫代环吡咯酮化合物或其药学上可接受的盐，其中X1，R1，R2，R3，R4如描述中所定义。 本发明还公开了这样的化合物的制备，以及这些化合物在制备用于增加外周白细胞的药物中的用途以及用于抑制放射治疗或化学疗法中外周白细胞减少的辅助药物。
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8.发明授权公开(公告)号：US08742167B2
公开(公告)日：2014-06-03
申请号：US12811477
申请日：2009-01-08
申请人： Ying Liu , Quanhai Liu , Yan Qin , Tong Wu , Zhiru Xu , Min-yu Liu , Fei Li , Yan Li , Michael J. Newman
发明人： Ying Liu , Quanhai Liu , Yan Qin , Tong Wu , Zhiru Xu , Min-yu Liu , Fei Li , Yan Li , Michael J. Newman
IPC分类号： C07C61/29
CPC分类号： C07J63/008
摘要： A highly pure asiaticoside and a pharmaceutical grade asiatic acid can be prepared, along with salts of asiatic acid, for use in formulating therapeutic compositions that are suitable for treating arthritis, psoriasis and other inflammatory diseases, as well as pulmonary fibrosis, diabetic nephropathy, and other fibrotic diseases.
摘要翻译： 可以制备高纯度积雪草苷和药物级积雪草酸以及积雪草酸盐，用于配制适合于治疗关节炎，牛皮癣和其它炎性疾病以及肺纤维化，糖尿病性肾病和 其他纤维化疾病。
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9.发明申请公开(公告)号：US20100331413A1
公开(公告)日：2010-12-30
申请号：US12811477
申请日：2009-01-08
申请人： Ying Liu , Quanhai Liu , Yan Qin , Tong Wu , Zhiru Xu , Min-yu Liu , Fei Li , Yan Li , Michael J. Newman
发明人： Ying Liu , Quanhai Liu , Yan Qin , Tong Wu , Zhiru Xu , Min-yu Liu , Fei Li , Yan Li , Michael J. Newman
IPC分类号： A61K31/19 , C07C62/32 , C07C233/00 , C07C69/74 , C07H13/02 , A61P11/00 , A61P3/10 , A61P1/00 , A61P17/06 , A61P19/02
CPC分类号： C07J63/008
摘要： A highly pure asiaticoside and a pharmaceutical grade asiatic acid can be prepared, along with salts of asiatic acid, for use in formulating therapeutic compositions that are suitable for treating arthritis, psoriasis and other inflammatory diseases, as well as pulmonary fibrosis, diabetic nephropathy, and other fibrotic diseases.
摘要翻译： 可以制备高纯度积雪草苷和药物级积雪草酸以及积雪草酸盐，用于配制适合于治疗关节炎，牛皮癣和其它炎性疾病以及肺纤维化，糖尿病性肾病和 其他纤维化疾病。
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公开(公告)号：US20090281049A1
公开(公告)日：2009-11-12
申请号：US12311081
申请日：2007-08-06
申请人： Quanhai Liu , Pei Zhou , Hua Bai , Wei Zhou , Jingjing Li , Meiqing Feng , Moli Hua , Jingyue Xu
发明人： Quanhai Liu , Pei Zhou , Hua Bai , Wei Zhou , Jingjing Li , Meiqing Feng , Moli Hua , Jingyue Xu
IPC分类号： A61K31/7032 , A61P19/02
CPC分类号： A61K31/704
摘要： Use of ginsenoside Compound-K, which structural formula is the following: in manufacturing medicaments for prevention or treatment of arthritis.
摘要翻译： 使用人参皂甙化合物K，其结构式如下：制备用于预防或治疗关节炎的药物。
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