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    Optimizing therapy outcomes for peritoneal dialysis
    2.
    发明授权
    Optimizing therapy outcomes for peritoneal dialysis 有权
    优化腹膜透析治疗效果

    公开(公告)号：US09348975B2

    公开(公告)日：2016-05-24

    申请号：US12431458

    申请日：2009-04-28

    申请人： Ying-Cheng Lo ,  Alp Akonur ,  Isaac Martis

    发明人： Ying-Cheng Lo ,  Alp Akonur ,  Isaac Martis

    IPC分类号： G06F19/00 ,  A61M1/28

    CPC分类号： G06F19/3481 ,  A61M1/28 ,  A61M1/281 ,  A61M1/282 ,  A61M2205/3569 ,  A61M2205/52 ,  A61M2205/6018 ,  A61M2205/6054 ,  A61M2205/6072 ,  G06F19/00

    摘要： Peritoneal dialysis therapy outcomes have been calculated for a variety of dwell times of peritoneal dialysis fluids in the peritoneal cavities of dialysis patients using kinetic modeling. The length of dwell time should not be the same for every patient, but should vary according to the patient condition and needs. Some patients have a potential for expressing greater ultrafiltrate into the dialysis fluid, and these patients can benefit from a longer dwell time, whereas other patients with less potential will not benefit from a longer dwell time. An optimal or peak time is observed for each peritoneal dialysis therapy outcome, such as ultrafiltrate volume rate, urea clearance (Kt/V), and creatinine clearance, while minimizing hydrocarbon absorption. These values and input parameters can be used to tailor the peritoneal dialysis dwell time for each patient, estimating the peak dwell time that will yield the best therapy outcome for each patient.

    摘要翻译： 已经使用动力学模型计算了透析患者腹膜腔腹膜透析液的各种停留时间的腹膜透析治疗结果。 每个患者的停留时间长度不应相同，但应根据患者情况和需要而变化。 一些患者有可能在透析液中表达更多的超滤液，这些患者可以从更长的停留时间中受益，而潜在的潜力较小的患者不会受益于更长的停留时间。 对于每个腹膜透析治疗结果，观察到最佳或高峰时间，例如超滤液体积率，尿素清除率（Kt / V）和肌酐清除率，同时使烃吸收最小化。 这些值和输入参数可用于定制每个患者的腹膜透析停留时间，估计将为每位患者产生最佳治疗结果的峰值停留时间。

    OPTIMIZING THERAPY OUTCOMES FOR PERITONEAL DIALYSIS
    3.
    发明申请
    OPTIMIZING THERAPY OUTCOMES FOR PERITONEAL DIALYSIS 有权
    优化治疗结果进行透析

    公开(公告)号：US20090275881A1

    公开(公告)日：2009-11-05

    申请号：US12431458

    申请日：2009-04-28

    申请人： Ying-Cheng Lo ,  Alp Akonur ,  Isaac Martis

    发明人： Ying-Cheng Lo ,  Alp Akonur ,  Isaac Martis

    IPC分类号： A61M1/28 ,  A61B5/00 ,  A61B5/107 ,  G06F17/10 ,  G06F17/30

    CPC分类号： G06F19/3481 ,  A61M1/28 ,  A61M1/281 ,  A61M1/282 ,  A61M2205/3569 ,  A61M2205/52 ,  A61M2205/6018 ,  A61M2205/6054 ,  A61M2205/6072 ,  G06F19/00

    摘要： Peritoneal dialysis therapy outcomes have been calculated for a variety of dwell times of peritoneal dialysis fluids in the peritoneal cavities of dialysis patients using kinetic modeling. The length of dwell time should not be the same for every patient, but should vary according to the patient condition and needs. Some patients have a potential for expressing greater ultrafiltrate into the dialysis fluid, and these patients can benefit from a longer dwell time, whereas other patients with less potential will not benefit from a longer dwell time. An optimal or peak time is observed for each peritoneal dialysis therapy outcome, such as ultrafiltrate volume rate, urea clearance (Kt/V), and creatinine clearance, while minimizing hydrocarbon absorption. These values and input parameters can be used to tailor the peritoneal dialysis dwell time for each patient, estimating the peak dwell time that will yield the best therapy outcome for each patient.

    摘要翻译： 已经使用动力学模型计算了透析患者腹膜腔腹膜透析液的各种停留时间的腹膜透析治疗结果。 每个患者的停留时间长度不应相同，但应根据患者情况和需要而变化。 一些患者有可能在透析液中表达更多的超滤液，这些患者可以从更长的停留时间中受益，而潜在的潜力较小的患者不会受益于更长的停留时间。 对于每个腹膜透析治疗结果观察到最佳或高峰时间，例如超滤液体积率，尿素清除率（Kt / V）和肌酐清除率，同时使烃吸收最小化。 这些值和输入参数可用于定制每个患者的腹膜透析停留时间，估计将为每位患者产生最佳治疗结果的峰值停留时间。

    Peritoneal dialysis therapy with large dialysis solution volumes
    4.
    发明授权
    Peritoneal dialysis therapy with large dialysis solution volumes 有权
    腹膜透析治疗大量透析液量

    公开(公告)号：US08926551B2

    公开(公告)日：2015-01-06

    申请号：US12498853

    申请日：2009-07-07

    申请人： Ying-Cheng Lo ,  Alp Akonur ,  Yuanpang S. Ding

    发明人： Ying-Cheng Lo ,  Alp Akonur ,  Yuanpang S. Ding

    IPC分类号： A61M1/00 ,  A61M1/28

    CPC分类号： A61M1/28 ,  A61M1/282

    摘要： Patients suffering from acute renal failure must be diagnosed and treated quickly so that a physician can confidently prescribe either peritoneal dialysis or hemodialysis. In one way of quickly treating the patients, software is used to calculate a suitable peritoneal dialysis prescription without regard to how short or how long a dialysis cycle is used, and without regard to a total dialysate fluid volume for a therapy. For patients with suitable peritoneal membrane transport properties, the software program suggests that, at least over a short period of time, unexpectedly high ultrafiltrate volumes and high clearances may be achieved.

    摘要翻译： 患急性肾衰竭的患者必须迅速诊断和治疗，以便医生可以自信地开出腹膜透析或血液透析。 以快速治疗患者的一种方式，使用软件来计算合适的腹膜透析处方，而不考虑使用透析循环的短暂或多长时间，并且不考虑用于治疗的总透析液体积。 对于具有适当腹膜转运性质的患者，软件程序表明，至少在短时间内，可能会实现出乎意料的高超滤液体积和高清除率。

    Simplified peritoneal equilibration test for peritoneal dialysis
    5.
    发明授权
    Simplified peritoneal equilibration test for peritoneal dialysis 有权
    腹膜透析简化腹膜平衡试验

    公开(公告)号：US08180574B2

    公开(公告)日：2012-05-15

    申请号：US12498847

    申请日：2009-07-07

    申请人： Ying-Cheng Lo ,  Alp Akonur ,  Sarah Stobo Prichard

    发明人： Ying-Cheng Lo ,  Alp Akonur ,  Sarah Stobo Prichard

    IPC分类号： G01N33/48 ,  G06F19/00

    CPC分类号： A61M1/28 ,  A61M1/1619

    摘要： A simplified peritoneal equilibration test (S-PET) is disclosed. Instead of a lengthy peritoneal equilibration test (PET), the simplified procedure requires no blood sample and may use data from as few as two or three samples to classify a peritoneal membrane of a user. Typically, a peritoneal membrane or peritoneum of a dialysis patient, or other person, is classed as a high transport membrane, high-average transport membrane, a low-average transport membrane or a low transporter membrane. The S-PET may be performed at home by a user without the need to submit a blood sample. Kits for analyzing the samples may be furnished for home use. The kits may use disposable strips, microfluidic analyzers or chemical reagents, or may alternatively include reusable analysis equipment, such as optical or conductivity analysis equipment.

    摘要翻译： 公开了一种简化的腹膜平衡试验（S-PET）。 代替长时间的腹膜平衡试验（PET），简化的程序不需要血液样品，并且可以使用少至两个或三个样品的数据来分类用户的腹膜。 通常，透析患者或其他人的腹膜或腹膜被分类为高运输膜，高平均运输膜，低平均运输膜或低转运膜。 S-PET可以由用户在家进行，而不需要提交血样。 用于分析样品的试剂盒可供家庭使用。 试剂盒可以使用一次性条，微流控分析仪或化学试剂，或者可以替代地包括可重复使用的分析设备，例如光学或电导率分析设备。

    Simulation of patient drain phase in peritoneal dialysis
    8.
    发明授权
    Simulation of patient drain phase in peritoneal dialysis 有权
    模拟腹膜透析患者排水期

    公开(公告)号：US08521482B2

    公开(公告)日：2013-08-27

    申请号：US12389886

    申请日：2009-02-20

    申请人： Alp Akonur ,  Ying-Cheng Lo

    发明人： Alp Akonur ,  Ying-Cheng Lo

    IPC分类号： G06F7/60

    CPC分类号： G16H50/50 ,  A61M1/28 ,  A61M1/282

    摘要： A method of modeling a patient's peritoneal dialysis drain phase includes (i) modeling a first segment of a drain phase curve as having a constant flowrate; (ii) modeling a second segment of a drain phase curve as having a decaying exponential flowrate; and (iii) incorporating a switching component into the first and second components so that (a) at a first time the first segment is active and while the second segment is inactive and (b) at a second time the first segment is inactive and while the second segment is active.

    摘要翻译： 建模患者腹膜透析排泄阶段的方法包括（i）将排水相曲线的第一段建模为具有恒定的流速; （ii）将排水相曲线的第二段建模为具有衰减指数流速; 以及（iii）将切换组件并入到所述第一和第二组件中，使得（a）在第一时间第一段处于活动状态，而第二段处于非活动状态，并且（b）在第二时间段，第一段无效，而 第二段是活跃的。

    PERITONEAL DIALYSIS THERAPY WITH LARGE DIALYSIS SOLUTION VOLUMES
    9.
    发明申请
    PERITONEAL DIALYSIS THERAPY WITH LARGE DIALYSIS SOLUTION VOLUMES 有权
    大量透析溶液的腹膜透析治疗

    公开(公告)号：US20110009810A1

    公开(公告)日：2011-01-13

    申请号：US12498853

    申请日：2009-07-07

    申请人： Ying-Cheng Lo ,  Alp Akonur ,  Yuanpang S. Ding

    发明人： Ying-Cheng Lo ,  Alp Akonur ,  Yuanpang S. Ding

    IPC分类号： A61M1/28

    CPC分类号： A61M1/28 ,  A61M1/282

    摘要： Patients suffering from acute renal failure must be diagnosed and treated quickly so that a physician can confidently prescribe either peritoneal dialysis or hemodialysis. In one way of quickly treating the patients, software is used to calculate a suitable peritoneal dialysis prescription without regard to how short or how long a dialysis cycle is used, and without regard to a total dialysate fluid volume for a therapy. For patients with suitable peritoneal membrane transport properties, the software program suggests that, at least over a short period of time, unexpectedly high ultrafiltrate volumes and high clearances may be achieved.

    摘要翻译： 患急性肾衰竭的患者必须迅速诊断和治疗，以便医生可以自信地开出腹膜透析或血液透析。 以快速治疗患者的一种方式，使用软件来计算合适的腹膜透析处方，而不考虑使用透析循环的短暂或多长时间，并且不考虑用于治疗的总透析液体积。 对于具有适当腹膜转运性质的患者，软件程序表明，至少在短时间内，可能会实现出乎意料的高超滤液体积和高清除率。