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1.发明授权公开(公告)号：US07225083B2
公开(公告)日：2007-05-29
申请号：US10878851
申请日：2004-06-28
申请人： Roberto Weinmann , Howard M. Einspahr , Stanley R. Krystek , John S. Sack , Mark E. Salvati , John S. Tokarski , Ricardo M. Attar , Chihuei Wang
发明人： Roberto Weinmann , Howard M. Einspahr , Stanley R. Krystek , John S. Sack , Mark E. Salvati , John S. Tokarski , Ricardo M. Attar , Chihuei Wang
CPC分类号： C07K14/721 , G01N33/743 , G01N2333/723
摘要： The first crystal structure of the androgen receptor ligand binding domain has been determined to 2.0 angstrom resolution. Disclosed are the coordinates for the crystal structure, and methods for determining agonists, partial agonists, antagonists, partial antagonists and selective androgen receptors modulators (SARMs) of the androgen receptor.
摘要翻译： 雄激素受体配体结合结构域的第一个晶体结构已经确定为2.0埃的分辨率。 公开了晶体结构的坐标，以及用于确定雄激素受体的激动剂，部分激动剂，拮抗剂，部分拮抗剂和选择性雄激素受体调节剂（SARM）的方法。
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公开(公告)号：US07705134B2
公开(公告)日：2010-04-27
申请号：US12283245
申请日：2008-09-10
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention provides novel polynucleotides encoding BGS-4 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing the polypeptides of the present invention. The invention further relates to diagnostic and therapeutic methods for applying these novel BGS-4 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供了编码BGS-4多肽的新型多核苷酸，其片段和同源物。 还提供载体，宿主细胞，抗体，以及用于产生本发明多肽的重组和合成方法。 本发明还涉及将这些新型BGS-4多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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公开(公告)号：US07285633B2
公开(公告)日：2007-10-23
申请号：US11313356
申请日：2005-12-21
申请人： Shujian Wu , Jian Chen , John N. Feder , Liana Lee , Stanley R. Krystek
发明人： Shujian Wu , Jian Chen , John N. Feder , Liana Lee , Stanley R. Krystek
IPC分类号： A61K38/17
CPC分类号： C12N9/6489
摘要： The present invention provides novel polynucleotides encoding MMP-29 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel MMP-29 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供了编码MMP-29多肽的新型多核苷酸，其片段和同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型MMP-29多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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公开(公告)号：US07811787B2
公开(公告)日：2010-10-12
申请号：US11789322
申请日：2007-04-24
申请人： Donald G. Jackson , Stanley R. Krystek, Jr. , Donna A. Bassolino , Rolf-Peter Ryseck , Thomas C. Nelson , Gena S. Whitney
发明人： Donald G. Jackson , Stanley R. Krystek, Jr. , Donna A. Bassolino , Rolf-Peter Ryseck , Thomas C. Nelson , Gena S. Whitney
CPC分类号： G01N33/6893 , C07K14/47 , G01N33/564 , G01N33/57407 , G01N33/57426 , G01N33/57484 , G01N2800/065 , G01N2800/102 , G01N2800/104 , G01N2800/12 , G01N2800/122 , G01N2800/205 , G01N2800/24 , G01N2800/245
摘要： The invention relates to the identification and cloning of a two novel full-length human SLAP-2 variants and their encoded polypeptides, hSLAP-2v3 and hSLAP-2v4. hSLAP-2v3 and hSLAP-2v4 are members of the SLAP family of adapter proteins and are involved in the negative regulation of intracellular T-cell signal transduction. The invention further relates to the use of these novel hSLAP-2v3 and hSLAP-2v4 polynucleotides and their encoded polypeptides as targets for therapeutic intervention in immunological and inflammatory disorders, autoimmune diseases, pulmonary diseases, proliferative immune disorders, and cancer.
摘要翻译： 本发明涉及两种新型全长人SLAP-2变体及其编码多肽hSLAP-2v3和hSLAP-2v4的鉴定和克隆。 hSLAP-2v3和hSLAP-2v4是SLAP家族接头蛋白的成员，并且参与细胞内T细胞信号转导的负调控。 本发明还涉及这些新型hSLAP-2v3和hSLAP-2v4多核苷酸及其编码多肽作为免疫学和炎症性疾病，自身免疫疾病，肺部疾病，增殖性免疫病症和癌症中的治疗性干预的靶标的用途。
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5.发明授权Polynucleotides encoding three novel human cell surface proteins with leucine rich repeats and immunologobulin folds, BGS2, 3, and 4 and variants thereof 失效编码具有富含亮氨酸重复序列和免疫球蛋白折叠的三种新型人细胞表面蛋白的多核苷酸，BGS2,3和4及其变体公开(公告)号：US07223558B2
公开(公告)日：2007-05-29
申请号：US10193477
申请日：2002-07-11
申请人： Shujian Wu , Stanley R. Krystek , Liana Lee , John N. Feder , Janet D. Cheng
发明人： Shujian Wu , Stanley R. Krystek , Liana Lee , John N. Feder , Janet D. Cheng
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention provides novel polynucleotides encoding BGS-2, 3, and 4 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel BGS-2, 3, and 4 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供了编码BGS-2,3和4多肽的新型多核苷酸，其片段及其同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型BGS-2,3和4多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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公开(公告)号：US20090088385A1
公开(公告)日：2009-04-02
申请号：US12283245
申请日：2008-09-10
申请人： Shujian Wu , Stanley R. Krystek , Liana Lee , John N. Feder , Janet D. Cheng
发明人： Shujian Wu , Stanley R. Krystek , Liana Lee , John N. Feder , Janet D. Cheng
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention provides novel polynucleotides encoding BGS-4 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing the polypeptides of the present invention. The invention further relates to diagnostic and therapeutic methods for applying these novel BGS-4 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供了编码BGS-4多肽的新型多核苷酸，其片段和同源物。 还提供载体，宿主细胞，抗体，以及用于产生本发明多肽的重组和合成方法。 本发明还涉及将这些新型BGS-4多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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7.发明授权公开(公告)号：US06795776B1
公开(公告)日：2004-09-21
申请号：US09687609
申请日：2000-10-13
申请人： Roberto Weinmann , Howard M. Einspahr , Stanley R. Krystek , John S. Sack , Mark E. Salvati , John S. Tokarski , Ricardo M. Attar , Chihuei Wang
发明人： Roberto Weinmann , Howard M. Einspahr , Stanley R. Krystek , John S. Sack , Mark E. Salvati , John S. Tokarski , Ricardo M. Attar , Chihuei Wang
IPC分类号： G01N3100
CPC分类号： C07K14/721 , G01N33/743 , G01N2333/723
摘要： The first crystal structure of the androgen receptor ligand binding domain has been determined to 2.0 angstrom resolution. Disclosed are the coordinates for the crystal structure, and methods for determining agonists, partial agonists, antagonists, partial antagonists and selective androgen receptors modulators (SARMs) of the androgen receptor.
摘要翻译： 雄激素受体配体结合结构域的第一个晶体结构已经确定为2.0埃的分辨率。 公开了晶体结构的坐标，以及用于确定雄激素受体的激动剂，部分激动剂，拮抗剂，部分拮抗剂和选择性雄激素受体调节剂（SARM）的方法。
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公开(公告)号：US20110077395A1
公开(公告)日：2011-03-31
申请号：US12958706
申请日：2010-12-02
申请人： James J. Li , Lawrence G. Hamann , Zheming Ruan , Christopher B. Cooper , Shung C. Wu , Ligaya M. Simpkins , Haixia Wang , Akbar Nayeem , Stanley R. Krystek
发明人： James J. Li , Lawrence G. Hamann , Zheming Ruan , Christopher B. Cooper , Shung C. Wu , Ligaya M. Simpkins , Haixia Wang , Akbar Nayeem , Stanley R. Krystek
IPC分类号： C07D401/06 , C07D401/12 , C07D213/82 , C07D413/06 , C07D401/14 , C07D487/04
CPC分类号： C07D213/70 , A61K31/421 , A61K31/426 , A61K31/4439 , A61K31/4965 , A61K31/497 , A61K31/506 , C07D213/71 , C07D213/81 , C07D213/82 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/14 , C07D487/04 , C07D487/08
摘要： Novel compounds are provided which are 11-beta-hydroxysteroid dehydrogenase type I inhibitors. 11-beta-hydroxysteroid dehydrogenase type I inhibitors are useful in treating, preventing, or slowing the progression of diseases requiring 11-beta-hydroxysteroid dehydrogenase type I inhibitor therapy. These novel compounds have the structure: or stereoisomers or prodrugs or pharmaceutically acceptable salts thereof, wherein G, L, Q, Z, R6, R7, and R8 are defined herein.
摘要翻译： 提供了新的化合物，其为11-β-羟基类固醇脱氢酶I型抑制剂。 11-β-羟基类固醇脱氢酶I型抑制剂可用于治疗，预防或减缓需要11-β-羟基类固醇脱氢酶I型抑制剂治疗的疾病进展。 这些新化合物具有以下结构：其立体异构体或前药或其药学上可接受的盐，其中G，L，Q，Z，R 6，R 7和R 8在本文中定义。
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公开(公告)号：US07456256B2
公开(公告)日：2008-11-25
申请号：US11726220
申请日：2007-03-21
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention provides novel polynucleotides encoding BGS-2, 3, and 4 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing the polypeptides of the present invention. The invention further relates to diagnostic and therapeutic methods for applying these novel BGS-2, 3, and 4 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供了编码BGS-2,3和4多肽的新型多核苷酸，其片段及其同源物。 还提供载体，宿主细胞，抗体，以及用于产生本发明多肽的重组和合成方法。 本发明还涉及将这些新型BGS-2,3和4多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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10.发明授权Method for the treatment of a condition remediable by administration of a selective androgen receptor modulator 有权用于治疗通过施用选择性雄激素受体调节剂可治疗的病症的方法公开(公告)号：US06960474B2
公开(公告)日：2005-11-01
申请号：US09885827
申请日：2001-06-20
申请人： Mark E. Salvati , Marco M. Gottardis , Ricardo M. Attar , Stanley R. Krystek, Jr. , John S. Sack
发明人： Mark E. Salvati , Marco M. Gottardis , Ricardo M. Attar , Stanley R. Krystek, Jr. , John S. Sack
IPC分类号： G01N33/483 , A61K31/00 , A61K31/407 , A61K31/4155 , A61K31/416 , A61K31/4196 , A61K31/42 , A61K31/433 , A61K31/4439 , A61K31/4709 , A61K31/4995 , A61K31/506 , A61K31/655 , A61K31/675 , A61K45/00 , A61P5/28 , A61P13/08 , A61P35/00 , C07D471/18 , C07D487/08 , C07D487/18 , C07D491/08 , C07D491/18 , C07D491/22 , C07D493/18 , C07D495/18 , C07D519/00 , C07K14/72 , C12Q1/02 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/48
CPC分类号： C07D487/08 , A61K31/00 , A61K31/407 , A61K31/655 , A61K31/675 , A61K2300/00
摘要： Selective androgen receptor modulators (SARMs) having antagonist activity in hormone-dependent tumors while exhibiting no activity or agonist activity against other nontumor tissues containing the androgen receptor as well as methods for identifying, designing and using SARMs are provided.
摘要翻译： 提供了在激素依赖性肿瘤中具有拮抗剂活性的选择性雄激素受体调节剂（SARM），同时对包含雄激素受体的其它非肿瘤组织没有活性或激动剂活性以及鉴定，设计和使用SARMs的方法。
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