公开(公告)号：US06471940B1

公开(公告)日：2002-10-29

申请号：US09669891

申请日：2000-09-27

申请人： Yohei Kurata ,  Hideaki Hamada ,  Takaaki Hanaoka ,  Yoshihiro Sugi ,  Yoshihiro Kubota

发明人： Yohei Kurata ,  Hideaki Hamada ,  Takaaki Hanaoka ,  Yoshihiro Sugi ,  Yoshihiro Kubota

IPC分类号： C01B3948

CPC分类号： C01B39/04 ,  C01B39/48

摘要： A process is provided for preparing zeolite, particularly [Al]-SSZ-31, which comprises the steps of providing a mixture of a zeolite source, an aluminum-containing material, an organic structure directing substance, preferably at least one selected from the group consisting of N,N′-bis-triethyl-1,6-hexanediyl-diammonium dihydroxide, N,N′-bis-triethyl-1,7-heptanediyl-diammonium dihydroxide, N,N′-bis-triethyl-1,8-octanediyl-diammonium dihydroxide, N,N′-bis-triethyl-1,9-nonanediyl-diammonium dihydroxide, N,N′-bis-triethyl-1,10-decanediyl-diammonium dihydroxide, and their salts, and water; drying said mixture to form a powdered dry gel; and contacting and reacting said dry gel with steam at a saturated vapor pressure to produce an aluminum-containing zeolite [Al]-SSZ-31.

摘要翻译： 提供了一种制备沸石，特别是[Al] -SSZ-31的沸石的方法，该方法包括以下步骤：提供沸石源，含铝材料，有机结构导向物质，优选选自下组的至少一种： 由N，N'-二 - 三乙基-1,6-己二基二铵二氢氧化物，N，N'-二 - 三乙基-1,7-庚二基二铵二氧化物，N，N'-二 - 三乙基-1,8 N，N'-二 - 三乙基-1,9-壬二基二铵二氢氧化物，N，N'-二 - 三乙基-1,10-癸二基二铵二氢氧化物及其盐和水; 干燥所述混合物以形成粉末状干凝胶; 并使所述干凝胶与饱和蒸汽压的蒸汽接触并反应，生成含铝沸石[Al] -SSZ-31。

公开(公告)号：US20090240070A1

公开(公告)日：2009-09-24

申请号：US12278479

申请日：2007-02-05

申请人： Harumi Kamachi ,  Hirobumi Aoki ,  Yohei Kurata ,  Jiro Takata

发明人： Harumi Kamachi ,  Hirobumi Aoki ,  Yohei Kurata ,  Jiro Takata

IPC分类号： C07D311/72

CPC分类号： A61K31/355 ,  A61K8/498 ,  A61K8/678 ,  A61Q19/02

摘要： Disclosed is a dermatological preparation that are safe and are excellent in inhibiting and removing skin pigmentation and in inhibiting skin roughness. A dermatological preparation comprising a tocopherol aminoalkylcarboxylate and/or a salt thereof, the tocopherol aminoalkylcarboxylate being represented by Formula (I): wherein R1 is a hydrogen atom or a lower alkyl group; R2 and R3 are each independently a hydrogen atom or a methyl group; X is a cycloalkylene group of 3 to 6 carbon atoms; and n is 0 or 1.

摘要翻译： 公开了一种安全的皮肤病学制剂，并且在抑制和去除皮肤色素沉着和抑制皮肤粗糙度方面优异。 一种包含生育酚氨基烷基羧酸盐和/或其盐的皮肤病学制剂，所述生育酚氨基烷基羧酸盐由式（I）表示：其中R1是氢原子或低级烷基; R2和R3各自独立地为氢原子或甲基; X为3〜6个碳原子的亚环烷基; n为0或1。

公开(公告)号：US08551509B2

公开(公告)日：2013-10-08

申请号：US12445184

申请日：2007-10-12

申请人： Hirobumi Aoki ,  Yohei Kurata ,  Harumi Kamachi ,  Hirotsugu Nakanishi

发明人： Hirobumi Aoki ,  Yohei Kurata ,  Harumi Kamachi ,  Hirotsugu Nakanishi

IPC分类号： A61K8/02 ,  A61K38/43 ,  C07C39/10 ,  C07F9/02

CPC分类号： A61K8/556 ,  A61K8/0212 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q19/00 ,  A61Q19/007 ,  A61Q19/08 ,  A61Q19/10

摘要： A skin agent for external use and a cosmetic agent are provided, by transdermal administration of which expected actions and effects of ubiquinone derivatives, salts thereof, ubiquinones and ubiquinols are effectively obtained.The skin agent for external use includes a ubiquinone derivative or a salt thereof as an active ingredient. The ubiquinone derivative is represented by the formula (1): wherein R1 and R2 are each a hydrogen atom or a phosphoric group, at least one of R1 and R2 is a phosphoric group, and n is an integer in the range of 1 to 9.

摘要翻译： 提供外用的皮肤剂和美容剂，通过透皮给药，有效地获得泛醌衍生物，其盐，泛醌和泛醇的预期作用和作用。 用于外用的皮肤剂包括泛醌衍生物或其盐作为活性成分。 泛醌衍生物由式（1）表示：其中R1和R2各自为氢原子或磷酸基，R1和R2中的至少一个为磷酸基，n为1〜9的整数。 。

公开(公告)号：US20090234153A1

公开(公告)日：2009-09-17

申请号：US12088792

申请日：2006-09-21

申请人： Hirobumi Aoki ,  Harumi Kamachi ,  Yohei Kurata

发明人： Hirobumi Aoki ,  Harumi Kamachi ,  Yohei Kurata

IPC分类号： C07C69/34

CPC分类号： A61Q19/00 ,  A61K8/0212 ,  A61K8/44 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q19/008 ,  A61Q19/10

摘要： To provide novel carnitine derivatives and salts thereof that are resistant to hydrolysis in the presence of aqueous media, and also provide external skin preparations and cosmetics that are excellent in storage stability, product life, skin affinity and percutaneous absorption properties. In particular, to provide novel α-branched acyl carnitine derivatives and salts thereof, external skin preparations and cosmetics comprising specific α-branched acyl carnitine derivatives and/or salts thereof.

摘要翻译： 提供在含水介质存在下耐水解的新型肉碱衍生物及其盐，还提供保存稳定性，产品寿命，皮肤亲和性和经皮吸收性优异的外用皮肤制剂和化妆品。 特别地，提供新的α-支链酰基肉碱衍生物及其盐，外用皮肤制剂和包含特定的α-支链酰基肉碱衍生物和/或其盐的化妆品。

公开(公告)号：US6046181A

公开(公告)日：2000-04-04

申请号：US342228

申请日：1999-06-29

申请人： Yutaka Oonishi ,  Tsutomu Nozawa ,  Takami Ooe ,  Keisuke Mano ,  Naoaki Misu ,  Yohei Kurata ,  Shinobu Ito ,  Eiji Ogata

发明人： Yutaka Oonishi ,  Tsutomu Nozawa ,  Takami Ooe ,  Keisuke Mano ,  Naoaki Misu ,  Yohei Kurata ,  Shinobu Ito ,  Eiji Ogata

IPC分类号： A61K8/02 ,  A61K8/67 ,  A61Q1/02 ,  A61Q1/04 ,  A61Q5/02 ,  A61Q7/00 ,  A61Q11/00 ,  A61Q19/00 ,  A61Q19/10 ,  C07F9/655 ,  G01N30/02 ,  G01N30/88 ,  G01N33/82 ,  A61K7/035 ,  A61K7/00 ,  A61K7/02 ,  A61K7/021 ,  A61K7/027

CPC分类号： G01N33/82 ,  A61K8/0212 ,  A61K8/678 ,  A61Q19/00 ,  C07F9/65522 ,  A61Q1/02 ,  A61Q1/04 ,  A61Q11/00 ,  A61Q19/10 ,  A61Q5/02 ,  A61Q7/00 ,  G01N2030/884 ,  G01N30/02 ,  Y10S514/846

摘要： Disclosed herein are a highly purified tocopheryl phosphate and/or a salt thereof (tocopheryl phosphates) wherein a P,P'-bistocopheryl hypophosphate and/or a salt thereof (P,P'-bistocopheryl diphoshates) is contained in a proportion of not higher than 3% by weight; a process for producing a highly purified tocopheryl phosphate and/or a salt thereof, which comprises the steps of reacting a tocopherol with an oxyphosphorus trihalide followed by treating with an acid or basic aqueous solution to thereby form tocopheryl phosphates (i) in which P,P'-bistocopheryl diphoshates (ii) formed as by-products are contained, hydrolyzing the P,P'-bistocopheryl diphoshates (ii) under acid condition, and, optionally, rendering the hydrolyzate neutral or basic under basic condition; and a method of analyzing tocopheryl phosphates, comprising analyzing a sample containing components (i) and (ii) with the use of a high-performance liquid chromatograph column packed with a gel of a polymethacrylate having, bonded thereto, long-chain alkyl groups. None or only an extremely minute amount of P,P'-bistocopheryl diphoshates are contained in the highly purified tocopheryl phosphates, so that the highly purified tocopheryl phosphates exhibit antioxidant and blood circulation promoting effects, have excellent water solubility, are powdery so that the handling thereof is extremely easy, are free from cutaneous irritation and allergenecity and ensure dermal safety. Therefore, the highly purified tocopheryl phosphates are useful as cosmetic ingredients. The amounts of components (i) and (ii) can be simply measured with high accuracy by the above method.

摘要翻译： 本文公开了高纯度的生育磷酸酯和/或其盐（生育磷酸酯），其中P，P'-二生育酚低磷酸盐和/或其盐（P，P'-二生育基二磷酸酯）的含量不高于 超过3％重量; 一种生产高纯度生育磷酸酯和/或其盐的方法，其包括使生育酚与三卤氧磷反应，然后用酸或碱性水溶液处理，从而形成生育磷酸酯（i），其中P， 含有作为副产物形成的P'-二生育基二磷酸酯（ⅱ），在酸性条件下水解P，P'-二生育基二磷酸酯（ⅱ），任选地在碱性条件下使水解产物中性或碱性。 以及分析生育磷酸酯的方法，包括使用填充有与其键合的聚甲基丙烯酸酯的凝胶的高效液相色谱柱分析含有成分（i）和（ii）的样品的长链烷基。 高纯度的生育磷酸酯中没有或仅有非常少量的P，P'-二生育基二磷酸酯，因此高纯度的生育磷酸酯表现出抗氧化和促进血液循环的作用，具有优异的水溶性，是粉末状的， 它非常容易，没有皮肤刺激和过敏原，并确保皮肤安全。 因此，高纯度的生育磷酸酯可用作化妆品成分。 组分（i）和（ii）的量可以通过上述方法以高精度简单地测量。

公开(公告)号：US07842726B2

公开(公告)日：2010-11-30

申请号：US12088792

申请日：2006-09-21

申请人： Hirobumi Aoki ,  Harumi Kamachi ,  Yohei Kurata

发明人： Hirobumi Aoki ,  Harumi Kamachi ,  Yohei Kurata

IPC分类号： A61K31/225 ,  C07C229/00

CPC分类号： A61Q19/00 ,  A61K8/0212 ,  A61K8/44 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q19/008 ,  A61Q19/10

摘要： To provide novel carnitine derivatives and salts thereof that are resistant to hydrolysis in the presence of aqueous media, and also provide external skin preparations and cosmetics that are excellent in storage stability, product life, skin affinity and percutaneous absorption properties. In particular, to provide novel α-branched acyl carnitine derivatives and salts thereof, external skin preparations and cosmetics comprising specific α-branched acyl carnitine derivatives and/or salts thereof.

摘要翻译： 提供在含水介质存在下耐水解的新型肉碱衍生物及其盐，还提供保存稳定性，产品寿命，皮肤亲和性和经皮吸收性优异的外用皮肤制剂和化妆品。 特别地，提供新的α-支链酰基肉碱衍生物及其盐，外用皮肤制剂和包含特定的α-支链酰基肉毒碱衍生物和/或其盐的化妆品。

公开(公告)号：US20100074879A1

公开(公告)日：2010-03-25

申请号：US12445184

申请日：2007-10-15

申请人： Hirobumi Aoki ,  Yohei Kurata ,  Harumi Kamachi ,  Hirotsugu Nakanishi

发明人： Hirobumi Aoki ,  Yohei Kurata ,  Harumi Kamachi ,  Hirotsugu Nakanishi

IPC分类号： A61K38/43 ,  C07C39/10 ,  C07F9/06 ,  A61P39/06

CPC分类号： A61K8/556 ,  A61K8/0212 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q19/00 ,  A61Q19/007 ,  A61Q19/08 ,  A61Q19/10

摘要： A skin agent for external use and a cosmetic agent are provided, by transdermal administration of which expected actions and effects of ubiquinone derivatives, salts thereof, ubiquinones and ubiquinols are effectively obtained.The skin agent for external use includes a ubiquinone derivative or a salt thereof as an active ingredient. The ubiquinone derivative is represented by the formula (1): wherein R1 and R2 are each a hydrogen atom or a phosphoric group, at least one of R1 and R2 is a phosphoric group, and n is an integer in the range of 1 to 9.

摘要翻译： 提供外用的皮肤剂和美容剂，通过透皮给药，有效地获得泛醌衍生物，其盐，泛醌和泛醇的预期作用和作用。 用于外用的皮肤剂包括泛醌衍生物或其盐作为活性成分。 泛醌衍生物由式（1）表示：其中R1和R2各自为氢原子或磷酸基，R1和R2中的至少一个为磷酸基，n为1〜9的整数。 。

公开(公告)号：US5965750A

公开(公告)日：1999-10-12

申请号：US849052

申请日：1997-05-29

申请人： Yutaka Oonishi ,  Tsutomu Nozawa ,  Takami Ooe ,  Keisuke Mano ,  Naoaki Misu ,  Yohei Kurata ,  Shinobu Ito ,  Eiji Ogata

发明人： Yutaka Oonishi ,  Tsutomu Nozawa ,  Takami Ooe ,  Keisuke Mano ,  Naoaki Misu ,  Yohei Kurata ,  Shinobu Ito ,  Eiji Ogata

IPC分类号： A61K8/02 ,  A61K8/67 ,  A61Q1/02 ,  A61Q1/04 ,  A61Q5/02 ,  A61Q7/00 ,  A61Q11/00 ,  A61Q19/00 ,  A61Q19/10 ,  C07F9/655 ,  G01N30/02 ,  G01N30/88 ,  G01N33/82 ,  C07F9/06

CPC分类号： G01N33/82 ,  A61K8/0212 ,  A61K8/678 ,  A61Q19/00 ,  C07F9/65522 ,  A61Q1/02 ,  A61Q1/04 ,  A61Q11/00 ,  A61Q19/10 ,  A61Q5/02 ,  A61Q7/00 ,  G01N2030/884 ,  G01N30/02 ,  Y10S514/846

摘要： Disclosed herein are a highly purified tocopheryl phosphate and/or a salt thereof (tocopheryl phosphates) wherein a P,P'-bistocopheryl hypophosphate and/or a salt thereof (P,P'-bistocopheryl diphoshates) is contained in a proportion of not higher than 3% by weight; a process for producing a highly purified tocopheryl phosphate and/or a salt thereof, which comprises the steps of reacting a tocopherol with an oxyphosphorus trihalide followed by treating with an acid or basic aqueous solution to thereby form tocopheryl phosphates (i) in which P,P'-bistocopheryl diphoshates (ii) formed as by-products are contained, hydrolyzing the P,P'-bistocopheryl diphoshates (ii) under acid condition, and, optionally, rendering the hydrolyzate neutral or basic under basic condition; and a method of analyzing tocopheryl phosphates, comprising analyzing a sample containing components (i) and (ii) with the use of a high-performance liquid chromatograph column packed with a gel of a polymethacrylate having, bonded thereto, long-chain alkyl groups. None or only an extremely minute amount of P,P'-bistocopheryl diphoshates are contained in the highly purified tocopheryl phosphates, so that the highly purified tocopheryl phosphates exhibit antioxidant and blood circulation promoting effects, have excellent water solubility, are powdery so that the handling thereof is extremely easy, are free from cutaneous irritation and allergenecity and ensure dermal safety. Therefore, the highly purified tocopheryl phosphates are useful as cosmetic ingredients. The amounts of components (i) and (ii) can be simply measured with high accuracy by the above method.

公开(公告)号：US5110951A

公开(公告)日：1992-05-05

申请号：US542550

申请日：1990-06-25

申请人： Yoshimasa Ishimura ,  Yohei Kurata

发明人： Yoshimasa Ishimura ,  Yohei Kurata

IPC分类号： C07F9/655

CPC分类号： C07F9/65515 ,  Y02P20/55

摘要： A method for producing L-ascorbic acid 2-phosphates, is disclosed which comprises phosphorylating L-ascorbic acid whose hydroxyl groups at the 5- and 6-positions are unprotected or protected with a protective group, or salts thereof, with a phosphorus oxyhalide to form corresponding L-ascorbic acid 2-phosphates, wherein a reaction mixture obtained after the phosphorylation reaction is heated to convert by-products derived from L-ascorbic acid into L-ascorbic acid, which again is subjected to the phosphorylation reaction with the phosphorus oxyhalide. The method produce L-ascorbic acid 2-phosphates in a high yield and at a high purity with simple operations.

摘要翻译： 公开了一种L-抗坏血酸2-磷酸酯的制备方法，其包括将5-抗坏血酸磷酸化，其5-位和5-位上的羟基被保护基团或其盐或其盐与磷酰卤反应至 形成相应的L-抗坏血酸2-磷酸酯，其中加热磷酸化反应后得到的反应混合物，将由L-抗坏血酸衍生的副产物转化成L-抗坏血酸，L-抗坏血酸再次与磷酰卤进行磷酸化反应 。 该方法以简单的操作以高产率和高纯度产生L-抗坏血酸2-磷酸酯。