公开(公告)号：US20140289882A1

公开(公告)日：2014-09-25

申请号：US14233390

申请日：2012-07-19

申请人： Yong Zhu ,  Shili Wu ,  Jun Bao ,  Cong-Qiu Chu

发明人： Yong Zhu ,  Shili Wu ,  Jun Bao ,  Cong-Qiu Chu

IPC分类号： C07K17/06 ,  C12N5/074 ,  G01N33/50 ,  A61K47/48

CPC分类号： C07K17/06 ,  A61K38/00 ,  A61K47/64 ,  A61K47/645 ,  A61L27/3612 ,  A61L27/3654 ,  C07K14/4702 ,  C07K14/4703 ,  C07K14/4716 ,  C07K2319/21 ,  C07K2319/60 ,  C12N5/0637 ,  C12N5/0655 ,  C12N5/0676 ,  C12N5/0696 ,  C12N2501/60 ,  C12N2501/602 ,  C12N2501/603 ,  C12N2501/604 ,  C12N2501/606 ,  C12N2506/14 ,  G01N33/5073

摘要： The present inventions are directed to compositions and methods regarding the reprogramming of other cells (such as embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), MSCs, fibroblasts, hematopoietic stem cells, endothelian stem cells, adipocytes, chondrocytes, osteoblasts, osteoclasts and endothelial cells) into chondrogenic cells without introducing exogenous genes to the samples. In particular, the present inventions are directed to transducible materials that are capable of transducing into the biological samples but are not genes or causing genetic modifications. The present inventions also are directed to methods of reprogramming the path of biological samples or treating diseases using the tranducible compositions thereof.

摘要翻译： 本发明涉及关于其他细胞（例如胚胎干细胞（ESCs），诱导多能干细胞（iPSCs），MSC，成纤维细胞，造血干细胞，内皮干细胞，脂肪细胞，软骨细胞，成骨细胞的重编程的组合物和方法 ，破骨细胞和内皮细胞）成软骨形成细胞，而不向样品中引入外源基因。 特别地，本发明涉及能够转导到生物样品但不是基因或引起遗传修饰的可导纳材料。 本发明还涉及使用其可转导组合物重新编程生物样品的路径或治疗疾病的方法。

公开(公告)号：US20130097717A1

公开(公告)日：2013-04-18

申请号：US13806781

申请日：2011-06-23

申请人： Yong Zhu ,  Shili Wu ,  Jun Bao

发明人： Yong Zhu ,  Shili Wu ,  Jun Bao

IPC分类号： A61K38/16

CPC分类号： A61K38/16 ,  A61K38/00 ,  B82Y5/00 ,  C12N5/0637 ,  C12N5/0696 ,  C12N2501/60 ,  C12N2501/602 ,  C12N2501/603 ,  C12N2501/604 ,  C12N2501/606 ,  Y10S977/773

摘要： The present inventions are directed to compositions and methods regarding the reprogramming of other cells (such as fibroblast cells) into cardiomyocytes without introducing exogenous genes to the samples. In particular, the present inventions are directed to transducible materials that are capable of transducing into the biological samples but are not genes or causing genetic modifications. The present inventions also are directed to methods of reprogramming the path of biological samples or treating diseases using the tranducible compositions thereof.

摘要翻译： 本发明涉及关于将其它细胞（例如成纤维细胞）重编程成心肌细胞而不向样品中引入外源基因的组合物和方法。 特别地，本发明涉及能够转导到生物样品但不是基因或引起遗传修饰的可导纳材料。 本发明还涉及使用其可转导组合物重新编程生物样品的路径或治疗疾病的方法。

公开(公告)号：US20110258713A1

公开(公告)日：2011-10-20

申请号：US13141326

申请日：2009-12-23

申请人： Yong Zhu ,  Shili Wu ,  Jun Bao

发明人： Yong Zhu ,  Shili Wu ,  Jun Bao

IPC分类号： A01K67/033 ,  C12N5/04 ,  C12N5/07 ,  C12N5/071 ,  C12N5/0783 ,  C12Q1/02 ,  C07K14/435 ,  A61K38/17 ,  A61P35/00 ,  A61P3/00 ,  A61P29/00 ,  A61P9/00 ,  A61P25/00 ,  A61P37/00 ,  A61P3/10 ,  A61P25/28 ,  A61P25/16 ,  A61P7/06 ,  A61P19/02 ,  A61P17/02 ,  A61P17/00 ,  A61P1/16 ,  A61P27/16 ,  A61P1/04 ,  A61P21/04 ,  A61P25/18 ,  A61K49/00 ,  A61M37/00 ,  C12N1/00 ,  B82Y5/00

CPC分类号： C12N5/0696 ,  A61K2035/122 ,  C12N5/0637 ,  C12N5/0676 ,  C12N2501/60 ,  C12N2501/602 ,  C12N2501/603 ,  C12N2501/604 ,  C12N2501/606

摘要： The present inventions are directed to compositions and methods regarding the reprogramming of biological samples (such as cells) without introducing exogenous genes to the samples. In particular, the present inventions are directed to transducible materials that are capable of transducing into the biological samples but are not genes or causing genetic modifications. The present inventions also are directed to methods of reprogramming the path of biological samples or treating diseases using the tranducible compositions thereof.

摘要翻译： 本发明涉及关于生物样品（例如细胞）的重新编程而不向样品中引入外源基因的组合物和方法。 特别地，本发明涉及能够转导到生物样品但不是基因或引起遗传修饰的可导纳材料。 本发明还涉及使用其可转导组合物重新编程生物样品的路径或治疗疾病的方法。

公开(公告)号：US20120301446A1

公开(公告)日：2012-11-29

申请号：US13576394

申请日：2011-02-01

申请人： Yong Zhu ,  Shili Wu ,  Jun Bao

发明人： Yong Zhu ,  Shili Wu ,  Jun Bao

IPC分类号： A61K38/16 ,  C12N5/071 ,  G01N21/76 ,  A61K35/12 ,  A61P31/00 ,  A61P25/28 ,  A61P25/16 ,  A61P25/18 ,  A61P25/08 ,  A61P25/06 ,  C07K14/00 ,  A61P25/00

CPC分类号： C12N5/0636 ,  A61K38/00 ,  C07K14/08 ,  C12N5/0619 ,  C12N5/0676 ,  C12N5/0696 ,  C12N2501/065 ,  C12N2501/60 ,  C12N2501/602 ,  C12N2501/603 ,  C12N2501/604 ,  C12N2501/606 ,  C12N2502/99 ,  C12N2506/08 ,  C12N2506/11 ,  C12N2506/1307 ,  C12N2506/14 ,  C12N2770/30041 ,  C12N2770/30045

摘要： The present inventions are directed to compositions and methods regarding the reprogramming of other cells (such as glial cells) into neurons without introducing exogenous genes to the samples. In particular, the present inventions are directed to transducible materials that are capable of transducing into the biological samples but are not genes or causing genetic modifications. The present inventions also are directed to methods of reprogramming the path of biological samples or treating diseases using the transducible compositions thereof.

摘要翻译： 本发明涉及关于将其它细胞（例如神经胶质细胞）重编程成神经元而不向样品中引入外源基因的组合物和方法。 特别地，本发明涉及能够转导到生物样品但不是基因或引起遗传修饰的可导纳材料。 本发明还涉及使用其可转导组合物重新编程生物样品的路径或治疗疾病的方法。

公开(公告)号：US20120108507A1

公开(公告)日：2012-05-03

申请号：US13288040

申请日：2011-11-03

申请人： Yong Zhu ,  Shili Wu ,  Jun Bao

发明人： Yong Zhu ,  Shili Wu ,  Jun Bao

IPC分类号： A61K38/02 ,  A61K31/7088 ,  A61P3/10 ,  A61P9/00 ,  G01N33/53 ,  A61P25/16 ,  A61P25/28 ,  C12Q1/02 ,  C12Q1/68 ,  C12N5/071 ,  A61P19/00

CPC分类号： G01N33/5073 ,  A61K31/7088 ,  G01N33/56966

摘要： The present disclosure provides a new technology platform that converts one type of cells (substrate cells) to another type of cells (product cells).

摘要翻译： 本公开提供了将一种类型的细胞（底物细胞）转换成另一种细胞（产品细胞）的新技术平台。