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公开(公告)号：US07612089B2
公开(公告)日：2009-11-03
申请号：US11284805
申请日：2005-11-21
申请人： Yonghong Song , Bing-Yan Zhu , Shumei Wang , Shawn Bauer , Robert M. Scarborough
发明人： Yonghong Song , Bing-Yan Zhu , Shumei Wang , Shawn Bauer , Robert M. Scarborough
IPC分类号： C07D498/02 , C07D217/12 , C07D217/02 , C07D209/42 , A61K31/4743 , A61K31/47 , A61K31/405
CPC分类号： C07D209/44 , C07D217/26 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12 , C07D495/04
摘要： The present invention is directed to compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof which are inhibitors of Factor Xa. The present invention is also directed to and intermediates used in making such compounds, pharmaceutical compositions containing such compounds, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.
摘要翻译： 本发明涉及由式I表示的化合物及其作为因子Xa抑制剂的药学上可接受的盐，溶剂合物，水合物和前药。 本发明还涉及用于制备这种化合物的中间体，含有这些化合物的药物组合物，预防或治疗多种不想要的血栓形成特征的病症的方法以及抑制血液样品凝固的方法。
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公开(公告)号：US07678913B2
公开(公告)日：2010-03-16
申请号：US11298317
申请日：2005-12-07
IPC分类号： A61K31/48 , C07D207/40 , C07D215/38
CPC分类号： C07D213/40 , C07C275/30 , C07D211/26 , C07D211/58 , C07D213/64 , C07D213/74 , C07D213/89 , C07D215/227 , C07D233/24 , C07D233/64 , C07D243/08 , C07D263/04 , C07D265/32 , C07D277/04 , C07D295/195 , C07D333/22 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/10 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/04
摘要： The present invention is directed to compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof which are inhibitors of Factor Xa. The present invention is also directed to and intermediates used in making such compounds, pharmaceutical compositions containing such compounds, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.
摘要翻译： 本发明涉及由式I表示的化合物及其作为因子Xa抑制剂的药学上可接受的盐，溶剂合物，水合物和前药。 本发明还涉及用于制备这种化合物的中间体，含有这些化合物的药物组合物，预防或治疗多种不想要的血栓形成特征的病症的方法以及抑制血液样品凝固的方法。
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公开(公告)号：US20060160840A1
公开(公告)日：2006-07-20
申请号：US11284805
申请日：2005-11-21
申请人： Yonghong Song , Bing-Yan Zhu , Shumei Wang , Shawn Bauer , Robert Scarborough
发明人： Yonghong Song , Bing-Yan Zhu , Shumei Wang , Shawn Bauer , Robert Scarborough
IPC分类号： C07D498/02 , C07D217/12 , C07D217/06 , C07D209/42 , A61K31/4743 , A61K31/47 , A61K31/405
CPC分类号： C07D209/44 , C07D217/26 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12 , C07D495/04
摘要： The present invention is directed to compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof which are inhibitors of Factor Xa. The present invention is also directed to and intermediates used in making such compounds, pharmaceutical compositions containing such compounds, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.
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公开(公告)号：US20060160821A1
公开(公告)日：2006-07-20
申请号：US11298317
申请日：2005-12-07
申请人： Yonghong Song , Bing-Yan Zhu , Shumei Wang , Chhaya Bhakta , Robert Scarborough
发明人： Yonghong Song , Bing-Yan Zhu , Shumei Wang , Chhaya Bhakta , Robert Scarborough
IPC分类号： A61K31/496 , A61K31/4709 , A61K31/454 , A61K31/4015 , C07D403/02 , C07D401/02
CPC分类号： C07D213/40 , C07C275/30 , C07D211/26 , C07D211/58 , C07D213/64 , C07D213/74 , C07D213/89 , C07D215/227 , C07D233/24 , C07D233/64 , C07D243/08 , C07D263/04 , C07D265/32 , C07D277/04 , C07D295/195 , C07D333/22 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/10 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/04
摘要： The present invention is directed to compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof which are inhibitors of Factor Xa. The present invention is also directed to and intermediates used in making such compounds, pharmaceutical compositions containing such compounds, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.
摘要翻译： 本发明涉及由式I表示的化合物及其作为因子Xa抑制剂的药学上可接受的盐，溶剂合物，水合物和前药。 本发明还涉及用于制备这种化合物的中间体，含有这些化合物的药物组合物，预防或治疗多种不想要的血栓形成特征的病症的方法以及抑制血液样品凝固的方法。
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公开(公告)号：US08518977B2
公开(公告)日：2013-08-27
申请号：US13247937
申请日：2011-09-28
申请人： Bing-Yan Zhu , Penglie Zhang , Lingyan Wang , Wenrong Huang , Erick A. Goldman , Wenhao Li , Jingmei Zuckett , Yonghong Song , Robert M. Scarborough
发明人： Bing-Yan Zhu , Penglie Zhang , Lingyan Wang , Wenrong Huang , Erick A. Goldman , Wenhao Li , Jingmei Zuckett , Yonghong Song , Robert M. Scarborough
IPC分类号： C07D213/75 , A61K31/44
CPC分类号： A61K31/44 , A61K9/20 , A61K9/2013 , A61K9/2054 , A61K9/48 , A61K9/4858 , A61K9/4866 , A61K31/616 , A61K45/06 , A61K2201/094 , C07C237/42 , C07C255/60 , C07C257/18 , C07C259/18 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/75 , C07D213/81 , C07D213/82 , C07D217/22 , C07D231/12 , C07D233/56 , C07D233/64 , C07D249/08 , C07D295/125 , C07D333/38 , C07D401/12 , C07D409/12 , C07D409/14
摘要： Novel benzamide compounds including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa are described. Compositions containing such compounds are also described. The compounds and compositions are useful in vitro or in vivo for preventing or treating coagulation disorders.
摘要翻译： 描述了具有抗哺乳动物因子Xa活性的新型苯甲酰胺化合物，包括其药学上可接受的异构体，盐，水合物，溶剂合物和前药衍生物。 还描述了含有这些化合物的组合物。 化合物和组合物在体外或体内可用于预防或治疗凝血障碍。
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公开(公告)号：US07285565B2
公开(公告)日：2007-10-23
申请号：US11035767
申请日：2005-01-14
申请人： Bing-Yan Zhu , Penglie Zhang , Lingyan Wang , Wenrong Huang , Erick A. Goldman , Wenhao Li , Jingmei Zuckett , Yonghong Song , Robert M. Scarborough
发明人： Bing-Yan Zhu , Penglie Zhang , Lingyan Wang , Wenrong Huang , Erick A. Goldman , Wenhao Li , Jingmei Zuckett , Yonghong Song , Robert M. Scarborough
IPC分类号： C07D213/02 , A61K31/44
CPC分类号： C07D213/75 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/81 , C07D213/82 , C07D217/22 , C07D231/12 , C07D233/56 , C07D249/08 , C07D333/38 , C07D401/12 , C07D409/12 , C07D409/14
摘要： Novel benzamide compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
摘要翻译： 公开了与哺乳动物因子Xa有活性的新型苯甲酰胺化合物，其盐和与其有关的组合物。 该化合物在体外或体内可用于预防或治疗凝血障碍。
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公开(公告)号：US20130172310A1
公开(公告)日：2013-07-04
申请号：US13612597
申请日：2012-09-12
申请人： Bing-Yan Zhu , Penglie Zhang , Lingyan Wang , Wenrong Huang , Erick A. Goldman , Wenhao Li , Jingmei Zuckett , Yonghong Song , Robert M. Scarborough
发明人： Bing-Yan Zhu , Penglie Zhang , Lingyan Wang , Wenrong Huang , Erick A. Goldman , Wenhao Li , Jingmei Zuckett , Yonghong Song , Robert M. Scarborough
IPC分类号： C07D213/75 , C07D401/12
CPC分类号： A61K31/44 , A61K9/20 , A61K9/2013 , A61K9/2054 , A61K9/48 , A61K9/4858 , A61K9/4866 , A61K31/616 , A61K45/06 , A61K2201/094 , C07C237/42 , C07C255/60 , C07C257/18 , C07C259/18 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/75 , C07D213/81 , C07D213/82 , C07D217/22 , C07D231/12 , C07D233/56 , C07D233/64 , C07D249/08 , C07D295/125 , C07D333/38 , C07D401/12 , C07D409/12 , C07D409/14
摘要： Novel benzamide compounds including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa are described. Compositions containing such compounds are also described. The compounds and compositions are useful in vitro or in vivo for preventing or treating coagulation disorders.
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公开(公告)号：US07342013B2
公开(公告)日：2008-03-11
申请号：US11442060
申请日：2006-05-26
申请人： Bing-Yan Zhu , Penglie Zhang , Lingyan Wang , Wenrong Huang , Erick A. Goldman , Wenhao Li , Jingmei Zuckett , Yonghong Song , Robert M. Scarborough
发明人： Bing-Yan Zhu , Penglie Zhang , Lingyan Wang , Wenrong Huang , Erick A. Goldman , Wenhao Li , Jingmei Zuckett , Yonghong Song , Robert M. Scarborough
IPC分类号： C07D401/02 , A61K31/44
CPC分类号： A61K31/44 , A61K9/20 , A61K9/2013 , A61K9/2054 , A61K9/48 , A61K9/4858 , A61K9/4866 , A61K31/616 , A61K45/06 , A61K2201/094 , C07C237/42 , C07C255/60 , C07C257/18 , C07C259/18 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/75 , C07D213/81 , C07D213/82 , C07D217/22 , C07D231/12 , C07D233/56 , C07D233/64 , C07D249/08 , C07D295/125 , C07D333/38 , C07D401/12 , C07D409/12 , C07D409/14
摘要： Novel benzamide compounds including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa are described. Compositions containing such compounds are also described. The compounds and compositions are useful in vitro or in vivo for preventing or treating coagulation disorders.
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公开(公告)号：US06632815B2
公开(公告)日：2003-10-14
申请号：US09794214
申请日：2001-02-28
申请人： Bing-Yan Zhu , Zhaozhong Jon Jia , Wenrong Huang , Yonghong Song , James Kanter , Robert M. Scarborough
发明人： Bing-Yan Zhu , Zhaozhong Jon Jia , Wenrong Huang , Yonghong Song , James Kanter , Robert M. Scarborough
IPC分类号： C07D23112
CPC分类号： C07D213/75 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/81 , C07D213/82 , C07D217/22 , C07D231/12 , C07D231/14 , C07D233/56 , C07D249/08 , C07D277/56 , C07D333/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04
摘要： Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
摘要翻译： 公开了与哺乳动物因子Xa具有活性的新型化合物，其盐和与其相关的组合物。 这些化合物在体外或体内可用于预防或治疗凝血障碍
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公开(公告)号：US06545055B1
公开(公告)日：2003-04-08
申请号：US09576638
申请日：2000-05-24
IPC分类号： A61K3118
CPC分类号： C07C311/40 , C07C311/16 , C07C311/18 , C07C311/44 , C07C311/46
摘要： Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
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