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公开(公告)号：US20060160840A1
公开(公告)日：2006-07-20
申请号：US11284805
申请日：2005-11-21
申请人： Yonghong Song , Bing-Yan Zhu , Shumei Wang , Shawn Bauer , Robert Scarborough
发明人： Yonghong Song , Bing-Yan Zhu , Shumei Wang , Shawn Bauer , Robert Scarborough
IPC分类号： C07D498/02 , C07D217/12 , C07D217/06 , C07D209/42 , A61K31/4743 , A61K31/47 , A61K31/405
CPC分类号： C07D209/44 , C07D217/26 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12 , C07D495/04
摘要： The present invention is directed to compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof which are inhibitors of Factor Xa. The present invention is also directed to and intermediates used in making such compounds, pharmaceutical compositions containing such compounds, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.
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公开(公告)号：US20060160821A1
公开(公告)日：2006-07-20
申请号：US11298317
申请日：2005-12-07
申请人： Yonghong Song , Bing-Yan Zhu , Shumei Wang , Chhaya Bhakta , Robert Scarborough
发明人： Yonghong Song , Bing-Yan Zhu , Shumei Wang , Chhaya Bhakta , Robert Scarborough
IPC分类号： A61K31/496 , A61K31/4709 , A61K31/454 , A61K31/4015 , C07D403/02 , C07D401/02
CPC分类号： C07D213/40 , C07C275/30 , C07D211/26 , C07D211/58 , C07D213/64 , C07D213/74 , C07D213/89 , C07D215/227 , C07D233/24 , C07D233/64 , C07D243/08 , C07D263/04 , C07D265/32 , C07D277/04 , C07D295/195 , C07D333/22 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/10 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/04
摘要： The present invention is directed to compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof which are inhibitors of Factor Xa. The present invention is also directed to and intermediates used in making such compounds, pharmaceutical compositions containing such compounds, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.
摘要翻译： 本发明涉及由式I表示的化合物及其作为因子Xa抑制剂的药学上可接受的盐，溶剂合物，水合物和前药。 本发明还涉及用于制备这种化合物的中间体，含有这些化合物的药物组合物，预防或治疗多种不想要的血栓形成特征的病症的方法以及抑制血液样品凝固的方法。
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公开(公告)号：US20070185092A1
公开(公告)日：2007-08-09
申请号：US11620615
申请日：2007-01-05
申请人： Bing-Yan Zhu , Shawn Bauer , Zhaozhong Jia , Yonghong Song , Gary Probst , Yanchen Zhang , Robert Scarborough
发明人： Bing-Yan Zhu , Shawn Bauer , Zhaozhong Jia , Yonghong Song , Gary Probst , Yanchen Zhang , Robert Scarborough
IPC分类号： A61K31/551 , A61K31/502 , A61K31/513 , A61K31/497 , A61K31/496 , A61K31/454 , A61K31/4439 , C07D409/14
CPC分类号： C07D409/14 , C07D333/38 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention is directed to compounds represented by Formula (I) or a pharmaceutically acceptable salt, ester, or prodrug thereof which are inhibitors of Factor Xa. The present invention is also directed to and intermediates used in making such compounds, pharmaceutical compositions containing such compounds, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.
摘要翻译： 本发明涉及由式（I）表示的化合物或其药学上可接受的盐，酯或前药，其是因子Xa的抑制剂。 本发明还涉及用于制备这种化合物的中间体，含有这些化合物的药物组合物，预防或治疗多种不想要的血栓形成特征的病症的方法以及抑制血液样品凝固的方法。
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公开(公告)号：US20060241153A1
公开(公告)日：2006-10-26
申请号：US11442060
申请日：2006-05-26
申请人： Bing-Yan Zhu , Penglie Zhang , Lingyan Wang , Wenrong Huang , Erick Goldman , Wenhao Li , Jingmei Zuckett , Yonghong Song , Robert Scarborough
发明人： Bing-Yan Zhu , Penglie Zhang , Lingyan Wang , Wenrong Huang , Erick Goldman , Wenhao Li , Jingmei Zuckett , Yonghong Song , Robert Scarborough
IPC分类号： A61K31/445 , C07D213/72
CPC分类号： A61K31/44 , A61K9/20 , A61K9/2013 , A61K9/2054 , A61K9/48 , A61K9/4858 , A61K9/4866 , A61K31/616 , A61K45/06 , A61K2201/094 , C07C237/42 , C07C255/60 , C07C257/18 , C07C259/18 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/75 , C07D213/81 , C07D213/82 , C07D217/22 , C07D231/12 , C07D233/56 , C07D233/64 , C07D249/08 , C07D295/125 , C07D333/38 , C07D401/12 , C07D409/12 , C07D409/14
摘要： Novel benzamide compounds including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa are described. Compositions containing such compounds are also described. The compounds and compositions are useful in vitro or in vivo for preventing or treating coagulation disorders.
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公开(公告)号：US20060020039A1
公开(公告)日：2006-01-26
申请号：US11035767
申请日：2005-01-14
申请人： Bing-Yan Zhu , Penglie Zhang , Lingyan Wang , Wenrong Huang , Erick Goldman , Wenhao Li , Jingmei Zuckett , Yonghong Song , Robert Scarborough
发明人： Bing-Yan Zhu , Penglie Zhang , Lingyan Wang , Wenrong Huang , Erick Goldman , Wenhao Li , Jingmei Zuckett , Yonghong Song , Robert Scarborough
IPC分类号： A61K31/54 , A61K31/537 , A61K31/445 , A61K31/4172 , A61K31/40 , A61K31/397
CPC分类号： C07D213/75 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/81 , C07D213/82 , C07D217/22 , C07D231/12 , C07D233/56 , C07D249/08 , C07D333/38 , C07D401/12 , C07D409/12 , C07D409/14
摘要： Novel benzamide compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
摘要翻译： 公开了与哺乳动物因子Xa有活性的新型苯甲酰胺化合物，其盐和与其有关的组合物。 该化合物在体外或体内可用于预防或治疗凝血障碍。
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公开(公告)号：US20070021472A1
公开(公告)日：2007-01-25
申请号：US11488455
申请日：2006-07-17
申请人： Bing-Yan Zhu , Penglie Zhang , Lingyan Wang , Wenrong Huang , Erick Goldman , Wenhao Li , Jingmei Zuckett , Yonghong Song , Robert Scarborough
发明人： Bing-Yan Zhu , Penglie Zhang , Lingyan Wang , Wenrong Huang , Erick Goldman , Wenhao Li , Jingmei Zuckett , Yonghong Song , Robert Scarborough
IPC分类号： A61K31/44
CPC分类号： A61K31/44 , A61K9/20 , A61K9/2013 , A61K9/2054 , A61K9/48 , A61K9/4858 , A61K9/4866 , A61K31/616 , A61K45/06 , A61K2201/094 , C07C237/42 , C07C255/60 , C07C257/18 , C07C259/18 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/75 , C07D213/81 , C07D213/82 , C07D217/22 , C07D231/12 , C07D233/56 , C07D233/64 , C07D249/08 , C07D295/125 , C07D333/38 , C07D401/12 , C07D409/12 , C07D409/14
摘要： Novel benzamide compounds including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa are described. Compositions containing such compounds are also described. The compounds and compositions are useful in vitro or in vivo for preventing or treating coagulation disorders.
摘要翻译： 描述了具有抗哺乳动物因子Xa活性的新型苯甲酰胺化合物，包括其药学上可接受的异构体，盐，水合物，溶剂合物和前药衍生物。 还描述了含有这些化合物的组合物。 化合物和组合物在体外或体内可用于预防或治疗凝血障碍。
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公开(公告)号：US20060160790A1
公开(公告)日：2006-07-20
申请号：US11298296
申请日：2005-12-07
申请人： Yonghong Song , Bing-Yan Zhu , Chhaya Bhakta , Robert Scarborough
发明人： Yonghong Song , Bing-Yan Zhu , Chhaya Bhakta , Robert Scarborough
IPC分类号： A61K31/55 , A61K31/4709 , A61K31/454 , A61K31/4015 , C07D403/02 , C07D401/02
CPC分类号： C07D213/64 , C07C335/16 , C07D205/04 , C07D211/26 , C07D211/58 , C07D211/62 , C07D213/75 , C07D223/08 , C07D233/24 , C07D265/32 , C07D295/195 , C07D307/79 , C07D405/12 , C07D405/14
摘要： The present invention is directed to compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof which are inhibitors of Factor Xa. The present invention is also directed to and intermediates used in making such compounds, pharmaceutical compositions containing such compounds, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.
摘要翻译： 本发明涉及由式I表示的化合物及其作为因子Xa抑制剂的药学上可接受的盐，溶剂合物，水合物和前药。 本发明还涉及用于制备这种化合物的中间体，含有这些化合物的药物组合物，预防或治疗多种不想要的血栓形成特征的病症的方法以及抑制血液样品凝固的方法。
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公开(公告)号：US20050261346A1
公开(公告)日：2005-11-24
申请号：US10942733
申请日：2004-09-15
申请人： Bing-Yan Zhu , Penglie Zhang , Lingyan Wang , Wenrong Huang , Erick Goldman , Wenhao Li , Jingmei Zuckett , Yonghong Song , Robert Scarborough
发明人： Bing-Yan Zhu , Penglie Zhang , Lingyan Wang , Wenrong Huang , Erick Goldman , Wenhao Li , Jingmei Zuckett , Yonghong Song , Robert Scarborough
IPC分类号： A61K31/443 , A61K31/444 , A61P7/02 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/75 , C07D213/81 , C07D213/82 , C07D217/22 , C07D333/38 , C07D401/12 , C07D409/12 , C07D409/14 , C07D521/00 , C07D41/02 , C07D49/02
CPC分类号： A61K31/44 , A61K9/20 , A61K9/2013 , A61K9/2054 , A61K9/48 , A61K9/4858 , A61K9/4866 , A61K31/616 , A61K45/06 , A61K2201/094 , C07C237/42 , C07C255/60 , C07C257/18 , C07C259/18 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/75 , C07D213/81 , C07D213/82 , C07D217/22 , C07D231/12 , C07D233/56 , C07D233/64 , C07D249/08 , C07D295/125 , C07D333/38 , C07D401/12 , C07D409/12 , C07D409/14
摘要： Novel benzamide compounds including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa are described. Compositions containing such compounds are also described. The compounds and compositions are useful in vitro or in vivo for preventing or treating coagulation disorders.
摘要翻译： 描述了具有抗哺乳动物因子Xa活性的新型苯甲酰胺化合物，包括其药学上可接受的异构体，盐，水合物，溶剂合物和前药衍生物。 还描述了含有这些化合物的组合物。 化合物和组合物在体外或体内可用于预防或治疗凝血障碍。
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公开(公告)号：US20060100193A1
公开(公告)日：2006-05-11
申请号：US11158274
申请日：2005-06-20
申请人： Bing-Yan Zhu , Shawn Bauer , Zhaozhong Jia , Gary Probst , Yanchen Zhang , Robert Scarborough
发明人： Bing-Yan Zhu , Shawn Bauer , Zhaozhong Jia , Gary Probst , Yanchen Zhang , Robert Scarborough
IPC分类号： A61K31/5377 , A61K31/506 , A61K31/496 , A61K31/453 , A61K31/4745 , A61K31/422 , A61K31/397 , A61K31/381 , C07D413/02 , C07D409/02
CPC分类号： C07D413/14 , C07D333/38 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要： The present invention is directed to compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof which are inhibitors of Factor Xa. The present invention is also directed to and intermediates used in making such compounds, pharmaceutical compositions containing such compounds, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.
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公开(公告)号：US06228854B1
公开(公告)日：2001-05-08
申请号：US09132257
申请日：1998-08-11
申请人： Robert Scarborough , Bing-Yan Zhu
发明人： Robert Scarborough , Bing-Yan Zhu
IPC分类号： A61K3155
CPC分类号： C07K5/06139 , A61K38/00
摘要： Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
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