公开(公告)号：US20190211077A2

公开(公告)日：2019-07-11

申请号：US15321916

申请日：2015-06-24

申请人： Yoshiharu ASAOKA ,  Toru TANAKA ,  Yosuke TERAO ,  Naoki YAMANAKA ,  Natsuko KIZU ,  Masaru AOKI ,  Teruhiko IDE

发明人： Yoshiharu ASAOKA ,  Toru TANAKA ,  Yosuke TERAO ,  Naoki YAMANAKA ,  Natsuko KIZU ,  Masaru AOKI ,  Teruhiko IDE

IPC分类号： C07K14/735 ,  C07K1/22 ,  C07K16/00 ,  B01J20/281 ,  G01N33/68 ,  B01D15/38

CPC分类号： C07K14/70535 ,  B01D15/3809 ,  C07K1/22 ,  C07K16/00 ,  C07K16/065 ,  C07K2317/10 ,  C07K2317/41 ,  C07K2317/732 ,  C12N15/09 ,  C12P21/02 ,  G01N30/482 ,  G01N33/6854 ,  G01N2030/486 ,  G01N2400/02

摘要： Provided are: an Fc-binding protein having improved stability, particularly to heat and acid; a method for producing the protein; an antibody adsorbent using the protein; and a method for separating the antibodies using the adsorbent. Specifically provided are: an Fc-binding protein having improved stability to heat and acid, achieved by substituting an amino-acid residue in a specific position in the extracellular region of human FcyRIIIa with another specific amino acid; a method for producing the protein; an antibody adsorbent using the protein; and a method for separating the antibodies using the adsorbent.