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公开(公告)号：US08681152B2
公开(公告)日：2014-03-25
申请号：US12998797
申请日：2009-11-30
CPC分类号： G06T17/20 , A61B2034/105 , G06F19/00 , G06F19/3481 , G06T15/08 , G06T19/20 , G06T2210/41 , G06T2219/2021 , G16H50/50
摘要： The invention is directed to the provision of a method for generating a model for a preoperative simulation, wherein the method includes: a first step of constructing volume data for necessary organs by acquiring geometrical information from a medical image; a second step of manipulating the volume data to reposition and reorient an operator-designated organ to achieve a position and orientation appropriate for a surgical operation; a third step of generating a blood-vessel model, depicting a blood vessel to be joined to the designated organ, so as to match the position and orientation of the designated organ; a fourth step of generating volume data by forming a fat model of prescribed thickness around a prescribed organ contained in the earlier constructed volume data, after the blood-vessel model has been joined to the designated organ; a fifth step of thereafter meshing the organ represented by the generated volume data; a sixth step of manipulating a template model of a prescribed shape by using a template, and arranging the template model around the generated blood-vessel model; and a seventh step of generating a line-segment model based on the thus arranged template model.
摘要翻译： 本发明旨在提供一种用于产生用于术前模拟的模型的方法，其中所述方法包括：第一步骤，通过从医学图像获取几何信息来构建所需器官的体积数据; 操纵体积数据以重新定位和重新定向操作者指定的器官以实现适合外科手术的位置和取向的第二步骤; 产生血管模型的第三步骤，描绘要连接到指定器官的血管，以便与指定器官的位置和方向相匹配; 在血管模型已经结合到指定的器官之后，通过在早期构建的体积数据中包含的规定的器官周围形成规定厚度的脂肪模型来生成体数据的第四步骤; 其后，将生成的体数据表示的脏器啮合的第五步骤; 通过使用模板来操作规定形状的模板模型的第六步骤，以及围绕生成的血管模型布置模板模型; 以及基于由此布置的模板模型生成线段模型的第七步骤。
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公开(公告)号：US20110238395A1
公开(公告)日：2011-09-29
申请号：US12998797
申请日：2009-11-30
IPC分类号： G06G7/60
CPC分类号： G06T17/20 , A61B2034/105 , G06F19/00 , G06F19/3481 , G06T15/08 , G06T19/20 , G06T2210/41 , G06T2219/2021 , G16H50/50
摘要： The invention is directed to the provision of a method for generating a model for a preoperative simulation, wherein the method includes: a first step of constructing volume data for necessary organs by acquiring geometrical information from a medical image; a second step of manipulating the volume data to reposition and reorient an operator-designated organ to achieve a position and orientation appropriate for a surgical operation; a third step of generating a blood-vessel model, depicting a blood vessel to be joined to the designated organ, so as to match the position and orientation of the designated organ; a fourth step of generating volume data by forming a fat model of prescribed thickness around a prescribed organ contained in the earlier constructed volume data, after the blood-vessel model has been joined to the designated organ; a fifth step of thereafter meshing the organ represented by the generated volume data; a sixth step of manipulating a template model of a prescribed shape by using a template, and arranging the template model around the generated blood-vessel model; and a seventh step of generating a line-segment model based on the thus arranged template model.
摘要翻译： 本发明旨在提供一种用于产生用于术前模拟的模型的方法，其中所述方法包括：第一步骤，通过从医学图像获取几何信息来构建所需器官的体积数据; 操纵体积数据以重新定位和重新定向操作者指定的器官以实现适合外科手术的位置和取向的第二步骤; 产生血管模型的第三步骤，描绘要连接到指定器官的血管，以便与指定器官的位置和方向相匹配; 在血管模型已经结合到指定的器官之后，通过在早期构建的体积数据中包含的规定的器官周围形成规定厚度的脂肪模型来生成体数据的第四步骤; 其后，将生成的体数据表示的脏器啮合的第五步骤; 通过使用模板来操作规定形状的模板模型的第六步骤，以及围绕生成的血管模型布置模板模型; 以及基于由此布置的模板模型生成线段模型的第七步骤。
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3.发明授权Surgical simulation model generating method, surgical simulation method, and surgical simulator 有权手术模拟生成方法，手术模拟方法和手术模拟器公开(公告)号：US09214095B2
公开(公告)日：2015-12-15
申请号：US13376697
申请日：2010-06-04
申请人： Yoshinobu Kubota , Kazuhide Makiyama , Takaaki Kikukawa , Manabu Nagasaka , Hideo Sakamoto , Masato Ogata
发明人： Yoshinobu Kubota , Kazuhide Makiyama , Takaaki Kikukawa , Manabu Nagasaka , Hideo Sakamoto , Masato Ogata
CPC分类号： G06T7/204 , A61B2034/105 , G06F19/00 , G06K9/52 , G06K9/6201 , G06T7/0014 , G06T7/248 , G06T7/74 , G06T13/80 , G06T17/20 , G06T2207/30004 , G09B23/285
摘要： A surgical simulation model generating method includes: a first process in which a computing unit acquires geometrical information of an organ from a medical image stored in a storage unit, including an image of the organ, and generates volume data for the organ; a second process in which, after the first process, the computing unit forms nodal points by meshing the organ represented by the generated volume data; a third process in which the computing unit generates a simulated membrane that covers the organ represented by the volume data meshed in the second process; and a fourth process in which the computing unit generates a simulated organ by drawing an imaginary line so as to extend from each nodal point formed on a surface of the organ represented by the volume data meshed in the second process in a direction that intersects the simulated membrane and thereby forming a membrane nodal point at a point where the imaginary line intersects the simulated membrane generated in the third process, and by arranging on each imaginary line an imaginary inter-membrane spring that connects between the nodal point formed on the surface of the organ and the membrane nodal point, while also arranging an in-plane spring that connects between adjacent membrane nodal points on the simulated membrane.
摘要翻译： 手术模拟模型生成方法包括：第一处理，其中计算单元从存储在存储单元中的医学图像获取器官的几何信息，包括器官的图像，并且生成器官的体积数据; 第二处理，其中，在第一处理之后，计算单元通过对由生成的卷数据表示的器官进行啮合而形成节点; 第三处理，其中所述计算单元生成覆盖由在所述第二处理中筛选的所述体数据表示的所述器官的模拟膜; 以及第四处理，其中所述计算单元通过绘制假想线来生成模拟器官，以从形成在所述器官的表面上的所述器官的表面延伸，所述节点由所述第二处理中的网格化的体数据表示在与所述模拟 膜，从而在假想线与第三工艺中产生的模拟膜相交的点形成膜节点，并且通过在每个假想线上布置假想的膜间弹簧，其连接在形成在该表面上的节点之间 器官和膜节点，同时还布置连接在模拟膜上的相邻膜节点之间的平面内弹簧。
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4.发明申请SURGICAL SIMULATION MODEL GENERATING METHOD, SURGICAL SIMULATION METHOD, AND SURGICAL SIMULATOR 有权外科模拟模型生成方法，手术模拟方法和手术模拟器公开(公告)号：US20120081367A1
公开(公告)日：2012-04-05
申请号：US13376697
申请日：2010-06-04
申请人： Yoshinobu Kubota , Kazuhide Makiyama , Takaaki Kikukawa , Manabu Nagasaka , Hideo Sakamoto , Masato Ogata
发明人： Yoshinobu Kubota , Kazuhide Makiyama , Takaaki Kikukawa , Manabu Nagasaka , Hideo Sakamoto , Masato Ogata
IPC分类号： G06T15/00
CPC分类号： G06T7/204 , A61B2034/105 , G06F19/00 , G06K9/52 , G06K9/6201 , G06T7/0014 , G06T7/248 , G06T7/74 , G06T13/80 , G06T17/20 , G06T2207/30004 , G09B23/285
摘要： A surgical simulation model generating method includes: a first process in which a computing unit acquires geometrical information of an organ from a medical image stored in a storage unit, including an image of the organ, and generates volume data for the organ; a second process in which, after the first process, the computing unit forms nodal points by meshing the organ represented by the generated volume data; a third process in which the computing unit generates a simulated membrane that covers the organ represented by the volume data meshed in the second process; and a fourth process in which the computing unit generates a simulated organ by drawing an imaginary line so as to extend from each nodal point formed on a surface of the organ represented by the volume data meshed in the second process in a direction that intersects the simulated membrane and thereby forming a membrane nodal point at a point where the imaginary line intersects the simulated membrane generated in the third process, and by arranging on each imaginary line an imaginary inter-membrane spring that connects between the nodal point formed on the surface of the organ and the membrane nodal point, while also arranging an in-plane spring that connects between adjacent membrane nodal points on the simulated membrane.
摘要翻译： 手术模拟模型生成方法包括：第一处理，其中计算单元从存储在存储单元中的医学图像获取器官的几何信息，包括器官的图像，并且生成器官的体积数据; 第二处理，其中，在第一处理之后，计算单元通过对由生成的卷数据表示的器官进行啮合而形成节点; 第三处理，其中所述计算单元生成覆盖由在所述第二处理中筛选的所述体数据表示的所述器官的模拟膜; 以及第四处理，其中所述计算单元通过绘制假想线来生成模拟器官，以从形成在所述器官的表面上的所述器官的表面延伸，所述节点由所述第二处理中的网格化的体数据表示在与所述模拟 膜，从而在假想线与第三工艺中产生的模拟膜相交的点形成膜节点，并且通过在每个假想线上布置假想的膜间弹簧，其连接在形成在该表面上的节点之间 器官和膜节点，同时还布置连接在模拟膜上的相邻膜节点之间的平面内弹簧。
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公开(公告)号：US20130039612A1
公开(公告)日：2013-02-14
申请号：US13538094
申请日：2012-06-29
IPC分类号： G02F1/035
CPC分类号： G02F1/0356 , G02F1/2255 , G02F2201/07 , G02F2202/105 , G02F2203/21
摘要： An optical modulator comprises a substrate having an electro-optical effect, an optical waveguide formed in the substrate, a buffer layer provided above the optical waveguide, a semiconductor film provided above the buffer layer and having an aperture at a top of the optical waveguide, and an electrode provided above the buffer layer and electrically coupled to the semiconductor film.
摘要翻译： 光调制器包括具有电光效应的基板，在基板中形成的光波导，设置在光波导上方的缓冲层，设置在缓冲层上方并在光波导顶部具有孔的半导体膜， 以及设置在缓冲层上方并电耦合到半导体膜的电极。
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6.发明申请公开(公告)号：US20070077003A1
公开(公告)日：2007-04-05
申请号：US11320973
申请日：2005-12-30
申请人： Hirofumi Aota , Kohei Shibata , Tamotsu Akashi , Shinji Yamashita , Tsuyoshi Yamamoto , Shinichi Takeuchi , Yoshinobu Kubota , Nobuhiro Fukushima , Hiroyuki Furukawa , Toshiya Kishida
发明人： Hirofumi Aota , Kohei Shibata , Tamotsu Akashi , Shinji Yamashita , Tsuyoshi Yamamoto , Shinichi Takeuchi , Yoshinobu Kubota , Nobuhiro Fukushima , Hiroyuki Furukawa , Toshiya Kishida
IPC分类号： G02B6/35
CPC分类号： G02B6/29395 , G02B6/2931 , G02B6/29313 , G02B6/3512 , G02B6/4215
摘要： A wavelength selective optical switch of the present invention separates a WDM light emitted from an input port of an input and output optical system, according to wavelengths, by a diffraction grating, and thereafter, condenses the lights of respective wavelengths on MEMS mirrors respectively corresponding to the respective wavelengths, in a mirror array, to reflect them by a condenser optical system, to thereby switch optical paths for the respective lights. The condenser optical system is configured by combining a plurality of lenses whose focal distances are different from each other, and positions in an optical axis direction of the lenses are adjustable by a slide mechanism. Thus, despite an error in the focal distances of the condenser lenses, in a mounting angle of a spectral element or the like, a beam pitch at the condensing positions of the lights of respective wavelengths can be coincident with a mirror pitch in the mirror array.
摘要翻译： 本发明的波长选择性光开关根据波长通过衍射光栅分离从输入和输出光学系统的输入端口发射的WDM光，然后将分别对应于 反射镜阵列中的各个波长通过聚光器光学系统反射，从而切换各个光的光路。 聚光器系统通过组合焦距彼此不同的多个透镜来构成，透镜的光轴方向的位置通过滑动机构来调节。 因此，尽管聚光透镜的焦距存在误差，但是在光谱元件等的安装角度，各波长的光的聚光位置处的光束间距可以与镜阵列中的镜间距一致 。
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公开(公告)号：US20130344124A1
公开(公告)日：2013-12-26
申请号：US13994406
申请日：2010-12-22
申请人： Kazuhito Hashimoto , Kayano Sunada , Masahiro Miyauchi , Xiaoqing Qiu , Yoshinobu Kubota , Hitoshi Ishiguro , Ryuichi Nakano , Jitsuo Kajioka , Yanyan Yao
发明人： Kazuhito Hashimoto , Kayano Sunada , Masahiro Miyauchi , Xiaoqing Qiu , Yoshinobu Kubota , Hitoshi Ishiguro , Ryuichi Nakano , Jitsuo Kajioka , Yanyan Yao
摘要： An agent for virus inactivation capable of exhibiting inactivation action based on structural destruction such as degradation and decomposition against viruses, which comprises a monovalent copper compound such as cuprous oxide, cuprous sulfide, cuprous iodide, and cuprous chloride as an active ingredient, and a virus inactivation material, which contains the agent for virus inactivation on a surface of a substrate and/or inside of the substrate.
摘要翻译： 包含一价铜化合物如氧化亚铜，硫化亚铜，碘化亚铜和氯化亚铜作为活性成分的能够显示基于结构破坏（例如降解和分解）的灭活作用的病毒灭活剂，以及病毒 灭活材料，其含有在基材表面和/或基材内部的用于病毒灭活的试剂。
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8.发明申请Pharmaceutical Titanium Dioxide Composite Allowing Disappearance of Drug Efficacy By Light Irradiation 审中-公开药物二氧化钛复合物允许通过光照射消除药物功效公开(公告)号：US20100136115A1
公开(公告)日：2010-06-03
申请号：US11990040
申请日：2006-08-04
申请人： Shuji Sonezaki , Koki Kanehira , Yumi Ogami , Toshiaki Banzai , Yoshinobu Kubota
发明人： Shuji Sonezaki , Koki Kanehira , Yumi Ogami , Toshiaki Banzai , Yoshinobu Kubota
IPC分类号： A61K9/14 , A61K31/704 , A61K38/14 , A61P35/00
CPC分类号： A61K41/0028 , A61K9/0019 , A61K31/704 , A61K47/58 , A61K47/6923 , A61K47/6929 , B82Y5/00
摘要： Disclosed is a titanium dioxide composite material which can be dispersed in an aqueous solvent stably and can be administered to a living body in a simple manner and in which the pharmacological effect of a therapeutic compound carried on the composite material can be eliminated by irradiation with light. Also disclosed is a dispersion product of the composite material. The composite material comprises titanium dioxide which has a photocatalytic activity and a therapeutic compound attached to the titanium dioxide through a hydrophilic polymer. The composite material is stable in an aqueous solvent and can be administered to a living body in a simple manner. After the composite material is administered to a living body, a site on the living body where the pharmacological effect of the therapeutic compound is not needed to be developed can be irradiated with light to induce the light excitation of titanium dioxide at the site, thereby decomposing the therapeutic compound to reduce any adverse side effect of the therapeutic compound.
摘要翻译： 公开了一种二氧化钛复合材料，其可以稳定地分散在水性溶剂中，并且可以简单的方式施用于生物体，并且通过照射光可以消除携带在复合材料上的治疗化合物的药理作用 。 还公开了复合材料的分散体。 复合材料包括具有光催化活性的二氧化钛和通过亲水性聚合物连接到二氧化钛上的治疗化合物。 复合材料在水性溶剂中稳定，可以以简单的方式施用于生物体。 在将复合材料施用于生物体后，可以用光照射生物体上不需要开发治疗化合物的药理作用的部位，从而在该部位诱导二氧化钛的光激发，从而分解 该治疗化合物用于减少治疗化合物的任何副作用。
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9.发明授权Wavelength selective optical switch, and optical device provided with spectroscopic function 有权波长选择光开关，以及配有光谱功能的光学元件公开(公告)号：US07330617B2
公开(公告)日：2008-02-12
申请号：US11320973
申请日：2005-12-30
申请人： Hirofumi Aota , Kohei Shibata , Tamotsu Akashi , Shinji Yamashita , Tsuyoshi Yamamoto , Shinichi Takeuchi , Yoshinobu Kubota , Nobuhiro Fukushima , Hiroyuki Furukawa , Toshiya Kishida
发明人： Hirofumi Aota , Kohei Shibata , Tamotsu Akashi , Shinji Yamashita , Tsuyoshi Yamamoto , Shinichi Takeuchi , Yoshinobu Kubota , Nobuhiro Fukushima , Hiroyuki Furukawa , Toshiya Kishida
IPC分类号： G02B6/26
CPC分类号： G02B6/29395 , G02B6/2931 , G02B6/29313 , G02B6/3512 , G02B6/4215
摘要： A wavelength selective optical switch of the present invention separates a WDM light emitted from an input port of an input and output optical system, according to wavelengths, by a diffraction grating, and thereafter, condenses the lights of respective wavelengths on MEMS mirrors respectively corresponding to the respective wavelengths, in a mirror array, to reflect them by a condenser optical system, to thereby switch optical paths for the respective lights. The condenser optical system is configured by combining a plurality of lenses whose focal distances are different from each other, and positions in an optical axis direction of the lenses are adjustable by a slide mechanism. Thus, despite an error in the focal distances of the condenser lenses, in a mounting angle of a spectral element or the like, a beam pitch at the condensing positions of the lights of respective wavelengths can be coincident with a mirror pitch in the mirror array.
摘要翻译： 本发明的波长选择性光开关根据波长通过衍射光栅分离从输入和输出光学系统的输入端口发射的WDM光，然后将分别对应于 反射镜阵列中的各个波长通过聚光器光学系统反射，从而切换各个光的光路。 聚光器系统通过组合焦距彼此不同的多个透镜来构成，透镜的光轴方向的位置通过滑动机构来调节。 因此，尽管聚光透镜的焦距存在误差，但是在光谱元件等的安装角度，各波长的光的聚光位置处的光束间距可以与镜阵列中的镜间距一致 。
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10.发明授权Acousto-optic variable-wavelength TE/TM mode converter, and a variable-wavelength optical filter using this converter 失效声光可变波长TE / TM模式转换器和使用该转换器的可变波长光学滤波器公开(公告)号：US06466705B2
公开(公告)日：2002-10-15
申请号：US09748180
申请日：2000-12-27
申请人： Takehito Tanaka , Yoshinobu Kubota
发明人： Takehito Tanaka , Yoshinobu Kubota
IPC分类号： G02F1335
摘要： An acousto-optic variable-wavelength TE/TM mode converter is configured by comprising an optical waveguide, a coupled acoustic waveguide composed of two acoustic waveguides, comb electrodes arranged at the acoustic waveguides, and surface acoustic wave absorbers arranged at the acoustic waveguide. If high-frequency electric signals having different frequencies are applied to the electrodes, surface acoustic waves W11 and W12 occur on the surface of the piezoelectric substrate, meander and propagate in the substrate, and are finally absorbed by the absorbers. The intensity distributions of the surface acoustic waves W11 and W12 are distributions where the intensity is high in a middle portion of the optical guide, and low at both ends of the optical waveguide. The peak positions of the intensities are different, and the bases of the distributions partially overlap between the two absorbers.
摘要翻译： 声光可变波长TE / TM模式转换器通过包括光波导，由两个声波导构成的耦合声波导，布置在声波导上的梳状电极以及布置在声波导上的表面声波吸收器构成。 如果将具有不同频率的高频电信号施加到电极，则表面声波W11和W12出现在压电基板的表面上，在基板中弯曲并传播，并最终被吸收体吸收。 表面声波W11和W12的强度分布是光导体的中间部分的强度高的部分，在光波导的两端处的低分布。 强度的峰值位置不同，两个吸收体之间的分布基本部分重叠。
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