公开(公告)号：US20100228498A1

公开(公告)日：2010-09-09

申请号：US12767135

申请日：2010-04-26

Applicant: Kazuo Yamauchi ,  Yoshitake Yamamoto ,  Yoshikatsu Umemura

Inventor： Kazuo Yamauchi ,  Yoshitake Yamamoto ,  Yoshikatsu Umemura

IPC: H01J49/26 ,  G06F19/00

CPC classification number: H01J49/0036 ,  G06F19/703 ,  Y10T436/24

Abstract: In a mass analysis data analyzing apparatus, centroid data is used as mass spectrum data to be analyzed. First, peaks on the centroid data are specified in order of intensity as a standard peak for identifying an isotopic cluster. The isotopic cluster is detected by comparing an emerging pattern of peaks near the standard peak and an emerging pattern of peaks of an expected isotopic cluster in the case where each valence is assumed. The valence of the determined isotopic cluster is set as the valence of the peaks belonging to the isotopic cluster, and the peak at the forefront of cluster is selected as a monoisotopic peak. With such a mass analysis data analyzing apparatus, it is possible to determine the valence of each peak and identify the monoisotopic peak in a mass spectrum.

Abstract translation: 在质量分析数据分析装置中，质心数据用作要分析的质谱数据。 首先，质心数据的峰值以强度的顺序指定为用于识别同位素簇的标准峰。 通过比较在假定每个化合价的情况下，标准峰附近出现的峰出现和预期同位素簇的峰出现模式，可以检测同位素簇。 确定的同位素簇的价态被设置为属于同位素簇的峰的价态，并且选择簇的最前沿的峰作为单同位素峰。 利用这样的质量分析数据分析装置，可以确定每个峰的价态并识别质谱中的单同位素峰。

公开(公告)号：US08067729B2

公开(公告)日：2011-11-29

申请号：US12767135

申请日：2010-04-26

Applicant: Kazuo Yamauchi ,  Yoshitake Yamamoto ,  Yoshikatsu Umemura

Inventor： Kazuo Yamauchi ,  Yoshitake Yamamoto ,  Yoshikatsu Umemura

IPC: B01D59/44

CPC classification number: H01J49/0036 ,  G06F19/703 ,  Y10T436/24

Abstract: In a mass analysis data analyzing apparatus, centroid data is used as mass spectrum data to be analyzed. First, peaks on the centroid data are specified in order of intensity as a standard peak for identifying an isotopic cluster. The isotopic cluster is detected by comparing an emerging pattern of peaks near the standard peak and an emerging pattern of peaks of an expected isotopic cluster in the case where each valence is assumed. The valence of the determined isotopic cluster is set as the valence of the peaks belonging to the isotopic cluster, and the peak at the forefront of cluster is selected as a monoisotopic peak. With such a mass analysis data analyzing apparatus, it is possible to determine the valence of each peak and identify the monoisotopic peak in a mass spectrum.

Abstract translation: 在质量分析数据分析装置中，质心数据用作要分析的质谱数据。 首先，质心数据的峰值以强度的顺序指定为用于识别同位素簇的标准峰。 通过比较在假定每个化合价的情况下，标准峰附近出现的峰出现和预期同位素簇的峰出现模式，可以检测同位素簇。 确定的同位素簇的价态被设置为属于同位素簇的峰的价态，并且选择簇的最前沿的峰作为单同位素峰。 利用这样的质量分析数据分析装置，可以确定每个峰的价态并识别质谱中的单同位素峰。

公开(公告)号：US07558682B2

公开(公告)日：2009-07-07

申请号：US11790355

申请日：2007-04-25

Applicant: Yoshitake Yamamoto

Inventor： Yoshitake Yamamoto

IPC: G06F19/00

CPC classification number: H01J49/0036 ,  H01J49/0009

Abstract: An exact centroid spectrum with a mass number corrected is determined from a profile spectrum adjacent to a plurality of peaks. Regarding a profile spectrum determined by a mass spectrometer, overlapping with adjacent peaks occurs, and compounds having a plurality of peaks with different overlapping degrees is measured, a correction function is created from a relationship between an overlapping degrees with respect to the plurality of peaks and a shift of the mass number, and a centroid peak is corrected by the correction function when the profile spectrum is converted into the centroid spectrum.

Abstract translation: 从与多个峰相邻的轮廓谱确定具有校正质量数的精确质心谱。 关于由质谱仪确定的分布光谱，发生与相邻峰值重叠的测量，并且测量具有不同重叠度的多个峰值的化合物，根据与多个峰值的重叠度之间的关系产生校正函数，以及 当轮廓谱转换为质心谱时，通过校正函数校正质量数的偏移，质心峰被校正。

公开(公告)号：US20090001264A1

公开(公告)日：2009-01-01

申请号：US12078220

申请日：2008-03-28

Applicant: Yoshitake Yamamoto

Inventor： Yoshitake Yamamoto

IPC: H01J49/04

CPC classification number: G01N30/8624 ,  G01N30/7233 ,  G01N30/7293 ,  G01N30/8631 ,  G01N30/8641 ,  G01N2030/027 ,  G01N2030/626 ,  H01J49/04 ,  Y10T436/24

Abstract: A method for fractionating a sample solution includes the steps of setting a first mass spectrometry condition and mass range information; setting a second mass spectrometry condition and mass range information; executing a mass scan by the mass spectrum acquisition portion under the first mass spectrometry condition and obtaining first mass spectrum data; extracting first chromatogram data from the first mass spectrum data based on the first mass range information; executing a mass scan by the mass spectrum acquisition portion under the second mass spectrometry condition to obtain second mass spectrum data; extracting second chromatogram data from the second mass spectrum data based on the second mass range information; switching the first and second spectrometry conditions and repeating the mass scan cyclically; adding the first and second chromatograph data to obtain a chromatogram data; and operating the fraction collector based on the chromatogram data.

Abstract translation: 分离样品溶液的方法包括设定第一质谱条件和质量范围信息的步骤; 设置第二个质谱条件和质量范围信息; 在第一质谱条件下由质谱获取部分进行质量扫描，获得第一质谱数据; 基于第一质量范围信息从第一质谱数据中提取第一色谱图数据; 在第二质谱条件下通过质谱采集部分进行质量扫描以获得第二质谱数据; 基于第二质量范围信息从第二质谱数据中提取第二色谱图数据; 切换第一和第二光谱测定条件并循环重复质谱; 加入第一和第二色谱数据以获得色谱数据; 并基于色谱图数据操作馏分收集器。

公开(公告)号：US08044347B2

公开(公告)日：2011-10-25

申请号：US12425114

申请日：2009-04-16

Applicant: Yoshitake Yamamoto ,  Yoshikatsu Umemura

Inventor： Yoshitake Yamamoto ,  Yoshikatsu Umemura

IPC: H01J49/00

CPC classification number: H01J49/0036

Abstract: Intensity data of the signals produced by an ion detector are sequentially stored in a data processor, with each piece of intensity data being associated with time t required for each of the various ions ejected from an ion trap to fly through a time-of-flight space and reach the ion detector. The data obtained within a time range T2 corresponding to a measurement mass range are extracted as profile data. The data obtained within either a time range T1 before the arrival of an ion having the smallest m/z value or a time range T3 after the arrival of an ion having the largest m/z value are extracted as noise component data. Various kinds of noise information such as the noise level or standard deviation are calculated from the noise component data. Based on this noise information, a noise component is removed from the profile data. For every mass scan cycle, the noise component data and profile data are almost simultaneously obtained. Therefore, even if the electrical noise from the ion detector changes with time, the noise can be properly removed with little influence from that change of the noise.

Abstract translation: 由离子检测器产生的信号的强度数据被顺序地存储在数据处理器中，每个强度数据与从离子阱排出的各种离子中的每一个所需的时间t相关联，以飞过飞行时间 空间并到达离子检测器。 在与测量质量范围对应的时间范围T2内获得的数据被提取为简档数据。 在具有最小m / z值的离子到达之后的时间范围T1内或在具有最大m / z值的离子到达之后的时间范围T3中获得的数据被提取作为噪声分量数据。 根据噪声分量数据计算噪声电平或标准偏差等各种噪声信息。 基于该噪声信息，从轮廓数据中去除噪声分量。 对于每个质量扫描周期，几乎同时获得噪声分量数据和轮廓数据。 因此，即使来自离子检测器的电噪声随时间而变化，也可以从噪声的变化几乎没有影响地适当地去除噪声。

公开(公告)号：US20070284520A1

公开(公告)日：2007-12-13

申请号：US11790355

申请日：2007-04-25

Applicant: Yoshitake Yamamoto

Inventor： Yoshitake Yamamoto

IPC: G06F19/00 ,  H01J49/34

CPC classification number: H01J49/0036 ,  H01J49/0009

Abstract: An exact centroid spectrum with a mass number corrected is determined from a profile spectrum adjacent to a plurality of peaks. Regarding a profile spectrum determined by a mass spectrometer, overlapping with adjacent peaks occurs, and compounds having a plurality of peaks with different overlapping degrees is measured, a correction function is created from a relationship between an overlapping degrees with respect to the plurality of peaks and a shift of the mass number, and a centroid peak is corrected by the correction function when the profile spectrum is converted into the centroid spectrum.

Abstract translation: 从与多个峰相邻的轮廓谱确定具有校正质量数的精确质心谱。 关于由质谱仪确定的分布光谱，发生与相邻峰值重叠的测量，并且测量具有不同重叠度的多个峰值的化合物，根据与多个峰值的重叠度之间的关系产生校正函数，以及 当轮廓谱转换为质心谱时，通过校正函数校正质量数的偏移，质心峰被校正。

公开(公告)号：US07901628B2

公开(公告)日：2011-03-08

申请号：US12078220

申请日：2008-03-28

Applicant: Yoshitake Yamamoto

Inventor： Yoshitake Yamamoto

IPC: G01N30/02 ,  H01J49/00 ,  B01D59/44 ,  G01N15/06

CPC classification number: G01N30/8624 ,  G01N30/7233 ,  G01N30/7293 ,  G01N30/8631 ,  G01N30/8641 ,  G01N2030/027 ,  G01N2030/626 ,  H01J49/04 ,  Y10T436/24

Abstract: A method for fractionating a sample solution includes the steps of setting a first mass spectrometry condition and mass range information; setting a second mass spectrometry condition and mass range information; executing a mass scan by the mass spectrum acquisition portion under the first mass spectrometry condition and obtaining first mass spectrum data; extracting first chromatogram data from the first mass spectrum data based on the first mass range information; executing a mass scan by the mass spectrum acquisition portion under the second mass spectrometry condition to obtain second mass spectrum data; extracting second chromatogram data from the second mass spectrum data based on the second mass range information; switching the first and second spectrometry conditions and repeating the mass scan cyclically; adding the first and second chromatograph data to obtain a chromatogram data; and operating the fraction collector based on the chromatogram data.

Abstract translation: 分离样品溶液的方法包括设定第一质谱条件和质量范围信息的步骤; 设置第二个质谱条件和质量范围信息; 在第一质谱条件下由质谱获取部分进行质量扫描，获得第一质谱数据; 基于第一质量范围信息从第一质谱数据中提取第一色谱图数据; 在第二质谱条件下通过质谱采集部分进行质量扫描以获得第二质谱数据; 基于第二质量范围信息从第二质谱数据中提取第二色谱图数据; 切换第一和第二光谱测定条件并循环重复质谱; 加入第一和第二色谱数据以获得色谱数据; 并基于色谱图数据操作馏分收集器。

公开(公告)号：US07535004B2

公开(公告)日：2009-05-19

申请号：US11946318

申请日：2007-11-28

Applicant: Yoshitake Yamamoto

Inventor： Yoshitake Yamamoto

IPC: G01B9/02 ,  G01J3/45 ,  G01J3/453

CPC classification number: G01J3/45 ,  G01J3/02 ,  G01J3/027

Abstract: Disclosed is a Fourier transform infrared spectrophotometer, which comprises: a main interferometer section including a beam splitter, a fixed mirror, a movable mirror, and a phase plate disposed between the beam splitter and the fixed mirror; a control interferometer section having a quadrature control system for calculating a position of the movable mirror; a center-burst-position detection section operable, based on an input of interference signals and interferograms, to subject respective intensities of the interferograms to an addition processing while correcting a positional deviation of the movable mirror, so as to obtain a cumulative interferogram, and detecting a center burst position having a maximum intensity value in the cumulative interferogram; a center-burst-position storage section operable to store the detected center burst position; and a measurement-start-position determination section operable, based on the stored center burst position, to determine a measurement start position of the movable mirror during the measurement operation.

Abstract translation: 公开了一种傅里叶变换红外分光光度计，其包括：主干涉仪部分，包括分束器，固定镜，可移动反射镜和设置在分束器和固定镜之间的相位板; 控制干涉仪部分，具有用于计算可移动反射镜的位置的正交控制系统; 中央突发位置检测部，其基于干涉信号和干涉图的输入，在校正可动镜的位置偏差的同时对干涉图的各个强度进行加法处理，以获得累积干涉图;以及 检测累积干涉图中具有最大强度值的中心脉冲串位置; 中央突发位置存储部分，用于存储检测到的中心突发位置; 以及测量开始位置确定部，其基于所存储的中心突发位置可操作，以在测量操作期间确定可移动镜的测量开始位置。

公开(公告)号：US20080315103A1

公开(公告)日：2008-12-25

申请号：US11946318

申请日：2007-11-28

Applicant: Yoshitake Yamamoto

Inventor： Yoshitake Yamamoto

IPC: G01J5/02

CPC classification number: G01J3/45 ,  G01J3/02 ,  G01J3/027

Abstract: Disclosed is a Fourier transform infrared spectrophotometer, which comprises: a main interferometer section including a beam splitter, a fixed mirror, a movable mirror, and a phase plate disposed between the beam splitter and the fixed mirror; a control interferometer section having a quadrature control system for calculating a position of the movable mirror; a center-burst-position detection section operable, based on an input of interference signals and interferograms, to subject respective intensities of the interferograms to an addition processing while correcting a positional deviation of the movable mirror, so as to obtain a cumulative interferogram, and detecting a center burst position having a maximum intensity value in the cumulative interferogram; a center-burst-position storage section operable to store the detected center burst position; and a measurement-start-position determination section operable, based on the stored center burst position, to determine a measurement start position of the movable mirror during the measurement operation.

Abstract translation: 公开了一种傅里叶变换红外分光光度计，其包括：主干涉仪部分，包括分束器，固定镜，可移动反射镜和设置在分束器和固定镜之间的相位板; 控制干涉仪部分，具有用于计算可移动反射镜的位置的正交控制系统; 中央突发位置检测部，其基于干涉信号和干涉图的输入，在校正可动镜的位置偏差的同时对干涉图的各个强度进行加法处理，以获得累积干涉图;以及 检测累积干涉图中具有最大强度值的中心脉冲串位置; 中央突发位置存储部分，用于存储检测到的中心突发位置; 以及测量开始位置确定部，其基于所存储的中心突发位置可操作，以在测量操作期间确定可移动镜的测量开始位置。

公开(公告)号：US06472661B1

公开(公告)日：2002-10-29

申请号：US09535207

申请日：2000-03-27

Applicant: Yasufumi Tanaka ,  Yoshitake Yamamoto

Inventor： Yasufumi Tanaka ,  Yoshitake Yamamoto

IPC: H01J4900

CPC classification number: H01J49/42 ,  G01N30/7273

Abstract: A mass spectrometer for a liquid chromatograph includes an atomization chamber into which a liquid sample from the liquid chromatograph is sprayed to be converted into ions, an intermediate chamber at a reduced inner pressure and a detection chamber containing a mass analyzer. A solvent-removing tube is between the atomization chamber and the intermediate chamber for causing liquid droplets containing these ions to pass through. A deflector with at least one pair of planar electrodes is disposed inside the intermediate chamber and opposite each other sandwiching in between the travel path of the ions. Voltage sources apply a variable DC voltage to the solvent-removing tube and different variable DC voltages to each of the electrodes. Data on voltages to be applied to the solvent-removing tube and to the electrodes for optimizing efficiency with which ions with different mass numbers are received by the mass analyzer are preliminarily obtained by using standard samples and stored in a memory device. A control unit serves to apply a specified voltage to the mass analyzer and simultaneously controls the voltage sources so as to have selected voltages applied to the solvent-removing tube and to the electrodes, according to the data stored in the memory.

Abstract translation: 用于液相色谱的质谱仪包括：雾化室，其中喷射来自液相色谱仪的液体样品转化成离子，内部减压的中间室和含有质量分析器的检测室。 溶剂去除管位于雾化室和中间室之间，用于使含有这些离子的液滴通过。 具有至少一对平面电极的偏转器设置在中间室的内部并且彼此相对地夹在离子的行进路径之间。 电压源对溶剂去除管施加可变的直流电压，并向每个电极施加不同的可变直流电压。 通过使用标准样品并存储在存储器件中，预先获得施加到溶剂去除管和电极上的电压的数据，以优化由质量分析器接收质量不同的离子的效率。 控制单元用于根据存储在存储器中的数据，向质量分析器施加指定的电压并且同时控制电压源以便选择施加到溶剂去除管和电极的电压。