公开(公告)号：US06383175B1

公开(公告)日：2002-05-07

申请号：US09406734

申请日：1999-09-28

申请人： Yoshiteru Ii ,  Akira Kaneda ,  Takayoshi Yuzu ,  Toshiyoshi Yamamoto ,  Harubumi Kato ,  Katsuo Aizawa

发明人： Yoshiteru Ii ,  Akira Kaneda ,  Takayoshi Yuzu ,  Toshiyoshi Yamamoto ,  Harubumi Kato ,  Katsuo Aizawa

IPC分类号： A61B1822

CPC分类号： A61N5/062 ,  A61N2005/0644 ,  A61N2005/067

摘要： In photodynamic diagnosis and photodynamic therapy, the oscillating wavelength of laser light from a light source is fitted to a plurality of different kinds of photosensitizers and exciting conditions thereof. Moreover, diagnosis and treatment are achieved using a single light source. Concurrent diagnosis during treatment is realized as well. A semiconductor laser generates laser light having an oscillating wavelength which is variable and a full width at half maximum which is narrow. A light transmission line guides an irradiated laser light the vicinity of a focus, an image transmission line observes the focus and the periphery thereof, a fluorescence light extracting device extracts only the fluorescence light emitted from a photosensitizer excited by the irradiated laser light, an image-pick-up/analyzing device picks up and analyzes an image of the extracted fluorescence light and an image display device displays the analyzing result.

摘要翻译： 在光动力学诊断和光动力学治疗中，来自光源的激光的振荡波长适合于多种不同种类的光敏剂和激发条件。 此外，使用单个光源实现诊断和治疗。 治疗期间同时诊断也得到实现。 半导体激光器产生具有可变的振荡波长的激光，半波长的半峰全宽。 光传输线引导照射的激光附近的焦点，图像传输线观察其焦点和周围，荧光提取装置仅提取由照射的激光激发的光敏剂发射的荧光，图像 提取/分析装置拾取并分析所提取的荧光的图像，并且图像显示装置显示分析结果。

公开(公告)号：US07016718B2

公开(公告)日：2006-03-21

申请号：US10097259

申请日：2002-03-15

申请人： Yoshiteru Ii ,  Akira Kaneda ,  Takayoshi Yuzu ,  Toshiyoshi Yamamoto ,  Harubumi Kato ,  Katsuo Aizawa

发明人： Yoshiteru Ii ,  Akira Kaneda ,  Takayoshi Yuzu ,  Toshiyoshi Yamamoto ,  Harubumi Kato ,  Katsuo Aizawa

IPC分类号： A61F9/008

CPC分类号： A61N5/062 ,  A61N2005/0644 ,  A61N2005/067

摘要： In photodynamic diagnosis and photodynamic therapy, the oscillating wavelength of laser light from a light source is fitted to a plurality of different kinds of photosensitizers and exciting conditions thereof. Moreover, diagnosis and treatment are achieved using concurrent diagnosis during treatment is realized as well. A semiconductor laser generates laser light having an oscillating wavelength which is variable and a full width at half maximum which is narrow. A light transmission line guides an irradiated laser light to the vicinity of a focus, an image transmission line observes the focus and the periphery thereof, a fluorescence light extracting device extracts only the fluorescence light emitted from a photosensitizer excited by the irradiated laser light, an image-pick-up/analyzing device picks up and analyzes an image of the extracted fluorescence light and an image display device displays the analyzing result.

公开(公告)号：US06214033B1

公开(公告)日：2001-04-10

申请号：US08545101

申请日：1995-10-19

申请人： Yoshiteru Ii ,  Akira Kaneda ,  Takayoshi Yuzu ,  Toshiyoshi Yamamoto ,  Harubumi Kato ,  Katsuo Aizawa

发明人： Yoshiteru Ii ,  Akira Kaneda ,  Takayoshi Yuzu ,  Toshiyoshi Yamamoto ,  Harubumi Kato ,  Katsuo Aizawa

IPC分类号： A61N506

CPC分类号： A61N5/062 ,  A61N2005/0644 ,  A61N2005/067

摘要： In photodynamic diagnosis and photodynamic therapy, the oscillating wavelength of laser light from a light source is fitted to a plurality of different kinds of photosensitizers and exciting conditions thereof. Moreover, diagnosis and treatment are achieved using a single light source. Concurrent diagnosis during treatment is realized as well. A semiconductor laser generates laser light having an oscillating wavelength which is variable and a full width at half maximum which is narrow. A light transmission line guides an irradiated laser light to the vicinity of a focus, an image transmission line observes the focus and the periphery thereof, a fluorescence light extracting device extracts only the fluorescence light emitted from a photosensitizer excited by the irradiated laser light, an image-pick-up/analyzing device picks up and analyzes an image of the extracted fluorescence light and an image display device displays the analyzing result.

摘要翻译： 在光动力学诊断和光动力学治疗中，来自光源的激光的振荡波长适合于多种不同种类的光敏剂和激发条件。 此外，使用单个光源实现诊断和治疗。 治疗期间同时诊断也得到实现。 半导体激光器产生具有可变的振荡波长的激光，半波长的半峰全宽。 光传输线将照射的激光引导到焦点附近，图像传输线观察其焦点和周围，荧光提取装置仅提取由照射的激光激发的光敏剂发射的荧光， 图像拾取/分析装置拾取并分析提取的荧光的图像，并且图像显示装置显示分析结果。

公开(公告)号：US5871521A

公开(公告)日：1999-02-16

申请号：US698201

申请日：1996-08-14

申请人： Akira Kaneda ,  Yoshiteru Ii ,  Shinichi Nakahara ,  Jiro Minehisa

发明人： Akira Kaneda ,  Yoshiteru Ii ,  Shinichi Nakahara ,  Jiro Minehisa

IPC分类号： A61B18/20 ,  A61B17/00 ,  A61B18/22 ,  A61B19/00 ,  A61N5/06 ,  A61N5/00

CPC分类号： A61N5/062 ,  A61N5/0601 ,  A61B2017/00336 ,  A61B2018/2261 ,  A61B2018/2272 ,  A61B2090/0454

摘要： A medical laser probe to be used as a laser irradiation unit in laser treatment that is performed by irradiating a living body with laser light. The laser probe irradiates laser light uniformly, utilizing laser light effectively by concentration thereof, achieving limited irradiation of laser light and taking countermeasures against stains forming on the probe. The laser probe is provided with (1) a transparent light diffuser for radiating laser light received by a light-guide fiber in the direction along the longitudinal axis of the light diffuser and in radial directions from this axis to the peripheral side surface thereof and (2) a detachable protective diffusion tube for further diffusing laser light radiated from the transparent light diffuser. A reflector may be provided between the light diffuser and the diffusion tube. Further, shielding plates may be provided on the protective diffusion tube.

摘要翻译： 一种医用激光探针，用于激光治疗中的激光照射单元，其通过用激光照射生物体而进行。 激光探头通过浓度有效地激发激光，均匀地照射激光，实现有限的激光照射，并且对抗探针上的污渍形成对策。 激光探针设置有（1）透明光扩散器，用于沿着光扩散器的纵向轴线的方向和从该轴向其周边侧表面的径向辐射由光导纤维接收的激光，并且 2）可拆卸保护扩散管，用于进一步扩散从透明光扩散器辐射的激光。 可以在光扩散器和扩散管之间设置反射器。 此外，可以在保护扩散管上设置屏蔽板。

公开(公告)号：US4596659A

公开(公告)日：1986-06-24

申请号：US570322

申请日：1984-01-13

申请人： Junji Nomura ,  Yuzuru Ishibashi ,  Akira Kaneda

发明人： Junji Nomura ,  Yuzuru Ishibashi ,  Akira Kaneda

IPC分类号： B01J20/06 ,  B01J20/28 ,  C02F1/28

CPC分类号： B01J20/28019 ,  B01J20/06 ,  B01J20/28004 ,  B01J20/2803 ,  C02F1/281

摘要： Borate ions dissolved at low concentration in water are separated efficiently with the use of a hydroxide or hydrous oxide of a rare earth element as the adsorbent. By contacting a borate ion-containing water with the adsorbent, borate ions are separated by adsorption, and the adsorbent having adsorbed borate ions is desorbed and regenerated for reuse with a desorbing solution adjusted to pH about 2 to about 4 or pH about 12 to about 14.

摘要翻译： 使用稀土元素的氢氧化物或含水氧化物作为吸附剂有效地分离在水中以低浓度溶解的硼酸根离子。 通过使含硼酸根离子的水与吸附剂接触，通过吸附分离硼酸根离子，并且吸附有硼酸根离子的吸附剂被解吸并再生以用于约2至约4或约12至约pH约12至约4的解吸溶液再利用 14。

公开(公告)号：US4666883A

公开(公告)日：1987-05-19

申请号：US808581

申请日：1985-12-13

申请人： Junji Nomura ,  Yuzuru Ishibashi ,  Akira Kaneda

发明人： Junji Nomura ,  Yuzuru Ishibashi ,  Akira Kaneda

IPC分类号： B01J20/06 ,  B01J20/28 ,  C02F1/28

CPC分类号： B01J20/28019 ,  B01J20/06 ,  B01J20/28004 ,  B01J20/2803 ,  C02F1/281

摘要： Borate ions dissolved at low concentration in water are separated efficiently with the use of a hydroxide or hydrous oxide of a rare earth element as the adsorbent. By contacting a borate ion-containing water with the absorbent, borate ions are separated by adsorption, and the adsorbent having adsorbed borate ions is desorbed and the regenerated for reuse with a desorbing solution adjusted to pH about 2 to about 4 or pH about 12 to about 14.

摘要翻译： 使用稀土元素的氢氧化物或含水氧化物作为吸附剂有效地分离在水中以低浓度溶解的硼酸根离子。 通过使含硼酸根离子的水与吸收剂接触，通过吸附分离硼酸根离子，并且吸附有硼酸根离子的吸附剂被解吸，并且再生再利用，其解吸溶液被调节至pH约2至约4或pH约12至 约14。