公开(公告)号：US06383175B1

公开(公告)日：2002-05-07

申请号：US09406734

申请日：1999-09-28

申请人： Yoshiteru Ii ,  Akira Kaneda ,  Takayoshi Yuzu ,  Toshiyoshi Yamamoto ,  Harubumi Kato ,  Katsuo Aizawa

发明人： Yoshiteru Ii ,  Akira Kaneda ,  Takayoshi Yuzu ,  Toshiyoshi Yamamoto ,  Harubumi Kato ,  Katsuo Aizawa

IPC分类号： A61B1822

CPC分类号： A61N5/062 ,  A61N2005/0644 ,  A61N2005/067

摘要： In photodynamic diagnosis and photodynamic therapy, the oscillating wavelength of laser light from a light source is fitted to a plurality of different kinds of photosensitizers and exciting conditions thereof. Moreover, diagnosis and treatment are achieved using a single light source. Concurrent diagnosis during treatment is realized as well. A semiconductor laser generates laser light having an oscillating wavelength which is variable and a full width at half maximum which is narrow. A light transmission line guides an irradiated laser light the vicinity of a focus, an image transmission line observes the focus and the periphery thereof, a fluorescence light extracting device extracts only the fluorescence light emitted from a photosensitizer excited by the irradiated laser light, an image-pick-up/analyzing device picks up and analyzes an image of the extracted fluorescence light and an image display device displays the analyzing result.

摘要翻译： 在光动力学诊断和光动力学治疗中，来自光源的激光的振荡波长适合于多种不同种类的光敏剂和激发条件。 此外，使用单个光源实现诊断和治疗。 治疗期间同时诊断也得到实现。 半导体激光器产生具有可变的振荡波长的激光，半波长的半峰全宽。 光传输线引导照射的激光附近的焦点，图像传输线观察其焦点和周围，荧光提取装置仅提取由照射的激光激发的光敏剂发射的荧光，图像 提取/分析装置拾取并分析所提取的荧光的图像，并且图像显示装置显示分析结果。

公开(公告)号：US07016718B2

公开(公告)日：2006-03-21

申请号：US10097259

申请日：2002-03-15

申请人： Yoshiteru Ii ,  Akira Kaneda ,  Takayoshi Yuzu ,  Toshiyoshi Yamamoto ,  Harubumi Kato ,  Katsuo Aizawa

发明人： Yoshiteru Ii ,  Akira Kaneda ,  Takayoshi Yuzu ,  Toshiyoshi Yamamoto ,  Harubumi Kato ,  Katsuo Aizawa

IPC分类号： A61F9/008

CPC分类号： A61N5/062 ,  A61N2005/0644 ,  A61N2005/067

摘要： In photodynamic diagnosis and photodynamic therapy, the oscillating wavelength of laser light from a light source is fitted to a plurality of different kinds of photosensitizers and exciting conditions thereof. Moreover, diagnosis and treatment are achieved using concurrent diagnosis during treatment is realized as well. A semiconductor laser generates laser light having an oscillating wavelength which is variable and a full width at half maximum which is narrow. A light transmission line guides an irradiated laser light to the vicinity of a focus, an image transmission line observes the focus and the periphery thereof, a fluorescence light extracting device extracts only the fluorescence light emitted from a photosensitizer excited by the irradiated laser light, an image-pick-up/analyzing device picks up and analyzes an image of the extracted fluorescence light and an image display device displays the analyzing result.

公开(公告)号：US06214033B1

公开(公告)日：2001-04-10

申请号：US08545101

申请日：1995-10-19

申请人： Yoshiteru Ii ,  Akira Kaneda ,  Takayoshi Yuzu ,  Toshiyoshi Yamamoto ,  Harubumi Kato ,  Katsuo Aizawa

发明人： Yoshiteru Ii ,  Akira Kaneda ,  Takayoshi Yuzu ,  Toshiyoshi Yamamoto ,  Harubumi Kato ,  Katsuo Aizawa

IPC分类号： A61N506

CPC分类号： A61N5/062 ,  A61N2005/0644 ,  A61N2005/067

摘要： In photodynamic diagnosis and photodynamic therapy, the oscillating wavelength of laser light from a light source is fitted to a plurality of different kinds of photosensitizers and exciting conditions thereof. Moreover, diagnosis and treatment are achieved using a single light source. Concurrent diagnosis during treatment is realized as well. A semiconductor laser generates laser light having an oscillating wavelength which is variable and a full width at half maximum which is narrow. A light transmission line guides an irradiated laser light to the vicinity of a focus, an image transmission line observes the focus and the periphery thereof, a fluorescence light extracting device extracts only the fluorescence light emitted from a photosensitizer excited by the irradiated laser light, an image-pick-up/analyzing device picks up and analyzes an image of the extracted fluorescence light and an image display device displays the analyzing result.

摘要翻译： 在光动力学诊断和光动力学治疗中，来自光源的激光的振荡波长适合于多种不同种类的光敏剂和激发条件。 此外，使用单个光源实现诊断和治疗。 治疗期间同时诊断也得到实现。 半导体激光器产生具有可变的振荡波长的激光，半波长的半峰全宽。 光传输线将照射的激光引导到焦点附近，图像传输线观察其焦点和周围，荧光提取装置仅提取由照射的激光激发的光敏剂发射的荧光， 图像拾取/分析装置拾取并分析提取的荧光的图像，并且图像显示装置显示分析结果。

公开(公告)号：US5871521A

公开(公告)日：1999-02-16

申请号：US698201

申请日：1996-08-14

申请人： Akira Kaneda ,  Yoshiteru Ii ,  Shinichi Nakahara ,  Jiro Minehisa

发明人： Akira Kaneda ,  Yoshiteru Ii ,  Shinichi Nakahara ,  Jiro Minehisa

IPC分类号： A61B18/20 ,  A61B17/00 ,  A61B18/22 ,  A61B19/00 ,  A61N5/06 ,  A61N5/00

CPC分类号： A61N5/062 ,  A61N5/0601 ,  A61B2017/00336 ,  A61B2018/2261 ,  A61B2018/2272 ,  A61B2090/0454

摘要： A medical laser probe to be used as a laser irradiation unit in laser treatment that is performed by irradiating a living body with laser light. The laser probe irradiates laser light uniformly, utilizing laser light effectively by concentration thereof, achieving limited irradiation of laser light and taking countermeasures against stains forming on the probe. The laser probe is provided with (1) a transparent light diffuser for radiating laser light received by a light-guide fiber in the direction along the longitudinal axis of the light diffuser and in radial directions from this axis to the peripheral side surface thereof and (2) a detachable protective diffusion tube for further diffusing laser light radiated from the transparent light diffuser. A reflector may be provided between the light diffuser and the diffusion tube. Further, shielding plates may be provided on the protective diffusion tube.

摘要翻译： 一种医用激光探针，用于激光治疗中的激光照射单元，其通过用激光照射生物体而进行。 激光探头通过浓度有效地激发激光，均匀地照射激光，实现有限的激光照射，并且对抗探针上的污渍形成对策。 激光探针设置有（1）透明光扩散器，用于沿着光扩散器的纵向轴线的方向和从该轴向其周边侧表面的径向辐射由光导纤维接收的激光，并且 2）可拆卸保护扩散管，用于进一步扩散从透明光扩散器辐射的激光。 可以在光扩散器和扩散管之间设置反射器。 此外，可以在保护扩散管上设置屏蔽板。

公开(公告)号：US20120316623A1

公开(公告)日：2012-12-13

申请号：US13578012

申请日：2011-01-28

申请人： Yoshiteru Ii ,  Takuo Shimada ,  Jiro Minehisa ,  Yuki Kawase

发明人： Yoshiteru Ii ,  Takuo Shimada ,  Jiro Minehisa ,  Yuki Kawase

IPC分类号： A61N5/06

CPC分类号： A61N5/0613 ,  A61N2005/063 ,  A61N2005/0643 ,  A61N2005/0659 ,  A61N2005/0666

摘要： Disclosed is a phototherapy device which can irradiate an affected part, which is to be irradiated with light, with light selectively and intensively and can prevent eyes to undergo the direct irradiation with intense light emitted from a light source. Specifically disclosed is a phototherapy device comprising: a light guide member which has a contact surface that contacts with an affected part and an opposed surface that faces the contact surface and which serves as a light guide path; and a first light source which can emit light having the main wavelength that depends on the wavelength range of infrared ray to the light guide path. In the phototherapy device, a material constituting the light guide member has a refractive index identical to or higher than the refractive index of a biological tissue.

摘要翻译： 公开了一种能够选择性地，集中地照射被照射光的受影响部位的光疗装置，能够防止眼睛从光源发出的强光直接照射。 具体公开了一种光疗装置，其特征在于，包括：导光部件，其具有与受影响部位接触的接触面和与所述接触面对置且用作导光路径的相对面; 以及第一光源，其可以发射具有取决于红外线的波长范围的主波长的光到光导路径。 在光疗装置中，构成导光体的材料具有与生物体组织的折射率相同或更高的折射率。