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    4-(Methyl sulfonyl amino) phenyl analogues as vanilloid antagonist showing excellent analgesic activity and the pharmaceutical compositions comprising the same
    3.
    发明申请
    4-(Methyl sulfonyl amino) phenyl analogues as vanilloid antagonist showing excellent analgesic activity and the pharmaceutical compositions comprising the same 失效
    4-（甲基磺酰基氨基）苯基类似物作为显示出极好的止痛活性的香草酸拮抗剂，以及含有它们的药物组合物

    公开(公告)号：US20060258884A1

    公开(公告)日：2006-11-16

    申请号：US10562698

    申请日：2004-07-02

    申请人： Jee Lee ,  Hee Kim ,  Hyun Choi ,  Hee Ha

    发明人： Jee Lee ,  Hee Kim ,  Hyun Choi ,  Hee Ha

    IPC分类号： C07C311/45

    CPC分类号： C07C311/08 ,  C07C335/12 ,  C07C335/14 ,  C07C2601/02 ,  C07C2602/10 ,  C07C2603/32 ,  C07D295/155

    摘要： 4-(methylsulfonylamino)phenyl analogues as potent vanilloid receptor antagonists and pharmaceutical compositions comprising the same. The compounds are useful as analgesics to prevent, alleviate or treat pain diseases or inflammatory disease including pain, acute pain, chronic pain, neuropathic pain, post-operative pain, migraine, arthralgia, neuropathies, nerve injury, diabetic neuropathy, neurodegeneration, neurotic skin disorder, stroke, urinary bladder hypersensitiveness, irritable bowel syndrome, a respiratory disorder such as asthma or chronic obstructive pulmonary disease, irritation of skin, eye or mucous membrane, fervescence, stomach-duodenal ulcer, inflammatory bowel disease, inflammatory disease and urgent urinary incontinence.

    摘要翻译： 4-（甲基磺酰基氨基）苯基类似物作为有效的香草酸受体拮抗剂和包含其的药物组合物。 这些化合物可用作止痛剂，以预防，减轻或治疗疼痛疾病或炎性疾病，包括疼痛，急性疼痛，慢性疼痛，神经性疼痛，手术后疼痛，偏头痛，关节痛，神经病，神经损伤，糖尿病性神经病变，神经变性，神经性皮肤 疾病，中风，膀胱过敏症，肠易激综合征，呼吸系统疾病如哮喘或慢性阻塞性肺疾病，皮肤，眼睛或粘膜的刺激​​，发炎，胃十二指肠溃疡，炎性肠病，炎性疾病和紧急尿失禁 。