公开(公告)号：US20110064886A1

公开(公告)日：2011-03-17

申请号：US12656855

申请日：2010-02-18

申请人： Yu-Chia Tsao ,  Min-Tzu Chao ,  Woo-Hu Tsai ,  Shu-Ting Chang ,  Hsiao-Ling Yeh

发明人： Yu-Chia Tsao ,  Min-Tzu Chao ,  Woo-Hu Tsai ,  Shu-Ting Chang ,  Hsiao-Ling Yeh

IPC分类号： B05D3/04

CPC分类号： G01N21/7703 ,  G01N21/553

摘要： A method for improving an optical sensor is disclosed, which includes the following steps: providing an optical sensor; acid-treating the surface of the optical sensor; forming a thin metal film on the acid-treated surface of the optical sensor; and plasma-modifying the thin metal film on the optical sensor. The aforesaid method is to clean the surface of the optical sensor and then to improve the hydrophilicity thereof by acid treatment. The thin metal film subsequently formed has good flatness and improved adhesion to the optical sensor. Once the optical sensor has the improved hydrophilicity, the plasma modification is performed to further improve optical performance of the optical sensor.

摘要翻译： 公开了一种改进光学传感器的方法，包括以下步骤：提供光学传感器; 对光学传感器的表面进行酸处理; 在光学传感器的酸处理表面上形成薄金属膜; 并对光学传感器上的薄金属膜进行等离子体修饰。 上述方法是清洁光学传感器的表面，然后通过酸处理改善其亲水性。 随后形成的薄金属膜具有良好的平整度和对光学传感器的改善的粘合性。 一旦光学传感器具有改善的亲水性，则进行等离子体修饰以进一步改善光学传感器的光学性能。

公开(公告)号：US20110171070A1

公开(公告)日：2011-07-14

申请号：US13069798

申请日：2011-03-23

申请人： Shu-Ting CHANG ,  Hsiao-Ling Yeh ,  Yu-Chia Tsao ,  Jung-Chien Chang ,  Jia-Huey Tsao ,  Ko-Shao Chen

发明人： Shu-Ting CHANG ,  Hsiao-Ling Yeh ,  Yu-Chia Tsao ,  Jung-Chien Chang ,  Jia-Huey Tsao ,  Ko-Shao Chen

IPC分类号： G01N33/48 ,  H05H1/24 ,  C08F2/48

CPC分类号： G01N33/54353 ,  C08F292/00 ,  C40B40/04 ,  C40B50/18 ,  G01N33/54386 ,  G01N33/54393 ,  C08F220/06

摘要： A method for surface-modifying a sensor device is disclosed, which includes the following steps: providing a sensor device, wherein a surface of the sensor device has a metal film; forming a surface-modification layer having a plurality of carboxyl groups on the metal film of the sensor device by isopropyl alcohol plasma; and forming a poly(acrylic acid) layer on the surface-modification layer, wherein the acrylic acid of the poly(acrylic acid) layer is grafted to the carboxyl of the surface-modification layer. A surface-modified sensor device is also disclosed.

摘要翻译： 公开了一种用于表面修饰传感器装置的方法，其包括以下步骤：提供传感器装置，其中传感器装置的表面具有金属膜; 通过异丙醇等离子体在传感器装置的金属膜上形成具有多个羧基的表面改性层; 并在表面改性层上形成聚（丙烯酸）层，其中聚（丙烯酸）层的丙烯酸接枝到表面改性层的羧基上。 还公开了表面改性的传感器装置。

公开(公告)号：US20110157590A1

公开(公告)日：2011-06-30

申请号：US12662545

申请日：2010-04-22

申请人： Chung-Pei Lee ,  Yu-Chia Tsao ,  Woo-Hu Tsai ,  Hsiang-Chih Hsu

发明人： Chung-Pei Lee ,  Yu-Chia Tsao ,  Woo-Hu Tsai ,  Hsiang-Chih Hsu

IPC分类号： G01N21/55

CPC分类号： G01N21/553 ,  G01N2201/0221

摘要： A surface plasmon resonance sensing device that is portable, and having the fiber sensing unit whose resonant wavelength being within the transmission range of a single-mode fiber or a multi-mode fiber, is disclosed. The disclosed sensing device comprises: a light source unit, a fiber sensing unit, an optical sensor, a plurality of fibers, and a computing and displaying unit. The fiber sensing unit includes a trench, a cladding layer, a core layer, a first metallic layer, and a plurality of dielectric thin film layers, wherein the first metallic layer covers the trench, and the plurality of dielectric thin film layers forms on the first metallic layer. The light source provided by the light source unit will become a light signal, after the light passes through the fiber sensing unit. The optical sensor transforms the light signal into a corresponding electric signal, for the usage of the computing and displaying unit.

摘要翻译： 公开了一种便携式的表面等离子体共振感测装置，其具有谐振波长在单模光纤或多模光纤的传输范围内的光纤传感单元。 所公开的感测装置包括：光源单元，光纤感测单元，光学传感器，多个光纤以及计算和显示单元。 光纤感测单元包括沟槽，包覆层，芯层，第一金属层和多个电介质薄膜层，其中第一金属层覆盖沟槽，并且多个电介质薄膜层形成在 第一金属层。 在光通过光纤感测单元之后，由光源单元提供的光源将成为光信号。 光学传感器将光信号转换成相应的电信号，以用于计算和显示单元的使用。

公开(公告)号：US20070153283A1

公开(公告)日：2007-07-05

申请号：US11484643

申请日：2006-07-12

申请人： Yu-Chia Tsao ,  Woo-Hu Tsai ,  Hong-Yu Lin ,  Jung-Chien Chang

发明人： Yu-Chia Tsao ,  Woo-Hu Tsai ,  Hong-Yu Lin ,  Jung-Chien Chang

IPC分类号： G01N21/55

CPC分类号： G01N21/553 ,  G01N21/7703 ,  G01N2021/7783

摘要： The present invention relates to a surface plasmon resonance detector, that is portable and easy to operate, and its optical-fiber biosensor unit can be readily replaced. The SPR detector of the present invention comprises: a light source; an optical-fiber biosensor unit having a well, a coating layer, and a core layer; an optical detector; a plurality of optical fibers connecting with the light source, the optical-fiber biosensor unit and the optical detector; and a calculation and display unit connecting with the optical detector, wherein the optical detector receives the optical signals from the optical detector and display the calculation results thereof. Besides, the SPR detector of the present invention has high sensitivity and is able to identify species of trace biomolecules.

摘要翻译： 本发明涉及便携式且易于操作的表面等离子体共振检测器，并且其光纤生物传感器单元可以容易地更换。 本发明的SPR检测器包括：光源; 具有阱，涂层和芯层的光纤生物传感器单元; 光学检测器; 与光源连接的多个光纤，光纤生物传感器单元和光检测器; 以及与光学检测器连接的计算和显示单元，其中光学检测器接收来自光学检测器的光信号并显示其计算结果。 此外，本发明的SPR检测器具有高灵敏度，并且能够识别微量生物分子的种类。

公开(公告)号：US08149413B2

公开(公告)日：2012-04-03

申请号：US12662545

申请日：2010-04-22

申请人： Chung-Pei Lee ,  Yu-Chia Tsao ,  Woo-Hu Tsai ,  Hsiang-Chih Hsu

发明人： Chung-Pei Lee ,  Yu-Chia Tsao ,  Woo-Hu Tsai ,  Hsiang-Chih Hsu

IPC分类号： G01N21/55

CPC分类号： G01N21/553 ,  G01N2201/0221

摘要： A surface plasmon resonance sensing device that is portable, and having the fiber sensing unit whose resonant wavelength being within the transmission range of a single-mode fiber or a multi-mode fiber, is disclosed. The disclosed sensing device comprises: a light source unit, a fiber sensing unit, an optical sensor, a plurality of fibers, and a computing and displaying unit. The fiber sensing unit includes a trench, a cladding layer, a core layer, a first metallic layer, and a plurality of dielectric thin film layers, wherein the first metallic layer covers the trench, and the plurality of dielectric thin film layers forms on the first metallic layer. The light source provided by the light source unit will become a light signal, after the light passes through the fiber sensing unit. The optical sensor transforms the light signal into a corresponding electric signal, for the usage of the computing and displaying unit.

摘要翻译： 公开了一种便携式的表面等离子体共振感测装置，其具有谐振波长在单模光纤或多模光纤的传输范围内的光纤传感单元。 所公开的感测装置包括：光源单元，光纤感测单元，光学传感器，多个光纤以及计算和显示单元。 光纤感测单元包括沟槽，包覆层，芯层，第一金属层和多个电介质薄膜层，其中第一金属层覆盖沟槽，并且多个电介质薄膜层形成在 第一金属层。 在光通过光纤感测单元之后，由光源单元提供的光源将成为光信号。 光学传感器将光信号转换成相应的电信号，以用于计算和显示单元的使用。

公开(公告)号：US20110065194A1

公开(公告)日：2011-03-17

申请号：US12662567

申请日：2010-04-23

申请人： Ren-Kun Liang ,  Yu-Chia Tsao ,  Woo-Hu Tsai

发明人： Ren-Kun Liang ,  Yu-Chia Tsao ,  Woo-Hu Tsai

IPC分类号： G01N21/00

CPC分类号： G01N21/553 ,  G01N21/8483 ,  G01N2201/08 ,  Y10T436/143333

摘要： A microfluidic detection device is disclosed, which includes a porous membrane, a wicking pad, and an optical sensor. The porous membrane has a first end and an opposite second end, and the first end has a sample-loading area for receiving sample molecules. The wicking pad is connected with the second end of the porous membrane to move the sample molecules from the sample-loading area of the porous membrane to the second end thereof. The optical sensor has a detection zone which faces the porous membrane for sensing the sample molecules. Also, a method for detecting molecules is disclosed, which uses the aforesaid device. The method and the device can achieve the purpose of real-time detection and fast-screening for molecules.

摘要翻译： 公开了一种微流体检测装置，其包括多孔膜，芯吸垫和光学传感器。 多孔膜具有第一端和相对的第二端，并且第一端具有用于接收样品分子的样品加载区域。 芯吸垫与多孔膜的第二端连接，以将样品分子从多孔膜的样品加载区移动到其第二端。 光学传感器具有面向多孔膜的检测区域，用于感测样品分子。 另外，公开了一种使用上述装置的分子检测方法。 该方法和装置可以实现分子的实时检测和快速筛选的目的。

公开(公告)号：US08377503B2

公开(公告)日：2013-02-19

申请号：US12662546

申请日：2010-04-22

申请人： Yu-Chia Tsao ,  Chung-Pei Lee ,  Ko-Shao Chen ,  Jia-Huey Tsao ,  Chun-Chih Lin ,  Ren-Kun Liang

发明人： Yu-Chia Tsao ,  Chung-Pei Lee ,  Ko-Shao Chen ,  Jia-Huey Tsao ,  Chun-Chih Lin ,  Ren-Kun Liang

IPC分类号： C23C14/54

CPC分类号： C23C16/44 ,  G01N21/553

摘要： A method for real-timely monitoring thickness change of a coating film is disclosed. In the method, a coating module having a chamber and a film thickness-monitoring module containing an SPR optical fiber sensor, a light source, a light-receiving detector, and optical fibers are first provided. The optical fibers are used to connect the SPR optical fiber sensor with the light source and the light-receiving detector. The SPR optical fiber sensor has a sensing area and is arranged in the chamber. The light source provides the SPR optical fiber sensor with light. Then, a substrate is put into the chamber. While coating process is performed on the substrate, a film is also formed on the sensing area of the SPR optical fiber sensor. The light-receiving detector receives signals output from the sensing area of the SPR optical fiber sensor and then outputs signals of light-intensity change.

摘要翻译： 公开了一种用于实时监测涂膜厚度变化的方法。 在该方法中，首先提供具有室的涂布模块和包含SPR光纤传感器，光源，光接收检测器和光纤的膜厚监测模块。 光纤用于将SPR光纤传感器与光源和光接收检测器连接。 SPR光纤传感器具有感测区域，并且布置在腔室中。 光源为SPR光纤传感器提供光源。 然后，将基板放入室中。 虽然在基板上进行涂布处理，但是也在SPR光纤传感器的感测区域上形成膜。 光接收检测器接收从SPR光纤传感器的感测区域输出的信号，然后输出光强变化的信号。

公开(公告)号：US20110306918A1

公开(公告)日：2011-12-15

申请号：US12805739

申请日：2010-08-18

申请人： Yu-Chia Tsao ,  Yi-Wen Yang ,  Jung-Chien Chang

发明人： Yu-Chia Tsao ,  Yi-Wen Yang ,  Jung-Chien Chang

IPC分类号： A61N5/06 ,  A61M35/00

CPC分类号： A61K9/0097 ,  A61K9/7084 ,  A61N5/0616 ,  A61N2005/0645 ,  A61N2005/0656 ,  A61N2005/0659 ,  A61N2005/0662

摘要： A phototherapy patch is disclosed, which includes: an adhesive layer, having a first surface and an opposite second surface; a pharmaceutical drug layer, disposed on the first surface of the adhesive layer; and a spontaneous emission layer, disposed over the pharmaceutical drug layer and capable of emitting therapeutic light by light illumination or a chemical reaction. Accordingly, the phototherapy patch according to the present invention has no power supply disposed therein, and thereby is suitable to be manufactured as a particularly thin and thus inconspicuous device.

摘要翻译： 公开了一种光疗贴片，其包括：具有第一表面和相对的第二表面的粘合剂层; 药物层，设置在粘合剂层的第一表面上; 以及设置在药物药物层上并能够通过光照射或化学反应发射治疗光的自发发射层。 因此，根据本发明的光疗贴片没有设置在其中的电源，因此适合制造为特别薄且因此不显眼的装置。

公开(公告)号：US20110151107A1

公开(公告)日：2011-06-23

申请号：US12662546

申请日：2010-04-22

申请人： Yu-Chia Tsao ,  Chung-Pei Lee ,  Ko-Shao Chen ,  Jia-Huey Tsao ,  Chun-Chih Lin ,  Ren-Kun Liang

发明人： Yu-Chia Tsao ,  Chung-Pei Lee ,  Ko-Shao Chen ,  Jia-Huey Tsao ,  Chun-Chih Lin ,  Ren-Kun Liang

IPC分类号： C23C16/44 ,  C23C16/00

CPC分类号： C23C16/44 ,  G01N21/553

摘要： A method for real-timely monitoring thickness change of a coating film is disclosed. In the method, a coating module having a chamber and a film thickness-monitoring module containing an SPR optical fiber sensor, a light source, a light-receiving detector, and optical fibers are first provided. The optical fibers are used to connect the SPR optical fiber sensor with the light source and the light-receiving detector. The SPR optical fiber sensor has a sensing area and is arranged in the chamber. The light source provides the SPR optical fiber sensor with light. Then, a substrate is put into the chamber. While coating process is performed on the substrate, a film is also formed on the sensing area of the SPR optical fiber sensor. The light-receiving detector receives signals output from the sensing area of the SPR optical fiber sensor and then outputs signals of light-intensity change.

摘要翻译： 公开了一种用于实时监测涂膜厚度变化的方法。 在该方法中，首先提供具有室的涂布模块和包含SPR光纤传感器，光源，光接收检测器和光纤的膜厚监视模块。 光纤用于将SPR光纤传感器与光源和光接收检测器连接。 SPR光纤传感器具有感测区域，并且布置在腔室中。 光源为SPR光纤传感器提供光源。 然后，将基板放入室中。 虽然在基板上进行涂布处理，但是也在SPR光纤传感器的感测区域上形成膜。 光接收检测器接收从SPR光纤传感器的感测区域输出的信号，然后输出光强变化的信号。

公开(公告)号：US20130190843A1

公开(公告)日：2013-07-25

申请号：US13470559

申请日：2012-05-14

申请人： Ming-Chieh TU ,  Yi-Wei Hsiao ,  Chung-Pei Lee ,  Jung-Chien Chang ,  Yu-Chia Tsao

发明人： Ming-Chieh TU ,  Yi-Wei Hsiao ,  Chung-Pei Lee ,  Jung-Chien Chang ,  Yu-Chia Tsao

IPC分类号： A61N5/06

CPC分类号： A61N5/0616 ,  A61N5/0624 ,  A61N2005/0652 ,  A61N2005/0663

摘要： Disclosed is a photo-stimulation method and device. The method includes the following steps: providing a light-emitting diode (LED) illuminant which is a yellow, red, or blue LED; and illuminating a subject by the LED illuminant to promote collagen synthesis, to suppress microbial growth, or to inhibit melanin synthesis, wherein the yellow LED is in an illuminance range from 1,000 to 3,500 lux, the red LED is in an illuminance range from 6,000 to 9,500 lux, and the blue LED is in an illuminance range from 3,000 to 7,000 lux.

摘要翻译： 公开了一种光刺激方法和装置。 该方法包括以下步骤：提供黄色，红色或蓝色LED的发光二极管（LED）光源; 并且通过LED照明器照射对象以促进胶原合成，抑制微生物生长或抑制黑色素合成，其中黄色LED的照度范围为1,000至3,500勒克司，红色LED的照度范围为6,000至 9,500勒克斯，蓝色LED的照度范围为3,000至7,000勒克斯。