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公开(公告)号：US07838498B2
公开(公告)日：2010-11-23
申请号：US12060767
申请日：2008-04-01
申请人： Yuanwei Chen , Yan Feng , Baihua Xu , Binhua Lv , Brian Seed , Michael J. Hadd , Huawei Cheng , Zelin Sheng , Min Xu , Congna Wang , Jiyan Du , Lili Zhang , Ge Xu , Yuelin Wu
发明人： Yuanwei Chen , Yan Feng , Baihua Xu , Binhua Lv , Brian Seed , Michael J. Hadd , Huawei Cheng , Zelin Sheng , Min Xu , Congna Wang , Jiyan Du , Lili Zhang , Ge Xu , Yuelin Wu
CPC分类号： C07H7/04 , A61K38/00 , C07D309/10
摘要： Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT inhibition.
摘要翻译： 提供对钠依赖性葡萄糖转运蛋白SGLT具有抑制作用的化合物。 本发明还提供药物组合物，制备化合物的方法，合成中间体，以及独立地或与其它治疗剂组合使用化合物治疗受SGLT抑制影响的疾病和病症的方法。
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公开(公告)号：US20080242596A1
公开(公告)日：2008-10-02
申请号：US12060767
申请日：2008-04-01
申请人： Yuanwei Chen , Yan Feng , Baihua Xu , Binhua Lv , Brian Seed , Michael J. Hadd , Huawei Cheng , Zelin Sheng , Min Xu , Congna Wang , Jiyan Du , Lili Zhang , Ge Xu , Yuelin Wu
发明人： Yuanwei Chen , Yan Feng , Baihua Xu , Binhua Lv , Brian Seed , Michael J. Hadd , Huawei Cheng , Zelin Sheng , Min Xu , Congna Wang , Jiyan Du , Lili Zhang , Ge Xu , Yuelin Wu
IPC分类号： A61K38/28 , C07H7/04 , A61P3/10 , A61K31/7034
CPC分类号： C07H7/04 , A61K38/00 , C07D309/10
摘要： Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT inhibition.
摘要翻译： 提供对钠依赖性葡萄糖转运蛋白SGLT具有抑制作用的化合物。 本发明还提供药物组合物，制备化合物的方法，合成中间体，以及独立地或与其它治疗剂组合使用化合物治疗受SGLT抑制影响的疾病和病症的方法。
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公开(公告)号：US08106021B2
公开(公告)日：2012-01-31
申请号：US12917367
申请日：2010-11-01
申请人： Yuanwei Chen , Huawei Cheng , Shengbin Li , Yuelin Wu , Yan Feng , Binhua Lv , Baihua Xu , Brian Seed , Michael J. Hadd , Yanli Song , Jiyan Du , Congna Wang , Jacques Y. Roberge
发明人： Yuanwei Chen , Huawei Cheng , Shengbin Li , Yuelin Wu , Yan Feng , Binhua Lv , Baihua Xu , Brian Seed , Michael J. Hadd , Yanli Song , Jiyan Du , Congna Wang , Jacques Y. Roberge
CPC分类号： C07H7/04 , C07D309/10 , C07D407/12
摘要： Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT inhibition.
摘要翻译： 提供对钠依赖性葡萄糖转运蛋白SGLT具有抑制作用的化合物。 本发明还提供药物组合物，制备化合物的方法，合成中间体，以及独立地或与其它治疗剂组合使用化合物治疗受SGLT抑制影响的疾病和病症的方法。
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公开(公告)号：US07838499B2
公开(公告)日：2010-11-23
申请号：US12197095
申请日：2008-08-22
申请人： Yuanwei Chen , Huawei Cheng , Shengbin Li , Yuelin Wu , Yan Feng , Binhua Lv , Baihua Xu , Brian Seed , Michael J. Hadd , Yanli Song , Jiyan Du , Congna Wang , Jacques Y. Roberge
发明人： Yuanwei Chen , Huawei Cheng , Shengbin Li , Yuelin Wu , Yan Feng , Binhua Lv , Baihua Xu , Brian Seed , Michael J. Hadd , Yanli Song , Jiyan Du , Congna Wang , Jacques Y. Roberge
CPC分类号： C07H7/04 , C07D309/10 , C07D407/12
摘要： Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT inhibition.
摘要翻译： 提供对钠依赖性葡萄糖转运蛋白SGLT具有抑制作用的化合物。 本发明还提供药物组合物，制备化合物的方法，合成中间体，以及独立地或与其它治疗剂组合使用化合物治疗受SGLT抑制影响的疾病和病症的方法。
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公开(公告)号：US20090118201A1
公开(公告)日：2009-05-07
申请号：US12197095
申请日：2008-08-22
申请人： Yuanwei Chen , Huawei Cheng , Shengbin Li , Yuelin Wu , Yan Feng , Binhua Lv , Baihua Xu , Brian Seed , Michael J. Hadd , Yanli Song , Jiyan Du , Congna Wang , Jacques Y. Roberge
发明人： Yuanwei Chen , Huawei Cheng , Shengbin Li , Yuelin Wu , Yan Feng , Binhua Lv , Baihua Xu , Brian Seed , Michael J. Hadd , Yanli Song , Jiyan Du , Congna Wang , Jacques Y. Roberge
IPC分类号： A61K31/7028 , C07H7/04 , C07H7/06 , A61P3/10
CPC分类号： C07H7/04 , C07D309/10 , C07D407/12
摘要： Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT inhibition.
摘要翻译： 提供对钠依赖性葡萄糖转运蛋白SGLT具有抑制作用的化合物。 本发明还提供药物组合物，制备化合物的方法，合成中间体，以及独立地或与其它治疗剂组合使用化合物治疗受SGLT抑制影响的疾病和病症的方法。
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公开(公告)号：US20120329732A1
公开(公告)日：2012-12-27
申请号：US13333295
申请日：2011-12-21
申请人： Yuanwei Chen , Huawei Cheng , Shengbin Li , Yuelin Wu , Yan Feng , Binhua Lv , Baihua Xu , Brian Seed , Michael J. Hadd , Yanli Song , Jiyan Du , Congna Wang , Jacques Y. Roberge
发明人： Yuanwei Chen , Huawei Cheng , Shengbin Li , Yuelin Wu , Yan Feng , Binhua Lv , Baihua Xu , Brian Seed , Michael J. Hadd , Yanli Song , Jiyan Du , Congna Wang , Jacques Y. Roberge
IPC分类号： A61K31/706 , C07H15/207 , A61P3/10 , C07H15/26
CPC分类号： C07H7/04 , C07D309/10 , C07D407/12
摘要： Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT inhibition.
摘要翻译： 提供对钠依赖性葡萄糖转运蛋白SGLT具有抑制作用的化合物。 本发明还提供药物组合物，制备化合物的方法，合成中间体，以及独立地或与其它治疗剂组合使用化合物治疗受SGLT抑制影响的疾病和病症的方法。
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公开(公告)号：US20110207661A1
公开(公告)日：2011-08-25
申请号：US12917367
申请日：2010-11-01
申请人： Yuanwei Chen , Huawei Cheng , Shengbin Li , Yuelin Wu , Yan Feng , Binhua Lv , Baihua Xu , Brian Seed , Michael J. Hadd , Yanli Song , Jiyan Du , Congna Wang , Jacques Y. Roberge
发明人： Yuanwei Chen , Huawei Cheng , Shengbin Li , Yuelin Wu , Yan Feng , Binhua Lv , Baihua Xu , Brian Seed , Michael J. Hadd , Yanli Song , Jiyan Du , Congna Wang , Jacques Y. Roberge
CPC分类号： C07H7/04 , C07D309/10 , C07D407/12
摘要： Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT inhibition.
摘要翻译： 提供对钠依赖性葡萄糖转运蛋白SGLT具有抑制作用的化合物。 本发明还提供药物组合物，制备化合物的方法，合成中间体，以及独立地或与其它治疗剂组合使用化合物治疗受SGLT抑制影响的疾病和病症的方法。
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公开(公告)号：US08575321B2
公开(公告)日：2013-11-05
申请号：US13333295
申请日：2011-12-21
申请人： Yuanwei Chen , Huawei Cheng , Shengbin Li , Yuelin Wu , Yan Feng , Binhua Lv , Baihua Xu , Brian Seed , Michael Hadd , Yanli Song , Jiyan Du , Congna Wang , Jacques Roberge
发明人： Yuanwei Chen , Huawei Cheng , Shengbin Li , Yuelin Wu , Yan Feng , Binhua Lv , Baihua Xu , Brian Seed , Michael Hadd , Yanli Song , Jiyan Du , Congna Wang , Jacques Roberge
IPC分类号： C07H1/00
CPC分类号： C07H7/04 , C07D309/10 , C07D407/12
摘要： Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT inhibition.
摘要翻译： 提供对钠依赖性葡萄糖转运蛋白SGLT具有抑制作用的化合物。 本发明还提供药物组合物，制备化合物的方法，合成中间体，以及独立地或与其它治疗剂组合使用化合物治疗受SGLT抑制影响的疾病和病症的方法。
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公开(公告)号：US20100063141A1
公开(公告)日：2010-03-11
申请号：US12503384
申请日：2009-07-15
申请人： Brian Seed , Binhua LV , Jacques Y. Roberge , Yuanwei Chen , Kun Peng , Jiajia Dong , Baihua Xu , Jiyan Du , Lili Zhang , Xinxing Tang , Ge Xu , Yan Feng , Min Xu
发明人： Brian Seed , Binhua LV , Jacques Y. Roberge , Yuanwei Chen , Kun Peng , Jiajia Dong , Baihua Xu , Jiyan Du , Lili Zhang , Xinxing Tang , Ge Xu , Yan Feng , Min Xu
IPC分类号： A61K31/35 , C07D315/00 , C07C15/16
CPC分类号： A61K45/06 , A61K31/35 , C07D309/10 , A61K2300/00
摘要： Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions that are affected by SGLT inhibition.
摘要翻译： 提供对钠依赖性葡萄糖转运蛋白SGLT具有抑制作用的化合物。 本发明还提供药物组合物，制备化合物的方法，合成中间体，以及独立地或与其它治疗剂组合使用该化合物用于治疗受SGLT抑制影响的疾病和病症的方法。
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公开(公告)号：US09061060B2
公开(公告)日：2015-06-23
申请号：US12503384
申请日：2009-07-15
申请人： Brian Seed , Binhua Lv , Jacques Y. Roberge , Yuanwei Chen , Kun Peng , Jiajia Dong , Baihua Xu , Jiyan Du , Lili Zhang , Xinxing Tang , Ge Xu , Yan Feng , Min Xu
发明人： Brian Seed , Binhua Lv , Jacques Y. Roberge , Yuanwei Chen , Kun Peng , Jiajia Dong , Baihua Xu , Jiyan Du , Lili Zhang , Xinxing Tang , Ge Xu , Yan Feng , Min Xu
IPC分类号： A01N43/16 , A61K31/35 , C07D315/00 , A61K45/06 , C07D309/10
CPC分类号： A61K45/06 , A61K31/35 , C07D309/10 , A61K2300/00
摘要： Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions that are affected by SGLT inhibition.
摘要翻译： 提供对钠依赖性葡萄糖转运蛋白SGLT具有抑制作用的化合物。 本发明还提供药物组合物，制备化合物的方法，合成中间体，以及独立地或与其它治疗剂组合使用该化合物用于治疗受SGLT抑制影响的疾病和病症的方法。
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