利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

254 条记录 (耗时 0.053 秒)

    Indole derivative having piperidine ring
    1.
    发明授权
    Indole derivative having piperidine ring 失效
    具有哌啶环的吲哚衍生物

    公开(公告)号：US07538123B2

    公开(公告)日：2009-05-26

    申请号：US11579903

    申请日：2005-05-11

    申请人： Yuichi Suzuki ,  Koichi Ito ,  Atsushi Sasaki ,  Koshi Ueno ,  Miyuki Sakai ,  Hiroki Ishihara ,  Atsuhiko Kubota

    发明人： Yuichi Suzuki ,  Koichi Ito ,  Atsushi Sasaki ,  Koshi Ueno ,  Miyuki Sakai ,  Hiroki Ishihara ,  Atsuhiko Kubota

    IPC分类号： A61K31/454

    CPC分类号： C07D491/08 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14

    摘要： The present invention relates to a compound represented by the following formula, a pharmacologically acceptable salt thereof, or a use thereof as a pharmaceutical: wherein R1 and R2 are substituents adjacent to each other, and together with two carbon atoms to each of which they attach, form a 5- to 7-membered non-aromatic carbocyclic group or the like, which may be substituted by 1 to 4 substituents selected from (1) an oxo group, (2) a hydroxyl group, and the like; R3 represents a hydrogen atom or the like; and R6 represents a hydrogen atom or the like. This compound has a superior strength of binding to a 5-HT1A receptor and an antagonism to the receptor, and is useful as an agent for treating or preventing lower urinary tract symptoms, and particularly symptoms regarding urinary storage.

    摘要翻译： 本发明涉及由下式表示的化合物，其药理学可接受的盐或其作为药物的用途：其中R 1和R 2是彼此相邻的取代基，并且与它们各自连接的两个碳原子一起 形成可被1〜4个选自（1）氧代基，（2）羟基等的取代基取代的5〜7元非芳族碳环基等。 R3表示氢原子等; R6表示氢原子等。 该化合物与5-HT 1A受体的结合强度优异，对受体具有拮抗作用，可用作治疗或预防下尿路症状的药剂，特别是有关尿液储存的症状。

    N,N-substituted cyclic amine derivatives
    5.
    发明授权
    N,N-substituted cyclic amine derivatives 失效
    N，N-取代的环胺衍生物

    公开(公告)号：US06737425B1

    公开(公告)日：2004-05-18

    申请号：US09743358

    申请日：2001-01-29

    申请人： Noboru Yamamoto ,  Makoto Komatsu ,  Yuichi Suzuki ,  Koki Kawano ,  Teiji Kimura ,  Koichi Ito ,  Satoshi Nagato ,  Yoshihiko Norimine ,  Tetsuhiro Niidome ,  Tetsuyuki Teramoto ,  Yoichi Iimura ,  Shinji Hatakeyama

    发明人： Noboru Yamamoto ,  Makoto Komatsu ,  Yuichi Suzuki ,  Koki Kawano ,  Teiji Kimura ,  Koichi Ito ,  Satoshi Nagato ,  Yoshihiko Norimine ,  Tetsuhiro Niidome ,  Tetsuyuki Teramoto ,  Yoichi Iimura ,  Shinji Hatakeyama

    IPC分类号： A61K31497

    CPC分类号： C07D213/64 ,  C07D213/57 ,  C07D215/20 ,  C07D217/02 ,  C07D233/54 ,  C07D239/34 ,  C07D239/80 ,  C07D295/15 ,  C07D317/64 ,  C07D333/24 ,  C07D333/38

    摘要： The invention provides an N,N-substituted cyclic amine compound represented by the following formula (VIII): wherein A represents an aryl group etc.; E represents a group represented by the formula —CO— or a group represented by the formula —CHOH—; G represents an oxygen atom etc.; J represents an aryl group which may be substituted; R1 represents a lower alkyl group etc.; Alk represents a linear or branched lower alkylene group; n, v, w, x and y are independent of each other and each represents 0 or 1; and p represents 2 or 3, or a pharmacologically acceptable salt thereof. The compound of the present invention or a salt thereof is effective to treat a disease against which calcium antagonism is effective. The disease may include acute ischemic stroke, cerebral apoplexy, cerebral infarction, head trauma, cerebral nerve cell death, Alzheimer disease, Parkinson disease, amyotrophic lateral sclerosis, Huntington disease, cerebral circulatory metabolism disturbance, cerebral function disturbance, pain, spasm, schizophrenia, migraine, epilepsy, maniac-depressive psychosis, nerve degenerative diseases, cerebral ischemia, AIDS dementia complications, edema, anxiety disorder (generalized anxiety disorder) and diabetic neuropathy.

    摘要翻译： 本发明提供由下式（VIII）表示的N，N-取代的环胺化合物：其中A表示芳基等; E表示由式-CO-表示的基团或由式-CHOH-表示的基团; G表示氧原子等。 J表示可被取代的芳基; R 1表示低级烷基等。 Alk表示直链或支链低级亚烷基; n，v，w，x和y彼此独立，各自表示0或1; 和p表示2或3，或其药理学上可接受的盐。 本发明的化合物或其盐可有效治疗钙拮抗作用有效的疾病。 该疾病可能包括急性缺血性脑卒中，脑中风，脑梗塞，头部创伤，脑神经细胞死亡，阿尔茨海默病，帕金森病，肌萎缩性侧索硬化，亨廷顿病，脑循环代谢障碍，脑功能障碍，疼痛，痉挛，精神分裂症， 偏头痛，癫痫，疯子抑郁精神病，神经退行性疾病，脑缺血，艾滋病痴呆并发症，水肿，焦虑症（广泛性焦虑症）和糖尿病性神经病变。

    Nitrile compound
    7.
    发明授权
    Nitrile compound 失效
    腈化合物

    公开(公告)号：US06667412B1

    公开(公告)日：2003-12-23

    申请号：US09914349

    申请日：2001-08-27

    申请人： Yuichi Suzuki ,  Noboru Yamamoto ,  Koki Kawano ,  Teiji Kimura ,  Koichi Ito ,  Satoshi Nagato ,  Yoshihiko Norimine ,  Yoichi Iimura

    发明人： Yuichi Suzuki ,  Noboru Yamamoto ,  Koki Kawano ,  Teiji Kimura ,  Koichi Ito ,  Satoshi Nagato ,  Yoshihiko Norimine ,  Yoichi Iimura

    IPC分类号： C07C25536

    CPC分类号： C07D295/145 ,  C07C255/36 ,  C07C255/41 ,  C07D295/14

    摘要： The present invention provides a novel nitrile compound useful as an intermediate for the production of, for example, N,N-substituted cyclic amine derivatives or phenylacetonitrile derivatives that are useful as a medicine. Specifically it provides a nitrile carboxylic acid compound, nitrile ester compound and nitrile alcohol compound. That is, it provides a nitrile compound represented by the following formula (I): wherein R1 and R2 means substituents; m means 0 or an integer of from 1 to 6; n means 0 or an integer of from 1 to 5; and R3 means carboxyl group, a lower alkoxycarbonyl group or hydroxymethyl group.

    摘要翻译： 本发明提供了可用作制备例如可用作药物的N，N-取代的环胺衍生物或苯乙腈衍生物的中间体的新型腈化合物。 具体地说，它提供了一种腈羧酸化合物，腈酯化合物和腈醇化合物。 也就是说，它提供由下式（I）表示的腈化合物：其中R 1和R 2表示取代基; m表示0或1〜6的整数; n表示0或1至5的整数; R 3表示羧基，低级烷氧基羰基或羟甲基。

    IMAGE FORMING APPARATUS, CONTROLLING METHOD FOR SAME, AND STORAGE MEDIUM
    10.
    发明申请
    IMAGE FORMING APPARATUS, CONTROLLING METHOD FOR SAME, AND STORAGE MEDIUM 失效
    图像形成装置，控制方法和存储介质

    公开(公告)号：US20120162706A1

    公开(公告)日：2012-06-28

    申请号：US13312337

    申请日：2011-12-06

    申请人： Koichi Ito

    发明人： Koichi Ito

    IPC分类号： G06F3/12

    CPC分类号： G06F3/1215 ,  G06F3/1243 ,  G06F3/1285

    摘要： A main body controller provided in an image forming apparatus receives a VDP job from an external computer, and arranges image data of a reusable object and a variable object, which correspond to the VDP job, on a page for printout. An inspection controller performs inspection processing for printed matter for each page, and the main body controller preferentially stores image data of the reusable object, which corresponds to the page for which the printing has been determined to be defective as a result of inspection processing, in a cache unit. The main body controller acquires the reusable object, which corresponds to the page for which the printing has been determined to be defective, from the cache unit, and executes page reprint processing using the acquired reusable object.

    摘要翻译： 设置在图像形成装置中的主体控制器从外部计算机接收VDP作业，并将与VDP作业对应的可重复使用对象和可变对象的图像数据排列在打印页面上。 检查控制器对每页的打印物执行检查处理，并且主体控制器优先存储与作为检查处理的结果被确定为有缺陷的页面相对应的可重复使用对象的图像数据， 缓存单元。 主体控制器从高速缓存单元获取与已经确定有缺陷的打印页相对应的可重用对象，并使用所获取的可重用对象执行页面重新打印处理。