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18 条记录 (耗时 0.057 秒)

    N,N-substituted cyclic amine derivatives
    1.
    发明授权
    N,N-substituted cyclic amine derivatives 失效
    N，N-取代的环胺衍生物

    公开(公告)号：US06737425B1

    公开(公告)日：2004-05-18

    申请号：US09743358

    申请日：2001-01-29

    申请人： Noboru Yamamoto ,  Makoto Komatsu ,  Yuichi Suzuki ,  Koki Kawano ,  Teiji Kimura ,  Koichi Ito ,  Satoshi Nagato ,  Yoshihiko Norimine ,  Tetsuhiro Niidome ,  Tetsuyuki Teramoto ,  Yoichi Iimura ,  Shinji Hatakeyama

    发明人： Noboru Yamamoto ,  Makoto Komatsu ,  Yuichi Suzuki ,  Koki Kawano ,  Teiji Kimura ,  Koichi Ito ,  Satoshi Nagato ,  Yoshihiko Norimine ,  Tetsuhiro Niidome ,  Tetsuyuki Teramoto ,  Yoichi Iimura ,  Shinji Hatakeyama

    IPC分类号： A61K31497

    CPC分类号： C07D213/64 ,  C07D213/57 ,  C07D215/20 ,  C07D217/02 ,  C07D233/54 ,  C07D239/34 ,  C07D239/80 ,  C07D295/15 ,  C07D317/64 ,  C07D333/24 ,  C07D333/38

    摘要： The invention provides an N,N-substituted cyclic amine compound represented by the following formula (VIII): wherein A represents an aryl group etc.; E represents a group represented by the formula —CO— or a group represented by the formula —CHOH—; G represents an oxygen atom etc.; J represents an aryl group which may be substituted; R1 represents a lower alkyl group etc.; Alk represents a linear or branched lower alkylene group; n, v, w, x and y are independent of each other and each represents 0 or 1; and p represents 2 or 3, or a pharmacologically acceptable salt thereof. The compound of the present invention or a salt thereof is effective to treat a disease against which calcium antagonism is effective. The disease may include acute ischemic stroke, cerebral apoplexy, cerebral infarction, head trauma, cerebral nerve cell death, Alzheimer disease, Parkinson disease, amyotrophic lateral sclerosis, Huntington disease, cerebral circulatory metabolism disturbance, cerebral function disturbance, pain, spasm, schizophrenia, migraine, epilepsy, maniac-depressive psychosis, nerve degenerative diseases, cerebral ischemia, AIDS dementia complications, edema, anxiety disorder (generalized anxiety disorder) and diabetic neuropathy.

    摘要翻译： 本发明提供由下式（VIII）表示的N，N-取代的环胺化合物：其中A表示芳基等; E表示由式-CO-表示的基团或由式-CHOH-表示的基团; G表示氧原子等。 J表示可被取代的芳基; R 1表示低级烷基等。 Alk表示直链或支链低级亚烷基; n，v，w，x和y彼此独立，各自表示0或1; 和p表示2或3，或其药理学上可接受的盐。 本发明的化合物或其盐可有效治疗钙拮抗作用有效的疾病。 该疾病可能包括急性缺血性脑卒中，脑中风，脑梗塞，头部创伤，脑神经细胞死亡，阿尔茨海默病，帕金森病，肌萎缩性侧索硬化，亨廷顿病，脑循环代谢障碍，脑功能障碍，疼痛，痉挛，精神分裂症， 偏头痛，癫痫，疯子抑郁精神病，神经退行性疾病，脑缺血，艾滋病痴呆并发症，水肿，焦虑症（广泛性焦虑症）和糖尿病性神经病变。

    Nitrile compound
    2.
    发明授权
    Nitrile compound 失效
    腈化合物

    公开(公告)号：US06667412B1

    公开(公告)日：2003-12-23

    申请号：US09914349

    申请日：2001-08-27

    申请人： Yuichi Suzuki ,  Noboru Yamamoto ,  Koki Kawano ,  Teiji Kimura ,  Koichi Ito ,  Satoshi Nagato ,  Yoshihiko Norimine ,  Yoichi Iimura

    发明人： Yuichi Suzuki ,  Noboru Yamamoto ,  Koki Kawano ,  Teiji Kimura ,  Koichi Ito ,  Satoshi Nagato ,  Yoshihiko Norimine ,  Yoichi Iimura

    IPC分类号： C07C25536

    CPC分类号： C07D295/145 ,  C07C255/36 ,  C07C255/41 ,  C07D295/14

    摘要： The present invention provides a novel nitrile compound useful as an intermediate for the production of, for example, N,N-substituted cyclic amine derivatives or phenylacetonitrile derivatives that are useful as a medicine. Specifically it provides a nitrile carboxylic acid compound, nitrile ester compound and nitrile alcohol compound. That is, it provides a nitrile compound represented by the following formula (I): wherein R1 and R2 means substituents; m means 0 or an integer of from 1 to 6; n means 0 or an integer of from 1 to 5; and R3 means carboxyl group, a lower alkoxycarbonyl group or hydroxymethyl group.

    摘要翻译： 本发明提供了可用作制备例如可用作药物的N，N-取代的环胺衍生物或苯乙腈衍生物的中间体的新型腈化合物。 具体地说，它提供了一种腈羧酸化合物，腈酯化合物和腈醇化合物。 也就是说，它提供由下式（I）表示的腈化合物：其中R 1和R 2表示取代基; m表示0或1〜6的整数; n表示0或1至5的整数; R 3表示羧基，低级烷氧基羰基或羟甲基。

    Pyridazinone and triazinone compounds and use thereof as pharmaceutical preparations
    4.
    发明申请
    Pyridazinone and triazinone compounds and use thereof as pharmaceutical preparations 审中-公开
    哒嗪酮和三嗪酮化合物及其作为药物制剂的用途

    公开(公告)号：US20060189622A1

    公开(公告)日：2006-08-24

    申请号：US11408078

    申请日：2006-04-21

    申请人： Satoshi Nagato ,  Koki Kawano ,  Koichi Ito ,  Yoshihiko Norimine ,  Kohshi Ueno ,  Takahisa Hanada ,  Hiroyuki Amino ,  Makoto Ogo ,  Shinji Hatakeyama ,  Masataka Ueno ,  Anthony Groom ,  Leanne Rivers ,  Terence Smith

    发明人： Satoshi Nagato ,  Koki Kawano ,  Koichi Ito ,  Yoshihiko Norimine ,  Kohshi Ueno ,  Takahisa Hanada ,  Hiroyuki Amino ,  Makoto Ogo ,  Shinji Hatakeyama ,  Masataka Ueno ,  Anthony Groom ,  Leanne Rivers ,  Terence Smith

    IPC分类号： A61K31/506 ,  A61K31/501 ,  A61K31/50 ,  C07D409/02 ,  C07D403/02 ,  C07D405/02

    CPC分类号： C07D237/24 ,  C07D237/14 ,  C07D401/04 ,  C07D491/04

    摘要： The present invention provides a novel compound exhibiting an excellent inhibitory action on AMPA receptor and/or kainate receptor. That is, it provides a compound represented by the following formula, a salt thereof or a hydrate of them. In the formula, A1, A2 and A3 are independent of each other and each represents a C3-8 cycloalkyl group, a C3-8 cycloalkenyl group, a 5- to 14-membered non-aromatic heterocyclic group, a C6-14 aromatic hydrocarbon cyclic group or a 5- to 14-membered aromatic heterocyclic group, each of which may be substituted; Q represents O, S or NH; Z represents C or N; X1, X2 and X3 are independent of each other and each represents a single bond, an optionally substituted C1-6 alkylene group, an optionally substituted C2-6 alkenylene group, an optionally substituted C2-6 alkynylene group, —NH—, —O—, —NHCO—, —CONH—, —SO0-2—, etc.; R1 and R2 are independent of each other and each represents a hydrogen atom or an optionally substituted C1-6 alkyl group, or R1 and R2 may be bound together such that CR2-ZR1 forms C═C; and R3 represents a hydrogen atom or an optionally substituted C1-6 alkyl group etc., or may be bound to any atom in A1 or A3 to form, together with the atom, an optionally substituted C5-8 hydrocarbon ring or an optionally substituted 5- to 8-membered heterocyclic ring.

    摘要翻译： 本发明提供了对AMPA受体和/或红藻氨酸受体具有优异抑制作用的新化合物。 也就是说，它提供由下式表示的化合物，其盐或它们的水合物。 在该式中，A 1，A 2和A 3彼此独立，并且各自表示C 3-8， 环烷基，C 3-8环烯基，5至14元非芳族杂环基，C 6-14芳族烃环基 或5〜14元芳族杂环基，其各自可以被取代; Q表示O，S或NH; Z表示C或N; X 1，X 2和X 3 3彼此独立，各自表示单键，任选取代的C 1〜 6个亚烷基，任选取代的C 2-6亚烯基，任选取代的C 2-6亚炔基，-NH-，-O-， -NHCO - ， - CONH - ， - SO 2 - 等; R 1和R 2彼此独立，各自表示氢原子或任选取代的C 1-6烷基，或R 可以将“1”和“R”2结合在一起，使得CR 2 -ZR 1'形成CC; 和R 3表示氢原子或任选取代的C 1-6烷基等，或者可以与A 1〜O 2中的任何原子结合 >或A <3>，以与原子一起形成任选取代的C 5 -C 8烃环或任选取代的5至8元杂环。