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公开(公告)号：US07613502B2
公开(公告)日：2009-11-03
申请号：US11205184
申请日：2005-08-17
IPC分类号： A61B5/00
CPC分类号： A61B5/14553 , A61B5/0042 , A61B5/064 , A61B5/6814 , A61B5/7425 , A61B5/743 , A61B34/20 , A61B2034/2051 , A61B2034/2055 , A61B2034/2063
摘要： In a probe positioning technology, an optical bioinstrumentation includes a region selecting unit that is used to delineate a region of interest in an anatomical image of a subject, a computing unit that determines a recommended probe position according to the region of interest, a probe position sensor that detects a current probe position, a computing unit that calculates the distance between the recommended probe position and the current probe position, and an alarm device that generates an alarm sound or the like when the distance falls within a predetermined range. Moreover, the optical bioinstrumentation for living body further includes a memory unit in which the probe position is saved together with measurement data.
摘要翻译： 在探针定位技术中，光学生物仪器包括区域选择单元，其用于描绘对象的解剖图像中的感兴趣区域，计算单元，其根据感兴趣的区域确定推荐的探针位置，探针位置 检测当前探头位置的传感器，计算推荐探测位置与当前探测位置之间的距离的计算单元，以及当距离在预定范围内时产生报警声等的报警装置。 此外，生物体的光学生物仪器还包括存储单元，其中探测位置与测量数据一起被保存。
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公开(公告)号：US20060100526A1
公开(公告)日：2006-05-11
申请号：US11205184
申请日：2005-08-17
IPC分类号： A61B6/00
CPC分类号： A61B5/14553 , A61B5/0042 , A61B5/064 , A61B5/6814 , A61B5/7425 , A61B5/743 , A61B34/20 , A61B2034/2051 , A61B2034/2055 , A61B2034/2063
摘要： In a probe positioning technology, an optical bioinstrumentation includes a region selecting unit that is used to delineate a region of interest in an anatomical image of a subject, a computing unit that determines a recommended probe position according to the region of interest, a probe position sensor that detects a current probe position, a computing unit that calculates the distance between the recommended probe position and the current probe position, and an alarm device that generates an alarm sound or the like when the distance falls within a predetermined range. Moreover, the optical bioinstrumentation for living body further includes a memory unit in which the probe position is saved together with measurement data.
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3.发明授权公开(公告)号：US07974671B2
公开(公告)日：2011-07-05
申请号：US10572357
申请日：2004-09-03
申请人： Michiyuki Fujiwara , Tsuneaki Kawaguchi , Fumio Kawaguchi , Shingo Kawasaki , Atsushi Maki , Yukiko Hirabayashi , Yukari Yamamoto , Masashi Kiguchi , Hiroki Sato , Tsuyoshi Yamamoto , Takushige Katsura , Hideo Kawaguchi
发明人： Michiyuki Fujiwara , Tsuneaki Kawaguchi , Fumio Kawaguchi , Shingo Kawasaki , Atsushi Maki , Yukiko Hirabayashi , Yukari Yamamoto , Masashi Kiguchi , Hiroki Sato , Tsuyoshi Yamamoto , Takushige Katsura , Hideo Kawaguchi
IPC分类号： A61B5/00
CPC分类号： A61B5/14553 , A61B5/0042 , A61B5/0059 , A61B5/0261 , A61B5/0476 , A61B5/0478 , A61B5/0482 , A61B5/0484 , A61B5/0488 , A61B5/11 , A61B5/6822 , A61B5/742 , A61B2562/0209 , A61B2562/0233 , A61B2562/046
摘要： A living body information signal processing system (100) combining organically a living body optical measurement apparatus and a brain wave measurement apparatus, the living body optical measurement apparatus (300) in which inspection light of from visible to near infrared is irradiated on a head portion of a subject (140) and the penetration light is received and which measures an optical characteristic variation induced by a brain activity inside the head portion as a living body optical signal and the brain wave measurement apparatus (400) which measures an electrical characteristic variation induced by a brain activity inside the head portion of the subject as a brain wave signal, is provided with a probe device (50) used for both apparatus; and a living body information signal processing and displaying device (200) which displays the living body optical signal corresponding to respective measurement positions from the living body optical measurement apparatus and the brain wave signal corresponding to respective measurement positions from the brain wave measurement apparatus on a common display device while correlating the respective measurement positions each other, thereby, with the system comprehensive observation of both data can be achieved.
摘要翻译： 一种生物体信息信号处理系统（100），其组织有机地生物体光学测量装置和脑电波测定装置，所述生物体光学测量装置（300）将从所述可见光到近红外线的检查光照射在头部 并且测量由头部内部的脑活动引起的作为生物体光信号的光学特性变化和测量电特性变化的脑波测量装置（400）的穿透光， 通过作为脑波信号的被检体头部内的脑活动，设置有用于两个装置的探针装置（50）; 以及生物体信息信号处理和显示装置（200），其从来自所述生物体光学测量装置的对应于各测量位置的生物体光信号和对应于来自所述脑波测量装置的各测量位置的脑波信号 共同显示装置，同时将各个测量位置相互关联，从而可以实现对两个数据的系统综合观察。
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公开(公告)号：US07991447B2
公开(公告)日：2011-08-02
申请号：US10577944
申请日：2004-07-01
申请人： Hiroki Sato , Masashi Kiguchi , Atsushi Maki , Tsuyoshi Yamamoto
发明人： Hiroki Sato , Masashi Kiguchi , Atsushi Maki , Tsuyoshi Yamamoto
IPC分类号： A61B5/1455
CPC分类号： A61B5/14553
摘要： To control information obtained from inside of a living body with higher precision as compared to that in the conventional technology by controlling a ratio of intensities of light, directed to a trial body, in a plurality of wavelength ranges different in peak wavelength from each other, a measurement error included in information obtained from the living body can be controlled by changing a ratio of intensity of the light in the first wavelength range against that of the light in the second wavelength range. When intensity of irradiated light is limited from the viewpoint of safety to the trial subject, keeping a ratio of the light irradiated to the trial body in the first wavelength range against that of the light in the second wavelength range under a prespecified value and also changing the ratio of irradiated light intensities under the prespecified value.
摘要翻译： 通过在峰值波长不同的多个波长范围内控制指向试验体的光的强度比，通过控制比现有技术更高的精度从内部获得的生物体的信息， 可以通过改变第一波长范围内的光的强度与第二波长范围内的光的强度的比例来控制从生物体获得的信息中包括的测量误差。 当照射光的强度从安全性的角度受限于试验对象时，将照射在试验体上的光的第1波长范围内的光与第2波长范围内的光的比例保持在规定值以下， 照射光强度的比例在预先指定的值之下。
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5.发明授权公开(公告)号：US07890270B2
公开(公告)日：2011-02-15
申请号：US12392207
申请日：2009-02-25
申请人： Hiroki Sato , Atsushi Maki , Tsuyoshi Yamamoto , Masashi Kiguchi
发明人： Hiroki Sato , Atsushi Maki , Tsuyoshi Yamamoto , Masashi Kiguchi
IPC分类号： G01N31/00
CPC分类号： A61B5/7264 , A61B5/0059 , A61B5/7425 , A61B5/743 , G06F19/00 , G16H40/63
摘要： A living body light measuring device including plural light-radiating devices for radiating light to a head of a subject, plural light-receiving devices for detecting light which is transmitted through the head of the subject after radiation from the light-radiating devices, a calculator for calculating a change of concentration of oxidized and deoxidized hemoglobin in the head of the subject at a measurement point using a pair of each of the plural light-radiating devices and corresponding ones of the light-receiving devices. The calculator decides whether the oxidized hemoglobin concentration change and the deoxidized hemoglobin concentration change are statistically significant at each of the measurement points, and the display displays the decisions regarding the individual measurement points.
摘要翻译： 一种生物体光测量装置，包括：多个用于将光照射到被检体的头部的光辐射装置;多个光检测装置，用于检测从所述光辐射装置辐射后透过所述被检体的头部的光;计算器 用于使用多个光辐射装置和对应的光接收装置中的每一个来计算测量点处的受试者头部中的氧化和脱氧血红蛋白的浓度的变化。 计算器确定每个测量点氧化血红蛋白浓度变化和脱氧血红蛋白浓度变化是否具有统计学意义，显示显示各个测量点的决定。
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6.发明授权公开(公告)号：US07516021B2
公开(公告)日：2009-04-07
申请号：US11570558
申请日：2005-06-08
申请人： Hiroki Sato , Atsushi Maki , Tsuyoshi Yamamoto , Masashi Kiguchi
发明人： Hiroki Sato , Atsushi Maki , Tsuyoshi Yamamoto , Masashi Kiguchi
IPC分类号： G01N31/00
CPC分类号： A61B5/7264 , A61B5/0059 , A61B5/7425 , A61B5/743 , G06F19/00 , G16H40/63
摘要： Apparatus and method for hemoglobin measurement including irradiating light to a living body, detecting light that has propagated through the living body, and acquiring measured data that represents a change in the concentration of oxidized hemoglobin in the living body and a change in the concentration of deoxidized hemoglobin; irradiating light to the living body, detecting light that has propagated through the living body, and acquiring measured data that represents a change in the concentration of oxidized hemoglobin in the living body and a change in the concentration of deoxidized hemoglobin; classifying the data measured at the first step and the data measured at the second step according to each of an increase or a decrease in the concentration of oxidized hemoglobin and an increase or a decrease in the concentration of deoxidized hemoglobin; and displaying the classifications determined at the third step.
摘要翻译： 用于血红蛋白测量的装置和方法，包括向生物体照射光，检测通过活体传播的光，并获取表示生物体中氧化血红蛋白浓度变化的测量数据和脱氧浓度变化 血红蛋白 对生物体照射光，检测通过生物体传播的光，获取表示生物体中氧化血红蛋白浓度变化的测定数据和脱氧血红蛋白浓度的变化; 根据氧化血红蛋白浓度的增加或减少以及脱氧血红蛋白浓度的增加或减少，分别在第一步骤测量的数据和在第二步骤测量的数据; 并显示在第三步确定的分类。
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7.发明申请公开(公告)号：US20080040049A1
公开(公告)日：2008-02-14
申请号：US11570558
申请日：2005-06-08
申请人： Hiroki Sato , Atsushi Maki , Tsuyoshi Yamamoto , Masashi Kiguchi
发明人： Hiroki Sato , Atsushi Maki , Tsuyoshi Yamamoto , Masashi Kiguchi
IPC分类号： G06F19/00
CPC分类号： A61B5/7264 , A61B5/0059 , A61B5/7425 , A61B5/743 , G06F19/00 , G16H40/63
摘要： In the past, comparison of mean values or variances measured from multiple subjects with one another has been a mainstream of diagnostic support to be achieved using cerebral activity signals. However, in this case, it is hard to absorb individual differences, and the precision in a diagnostic support technology is low. In order to improve the precision in the diagnostic support technology, the property of data acquired by an optical organism measurement system is utilized in order to create and display information representing a change in the condition of each person. Thus, diagnosis of each person is effectively supported. Measured light signals are used to calculate and record changes in the concentrations of oxidized hemoglobin (Hb), deoxidized Hb, and total Hb respectively. Based on each data (representing the Hb concentration changes), two or more Hb concentration changes (for example, the oxidized Hb concentration change and deoxidized Hb concentration change) are classified according to whether the changes are increases or decreases, and indicated in the form of symbols, an image, or a graph. Thus, an examining person is provided with compressed and simplified information and supported in diagnosis.
摘要翻译： 在过去，从多个受试者相互测量的平均值或差异的比较已经成为使用脑活动信号来实现的诊断支持的主流。 然而，在这种情况下，难以吸收个体差异，诊断支持技术的精度低。 为了提高诊断支持技术的精度，利用光学生物测量系统获取的数据的属性来创建和显示表示每个人的状况变化的信息。 因此，有效地支持每个人的诊断。 测量光信号用于计算和记录氧化血红蛋白（Hb），脱氧Hb和总Hb的浓度变化。 基于每个数据（表示Hb浓度变化），根据变化是增加还是减少来分类两种或更多种Hb浓度变化（例如，氧化的Hb浓度变化和脱氧的Hb浓度变化），并以表格 的符号，图像或图形。 因此，检查人员被提供压缩和简化的信息并且在诊断中被支持。
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公开(公告)号：US07139597B2
公开(公告)日：2006-11-21
申请号：US10762498
申请日：2004-01-23
申请人： Atsushi Maki , Tsuyoshi Yamamoto
发明人： Atsushi Maki , Tsuyoshi Yamamoto
IPC分类号： A61B5/00
CPC分类号： A61B5/7207 , A61B5/0261 , A61B5/14553 , A61B5/16 , A61B2562/0233 , A61B2562/046
摘要： There has been no device for measuring changes in Hb concentrations associated with activities of the cerebral function of an infant or subject prone to movement during measurement. Removing and reducing any influences of body movement is needed. In the present invention, light is irradiated on the subject's head, and changes in Hb concentrations associated with activities of the cerebral function are measured from scattered light which has passed through the head. From this blood circulation movement, a parameter is inputted arbitrarily to judge the body movement component, and feed-back is applied to a stimulus device for giving a stimulus to the subject.
摘要翻译： 没有用于测量与测量期间容易运动的婴儿或受试者的脑功能活动相关的Hb浓度变化的装置。 需要去除和减少身体运动的任何影响。 在本发明中，将光照射到受检者的头部，并且通过头部的散射光测量与脑功能的活动有关的Hb浓度的变化。 从该血液循环运动中，任意地输入参数以判断身体运动成分，并且将反馈应用于刺激装置以对受试者施加刺激。
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公开(公告)号：US06895269B2
公开(公告)日：2005-05-17
申请号：US09987334
申请日：2001-11-14
CPC分类号： G06F3/015
摘要： A device for controlling equipment includes at least one light projector adapted to project light onto a head of a living body. A light collecting section for collecting the light having passed through the head, a light measuring section for measuring an intensity of the light collected by the light collecting section, a memory section for storing a previous history of changes of the intensity of the light measured, a signal judging section for judging if both the intensity of the light measured by said light measuring section and the previous history of changes of the intensity of the light satisfy a predetermined condition, a displaying section for displaying the intensity of the light measured and a result obtained by the signal judging section, and a control signal generating section for generating a control signal for external equipment.
摘要翻译： 一种用于控制设备的设备包括至少一个适于将光投射到生物体的头部上的投影仪。 用于收集通过头部的光的聚光部分，用于测量由聚光部分收集的光的强度的光测量部分，用于存储测量的光的强度变化的先前历史的存储部分， 信号判断部分，用于判断由所述光测量部分测量的光的强度和光的强度变化的先前历史是否都满足预定条件;显示部分，用于显示所测量的光的强度和结果 由信号判定部获得的控制信号生成部，生成外部设备的控制信号。
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公开(公告)号：US07359825B2
公开(公告)日：2008-04-15
申请号：US11378448
申请日：2006-03-20
IPC分类号： G01C17/00
CPC分类号： G01N21/49 , A61B5/0042 , A61B5/14553 , A61B5/7435
摘要： In order to provide an optical measurement system and an optical measurement method which is suitable for optically measuring a body to be inspected and easily obtaining an image of a desired item based on information obtained by the measurement, an optical measurement method including an initial display process for selectively instructing any one of selection of optical measurement, analysis of said optical measurement result and completion of a program; a process for inputting items of condition including a measurement mode; a process for displaying a light irradiation position and a light detection position and a state expressing measurement position relationship together with said mode; a process for instructing to form a file for storing said optical measurement result; a process for instructing a measurement condition to detect light signals from the inside of a body to be inspected which is irradiated by a multi-wavelength multi-channel; and a process for displaying said signals for each channel detected according to said instructed result.
摘要翻译： 为了提供一种光学测量系统和光学测量方法，该光学测量系统和光学测量方法适合于光学测量待检查的物体，并且基于通过测量获得的信息容易地获得期望项目的图像，包括初始显示处理 用于选择性地指示光学测量的选择，所述光学测量结果的分析和程序的完成中的任何一个; 用于输入包括测量模式的条件项目的处理; 用于显示光照射位置和光检测位置以及表示测量位置关系的状态与所述模式的过程; 用于指示形成用于存储所述光学测量结果的文件的处理; 用于指示测量条件从多波长多通道照射的被检体的内部检测光信号的处理; 以及用于显示根据所述指示结果检测的每个通道的所述信号的处理。
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