公开(公告)号：US06726901B2

公开(公告)日：2004-04-27

申请号：US10142140

申请日：2002-05-09

申请人： Yuling Yin ,  Jayant N. Sane ,  Yan-Fei Shen

发明人： Yuling Yin ,  Jayant N. Sane ,  Yan-Fei Shen

IPC分类号： A61K732

CPC分类号： A61K8/44 ,  A61K8/02 ,  A61K8/19 ,  A61K8/24 ,  A61K8/26 ,  A61K8/28 ,  A61K8/365 ,  A61K2800/31 ,  A61K2800/52 ,  A61Q15/00

摘要： Disclosed is an anhydrous topical antiperspirant composition comprising a dermatologically acceptable carrier and a perspiration reducing effective amount of a particulate antiperspirant salt suspended in the carrier. The antiperspirant salt comprises an aluminum-zirconium chlorohydrate having a metal to chloride ratio between about 0.9 and about 1.3. The composition also includes, separate from the antiperspirant salt, a stabilizing basic material in an amount sufficient to prevent degradation of the antiperspirant composition or to minimize acid odor. Also disclosed is a method of reducing perspiration from human skin by applying the aforementioned topical composition.

摘要翻译： 公开了一种无水局部止汗组合物，其包含皮肤病学可接受的载体和降低汗液的有效量的悬浮在载体中的颗粒止汗盐。 止汗盐包含金属氯化物比为约0.9至约1.3的水合氯化铝锆。 组合物还包括与止汗盐分开的稳定的碱性物质，其量足以防止止汗组合物的降解或使酸气味最小化。 还公开了通过应用上述局部组合物来减少人皮肤出汗的方法。

公开(公告)号：US5643558A

公开(公告)日：1997-07-01

申请号：US397451

申请日：1995-03-02

申请人： Stephen J. Provancal ,  Angel L. Carrillo ,  Thomas J. Fluhler ,  Richard Oryszczak ,  Jayant N. Sane

发明人： Stephen J. Provancal ,  Angel L. Carrillo ,  Thomas J. Fluhler ,  Richard Oryszczak ,  Jayant N. Sane

IPC分类号： A61K8/26 ,  A61K8/28 ,  A61K8/34 ,  A61K8/44 ,  A61Q15/00 ,  A61K7/34 ,  A61K7/38

CPC分类号： A61Q15/00 ,  A61K8/26 ,  A61K8/28 ,  A61K8/345 ,  A61K8/44

摘要： The present invention comprises a process of preparing a solution of an enhanced efficacy aluminum antiperspirant salt in a polyhydric alcohol by(a) providing an aqueous solution consisting essentially of about 5% to about 18% by weight of an enhanced efficacy aluminum antiperspirant salt in water, the enhanced efficacy aluminum antiperspirant salt having been prepared in situ without having been dried to a solid powder;(b) mixing the aqueous solution with a sufficient amount of a liquid polyhydric alcohol to provide a mixed solution which has an antiperspirant salt to polyhydric alcohol ratio of about 1:4 to about 1.2:1; and(c) rapidly evaporating the water from the mixed solution under vacuum to provide a final liquid polyhydric alcohol solution containing about 20 to 50% enhanced efficacy aluminum antiperspirant salt and about 2 to 16% water, with the balance being polyhydric alcohol.An alkaline glycinate salt, such as sodium, potassium or zinc glycinate, may be added to the polyhydric alcohol prior to the addition of the antiperspirant salt solution in order to raise the pH of the recovered product to about 4.1 to 5.0.

摘要翻译： 本发明包括通过（a）提供基本上由约5重量％至约18重量％的增强的功效铝止汗酸盐在水中的水溶液制备增强的功效性铝止汗药盐在多元醇中的溶液的方法 已经在原位制备了不再干燥成固体粉末的增强效力的铝止汗药; （b）将水溶液与足量的液体多元醇混合以提供具有止汗剂盐与多元醇比为约1:4至约1.2:1的混合溶液; 和（c）在真空下从混合溶液中快速蒸发水，以提供含有约20至50％增强效力的铝止汗剂盐和约2至16％水的最终液体多元醇溶液，余量为多元醇。 在加入止汗盐溶液之前，可以向多元醇中加入碱性甘氨酸盐，例如甘氨酸钠，钾或锌，以便将回收产物的pH提高至约4.1至5.0。

公开(公告)号：US5725846A

公开(公告)日：1998-03-10

申请号：US588618

申请日：1996-02-06

申请人： Tuan M. Vu ,  Carl F. Iovanni ,  Jayant N. Sane

发明人： Tuan M. Vu ,  Carl F. Iovanni ,  Jayant N. Sane

IPC分类号： A61K8/02 ,  A61K8/04 ,  A61K8/26 ,  A61K8/28 ,  A61K8/34 ,  A61K8/44 ,  A61K8/49 ,  A61K8/73 ,  A61Q15/00 ,  A61K7/32 ,  A61K7/34 ,  A61K7/36 ,  A61K7/38

CPC分类号： A61K8/042 ,  A61K8/0229 ,  A61K8/26 ,  A61K8/28 ,  A61K8/345 ,  A61K8/44 ,  A61K8/498 ,  A61K8/731 ,  A61Q15/00 ,  A61K2800/262 ,  A61K2800/51 ,  A61K2800/5422

摘要： A clear gel cosmetic stick includes a liquid vehicle, a dibenzylidene alditol as a gelling agent, an antiperspirant salt dissolved in the liquid vehicle, and a hydroxyalkyl cellulose co-gellant. The cosmetic stick comprises in percent by weight about 70% to about 95%, preferably 75 to 92%, of a liquid vehicle comprising a polyhydric alcohol having from 3 to 6 carbon atoms and from 2 to 6 hydroxyl groups, about 0.5% to about 1.5%, preferably 0.7% to 1.3%, of a dibenzylidene alditol, about 3% to about 22%, preferably 6% to 15%, of an antiperspirant salt dissolved in said vehicle, and about 0.1% to about 0.5%, preferably 0.2% to 0.4%, of a hydroxyalkyl cellulose. Preferably the liquid vehicle is substantially free of monohydric alcohol and is also substantially free of strong alkali such as NaOH and KOH. Preferably the cosmetic stick will have a pH greater than 4.4, more preferably greater than 4.7, a turbidity of less than about 120 NTU, more preferably less than 100 NTU, and a hardness of about 60 to 150. By lowering the dibenzylidene alditol level to 1.5% or lower, the clarity and odor characteristics of the stick are greatly improved. The hardness of the stick is maintained by the addition of the hydroxyalkyl cellulose.

摘要翻译： 透明的凝胶化妆棒包括液体载体，作为胶凝剂的二亚苄基糖醇，溶解在液体载体中的止汗盐，和羟烷基纤维素共凝胶剂。 化妆棒包含重量百分比约70％至约95％，优选75至92％的液体载体，其包含具有3至6个碳原子的多元醇和2至6个羟基，约0.5％至约 1.5％，优选0.7％至1.3％的二亚苄基糖醇，约3％至约22％，优选6％至15％的溶解在所述载体中的止汗剂盐，以及约0.1％至约0.5％，优选0.2 ％至0.4％的羟烷基纤维素。 优选地，液体载体基本上不含一元醇，并且还基本上不含强碱如NaOH和KOH。 优选地，化妆棒的pH值大于4.4，更优选大于4.7，浊度小于约120NTU，更优选小于100NTU，硬度为约60至150.通过将二亚苄基二醇水平降低至 1.5％以下，棒的透明度和气味特性大大提高。 通过加入羟烷基纤维素来维持棒的硬度。

公开(公告)号：US5716604A

公开(公告)日：1998-02-10

申请号：US713223

申请日：1996-09-24

申请人： Craig M. Coe ,  Chinyere E. Onyekachi Utaegbulam ,  Yanick Jean ,  Tuan M. Vu ,  Jayant N. Sane

发明人： Craig M. Coe ,  Chinyere E. Onyekachi Utaegbulam ,  Yanick Jean ,  Tuan M. Vu ,  Jayant N. Sane

IPC分类号： A61K8/34 ,  A61K8/36 ,  A61Q15/00 ,  A61Q19/00 ,  A61K7/32 ,  A61K7/00

CPC分类号： A61K8/345 ,  A61K8/0229 ,  A61K8/361 ,  A61Q15/00 ,  A61Q19/00 ,  A61K2800/262 ,  Y10S424/05

摘要： Soap-based clear cosmetic sticks are disclosed which include 2-methyl-1,3-propanediol in the composition to increase the set temperature, and also the stick hardness. A typical composition of the present invention comprises about 20 to 50%, preferably 28 to 46%, of 2-methyl-1,3-propanediol, about 3 to 12%, preferably 4 to 8%, of an alkali metal salt of a C.sub.12-22, preferably C.sub.14-18, fatty acid, about 10 to 42%, preferably 18 to 30%, of a polyhydric alcohol other than 2-methyl-1,3-propanediol, and about 5 to 35%, preferably 15 to 30%, water. To achieve the highest set temperature the composition should also contain an alkali metal salt, preferably a sodium or potassium salt, particularly an alkali metal halide such as sodium chloride or an alkali metal chelate such as di-, tri- or tetra-sodium EDTA. The composition will also typically contain a cosmetic active ingredient such as a deodorant active. Preferably the composition will contain less than 0.3%, most preferably less than 0.2%, of C.sub.20-22 soap in order to achieve maximum clarity.

摘要翻译： 公开了在组合物中包含2-甲基-1,3-丙二醇的皂基透明化妆棒，以提高设定温度，以及粘度硬度。 本发明的典型组合物包含约20至50％，优选28至46％的2-甲基-1,3-丙二醇，约3至12％，优选4至8％的碱金属盐 优选C 14-18，优选C 14-18，脂肪酸，约10至42％，优选18至30％的除2-甲基-1,3-丙二醇以外的多元醇，以及约5至35％，优选15至 30％，水。 为达到最高设定温度，组合物还应含有碱金属盐，优选钠盐或钾盐，特别是碱金属卤化物如氯化钠或碱金属螯合物，如二，三或四钠EDTA。 组合物还通常含有美容活性成分如除臭剂活性成分。 优选地，组合物将含有小于0.3％，最优选小于0.2％的C20-22皂以实现最大的清晰度。

公开(公告)号：US06936242B2

公开(公告)日：2005-08-30

申请号：US10298113

申请日：2002-11-15

申请人： David L. Elliott ,  Dennis J. Colwell ,  Jayant N. Sane ,  Tuan M. Vu ,  Cheryl Lynn Galante

发明人： David L. Elliott ,  Dennis J. Colwell ,  Jayant N. Sane ,  Tuan M. Vu ,  Cheryl Lynn Galante

IPC分类号： A61K8/02 ,  A61K8/28 ,  A61Q15/00 ,  A61K7/32 ,  A61K7/00

CPC分类号： A61K8/02 ,  A61K8/0229 ,  A61K8/0237 ,  A61K8/042 ,  A61K8/28 ,  A61K2800/262 ,  A61K2800/31 ,  A61Q15/00

摘要： Disclosed is a non-flowable anhydrous topical antiperspirant composition comprising a first portion and a second portion contiguous with the first portion. The first portion is semi-opaque to opaque and comprises a first hydrophobic carrier vehicle and a first gellant and has a particulate antiperspirant active suspended therein. The second portion is translucent to transparent and comprises a second hydrophobic carrier vehicle and a second gellant. Preferably, the second hydrophobic carrier vehicle has an average refractive index that approximately matches the refractive index of the second gellant. Ideally, for greater translucency the second portion will be substantially free of antiperspirant salt and/or other opacifying materials. Preferably, the first hydrophobic carrier vehicle also has an average refractive index that approximately matches the refractive index of the first gellant. Even more preferably, the second hydrophobic carrier vehicle and second gellant are comprised of substantially the same materials in substantially the same proportions as the first hydrophobic carrier vehicle and first gellant.

摘要翻译： 公开了一种不可流动的无水局部止汗组合物，其包含与第一部分邻接的第一部分和第二部分。 第一部分是不透明的，不透明的，并且包括第一疏水载体载体和第一胶凝剂，并且其中悬浮有颗粒止汗剂活性物质。 第二部分是透明的，透明的，并且包括第二疏水载体载体和第二胶凝剂。 优选地，第二疏水载体载体具有与第二胶凝剂的折射率近似匹配的平均折射率。 理想地，为了更大的半透明度，第二部分将基本上不含止汗盐和/或其它不透明的材料。 优选地，第一疏水载体载体还具有与第一胶凝剂的折射率近似匹配的平均折射率。 甚至更优选地，第二疏水载体载体和第二胶凝剂由与第一疏水载体载体和第一胶凝剂基本相同的比例的基本上相同的材料构成。

公开(公告)号：US5939057A

公开(公告)日：1999-08-17

申请号：US874232

申请日：1997-06-13

申请人： Stephen J. Provancal ,  Angel L. Carrillo ,  Thomas J. Fluhler ,  Richard Oryszczak ,  Jayant N. Sane

发明人： Stephen J. Provancal ,  Angel L. Carrillo ,  Thomas J. Fluhler ,  Richard Oryszczak ,  Jayant N. Sane

IPC分类号： A61K8/20 ,  A61K8/26 ,  A61K8/28 ,  A61K8/34 ,  A61K8/44 ,  A61K8/58 ,  A61K8/86 ,  A61Q15/00 ,  A61K7/34 ,  A61K7/38

CPC分类号： A61Q15/00 ,  A61K8/26 ,  A61K8/28 ,  A61K8/345 ,  A61K8/44

摘要： The present invention comprises a process of preparing a solution of an enhanced efficacy aluminum antiperspirant salt in a polyhydric alcohol by(a) providing an aqueous solution consisting essentially of about 5% to about 18% by weight of an enhanced efficacy aluminum antiperspirant salt in water, the enhanced efficacy aluminum antiperspirant salt having been prepared in situ without having been dried to a solid powder;(b) mixing the aqueous solution with a sufficient amount of a liquid polyhydric alcohol to provide a mixed solution which has an antiperspirant salt to polyhydric alcohol ratio of about 1:4 to about 1.2:1; and(c) rapidly evaporating the water from the mixed solution under vacuum to provide a final liquid polyhydric alcohol solution containing about 20 to 50% enhanced efficacy aluminum antiperspirant salt and about 2 to 16% water, with the balance being polyhydric alcohol.An alkaline glycinate salt, such as sodium, potassium or zinc glycinate, may be added to the polyhydric alcohol prior to the addition of the antiperspirant salt solution in order to raise the pH of the recovered product to about 4.1 to 5.0.

摘要翻译： 本发明包括通过（a）提供基本上由约5重量％至约18重量％的增强的功效铝止汗酸盐在水中的水溶液制备增强的功效性铝止汗药盐在多元醇中的溶液的方法 已经在原位制备了不再干燥成固体粉末的增强效力的铝止汗药; （b）将水溶液与足量的液体多元醇混合以提供具有止汗剂盐与多元醇比为约1:4至约1.2:1的混合溶液; 和（c）在真空下从混合溶液中快速蒸发水，以提供含有约20至50％增强效力的铝止汗塞盐和约2至16％水的最终液体多元醇溶液，余量为多元醇。碱性 可以在添加止汗盐溶液之前将甘氨酸盐，例如甘氨酸钠，钾或锌，加入到多元醇中，以将回收产物的pH提高至约4.1至5.0。

公开(公告)号：US5798094A

公开(公告)日：1998-08-25

申请号：US718884

申请日：1996-09-24

申请人： Tuan M. Vu ,  Jayant N. Sane ,  Craig M. Coe

发明人： Tuan M. Vu ,  Jayant N. Sane ,  Craig M. Coe

IPC分类号： A61K8/36 ,  A61Q15/00 ,  A61K7/32

CPC分类号： A61Q15/00 ,  A61K8/0229 ,  A61K8/361 ,  A61K2800/262 ,  A61K2800/51

摘要： Soap-based clear cosmetic sticks are disclosed which include an alkali metal salt of a chelating agent into the stick composition to increase the set temperature and the stick hardness and to prevent the formation of precipitates in the composition during aging. A typical composition of the present invention comprises about 40 to 90%, preferably about 50 to 80%, of a polyhydric alcohol, about 5 to 35%, preferably 15 to 30%, water, about 3 to 12%, preferably 4 to 8%, of an alkali metal salt of a C.sub.12-22, preferably C.sub.14-18, fatty acid, and about 0.3 to 1.6%, preferably about 0.5 to 1.3% of an alkali metal salt of a chelating agent, preferably a sodium or potassium salt of ethylene diamine tetraacetic acid (EDTA). The composition will also typically contain a cosmetic active ingredient such as a deodorant active. Preferably the composition will contain less than 0.3%, most preferably less than 0.2%, of C.sub.20-22 soap in order to achieve maximum clarity.

摘要翻译： 公开了一种基于皂的透明化妆棒，其包括螯合剂的碱金属盐进入棒状组合物中以提高设定温度和棒状硬度，并防止在老化期间在组合物中形成析出物。 本发明的典型组合物包含约40至90％，优选约50至80％的多元醇，约5至35％，优选15至30％的水，约3至12％，优选4至8 ％的C12-22的碱金属盐，优选C14-18，脂肪酸，和约0.3至1.6％，优选约0.5至1.3％的螯合剂的碱金属盐，优选钠或钾盐 的乙二胺四乙酸（EDTA）。 组合物还通常含有美容活性成分如除臭剂活性成分。 优选地，组合物将含有小于0.3％，最优选小于0.2％的C20-22皂以实现最大的清晰度。

公开(公告)号：US5705171A

公开(公告)日：1998-01-06

申请号：US695839

申请日：1996-07-10

申请人： Carl F. Iovanni ,  Tuan M. Vu ,  Jayant N. Sane

发明人： Carl F. Iovanni ,  Tuan M. Vu ,  Jayant N. Sane

IPC分类号： A61K8/02 ,  A61K8/04 ,  A61K8/26 ,  A61K8/28 ,  A61K8/34 ,  A61K8/44 ,  A61K8/49 ,  A61K8/73 ,  A61Q15/00 ,  A61K7/34

CPC分类号： A61K8/042 ,  A61K8/0229 ,  A61K8/26 ,  A61K8/28 ,  A61K8/345 ,  A61K8/44 ,  A61K8/498 ,  A61K8/731 ,  A61Q15/00 ,  A61K2800/262 ,  A61K2800/51 ,  A61K2800/5422

摘要： A clear gel cosmetic stick includes a liquid vehicle, a dibenzylidene alditol as a gelling agent, an antiperspirant salt dissolved in the liquid vehicle, and a chelating agent. The cosmetic stick comprises in percent by weight about 40% to about 95% of the liquid vehicle, from about 0.1% to about 5% of the dibenzylidene alditol, from about 0.5% to about 25% of the antiperspirant salt, and from about 0.05% to about 3% of the chelating agent. The cosmetic stick is preferably substantially free of alkaline gelling agent stabilizers such as NaOH and KOH.

摘要翻译： 透明凝胶化妆棒包括液体载体，作为胶凝剂的二亚苄基糖醇，溶解在液体载体中的止汗剂盐和螯合剂。 化妆棒包含重量百分比约为液体载体的约40％至约95％，约0.1％至约5％的二亚苄基糖醇，约0.5％至约25％的止汗盐，以及约0.05 ％至约3％的螯合剂。 化妆棒优选基本上不含碱性胶凝剂稳定剂如NaOH和KOH。

公开(公告)号：US5939055A

公开(公告)日：1999-08-17

申请号：US913739

申请日：1998-04-14

申请人： Tuan M. Vu ,  Carl F. Iovanni ,  Jayant N. Sane

发明人： Tuan M. Vu ,  Carl F. Iovanni ,  Jayant N. Sane

IPC分类号： A61K8/26 ,  A61K8/28 ,  A61K8/34 ,  A61K8/49 ,  A61K8/73 ,  A61Q15/00 ,  A61K7/32 ,  A61K7/00 ,  A61K7/34 ,  A61K7/38

CPC分类号： A61K8/042 ,  A61K8/26 ,  A61K8/28 ,  A61K8/34 ,  A61K8/498 ,  A61K8/731 ,  A61Q15/00 ,  A61K2800/262 ,  A61K2800/51 ,  A61K2800/5422 ,  Y10S424/05

摘要： A clear gel cosmetic stick is disclosed which includes a liquid vehicle, an antiperspirant salt dissolved in the liquid vehicle, a dibenzylidene alditol, and a co-gellant. The co-gellant is preferably a hydroxyalkyl cellulose and the stick optionally also includes a chelating agent. The cosmetic stick comprises in percent by weight about 70% to about 95%, preferably 75 to 92%, of a liquid vehicle, about 1% to about 22%, preferably 3% to 15%, of an antiperspirant salt dissolved in the vehicle, about 0.5% to about 2% of a dibenzylidene alditol, about 0.1% to about 0.5%, preferably 0.2% to 0.4%, of a hydroxyalkyl cellulose, and optionally about 0.05% to about 3%, preferably 0.1% to 2%, of a chelating agent. Preferably the liquid vehicle comprises a polyhydric alcohol having from 3 to 6 carbon atoms and from 2 to 6 hydroxyl groups and is substantially free of monohydric alcohol and strong alkali such as sodium hydroxide and potassium hydroxide. Preferably the cosmetic stick will have a turbidity of less than about 120 NTU, more preferably less than 100 NTU, and a hardness of about 60 to 150.

摘要翻译： PCT No.PCT / US96 / 02836 Sec。 371日期：1998年4月14日 102（e）1998年4月14日PCT PCT 1996年2月29日PCT公布。 公开号WO96 / 26709 日期1996年9月6日公开了一种透明的凝胶化妆棒，其包括液体载体，溶解在液体载体中的止汗剂盐，二亚苄基糖醇和共胶凝剂。 共胶凝剂优选为羟烷基纤维素，并且棒任选地还包含螯合剂。 化妆棒包括以重量计约70％至约95％，优选75至92％的液体载体，约1％至约22％，优选3％至15％的溶解在载体中的止汗盐 ，约0.5％至约2％的二亚苄基糖醇，约0.1％至约0.5％，优选0.2％至0.4％的羟烷基纤维素，以及约0.05％至约3％，优选0.1％至2％ 的螯合剂。 优选地，液体载体包含具有3至6个碳原子和2至6个羟基的多元醇，并且基本上不含一元醇和强碱如氢氧化钠和氢氧化钾。 优选地，化妆棒的浊度小于约120NTU，更优选小于100NTU，硬度为约60至150。

公开(公告)号：US4338295A

公开(公告)日：1982-07-06

申请号：US206126

申请日：1980-11-12

申请人： Derek R. Highley ,  Jayant N. Sane

发明人： Derek R. Highley ,  Jayant N. Sane

IPC分类号： A61K7/09 ,  A61K7/11

CPC分类号： A61Q5/04 ,  A61K8/84 ,  A61K2800/95

摘要： Compositions and method for imparting shampoo resistant body and settability to human hair comprising the application of an aqueous solution containing a precondensate of glyceraldehyde and resorcinol under conditions promoting in situ polymerization. Tendency for yellowing of gray hair is substantially avoided by incorporation in the solution of urea.

摘要翻译： 赋予洗发剂抵抗体和对人发的可固化性的组合物和方法，其包括在促进原位聚合的条件下应用含有甘油醛和间苯二酚的预缩合物的水溶液。 通过掺入尿素溶液中，可以显着避免灰白发变黄的倾向。