公开(公告)号：US08043215B2

公开(公告)日：2011-10-25

申请号：US11834792

申请日：2007-08-07

申请人： Yunlong Zhang ,  Yi Zhang

发明人： Yunlong Zhang ,  Yi Zhang

IPC分类号： A61B5/00

CPC分类号： A61M5/14276 ,  A61B5/0031 ,  A61B5/021 ,  A61B5/0215 ,  A61B5/076 ,  A61B5/0809 ,  A61B5/4839 ,  A61M2205/3523 ,  A61M2205/3561 ,  A61N1/3627 ,  A61N1/37282

摘要： A method for titrating a drug to provide a medical therapy to a patient. The method includes the steps of providing an implantable medical device having a controller, providing one or more implantable sensors configured to sense physical parameters of the patient and configured to transmit signals to the controller. The method further includes the step of receiving signals from the one or more sensors at the controller. The method additionally includes processing the received signals to determine at least two cardiopulmonary characteristics of the patient. The method also includes determining a composite index based on the at least two cardiopulmonary characteristics. In addition, the method includes generating a signal based on the composite index. Medical device systems are also disclosed.

摘要翻译： 滴定药物以向患者提供药物治疗的方法。 该方法包括以下步骤：提供具有控制器的可植入医疗设备，提供一个或多个可植入的传感器，其被配置为感测患者的物理参数并被配置为向控制器传输信号。 该方法还包括从控制器处的一个或多个传感器接收信号的步骤。 该方法还包括处理接收的信号以确定患者的至少两个心肺特征。 该方法还包括基于至少两个心肺特征确定复合指数。 另外，该方法包括基于复合索引生成信号。 还公开了医疗装置系统。

公开(公告)号：US20090227883A1

公开(公告)日：2009-09-10

申请号：US12396196

申请日：2009-03-02

申请人： Yunlong Zhang ,  Yi Zhang ,  Abhilash Patangay

发明人： Yunlong Zhang ,  Yi Zhang ,  Abhilash Patangay

IPC分类号： A61B5/04 ,  A61B5/00

CPC分类号： A61B5/0205 ,  A61B5/0816 ,  A61B5/7264 ,  A61B5/7275 ,  G06F19/3418 ,  G16H40/63 ,  G16H50/30

摘要： A system and method automatically classifies a patient's heart function status, such as by using an implantable medical device (IMD) to determine a physiological response to activity, and using that information to perform the classification. For example, a physical activity sensor and a physiological sensor are used to automatically classify patients into heart function status classes, such as NYHA classes or ACC/AHA classes. Changes in a patient's classification can be used to monitor heart function status over time and to monitor therapy responsiveness.

摘要翻译： 系统和方法自动对患者的心脏功能状态进行分类，例如通过使用可植入医疗装置（IMD）来确定对活动的生理反应，并使用该信息进行分类。 例如，身体活动传感器和生理传感器用于将患者自动分类为心脏功能状态类别，例如NYHA类别或ACC / AHA类别。 患者分类的变化可用于随时间监测心脏功能状态并监测治疗反应。

公开(公告)号：US20090043289A1

公开(公告)日：2009-02-12

申请号：US11834792

申请日：2007-08-07

申请人： Yunlong Zhang ,  Yi Zhang

发明人： Yunlong Zhang ,  Yi Zhang

IPC分类号： A61M5/14

CPC分类号： A61M5/14276 ,  A61B5/0031 ,  A61B5/021 ,  A61B5/0215 ,  A61B5/076 ,  A61B5/0809 ,  A61B5/4839 ,  A61M2205/3523 ,  A61M2205/3561 ,  A61N1/3627 ,  A61N1/37282

摘要： A method for titrating a drug to provide a medical therapy to a patient. The method includes the steps of providing an implantable medical device having a controller, providing one or more implantable sensors configured to sense physical parameters of the patient and configured to transmit signals to the controller. The method further includes the step of receiving signals from the one or more sensors at the controller. The method additionally includes processing the received signals to determine at least two cardiopulmonary characteristics of the patient. The method also includes determining a composite index based on the at least two cardiopulmonary characteristics. In addition, the method includes generating a signal based on the composite index. Medical device systems are also disclosed.

摘要翻译： 滴定药物以向患者提供药物治疗的方法。 该方法包括以下步骤：提供具有控制器的可植入医疗设备，提供一个或多个可植入的传感器，其被配置为感测患者的物理参数并被配置为向控制器传输信号。 该方法还包括从控制器处的一个或多个传感器接收信号的步骤。 该方法还包括处理接收的信号以确定患者的至少两个心肺特征。 该方法还包括基于至少两个心肺特征确定复合指数。 另外，该方法包括基于复合索引生成信号。 还公开了医疗装置系统。

公开(公告)号：US08321003B2

公开(公告)日：2012-11-27

申请号：US12508398

申请日：2009-07-23

申请人： Yi Zhang ,  Kenneth C. Beck ,  Aaron Lewicke ,  Yunlong Zhang

发明人： Yi Zhang ,  Kenneth C. Beck ,  Aaron Lewicke ,  Yunlong Zhang

IPC分类号： A61B5/04

CPC分类号： A61B5/0205 ,  A61B5/02055 ,  A61B5/0215 ,  A61B5/03 ,  A61B5/4519

摘要： Various method embodiments of the present invention concern sensing patient-internal pressure measurements indicative of physiological exertion, identifying one or more steady state periods of physiological exertion based on the patient-internal pressure measurements, sensing extra-cardiac response data and cardiac response data corresponding to the one or more physiological exertion steady state periods, respectively comparing the extra-cardiac response data and the cardiac response data to extra-cardiac response information and cardiac response information associated with equivalent levels of physiological exertion intensity of the one or more steady state periods, and determining the likelihood that myocardial ischemia occurred during the one or more steady state periods based on the comparison of the extra-cardiac response data to the extra-cardiac response information and the cardiac response data to the cardiac response information.

摘要翻译： 本发明的各种方法实施例涉及感测指示生理消耗的患者 - 内部压力测量，基于患者内部的压力测量，感测心脏外的心脏反应数据和对应于心脏的心脏反应数据来识别生理消耗的一个或多个稳定状态时段 一个或多个生理活动稳态时段，分别将心外反应数据和心脏响应数据与心脏外反应信息和与一个或多个稳态周期的等效生理消耗强度水平相关联的心脏反应信息进行比较， 以及基于心外反应数据与心外反应信息和对心脏反应信息的心脏反应数据的比较，确定在一个或多个稳态期间发生心肌缺血的可能性。

公开(公告)号：US20120035486A1

公开(公告)日：2012-02-09

申请号：US13275741

申请日：2011-10-18

申请人： Yunlong Zhang ,  Yi Zhang

发明人： Yunlong Zhang ,  Yi Zhang

IPC分类号： A61B5/0205 ,  A61B5/0452 ,  A61B5/02 ,  A61B5/0402

CPC分类号： A61M5/14276 ,  A61B5/0031 ,  A61B5/021 ,  A61B5/0215 ,  A61B5/076 ,  A61B5/0809 ,  A61B5/4839 ,  A61M2205/3523 ,  A61M2205/3561 ,  A61N1/3627 ,  A61N1/37282

摘要： A method of monitoring patient status is disclosed. Electrical signals are received from one or more implanted sensors of a cardiac rhythm management device. Two or more index values are calculated from the electrical signals. A composite index is determined from the two or more index values, and a status notification associated with the composite index is provided. In a system for monitoring patient status, a processor is configured to receive electrical signals from an implanted cardiac rhythm management device, calculate two or more index values from the electrical signals, and determine a composite index from the two or more index values. The system incorporates a memory that is in communication with the processor and an interface in communication with the processor, where the interface is configured to communicate a status notification associated with the composite index.

摘要翻译： 公开了一种监测患者状态的方法。 从心脏节律管理装置的一个或多个植入的传感器接收电信号。 从电信号计算出两个或多个索引值。 从两个或多个索引值确定复合索引，并提供与复合索引相关联的状态通知。 在用于监视患者状态的系统中，处理器被配置为从植入的心律管理装置接收电信号，从电信号计算两个或更多个索引值，并根据两个或更多个索引值确定复合索引。 该系统包括与处理器通信的存储器和与处理器通信的接口，其中接口被配置为传送与复合索引相关联的状态通知。

公开(公告)号：US08527064B2

公开(公告)日：2013-09-03

申请号：US12327601

申请日：2008-12-03

申请人： Yunlong Zhang ,  Haresh G. Sachanandani ,  Dan Li ,  Bin Mi

发明人： Yunlong Zhang ,  Haresh G. Sachanandani ,  Dan Li ,  Bin Mi

IPC分类号： A61N1/36

CPC分类号： A61N1/0587 ,  A61B5/4035 ,  A61B5/6862 ,  A61B5/6876 ,  A61N1/057 ,  A61N1/36114 ,  A61N1/36117 ,  A61N1/3627 ,  A61N1/37211 ,  A61N1/37288

摘要： Various implantable medical device embodiments stimulate an autonomic neural target from within a pulmonary artery, and comprise at least one electrode, a power supply, a neural stimulator connected to the power supply, and an anchor structure. The neural stimulator is configured to generate a neural stimulation signal for delivery to the neural stimulation target through the at least one electrode. The anchor structure is configured to chronically and securely implant the neural stimulator, the power supply and the at least one electrode within the pulmonary artery. The anchor structure, the neural stimulator, the power supply and the at least one electrode are configured to be implanted through a pulmonary valve into the pulmonary artery. In various embodiments, the neural stimulator is configured to be operational to implement a neural stimulation protocol when chronically implanted within the pulmonary artery without a wired connection through the pulmonary valve.

摘要翻译： 各种可植入医疗装置实施例从肺动脉内刺激自主神经靶标，并且包括至少一个电极，电源，连接到电源的神经刺激器和锚结构。 神经刺激器被配置为产生神经刺激信号，以通过至少一个电极传递到神经刺激靶。 锚结构被配置为长期且牢固地植入神经刺激器，电源和至少一个电极在肺动脉内。 锚结构，神经刺激器，电源和至少一个电极构造成通过肺动脉瓣植入肺动脉。 在各种实施例中，神经刺激器被配置为在长期植入肺动脉内而不通过肺动脉瓣的有线连接的情况下实施神经刺激方案。

公开(公告)号：US20130218221A1

公开(公告)日：2013-08-22

申请号：US13855570

申请日：2013-04-02

申请人： Yongxing Zhang ,  Yunlong Zhang

发明人： Yongxing Zhang ,  Yunlong Zhang

IPC分类号： A61N1/365 ,  A61N1/39

CPC分类号： A61N1/365 ,  A61N1/3605 ,  A61N1/36114 ,  A61N1/3622 ,  A61N1/3624 ,  A61N1/3627 ,  A61N1/368 ,  A61N1/395 ,  A61N1/3956

摘要： According to some method embodiments, a left pulmonary artery electrode is positioned in a left pulmonary artery, and the left pulmonary artery electrode is used to sense atrial activity, or capture cardiac tissue, or deliver neural stimulation. According to some method embodiments, a right pulmonary artery electrode is positioned in a right pulmonary artery and a left pulmonary artery electrode is positioned in a left pulmonary artery, the right pulmonary artery electrode is used to sense atrial activity, or capture cardiac tissue, or deliver neural stimulation, and the left pulmonary artery electrode is used to sense atrial activity, or capture cardiac tissue, or deliver neural stimulation.

摘要翻译： 根据一些方法实施例，左肺动脉电极位于左肺动脉中，并且左肺动脉电极用于感测心房活动或捕获心脏组织或递送神经刺激。 根据一些方法实施例，右肺动脉电极位于右肺动脉中，左肺动脉电极位于左肺动脉中，右肺动脉电极用于感测心房活动或捕获心脏组织，或 传递神经刺激，左肺动脉电极用于感测心房活动或捕获心脏组织，或传递神经刺激。

公开(公告)号：US08494618B2

公开(公告)日：2013-07-23

申请号：US11208922

申请日：2005-08-22

申请人： Yunlong Zhang ,  James O. Gilkerson ,  Yongxing Zhang ,  Boyce Moon

发明人： Yunlong Zhang ,  James O. Gilkerson ,  Yongxing Zhang ,  Boyce Moon

IPC分类号： A61B5/04 ,  A61N1/00

CPC分类号： A61N1/3962 ,  A61N1/3621 ,  A61N1/36521 ,  A61N1/3925

摘要： A system to measure intracardiac impedance includes implantable electrodes and a medical device. The electrodes sense electrical signals of a heart of a subject. The medical device includes a cardiac signal sensing circuit coupled to the implantable electrodes, an impedance measurement circuit coupled to the same or different implantable electrodes, and a controller circuit coupled to the cardiac signal sensing circuit and the impedance measurement circuit. The cardiac signal sensing circuit provides a sensed cardiac signal. The impedance measurement circuit senses intracardiac impedance between the electrodes to obtain an intracardiac impedance signal. The controller circuit determines cardiac cycles of the subject using the sensed cardiac signal, and detects tachyarrhythmia using cardiac-cycle to cardiac-cycle changes in a plurality of intracardiac impedance parameters obtained from the intracardiac impedance signal.

摘要翻译： 测量心内阻抗的系统包括可植入电极和医疗装置。 电极感测受试者心脏的电信号。 医疗装置包括耦合到可植入电极的心脏信号感测电路，耦合到相同或不同可植入电极的阻抗测量电路，以及耦合到心脏信号感测电路和阻抗测量电路的控制器电路。 心脏信号感测电路提供感测的心脏信号。 阻抗测量电路感测电极之间的心内阻抗，以获得心内阻抗信号。 控制器电路使用感测到的心脏信号来确定受试者的心脏周期，并且使用从心脏内阻抗信号获得的多个心内阻抗参数中的心脏周期与心脏周期变化来检测快速性心律失常。

公开(公告)号：US08417355B2

公开(公告)日：2013-04-09

申请号：US12940172

申请日：2010-11-05

申请人： Yongxing Zhang ,  Yunlong Zhang ,  Xuan Wei

发明人： Yongxing Zhang ,  Yunlong Zhang ,  Xuan Wei

IPC分类号： A61N1/05

CPC分类号： A61B5/224 ,  A61B5/0464 ,  A61B5/11 ,  A61B5/6846 ,  A61B5/686 ,  A61B5/6869 ,  A61N1/3627

摘要： A method and apparatus permit sensing one or more forces exerted by one or more portions of a heart. A force transducer and displacement sensor are disclosed. A movement of one or more portions of a heart can be translated into one or more signals indicative of force. These signals can be used to provide information such as to diagnose or treat one or more conditions.

摘要翻译： 一种方法和装置允许感测由心脏的一个或多个部分施加的一个或多个力。 公开了一种力传感器和位移传感器。 心脏的一个或多个部分的运动可以被转换为指示力的一个或多个信号。 这些信号可用于提供诸如诊断或治疗一种或多种病症的信息。

公开(公告)号：US08417354B2

公开(公告)日：2013-04-09

申请号：US12779177

申请日：2010-05-13

申请人： Yongxing Zhang ,  Yunlong Zhang

发明人： Yongxing Zhang ,  Yunlong Zhang

IPC分类号： A61N1/368

CPC分类号： A61N1/365 ,  A61N1/3605 ,  A61N1/36114 ,  A61N1/3622 ,  A61N1/3624 ,  A61N1/3627 ,  A61N1/368 ,  A61N1/395 ,  A61N1/3956

摘要： According to some method embodiments, a left pulmonary artery electrode is positioned in a left pulmonary artery, and the left pulmonary artery electrode is used to sense atrial activity, or capture cardiac tissue, or deliver neural stimulation. According to some method embodiments, a right pulmonary artery electrode is positioned in a right pulmonary artery and a left pulmonary artery electrode is positioned in a left pulmonary artery, the right pulmonary artery electrode is used to sense atrial activity, or capture cardiac tissue, or deliver neural stimulation, and the left pulmonary artery electrode is used to sense atrial activity, or capture cardiac tissue, or deliver neural stimulation.

摘要翻译： 根据一些方法实施例，左肺动脉电极位于左肺动脉中，并且左肺动脉电极用于感测心房活动或捕获心脏组织或递送神经刺激。 根据一些方法实施例，右肺动脉电极位于右肺动脉中，左肺动脉电极位于左肺动脉中，右肺动脉电极用于感测心房活动或捕获心脏组织，或 传递神经刺激，左肺动脉电极用于感测心房活动或捕获心脏组织，或传递神经刺激。