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公开(公告)号：US07230073B2
公开(公告)日：2007-06-12
申请号：US10809654
申请日：2004-03-25
IPC分类号： A61K38/00
CPC分类号： C07K16/28 , A01K2217/05 , A61K39/00 , C07K14/705
摘要： The present invention relates to sperm specific surface proteins, nucleic acid sequences encoding those proteins and antibodies raised against those proteins. Compositions comprising the sperm specific proteins or inhibitors of said proteins can be used in contraceptive applications.
摘要翻译： 本发明涉及精子比表面蛋白，编码这些蛋白质的核酸序列和针对这些蛋白产生的抗体。 包含精子特异性蛋白质或所述蛋白质抑制剂的组合物可用于避孕应用。
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公开(公告)号：US07094547B2
公开(公告)日：2006-08-22
申请号：US10809655
申请日：2004-03-25
CPC分类号： C07K16/28 , A01K2217/05 , A61K39/00 , C07K14/705
摘要： The present invention relates to sperm specific surface proteins, nucleic acid sequences encoding those proteins and antibodies raised against those proteins. Compositions comprising the sperm specific proteins or inhibitors of said proteins can be used in contraceptive applications.
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公开(公告)号：US06924121B2
公开(公告)日：2005-08-02
申请号：US10181642
申请日：2001-01-19
IPC分类号： G01N33/50 , A61K38/00 , A61K39/00 , A61K39/395 , A61K45/00 , A61P15/18 , C07H21/04 , C07K14/47 , C07K14/705 , C07K16/18 , C07K16/28 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/06 , C12N5/10 , C12N9/00 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , A61K30/395
CPC分类号： C07K16/28 , A01K2217/05 , A61K39/00 , C07K14/705
摘要： The present invention relates to sperm specific surface proteins, nucleic acid sequences encoding those proteins and antibodies raised against those proteins. Compositions comprising the sperm specific proteins or inhibitors of said proteins can be used in contraceptive applications.
摘要翻译： 本发明涉及精子比表面蛋白，编码这些蛋白质的核酸序列和针对这些蛋白产生的抗体。 包含精子特异性蛋白质或所述蛋白质抑制剂的组合物可用于避孕应用。
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公开(公告)号：US07125550B2
公开(公告)日：2006-10-24
申请号：US10181611
申请日：2001-01-19
IPC分类号： A61K39/395 , A61K39/40 , A61K39/42 , C12N5/00 , C12N5/02
CPC分类号： C12N9/2462 , A61K39/0006 , C07K16/40 , C12Y302/01017 , G01N2500/00 , Y10S514/841
摘要： The present invention relates to two novel, testis-specific proteins (C19 and C23) that arc lysozyme paralogues. The proteins are believed to play a role in capacitation of sperm and the fertilization of the ovum. Therefore these compounds make ideal targets for the design of contraceptive agents. The C19 and C23 proteins can also be modified to establish lysozyme activity and the modified proteins can then be used in all applications that currently exist for lysozymes.
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5.发明申请公开(公告)号：US20080318250A1
公开(公告)日：2008-12-25
申请号：US10588445
申请日：2005-02-07
CPC分类号： C07K16/28 , G01N33/56966
摘要： Methods and compositions for identifying and isolating sperm cells from samples containing multiple cell types are described. The methods and compositions employ antibodies that specifically bind to sperm-specific antigens located on or internal to the sperm plasma membrane. A reporter molecule may be conjugated to the antibodies to aid in the detection of sperm. The antibodies may be targeted to sperm-specific antigens in the head and/or tail of sperm to facilitate the identification and isolation of sperm cells from forensic samples prepared from sexual assault evidence. Purified DNA from the isolated sperm cells can be amplified by polymerase chain reaction to assist forensic analysis in sexual assault cases.
摘要翻译： 描述了从含有多种细胞类型的样品中鉴定和分离精子细胞的方法和组合物。 方法和组合物使用特异性结合位于精子质膜上或内部的精子特异性抗原的抗体。 报告分子可以与抗体缀合以帮助检测精子。 抗体可以针对精子头部和/或尾部的精子特异性抗原，以促进从性攻击证据准备的法医样品中鉴定和分离精子细胞。 可以通过聚合酶链反应扩增分离的精子细胞的纯化DNA，以协助性攻击病例的法医分析。
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