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公开(公告)号：US07541383B2
公开(公告)日：2009-06-02
申请号：US11986863
申请日：2007-11-26
申请人： Zice Fu , Xi Alan Huang , Jiwen Liu , Julio C. Medina , Michael J. Schmitt , H. Lucy Tang , Yingcai Wang , Qingge Xu
发明人： Zice Fu , Xi Alan Huang , Jiwen Liu , Julio C. Medina , Michael J. Schmitt , H. Lucy Tang , Yingcai Wang , Qingge Xu
CPC分类号： C07C205/37 , C07C205/56 , C07C233/75 , C07C271/28 , C07C275/42 , C07C311/08 , C07C311/21 , C07C311/29 , C07C317/44 , C07C2601/04 , C07C2601/08 , C07D209/22 , C07D209/26 , C07D213/71 , C07D215/36 , C07D233/84 , C07D243/12 , C07D243/24 , C07D257/04 , C07D295/192 , C07D307/91 , C07D333/34 , C07D333/62
摘要： Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of inflammatory and immune-related diseases and conditions. In particular, the invention provides compounds which modulate the function and/or expression of proteins involved in atopic diseases, inflammatory conditions and cancer. The subject compounds are carboxylic acid derivatives.
摘要翻译： 提供了可用于治疗炎症和免疫相关疾病和病症的化合物，药物组合物和方法。 特别地，本发明提供调节参与特应性疾病，炎性病症和癌症的蛋白质的功能和/或表达的化合物。 主题化合物是羧酸衍生物。
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公开(公告)号：US07321001B2
公开(公告)日：2008-01-22
申请号：US10742281
申请日：2003-12-19
申请人： Zice Fu , Xi Alan Huang , Jiwen Liu , Julio C. Medina , Michael J. Schmitt , H. Lucy Tang , Yingcai Wang , Qingge Xu
发明人： Zice Fu , Xi Alan Huang , Jiwen Liu , Julio C. Medina , Michael J. Schmitt , H. Lucy Tang , Yingcai Wang , Qingge Xu
IPC分类号： A61K31/18 , C07C311/30
CPC分类号： C07C205/37 , C07C205/56 , C07C233/75 , C07C271/28 , C07C275/42 , C07C311/08 , C07C311/21 , C07C311/29 , C07C317/44 , C07C2601/04 , C07C2601/08 , C07D209/22 , C07D209/26 , C07D213/71 , C07D215/36 , C07D233/84 , C07D243/12 , C07D243/24 , C07D257/04 , C07D295/192 , C07D307/91 , C07D333/34 , C07D333/62
摘要： Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of inflammatory and immune-related diseases and conditions. In particular, the invention provides compounds which modulate the function and/or expression of proteins involved in atopic diseases, inflammatory conditions and cancer. The subject compounds are carboxylic acid derivatives.
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公开(公告)号：US07714008B2
公开(公告)日：2010-05-11
申请号：US11900006
申请日：2007-09-06
申请人： Hilary Beck , Paul Dransfield , Zice Fu , Jonathan B. Houze , XianYun Jiao , Todd J. Kohn , SuJen Lai , Jinqian Liu , Jiwen Liu , Zhihua Ma , Julio C. Medina , Michael J. Schmitt , Rajiv Sharma , Wang Shen , Marc Vimolratana , Yingcai Wang , Zhongyu Wang
发明人： Hilary Beck , Paul Dransfield , Zice Fu , Jonathan B. Houze , XianYun Jiao , Todd J. Kohn , SuJen Lai , Jinqian Liu , Jiwen Liu , Zhihua Ma , Julio C. Medina , Michael J. Schmitt , Rajiv Sharma , Wang Shen , Marc Vimolratana , Yingcai Wang , Zhongyu Wang
IPC分类号： A61K31/192 , A61K31/422 , C07C59/11 , C07D261/06
CPC分类号： C07D261/08 , C07D409/12 , C07D413/06 , C07D413/12 , C07D417/12
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
摘要翻译： 本发明提供了可用于例如治疗受试者的代谢紊乱的化合物。 这些化合物具有通式I：其中本文提供变量的定义。 本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病例如II型糖尿病中的使用方法。
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公开(公告)号：US08003648B2
公开(公告)日：2011-08-23
申请号：US12613418
申请日：2009-11-05
申请人： Hilary Beck , Paul Dransfield , Zice Fu , Jonathan B. Houze , XianYun Jiao , Todd J. Kohn , SuJen Lai , Jinqian Liu , Jiwen Liu , Zhihua Ma , Julio C. Medina , Michael J. Schmitt , Rajiv Sharma , Wang Shen , Marc Vimolratana , Yingcai Wang , Zhongyu Wang
发明人： Hilary Beck , Paul Dransfield , Zice Fu , Jonathan B. Houze , XianYun Jiao , Todd J. Kohn , SuJen Lai , Jinqian Liu , Jiwen Liu , Zhihua Ma , Julio C. Medina , Michael J. Schmitt , Rajiv Sharma , Wang Shen , Marc Vimolratana , Yingcai Wang , Zhongyu Wang
IPC分类号： A61K31/498 , A61K31/42 , A61K31/426 , A61K31/4245 , A61K31/443 , C07D261/06 , C07D277/22 , C07D271/06 , C07D413/02 , C07D241/36 , A61P3/10 , A61P9/00
CPC分类号： C07D261/08 , C07D409/12 , C07D413/06 , C07D413/12 , C07D417/12
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
摘要翻译： 本发明提供了可用于例如治疗受试者的代谢紊乱的化合物。 这些化合物具有通式I：其中本文提供变量的定义。 本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病例如II型糖尿病中的使用方法。
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公开(公告)号：US20100075974A1
公开(公告)日：2010-03-25
申请号：US12613418
申请日：2009-11-05
申请人： Hilary Beck , Paul Dransfield , Zice Fu , Jonathan B. Houze , Xian Yun Jiao , Todd J. Kohn , SuJen Lai , Jinqian Liu , Jiwen Liu , Zhihua Ma , Julio C. Medina , Michael J. Schmitt , Rajiv Sharma , Wang Shen , Marc Vimolratana , Yingcai Wang , Zhongyu Wang
发明人： Hilary Beck , Paul Dransfield , Zice Fu , Jonathan B. Houze , Xian Yun Jiao , Todd J. Kohn , SuJen Lai , Jinqian Liu , Jiwen Liu , Zhihua Ma , Julio C. Medina , Michael J. Schmitt , Rajiv Sharma , Wang Shen , Marc Vimolratana , Yingcai Wang , Zhongyu Wang
IPC分类号： A61K31/498 , C07D261/06 , A61K31/42 , C07D277/22 , A61K31/426 , C07D271/06 , A61K31/4245 , C07D413/02 , A61K31/443 , C07D241/36 , A61P3/10 , A61P9/00
CPC分类号： C07D261/08 , C07D409/12 , C07D413/06 , C07D413/12 , C07D417/12
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
摘要翻译： 本发明提供了可用于例如治疗受试者的代谢紊乱的化合物。 这些化合物具有通式I：其中本文提供变量的定义。 本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病例如II型糖尿病中的使用方法。
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公开(公告)号：US20110190330A1
公开(公告)日：2011-08-04
申请号：US13119951
申请日：2009-10-13
申请人： Sean P. Brown , Paul Dransfield , Xiaohui Du , Zice Fu , Jonathan Houze , XianYun Jiao , Sujen Lai , An-Rong Li , Jiwen Liu , Zhihua Ma , Julio C. Medina , Vatee Pattaropong , Wang Shen , Marc Vimolratana , Yingcai Wang , Zhongyu Wang , Ming Yu , Liusheng Zhu
发明人： Sean P. Brown , Paul Dransfield , Xiaohui Du , Zice Fu , Jonathan Houze , XianYun Jiao , Sujen Lai , An-Rong Li , Jiwen Liu , Zhihua Ma , Julio C. Medina , Vatee Pattaropong , Wang Shen , Marc Vimolratana , Yingcai Wang , Zhongyu Wang , Ming Yu , Liusheng Zhu
IPC分类号： A61K31/4418 , C07C69/757 , C07C62/34 , C07D213/64 , C07D249/08 , C07D311/96 , C07D217/24 , C07D231/12 , A61K31/216 , A61K31/192 , A61K31/4196 , A61K31/352 , A61K31/415 , A61K31/426 , A61P3/10
CPC分类号： C07C62/34 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07D213/643 , C07D217/24 , C07D253/065 , C07D277/22 , C07D311/04 , C07D401/12
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula IA, IB, I′A or I′B: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
摘要翻译： 本发明提供了可用于例如治疗受试者的代谢紊乱的化合物。 这些化合物具有通式IA，IB，I'A或I'B：其中本文提供变量的定义。 本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病例如II型糖尿病中的使用方法。
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公开(公告)号：US08030354B2
公开(公告)日：2011-10-04
申请号：US12287036
申请日：2008-10-03
申请人： Sean P. Brown , Qiong Cao , Paul John Dransfield , Xiaohui Du , Zice Fu , Jonathan Houze , Xian Yun Jiao , Yong-Jae Kim , Todd J. Kohn , SuJen Lai , An-Rong Li , Daniel Lin , Jiwen Liu , Jian Luo , Julio C. Medina , Jeffrey D. Reagan , Vatee Pattaropong , Margrit Schwarz , Wang Shen , Yongli Su , Gayathri Swaminath , Marc Vimolratana , Yingcai Wang , Yumei Xiong , Li Yang , Ming Yu , Jie Zhang , Liusheng Zhu
发明人： Sean P. Brown , Qiong Cao , Paul John Dransfield , Xiaohui Du , Zice Fu , Jonathan Houze , Xian Yun Jiao , Yong-Jae Kim , Todd J. Kohn , SuJen Lai , An-Rong Li , Daniel Lin , Jiwen Liu , Jian Luo , Julio C. Medina , Jeffrey D. Reagan , Vatee Pattaropong , Margrit Schwarz , Wang Shen , Yongli Su , Gayathri Swaminath , Marc Vimolratana , Yingcai Wang , Yumei Xiong , Li Yang , Ming Yu , Jie Zhang , Liusheng Zhu
IPC分类号： A61K31/192 , C07C53/134
CPC分类号： C07C323/62 , C07C59/68 , C07C59/72 , C07C217/54 , C07C217/62 , C07C317/22 , C07C323/19 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/42 , C07C2603/74 , C07D213/64 , C07D309/12
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
摘要翻译： 本发明提供了可用于例如治疗受试者的代谢紊乱的化合物。 这些化合物具有通式I：其中本文提供变量的定义。 本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病例如II型糖尿病中的使用方法。
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公开(公告)号：US08748462B2
公开(公告)日：2014-06-10
申请号：US13119951
申请日：2009-10-13
申请人： Sean P. Brown , Paul Dransfield , Xiaohui Du , Zice Fu , Jonathan Houze , XianYun Jiao , Sujen Lai , An-Rong Li , Jiwen Liu , Zhihua Ma , Julio C. Medina , Vatee Pattaropong , Wang Shen , Marc Vimolratana , Yingcai Wang , Zhongyu Wang , Ming Yu , Liusheng Zhu
发明人： Sean P. Brown , Paul Dransfield , Xiaohui Du , Zice Fu , Jonathan Houze , XianYun Jiao , Sujen Lai , An-Rong Li , Jiwen Liu , Zhihua Ma , Julio C. Medina , Vatee Pattaropong , Wang Shen , Marc Vimolratana , Yingcai Wang , Zhongyu Wang , Ming Yu , Liusheng Zhu
IPC分类号： A61K31/19 , C07C69/76 , C07D211/72 , C07D211/84 , C07D213/62 , A61K31/44
CPC分类号： C07C62/34 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07D213/643 , C07D217/24 , C07D253/065 , C07D277/22 , C07D311/04 , C07D401/12
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula IA, IB, I′A or I′B: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
摘要翻译： 本发明提供了可用于例如治疗受试者的代谢紊乱的化合物。 这些化合物具有通式IA，IB，I'A或I'B：其中本文提供变量的定义。 本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病例如II型糖尿病中的使用方法。
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9.发明授权公开(公告)号：US07816367B2
公开(公告)日：2010-10-19
申请号：US10591214
申请日：2005-02-24
申请人： Michelle Akerman , Jonathan Houze , Daniel C. H. Lin , Jiwen Liu , Jian Luo , Julio C. Medina , Wei Qiu , Jeffrey D. Reagan , Rajiv Sharma , Stephen J. Shuttleworth , Ying Sun , Jian Zhang , Liusheng Zhu , Jinqian Liu , Zhihua Ma , Yingcai Wang , Michael J. Schmitt
发明人： Michelle Akerman , Jonathan Houze , Daniel C. H. Lin , Jiwen Liu , Jian Luo , Julio C. Medina , Wei Qiu , Jeffrey D. Reagan , Rajiv Sharma , Stephen J. Shuttleworth , Ying Sun , Jian Zhang , Liusheng Zhu , Jinqian Liu , Zhihua Ma , Yingcai Wang , Michael J. Schmitt
IPC分类号： A61K31/44 , C07D213/02
CPC分类号： C07D277/24 , C07D277/30
摘要： The present invention provides compounds useful, for example, for modulating insulin levels in a subject and that have the general formula Q-L1-P-L2-M-X-L3-A wherein the definitions of the variables Q, L1, P, L2, M, X, L3 and A are provided herein. The present invention also provides compositions and methods for use of the compounds, for instance, for treatment of type II diabetes.
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公开(公告)号：US07687526B2
公开(公告)日：2010-03-30
申请号：US11900014
申请日：2007-09-06
申请人： Sean P. Brown , Paul Dransfield , Jonathan B. Houze , Jinqian Liu , Jiwen Liu , Zhihua Ma , Julio C. Medina , Vatee Pattaropong , Michael J. Schmitt , Rajiv Sharma , Yingcai Wang
发明人： Sean P. Brown , Paul Dransfield , Jonathan B. Houze , Jinqian Liu , Jiwen Liu , Zhihua Ma , Julio C. Medina , Vatee Pattaropong , Michael J. Schmitt , Rajiv Sharma , Yingcai Wang
IPC分类号： A61K31/4192 , A61K31/192 , C07D249/04 , C07C59/13
CPC分类号： C07D233/64 , C07C51/09 , C07C51/367 , C07C51/47 , C07C235/34 , C07C2602/10 , C07D207/327 , C07D213/55 , C07D231/12 , C07D239/26 , C07D249/10 , C07D257/04 , C07D261/08 , C07D263/32 , C07D277/587 , C07D285/12 , C07D333/24 , C07C59/72
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables and A are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
摘要翻译： 本发明提供了可用于例如治疗受试者的代谢紊乱的化合物。 这些化合物具有通式I：其中本文提供变量和A的定义。 本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病例如II型糖尿病中的使用方法。
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