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公开(公告)号：US10953080B2
公开(公告)日：2021-03-23
申请号：US16166455
申请日：2018-10-22
申请人： Zoetis Services LLC
发明人： Paul Joseph Dominowski , Dennis L. Foss , Guillermo Gallo , John Morgan Hardham , Richard Lee Krebs , Sandra Ann Marie Lightle , Suman Mahan , Sangita Mediratta , Kaori Mohr , Duncan Mwangi , Sharath K. Rai , Sarah A. Salmon , Shaunak Vora , Lauren Wilmes
IPC分类号： A61K39/00 , A61K39/39 , A61K9/107 , A61K39/12 , A61K39/07 , A61K39/09 , A61K39/012 , A61K39/108 , A61K39/05 , A61K39/08 , A61K39/118 , A61K39/002 , A61K39/085 , G01N33/569
摘要： The instant invention provides various formulations comprising combinations of immunostimulating oligonucleotides, polycationic carriers, sterols, saponins, quaternary amines, TLR-3 agonists, glycolipids, and MPL-A or analogs thereof in oil emulsions, use thereof in preparations of immunogenic compositions and vaccines, and use thereof in the treatment of animals.
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公开(公告)号：US20190038737A1
公开(公告)日：2019-02-07
申请号：US16166455
申请日：2018-10-22
申请人： Zoetis Services LLC
发明人： Paul Joseph Dominowski , Dennis L. Foss , Guillermo Gallo , John Morgan Hardham , Richard Lee Krebs , Sandra Ann Marie Lightle , Suman Mahan , Sangita Mediratta , Kaori Mohr , Duncan Mwangi , Sharath K. Rai , Sarah A. Salmon , Shaunak Vora , Lauren Wilmes
IPC分类号： A61K39/09 , A61K39/00 , A61K39/002 , A61K39/012 , A61K39/108 , A61K39/05 , A61K39/08 , A61K39/085 , A61K39/118 , A61K39/12 , A61K39/39 , G01N33/569
摘要： The instant invention provides various formulations comprising combinations of immunostimulating oligonucleotides, polycationic carriers, sterols, saponins, quaternary amines, TLR-3 agonists, glycolipids, and MPL-A or analogs thereof in oil emulsions, use thereof in preparations of immunogenic compositions and vaccines, and use thereof in the treatment of animals.
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公开(公告)号：US10117921B2
公开(公告)日：2018-11-06
申请号：US14491414
申请日：2014-09-19
申请人： Zoetis Services LLC
发明人： Paul Joseph Dominowski , Dennis L. Foss , Guillermo Gallo , John Morgan Hardham , Richard Lee Krebs , Sandra Ann Marie Lightle , Suman Mahan , Sangita Mediratta , Kaori Mohr , Duncan Mwangi , Sharath K. Rai , Sarah A. Salmon , Shaunak Vora , Lauren Wilmes
IPC分类号： A61K39/00 , A61K39/12 , C12N7/00 , A61K31/404 , A61K39/39 , A61K39/09 , A61K39/012 , A61K39/108 , A61K39/05 , A61K39/08 , A61K39/118 , A61K39/002 , A61K39/085 , G01N33/569
摘要： The instant invention provides various formulations comprising combinations of immunostimulating oligonucleotides, polycationic carriers, sterols, saponins, quaternary amines, TLR-3 agonists, glycolipids, and MPL-A or analogs thereof in oil emulsions, use thereof in preparations of immunogenic compositions and vaccines, and use thereof in the treatment of animals.
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公开(公告)号：US20240358825A1
公开(公告)日：2024-10-31
申请号：US18406869
申请日：2024-01-08
申请人： Zoetis Services LLC
发明人： Paul Joseph Dominowski , Ramasamy Mannar Mannan , Richard Lee Krebs , James Richard Thompson , Tedd Alan Childers , Mary Kathryn Olsen , Robert John Yancey, Jr. , Risini Dhammika Weeratna , Shucheng Zhang , Cedo Martin Bagi
IPC分类号： A61K39/39 , A61K39/00 , A61K39/002 , A61K39/012 , A61K39/02 , A61K39/108 , A61K39/12 , A61K39/145 , A61K39/15 , A61K39/21 , A61K39/215 , A61P37/02
CPC分类号： A61K39/39 , A61K39/0011 , A61K39/002 , A61K39/012 , A61K39/0208 , A61K39/0241 , A61K39/0258 , A61K39/12 , A61K39/145 , A61K39/15 , A61K39/21 , A61K39/215 , A61P37/02 , A61K2039/521 , A61K2039/5252 , A61K2039/5254 , A61K2039/54 , A61K2039/55 , A61K2039/552 , A61K2039/55505 , A61K2039/55511 , A61K2039/55555 , A61K2039/55561 , A61K2039/55566 , A61K2039/55572 , A61K2039/55577 , C12N2720/12334 , C12N2720/12351 , C12N2740/13034 , C12N2740/13051 , C12N2760/16134 , C12N2760/16151 , C12N2770/20034 , C12N2770/20051 , C12N2770/24334 , C12N2770/24351 , Y02A50/30
摘要： This invention relates to adjuvant formulations comprising various combinations of triterpenoids, sterols, immunomodulators, polymers, and Th2 stimulators; methods for making the adjuvant compositions; and the use of the adjuvant formulations in immunogenic and vaccine compositions with different antigens. This invention further relates to the use of the formulations in the treatment of animals.
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公开(公告)号：US12121576B2
公开(公告)日：2024-10-22
申请号：US18318093
申请日：2023-05-16
申请人： Zoetis Services LLC
发明人： Paul Joseph Dominowski , Dennis L. Foss , Guillermo Gallo , John Morgan Hardham , Richard Lee Krebs , Sandra Ann Marie Lightle , Suman Mahan , Sangita Mediratta , Kaori Mohr , Duncan Mwangi , Sharath K. Rai , Sarah A. Salmon , Shaunak Vora , Lauren Wilmes
IPC分类号： A61K39/00 , A61K39/002 , A61K39/012 , A61K39/05 , A61K39/08 , A61K39/085 , A61K39/09 , A61K39/108 , A61K39/118 , A61K39/12 , A61K39/39 , C12N7/00 , G01N33/569
CPC分类号： A61K39/092 , A61K39/0002 , A61K39/0003 , A61K39/0005 , A61K39/002 , A61K39/012 , A61K39/0258 , A61K39/05 , A61K39/08 , A61K39/085 , A61K39/118 , A61K39/12 , A61K39/39 , G01N33/56944 , A61K2039/552 , A61K2039/55561 , A61K2039/55566 , A61K2039/55572 , A61K2039/55577 , A61K2039/55583 , G01N2333/315 , G01N2469/10 , Y02A50/30
摘要： The instant invention provides various formulations comprising combinations of immunostimulating oligonucleotides, polycationic carriers, sterols, saponins, quaternary amines, TLR-3 agonists, glycolipids, and MPL-A or analogs thereof in oil emulsions, use thereof in preparations of immunogenic compositions and vaccines, and use thereof in the treatment of animals.
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公开(公告)号：US20170304434A1
公开(公告)日：2017-10-26
申请号：US15494920
申请日：2017-04-26
申请人： Zoetis Services LLC
发明人： Paul Joseph Dominowski , Ramasamy Mannar Mannan , Richard Lee Krebs , James Richard Thompson , Tedd Alan Childers , Mary Kathryn Olsen , Robert John Yancey, Jr. , Risini Dhammika Weeratna , Shucheng Zhang , Cedo Martin Bagi
IPC分类号： A61K39/39 , A61K39/012 , A61K39/02 , A61K39/108 , A61K39/00 , A61K39/145 , A61K39/15 , A61K39/21 , A61K39/215 , A61K39/12 , A61K39/002
CPC分类号： A61K39/39 , A61K39/0011 , A61K39/002 , A61K39/012 , A61K39/0208 , A61K39/0241 , A61K39/0258 , A61K39/12 , A61K39/145 , A61K39/15 , A61K39/21 , A61K39/215 , A61K2039/521 , A61K2039/5252 , A61K2039/5254 , A61K2039/54 , A61K2039/55 , A61K2039/552 , A61K2039/55505 , A61K2039/55511 , A61K2039/55555 , A61K2039/55561 , A61K2039/55566 , A61K2039/55572 , A61K2039/55577 , C12N2720/12334 , C12N2720/12351 , C12N2740/13034 , C12N2740/13051 , C12N2760/16134 , C12N2760/16151 , C12N2770/20034 , C12N2770/20051 , C12N2770/24334 , C12N2770/24351 , Y02A50/474
摘要： This invention relates to adjuvant formulations comprising various combinations of triterpenoids, sterols, immunomodulators, polymers, and Th2 stimulators; methods for making the adjuvant compositions; and the use of the adjuvant formulations in immunogenic and vaccine compositions with different antigens. This invention further relates to the use of the formulations in the treatment of animals.
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公开(公告)号：US09662385B2
公开(公告)日：2017-05-30
申请号：US14013299
申请日：2013-08-29
申请人： Zoetis Services LLC
发明人： Paul Joseph Dominowski , Ramasamy Mannar Mannan , Richard Lee Krebs , James Richard Thompson , Tedd Alan Childers , Mary Kathryn Olsen , Robert John Yancey, Jr. , Risini Dhammika Weeratna , Shucheng Zhang , Cedo Martin Bagi
IPC分类号： A61K45/00 , A61K39/39 , A61K39/00 , A61K39/012 , A61K39/02 , A61K39/108 , A61K39/12 , A61K39/145 , A61K39/15 , A61K39/21 , A61K39/215 , A61K39/002
CPC分类号： A61K39/39 , A61K39/0011 , A61K39/002 , A61K39/012 , A61K39/0208 , A61K39/0241 , A61K39/0258 , A61K39/12 , A61K39/145 , A61K39/15 , A61K39/21 , A61K39/215 , A61K2039/521 , A61K2039/5252 , A61K2039/5254 , A61K2039/54 , A61K2039/55 , A61K2039/552 , A61K2039/55505 , A61K2039/55511 , A61K2039/55555 , A61K2039/55561 , A61K2039/55566 , A61K2039/55572 , A61K2039/55577 , C12N2720/12334 , C12N2720/12351 , C12N2740/13034 , C12N2740/13051 , C12N2760/16134 , C12N2760/16151 , C12N2770/20034 , C12N2770/20051 , C12N2770/24334 , C12N2770/24351 , Y02A50/474
摘要： This invention relates to adjuvant formulations comprising various combinations of triterpenoids, sterols, immunomodulators, polymers, and Th2 stimulators; methods for making the adjuvant compositions; and the use of the adjuvant formulations in immunogenic and vaccine compositions with different antigens. This invention further relates to the use of the formulations in the treatment of animals.
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公开(公告)号：US20210338810A1
公开(公告)日：2021-11-04
申请号：US17195003
申请日：2021-03-08
申请人： Zoetis Services LLC
发明人： Paul Joseph Dominowski , Ramasamy Mannar Mannan , Richard Lee Krebs , James Richard Thompson , Tedd Alan Childers , Mary Kathryn Olsen , Robert John Yancey, JR. , Risini Dhammika Weeratna , Shucheng Zhang , Cedo Martin Bagi
IPC分类号： A61K39/39 , A61K39/12 , A61K39/21 , A61K39/145 , A61K39/108 , A61K39/215 , A61K39/02 , A61K39/012 , A61K39/00 , A61K39/15 , A61P37/02 , A61K39/002
摘要： This invention relates to adjuvant formulations comprising various combinations of triterpenoids, sterols, immunomodulators, polymers, and Th2 stimulators; methods for making the adjuvant compositions; and the use of the adjuvant formulations in immunogenic and vaccine compositions with different antigens. This invention further relates to the use of the formulations in the treatment of animals.
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公开(公告)号：US20210170013A1
公开(公告)日：2021-06-10
申请号：US17176749
申请日：2021-02-16
申请人： Zoetis Services LLC
发明人： Paul Joseph Dominowski , Dennis L. Foss , Guillermo Gallo , John Morgan Hardham , Richard Lee Krebs , Sandra Ann Marie Lightle , Suman Mahan , Sangita Mediratta , Kaori Mohr , Duncan Mwangi , Sharath K. Rai , Sarah A. Salmon , Shaunak Vora , Lauren Wilmes
IPC分类号： A61K39/09 , A61K39/085 , A61K39/00 , A61K39/12 , A61K39/012 , G01N33/569 , A61K39/08 , A61K39/39 , A61K39/118 , A61K39/002 , A61K39/05 , A61K39/108
摘要： The instant invention provides various formulations comprising combinations of immunostimulating oligonucleotides, polycationic carriers, sterols, saponins, quaternary amines, TLR-3 agonists, glycolipids, and MPL-A or analogs thereof in oil emulsions, use thereof in preparations of immunogenic compositions and vaccines, and use thereof in the treatment of animals.
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公开(公告)号：US10238736B2
公开(公告)日：2019-03-26
申请号：US15494920
申请日：2017-04-26
申请人： Zoetis Services LLC
发明人： Paul Joseph Dominowski , Ramasamy Mannar Mannan , Richard Lee Krebs , James Richard Thompson , Tedd Alan Childers , Mary Kathryn Olsen , Robert John Yancey, Jr. , Risini Dhammika Weeratna , Shucheng Zhang , Cedo Martin Bagi
IPC分类号： A61K39/39 , A61K39/00 , A61K39/012 , A61K39/02 , A61K39/108 , A61K39/12 , A61K39/145 , A61K39/15 , A61K39/21 , A61K39/215 , A61K39/002
摘要： This invention relates to adjuvant formulations comprising various combinations of triterpenoids, sterols, immunomodulators, polymers, and Th2 stimulators; methods for making the adjuvant compositions; and the use of the adjuvant formulations in immunogenic and vaccine compositions with different antigens. This invention further relates to the use of the formulations in the treatment of animals.
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