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139 条记录 (耗时 0.097 秒)

    (1-azinone)-substituted pyridoindoles
    1.
    发明授权
    (1-azinone)-substituted pyridoindoles 有权

    公开(公告)号：US09650378B2

    公开(公告)日：2017-05-16

    申请号：US15045652

    申请日：2016-02-17

    申请人： Albany Molecular Research, Inc.

    发明人： Peter Guzzo ,  Matthew David Surman ,  Alan John Henderson ,  May Xiaowu Jiang ,  Mark Hadden ,  James Grabowski ,  Alexander Usyatinsky

    IPC分类号： C07D471/04 ,  C07D521/00 ,  C07D519/00

    CPC分类号： C07D471/04 ,  C07D519/00 ,  C07D521/00

    摘要： Substituted pyridoindoles for incorporation in pharmaceutical compositions employed in the treatment of various diseases correspond to formula (I) wherein R1 is H or optionally substituted alkyl; R2, R3, R4 are each independently selected from H, —O-alkyl, —S-alkyl, alkyl, halo, —CF3, and —CN; G is —CR12R13—NR5— or —NR5—CR12R13; R5 is H, optionally substituted alkyl, optionally substituted heterocycle, —C(═O)—R6, —C(═O)—O—R7, or —C(═O)—NR19R20; R6 and R7 are each optionally substituted alkyl or optionally substituted heterocycle; R8, R9, R10, R11, R12, R13, R19 and R20 are each independently selected from H or optionally substituted alkyl; R14 and R15 are each independently H or halogen; L is —CH2—O—, —CH2CH2—, —CH═CH— or a bond; and B is aryl or heteroaryl or cycloalkyl; with the proviso that, when L is a direct bond, B cannot be unsubstituted heteroaryl or heteroaryl monosubstituted with fluorine.