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    Serum protein-based detection of random sequence polymer compositions
    3.
    发明授权
    Serum protein-based detection of random sequence polymer compositions 有权
    随机序列聚合物组合物的基于蛋白质的血清检测

    公开(公告)号：US08790665B2

    公开(公告)日：2014-07-29

    申请号：US13510021

    申请日：2010-11-17

    申请人： Eric H. Zanelli ,  Jeff Krieger ,  Joe Connolly ,  Kathryn H. Collins

    发明人： Eric H. Zanelli ,  Jeff Krieger ,  Joe Connolly ,  Kathryn H. Collins

    IPC分类号： A61K39/00 ,  C07K1/22 ,  C07K1/00 ,  G01N33/68

    CPC分类号： C07K1/22 ,  C07K1/00 ,  G01N33/68

    摘要： There exist in the art methods of detecting simple peptides. However, methods to determine the effective plasma concentration of mixtures of peptides as a group, rather than for individual peptides with a defined amino acid sequence, are complicated by the heterogeneity of the peptides to be detected. This application provides improved methods of detecting and assessing random sequence polymer (RSP) compositions, methods for the detection and quantitation of RSP compositions, means to determine and enrich a subset of peptides in an RSP composition based on the subset's interactions with certain capture polypeptides, and methods for administering RSP compositions to a subject in need thereof, wherein the dosage regimen and quantity may be determined or evaluated based on the above-mentioned methods for detection and quantitation.

    摘要翻译： 在本领域中存在检测简单肽的方法。 然而，确定作为一组的肽的混合物的有效血浆浓度的方法，而不是具有确定的氨基酸序列的单个肽的方法由于待检测的肽的异质性而复杂化。 该应用提供了检测和评估随机序列聚合物（RSP）组合物的改进方法，用于检测和定量RSP组合物的方法，用于基于该子集与某些捕获多肽的相互作用来确定和富集RSP组合物中的肽亚组， 以及将RSP组合物施用于有需要的受试者的方法，其中可以基于上述检测和定量的方法来确定或评估所述剂量方案和量。

    Medication delivery device
    4.
    发明授权
    Medication delivery device 有权
    药物输送装置

    公开(公告)号：US08043254B2

    公开(公告)日：2011-10-25

    申请号：US11884007

    申请日：2006-01-23

    申请人： Enrico Chavez ,  Sandrine Piotelat ,  Vincent Pongpairochana

    发明人： Enrico Chavez ,  Sandrine Piotelat ,  Vincent Pongpairochana

    IPC分类号： A61M31/00

    CPC分类号： A61M5/31511 ,  A61M5/20 ,  A61M5/24 ,  A61M2005/31518 ,  A61M2205/14 ,  A61M2205/33

    摘要： The medication delivery device is designed to receive a replaceable medication container (5) and to determine an adjusted medication dose AD for each medication container (5) received if the amount of medication contained in the medication container (5) is not a multiple of a prescribed dose D. The adjusted medication dose is the dose to be delivered instead of the prescribed dose at each use of the medication delivery device with the medication container (5) received. The adjusted dose is determined by selecting one of a first dose, that is higher than the prescribed dose, and of a second dose, that is lower than the prescribed dose, as a function of a variable B that cumulates the values nAD. (AD−D), where nAD is equal to INT (Cont/AD) and Cont is the amount of medication in the medication container received.

    摘要翻译： 药物输送装置被设计成接收可更换的药物容器（5），并且如果药物容器（5）中所含的药物量不是一个或多个，则确定每个药物容器（5）接收的经调整的药物剂量AD 处方剂量D.调整后的药物剂量是在药物容器（5）接收时每次使用药物输送装置时，而不是规定的剂量。 通过选择低于规定剂量的第一剂量和低于规定剂量的第二剂量中的一种作为累积值nAD的变量B的函数来确定调整剂量。 （AD-D），其中nAD等于INT（Cont / AD），Cont是接收的药物容器中的药物量。

    Injection device
    5.
    外观设计
    Injection device 有权

    公开(公告)号：USD1034965S1

    公开(公告)日：2024-07-09

    申请号：US35518320

    申请日：2023-03-13

    申请人： ARES TRADING SA

    设计人： Maxime Ettori

    摘要： 1. Injection device.
    1.1 : Perspective
    1.2 : Perspective
    1.3 : Perspective
    1.4 : Perspective
    1.5 : Perspective
    1.6 : Front
    1.7 : Front view, deployed
    1.8 : Back
    1.9 : Top
    1.10 : Bottom
    1.11 : Left
    1.12 : Right
    The shape of the claimed design is elongated with height larger than width and width larger than depth; the front side features a rounded push-button and a rectangular display screen; on the left side is an oval power on-off button, a semi-rectangular cartridge door button with upper rounded edges, and a partially transparent rectangular cartridge door, deploy-able as shown in Fig. 1.7; on the bottom is a circular needle cavity surrounded by four elongated and curved anti-slip coverings, and an essentially rectangular battery cover that also partially fits the outer shape of the product; on the back are three protrusions for better grip, a rounded space intended to the device's labeling, and a bracket-like strap fixation means; on the right is a semi-rectangular push-button with upper rounded edges.

    METHODS FOR IMPROVING THE DESIGN, BIOAVAILABILITY, AND EFFICACY OF DIRECTED SEQUENCE POLYMER COMPOSITIONS VIA SERUM PROTEIN-BASED DETECTION OF DIRECTED SEQUENCE POLYMER COMPOSITIONS
    6.
    发明申请
    METHODS FOR IMPROVING THE DESIGN, BIOAVAILABILITY, AND EFFICACY OF DIRECTED SEQUENCE POLYMER COMPOSITIONS VIA SERUM PROTEIN-BASED DETECTION OF DIRECTED SEQUENCE POLYMER COMPOSITIONS 审中-公开
    通过基于蛋白质的指导序列聚合物组合物的检测来改进方向序列聚合物组合物的设计，生物利用度和效率的方法

    公开(公告)号：US20120282296A1

    公开(公告)日：2012-11-08

    申请号：US13510017

    申请日：2010-11-17

    申请人： Eric H. Zanelli ,  Jeff Krieger ,  Joe Connolly ,  Kathryn H. Collins

    发明人： Eric H. Zanelli ,  Jeff Krieger ,  Joe Connolly ,  Kathryn H. Collins

    IPC分类号： C40B30/04 ,  C40B40/10 ,  A61P37/06 ,  A61K38/02

    CPC分类号： C07K1/22 ,  C07K1/00 ,  G01N33/68

    摘要： There exist in the art methods of detecting simple peptides. However, methods to determine the effective plasma concentration of directed sequence polymers (DSPs), are complicated because DSPs are complex mixtures of peptides, as opposed to individual peptides with a defined amino acid sequence. This application provides improved methods of detecting and assessing DSP compositions, methods for the detection and quantitation of DSP compositions, means to determine and enrich a subset of peptides in a DSP composition based on the subset's interactions with certain capture polypeptides, and methods for administering DSP compositions to a subject in need thereof, wherein the dosage regimen and quantity may be determined or evaluated based on the above-mentioned methods for detection and quantitation.

    摘要翻译： 在本领域中存在检测简单肽的方法。 然而，确定定向序列聚合物（DSP）的有效血浆浓度的方法是复杂的，因为DSP是肽的复杂混合物，与具有确定的氨基酸序列的单个肽相反。 该应用提供了检测和评估DSP组合的改进方法，用于DSP组合物的检测和定量的方法，基于该子集与某些捕获多肽的相互作用来确定和丰富DSP组合中肽的子集的方法，以及用于管理DSP 可以根据上述检测和定量的方法确定或评估给药方案和剂量。

    METHODS OF TREATING DISEASE WITH RANDOM COPOLYMERS
    9.
    发明申请
    METHODS OF TREATING DISEASE WITH RANDOM COPOLYMERS 审中-公开
    用随机共聚物治疗疾病的方法

    公开(公告)号：US20140249089A1

    公开(公告)日：2014-09-04

    申请号：US14169672

    申请日：2014-01-31

    申请人： James Rasmussen ,  Jianxin Zhang ,  Sam Baldwin ,  Eric Zannelli ,  Bei Yu ,  Dustan Bonnin ,  Keith Johnson ,  Jeff Krieger

    发明人： James Rasmussen ,  Jianxin Zhang ,  Sam Baldwin ,  Eric Zannelli ,  Bei Yu ,  Dustan Bonnin ,  Keith Johnson ,  Jeff Krieger

    IPC分类号： C07K14/435

    CPC分类号： C07K14/435 ,  A61K9/0019 ,  A61K31/785 ,  A61K38/02

    摘要： The invention relates to novel methods and kits for treating or preventing disease through the administration of random copolymers. The invention also relates to the treatment of autoimmune diseases, such as multiple sclerosis, and to the administration of random copolymers in treatment regimen comprising formulations that are administered at intervals greater than 24 hours, or to sustained release formulations which administer the copolymer over a period greater than 24 hours. The invention further relates to methods for conducting a pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the formulations or dosing regimens of random copolymer described herein.

    摘要翻译： 本发明涉及通过施用无规共聚物治疗或预防疾病的新方法和试剂盒。 本发明还涉及自身免疫性疾病如多发性硬化的治疗，以及在包含以大于24小时的间隔施用的制剂的治疗方案中施用无规共聚物，或者涉及在一段时间内施用共聚物的持续释放制剂 超过24小时。 本发明还涉及用于进行药物业务的方法，其包括制造，许可或分发包含本文所述的无规共聚物的制剂或给药方案的试剂盒。

    Methods of treating disease with random copolymers
    10.
    发明授权
    Methods of treating disease with random copolymers 有权
    用无规共聚物治疗疾病的方法

    公开(公告)号：US08475779B2

    公开(公告)日：2013-07-02

    申请号：US12637723

    申请日：2009-12-14

    申请人： James Rasmussen ,  Jianxin Zhang ,  Sam Baldwin ,  Eric Zanelli ,  Bei Yu ,  Dustan Bonnin ,  Keith Johnson

    发明人： James Rasmussen ,  Jianxin Zhang ,  Sam Baldwin ,  Eric Zanelli ,  Bei Yu ,  Dustan Bonnin ,  Keith Johnson

    IPC分类号： A61K9/107 ,  A61K31/74 ,  A61K38/02

    CPC分类号： A61K38/02 ,  A61K38/16 ,  A61K2300/00

    摘要： The invention relates to novel methods and kits for treating or preventing disease through the administration of random copolymers comprising amino acids tyrosine (Y), phenylalanine (F), alanine (A), and lysine (K). The invention also relates to the treatment of autoimmune diseases, such as multiple sclerosis, and to the administration of random copolymers in treatment regimen comprising formulations that are administered at intervals greater than 24 hours, or to sustained release formulations which administer the copolymer over a period greater than 24 hours. The invention further relates to methods for conducting a pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the formulations or dosing regimens of random copolymer described herein.

    摘要翻译： 本发明涉及通过施用包含氨基酸酪氨酸（Y），苯丙氨酸（F），丙氨酸（A）和赖氨酸（K））的无规共聚物来治疗或预防疾病的新方法和试剂盒。 本发明还涉及自身免疫性疾病如多发性硬化的治疗，以及在包含以大于24小时的间隔施用的制剂的治疗方案中施用无规共聚物，或者涉及在一段时间内施用共聚物的持续释放制剂 超过24小时。 本发明还涉及用于进行药物业务的方法，其包括制造，许可或分发包含本文所述的无规共聚物的制剂或给药方案的试剂盒。