公开(公告)号：US08423132B2

公开(公告)日：2013-04-16

申请号：US10538521

申请日：2003-12-11

申请人： Shai Vaingast ,  Ehud Cohen

发明人： Shai Vaingast ,  Ehud Cohen

IPC分类号： A61N1/00

CPC分类号： A61N1/36142 ,  A61N1/36521 ,  A61N1/37 ,  A61N1/3716

摘要： A method for measuring impedance of a tissue (20), consisting of charging a capacitor (C15) to a potential, and discharging the capacitor for a discharge period through the tissue. The method further consists of measuring a voltage drop on the capacitor over the discharge period and determining the impedance of the tissue responsive to the potential, the voltage drop, and the discharge period.

摘要翻译： 一种用于测量组织（20）的阻抗的方法，包括将电容器（C15）充电到电位，并且通过所述组织将电容器放电放电期间。 该方法还包括在放电周期内测量电容器上的电压降，并根据电位，电压降和放电周期确定组织的阻抗。

公开(公告)号：US08386056B2

公开(公告)日：2013-02-26

申请号：US11070842

申请日：2005-02-24

申请人： Tamir Ben David ,  Shai Ayal ,  Ehud Cohen

发明人： Tamir Ben David ,  Shai Ayal ,  Ehud Cohen

IPC分类号： A61N1/00

CPC分类号： A61B5/412 ,  A61B5/024 ,  A61B5/4029 ,  A61B5/4041 ,  A61B5/7217 ,  A61N1/0551 ,  A61N1/0556 ,  A61N1/36114 ,  A61N1/3621 ,  A61N1/3627

摘要： Apparatus is provided that includes an electrode device, adapted to be coupled to a vagus nerve of a subject, and a control unit, adapted to drive the electrode device to apply to the vagus nerve a current that reduces heart rate variability of the subject. Also provided is a method comprising applying to a vagus nerve of a subject a current that reduces heart rate variability of the subject.

摘要翻译： 提供了包括适于联接到受试者的迷走神经的电极装置和控制单元的装置，所述控制单元适于驱动所述电极装置向所述迷走神经施加降低所述受试者心率变异性的电流。 还提供了一种方法，包括向受试者的迷走神经施加减少受试者心率变异性的电流。

公开(公告)号：US08116881B2

公开(公告)日：2012-02-14

申请号：US11978776

申请日：2007-10-29

申请人： Ehud Cohen ,  Tamir Ben-David ,  Shai Ayal ,  Omry Ben-Ezra

发明人： Ehud Cohen ,  Tamir Ben-David ,  Shai Ayal ,  Omry Ben-Ezra

IPC分类号： A61N1/05

CPC分类号： A61N1/0551 ,  A61N1/0556 ,  A61N1/36114

摘要： Apparatus is provided for applying current to a nerve, including a housing, configured to be placed in a vicinity of the nerve. At least one electrode is fixed to the housing such that the at least one electrode does not come in direct physical contact with the nerve when the housing is placed in the vicinity of the nerve, and such that the electrode surrounds greater than 180 degrees of a circumference of the nerve after the placement of the housing. Two end insulating elements are fixed to the housing such that the at least one electrode is between the end insulating elements, and the end insulating elements come in contact or practically in contact with the nerve when the housing is placed in the vicinity of the nerve. Other embodiments are also described.

摘要翻译： 提供了用于将电流施加到神经的装置，包括被配置为放置在神经附近的壳体。 至少一个电极被固定到壳体，使得当壳体放置在神经附近时，至少一个电极不会与神经直接物理接触，并且使得电极围绕大于180度的 放置外壳后神经的周长。 两个端部绝缘元件固定到壳体上，使得至少一个电极位于端部绝缘元件之间，并且当壳体放置在神经附近时，端部绝缘元件接触或实际上与神经接触。 还描述了其它实施例。

公开(公告)号：US07904151B2

公开(公告)日：2011-03-08

申请号：US11975407

申请日：2007-10-19

申请人： Tamir Ben-David ,  Shai Ayal ,  Omry Ben-Ezra ,  Ehud Cohen

发明人： Tamir Ben-David ,  Shai Ayal ,  Omry Ben-Ezra ,  Ehud Cohen

IPC分类号： A61N1/39

CPC分类号： A61N1/36114 ,  A61N1/3621

摘要： Apparatus is provided including an implantable sensor, adapted to sense an electrical parameter of a heart of a subject, and a first control unit, adapted to apply pulses to the heart responsively to the sensed parameter, the pulses selected from the list consisting of: pacing pulses and anti-arrhythmic energy. The apparatus further includes an electrode device, adapted to be coupled to a site of the subject selected from the list consisting of: a vagus nerve of the subject, an epicardial fat pad of the subject, a pulmonary vein of the subject, a carotid artery of the subject, a carotid sinus of the subject, a coronary sinus of the subject, a vena cava vein of the subject, a right ventricle of the subject, and a jugular vein of the subject; and a second control unit, adapted to drive the electrode device to apply to the site a current that increases parasympathetic tone of the subject and affects a heart rate of the subject. The first and second control units are not under common control. At least one of the control units is adapted to coordinate an aspect of its operation with an aspect of operation of the other control unit. Other embodiments are also described.

摘要翻译： 提供了包括适于感测对象的心脏的电参数的可植入传感器和适于响应于所感测的参数向心脏施加脉冲的第一控制单元，从列表中选择的脉冲包括：起搏 脉冲和抗心律变能。 所述装置还包括电极装置，适于耦合到选自以下列表的对象的部位：包括受试者的迷走神经，受试者的心外膜脂肪垫，受试者的肺静脉，颈动脉 受试者的颈动脉窦，受试者的冠状窦，受试者的腔静脉，受试者的右心室和受试者的颈静脉; 以及第二控制单元，其适于驱动所述电极装置向所述部位施加增加所述受试者的副交感神经紧张并影响所述受试者的心率的电流。 第一和第二控制单元不在一般控制之下。 控制单元中的至少一个适于将其操作的一个方面与其他控制单元的操作的一个方面协调。 还描述了其它实施例。

公开(公告)号：US07778711B2

公开(公告)日：2010-08-17

申请号：US10719659

申请日：2003-11-20

申请人： Tamir Ben-David ,  Shai Ayal ,  Omry Ben-Ezra ,  Ehud Cohen

发明人： Tamir Ben-David ,  Shai Ayal ,  Omry Ben-Ezra ,  Ehud Cohen

IPC分类号： A61N1/00

CPC分类号： A61B5/412 ,  A61B5/024 ,  A61B5/4029 ,  A61B5/4041 ,  A61B5/7217 ,  A61N1/0551 ,  A61N1/0556 ,  A61N1/36114 ,  A61N1/3621 ,  A61N1/3627

摘要： Apparatus is provided that includes an electrode device, adapted to be coupled to a vagus nerve of a subject, and a control unit, adapted to drive the electrode device to apply to the vagus nerve a current that reduces heart rate variability of the subject. Also provided is a method comprising applying to a vagus nerve of a subject a current that reduces heart rate variability of the subject.

摘要翻译： 提供了包括适于联接到受试者的迷走神经的电极装置和控制单元的装置，所述控制单元适于驱动所述电极装置向所述迷走神经施加降低所述受试者心率变异性的电流。 还提供了一种方法，包括向受试者的迷走神经施加减少受试者心率变异性的电流。

公开(公告)号：US07778702B2

公开(公告)日：2010-08-17

申请号：US11975240

申请日：2007-10-17

申请人： Tamir Ben-David ,  Omry Ben-Ezra ,  Ehud Cohen

发明人： Tamir Ben-David ,  Omry Ben-Ezra ,  Ehud Cohen

IPC分类号： A61N1/18

CPC分类号： A61N1/36114 ,  A61N1/36117 ,  A61N1/3621 ,  A61N1/395 ,  A61N1/3962

摘要： A method is provided for treating a subject, including applying a current to a site of the subject selected from the list consisting of: a vagus nerve of the subject, an epicardial fat pad of the subject, a pulmonary vein of the subject, a carotid artery of the subject, a carotid sinus of the subject, a vena cava vein of the subject, and an internal jugular vein of the subject. The method also includes configuring the current so as to treat a condition of the subject selected from the list consisting of: an autoimmune disease, an autoimmune inflammatory disease, multiple sclerosis, encephalitis, myelitis, immune-mediated neuropathy, myositis, dermatomyositis, polymyositis, inclusion body myositis, inflammatory demyelinating polyradiculoneuropathy, Guillain Barre syndrome, myasthenia gravis, inflammation of the nervous system, inflammatory bowel disease, Crohn's disease, ulcerative colitis, SLE (systemic lupus erythematosus), rheumatoid arthritis, vasculitis, polyarteritis nodosa, Sjogren syndrome, mixed connective tissue disease, glomerulonephritis, thyroid autoimmune disease, sepsis, meningitis, a bacterial infection, a viral infection, a fungal infection, sarcoidosis, hepatitis, and portal vein hypertension.

摘要翻译： 提供了一种用于治疗受试者的方法，包括将电流施加到从包括受试者的迷走神经，受试者的心外膜脂肪垫，受试者的肺静脉，颈动脉 受试者的动脉，受试者的颈动脉窦，受试者的腔静脉和受试者的颈内静脉。 该方法还包括配置电流以便治疗从以下列表中选择的受试者的状况：自身免疫疾病，自身免疫性炎性疾病，多发性硬化症，脑炎，脊髓炎，免疫介导的神经病，肌炎，皮肌炎，多发性肌炎， 包涵体肌炎，炎性脱髓鞘多发性神经病，吉兰巴利综合征，重症肌无力，神经系统炎症，炎性肠病，克罗恩病，溃疡性结肠炎，SLE（系统性红斑狼疮），类风湿性关节炎，血管炎，结节性多动脉炎，干燥综合征，混合 结缔组织病，肾小球性肾炎，甲状腺自身免疫性疾病，败血症，脑膜炎，细菌感染，病毒感染，真菌感染，结节病，肝炎和门静脉高血压。

公开(公告)号：US08909355B2

公开(公告)日：2014-12-09

申请号：US13661512

申请日：2012-10-26

申请人： Bio Control Medical (B.C.M.) Ltd.

发明人： Shai Ayal ,  Ehud Cohen

IPC分类号： A61N1/05 ,  A61N1/36

CPC分类号： A61N1/0556 ,  A61N1/36017 ,  A61N1/3605

摘要： Apparatus is provided for applying current to a nerve, including a housing, adapted to be placed in a vicinity of the nerve, and at least one cathode and at least one anode, fixed to the housing. The apparatus further includes two or more passive electrodes, fixed to the housing, and a conducting element, which electrically couples the passive electrodes to one another. Other embodiments are also described.

摘要翻译： 提供了用于向包括适于放置在神经附近的包括壳体的神经施加电流的装置，以及固定到壳体的至少一个阴极和至少一个阳极。 该装置还包括固定到壳体的两个或多个无源电极和将无源电极彼此电耦合的导电元件。 还描述了其它实施例。

公开(公告)号：US08880192B2

公开(公告)日：2014-11-04

申请号：US13437114

申请日：2012-04-02

申请人： Tamir Ben-David ,  Noam Gavish ,  Tsachi Czaczkes

发明人： Tamir Ben-David ,  Noam Gavish ,  Tsachi Czaczkes

IPC分类号： A61N1/00

CPC分类号： A61N1/0556 ,  A61N1/3605

摘要： An electrode assembly includes electrodes and a cuff, shaped so as to define a tubular housing that defines a longitudinal axis therealong, two edges, and a slit between the two edges. When the housing is closed, respective contact surfaces of the two edges touch each other, and the housing defines an inner surface that faces and surrounds the axis, to which inner surface the electrodes are fixed. The cuff further defines three or more annular insulating elements that extend toward the axis from the inner surface of the housing at respective longitudinal positions along the housing, such that the inner surface of the housing and pairs of the insulating elements define, at respective longitudinal positions along the housing, respective chambers open toward the axis. The housing is shaped such that the contact surfaces of the two edges extend toward the axis and protrude into the chambers.

摘要翻译： 电极组件包括电极和袖带，其形状为限定一个管状外壳，其限定其纵向轴线，两个边缘和两个边缘之间的狭缝。 当壳体关闭时，两个边缘的相应的接触表面彼此接触，并且壳体限定面向并围绕轴线的内表面，电极固定到内表面。 袖带进一步限定三个或更多个环形绝缘元件，其在沿着壳体的相应纵向位置处从壳体的内表面朝着轴线延伸，使得壳体的内表面和成对的绝缘元件在相应的纵向位置 沿着壳体，各个腔室朝向轴线开口。 壳体被成形为使得两个边缘的接触表面朝着轴线延伸并突出到腔室中。

公开(公告)号：US08571653B2

公开(公告)日：2013-10-29

申请号：US13022279

申请日：2011-02-07

申请人： Tamir Ben-David ,  Ehud Cohen ,  Yossi Gross ,  Shai Ayal

发明人： Tamir Ben-David ,  Ehud Cohen ,  Yossi Gross ,  Shai Ayal

IPC分类号： A61N1/00

CPC分类号： A61N1/36071 ,  A61N1/36075 ,  A61N1/36114

摘要： A method is provided for treating heart failure in a subject in need of such treatment, including applying a stimulating current to parasympathetic nervous tissue of the subject, selected from the group consisting of: a vagus nerve and an epicardial fat pad. The stimulating current is configured to inhibit release of at least one proinflammatory cytokine sufficiently to the treat heart failure of the subject. A level of the at least one proinflammatory cytokine is measured. Optionally, the stimulating current is configured to change a level of Connexin 43 of the subject, and the level of Connexin 43 is also measured. Other embodiments are also described.

摘要翻译： 提供了一种用于治疗需要这种治疗的受试者的心力衰竭的方法，包括向受试者的副交感神经组织施加刺激电流，所述副交感神经组织选自：迷走神经和心外膜脂肪垫。 刺激电流被配置为抑制至少一种促炎细胞因子释放足以治疗受试者的心力衰竭。 测量至少一种促炎细胞因子的水平。 可选地，刺激电流被配置为改变受试者的连接蛋白43的水平，并且还测量连接蛋白43的水平。 还描述了其它实施例。

公开(公告)号：US08494655B2

公开(公告)日：2013-07-23

申请号：US13271720

申请日：2011-10-12

申请人： Shai Ayal ,  Ehud Cohen

发明人： Shai Ayal ,  Ehud Cohen

IPC分类号： A61N1/05

CPC分类号： A61N1/0556 ,  A61N1/0551 ,  A61N1/36007 ,  A61N1/36071 ,  A61N1/36114

摘要： Apparatus is provided for applying current to a nerve. A cathode is adapted to be placed in a vicinity of a cathodic longitudinal site of the nerve and to apply a cathodic current to the nerve. A primary inhibiting anode is adapted to be placed in a vicinity of a primary anodal longitudinal site of the nerve and to apply a primary anodal current to the nerve. A secondary inhibiting anode is adapted to be placed in a vicinity of a secondary anodal longitudinal site of the nerve and to apply a secondary anodal current to the nerve, the secondary anodal longitudinal site being closer to the primary anodal longitudinal site than to the cathodic longitudinal site.

摘要翻译： 提供用于向神经施加电流的装置。 阴极适于放置在神经的阴极纵向位置附近，并将阴极电流施加于神经。 初级抑制阳极适于放置在神经的主要阳极纵向位置附近，并向神经施加初级阳极电流。 辅助抑制阳极适于放置在神经的次级阳极纵向位置附近，并将次要阳极电流施加到神经，次级阳极纵向位置比阴极纵向更靠近初级阳极纵向位置 现场。