公开(公告)号：US20110058176A1

公开(公告)日：2011-03-10

申请号：US12263948

申请日：2008-11-03

申请人： Christian Pflugl ,  Benjamin G. Lee ,  Laurent Diehl ,  Mikhail A. Belkin ,  Federico Capasso ,  Thomas J. Tague, JR.

发明人： Christian Pflugl ,  Benjamin G. Lee ,  Laurent Diehl ,  Mikhail A. Belkin ,  Federico Capasso ,  Thomas J. Tague, JR.

IPC分类号： G01J3/45 ,  G01J5/02

CPC分类号： G01J3/108 ,  B82Y20/00 ,  G01J3/4338 ,  H01S5/024 ,  H01S5/0612 ,  H01S5/3402 ,  H01S5/4062 ,  H01S5/4087

摘要： A mid infrared spectrometer comprises a high brightness broadband source that generates an output with a broad spectral range in the order of hundreds of wave numbers, a wavelength dispersive element and a detector. In one embodiment, the source comprises an array of semiconductor laser devices operating simultaneously. Each device emits light at wavelength different from the wavelengths emitted by the other devices in the array and the devices are arranged so that the combined output continuously covers the broad spectral range. In another embodiment, each of the lasers in the array is a quantum cascade laser device. In still another embodiment, the quantum cascade laser devices in the array are operated in the regime of Risken-Nummedal-Graham-Haken (RNGH) instabilities. In yet another embodiment, each of the lasers in the array is a mode-locked quantum cascade laser device.

摘要翻译： 中红外光谱仪包括高亮度宽带源，其产生具有数百个波数量级的宽光谱范围的输出，波长色散元件和检测器。 在一个实施例中，源包括同时操作的半导体激光器件阵列。 每个器件发射波长不同于阵列中其他器件发射的波长的光，并且器件被布置成使得组合输出连续地覆盖宽光谱范围。 在另一个实施例中，阵列中的每个激光器是量子级联激光器件。 在又一个实施例中，阵列中的量子级联激光器件在Risken-Nummedal-Graham-Haken（RNGH）不稳定的状态下运行。 在另一个实施例中，阵列中的每个激光器是锁模量子级联激光器件。

公开(公告)号：US07787117B1

公开(公告)日：2010-08-31

申请号：US12145018

申请日：2008-06-24

申请人： Marco Leona ,  Thomas J. Tague, Jr.

发明人： Marco Leona ,  Thomas J. Tague, Jr.

IPC分类号： G01J3/44 ,  G01N21/65

CPC分类号： G01N21/658 ,  G01J3/44

摘要： In apparatus for performing Surface Enhanced Raman Spectroscopy (SERS), rather than applying a sample to be analyzed to an SERS active substrate, the SERS active substrate is applied to the sample using an inkjet nozzle to apply a substance containing a colloidal metal, such as silver, to the sample. The prepared sample is then analyzed with a Raman spectrometer in a conventional fashion.

摘要翻译： 在用于进行表面增强拉曼光谱（SERS）的装置中，使用喷墨喷嘴将SERS活性基板施加到样品上，而不是将待分析的样品施加到SERS活性基板上，以将含有胶体金属的物质 银，样品。 然后用拉曼光谱仪以常规方式分析制备的样品。

公开(公告)号：US09581493B2

公开(公告)日：2017-02-28

申请号：US14179200

申请日：2014-02-12

申请人： Bruker Optics, Inc.

发明人： John B. Cooper ,  Mohamed F. Abdelkader ,  Kent L. Wise

IPC分类号： G01J3/44 ,  G01J3/10 ,  G01N21/65 ,  G01J3/02

CPC分类号： G01J3/10 ,  G01J3/027 ,  G01J3/44 ,  G01N21/65

摘要： A spectrometer is provided for acquiring a Raman spectrum from a sample. The spectrometer includes a first laser, a second laser, a detector and a processing device. The first laser is adapted to produce a first laser beam for generating first Raman spectra from the sample. The second laser is adapted to produce a second laser beam for generating second Raman spectra from the sample. The detector is adapted to collect the first Raman spectra and the second Raman spectra. The processing device is adapted to process the collected first and second Raman spectra to provide the Raman spectrum.

摘要翻译： 提供了一种用于从样品中获取拉曼光谱的光谱仪。 光谱仪包括第一激光器，第二激光器，检测器和处理装置。 第一激光器适于产生用于从样品产生第一拉曼光谱的第一激光束。 第二激光器适于产生用于从样品产生第二拉曼光谱的第二激光束。 检测器适于收集第一拉曼光谱和第二拉曼光谱。 处理装置适于处理所收集的第一和第二拉曼光谱以提供拉曼光谱。

公开(公告)号：US08570507B1

公开(公告)日：2013-10-29

申请号：US13605852

申请日：2012-09-06

申请人： John Cooper ,  Mohamed F. Abdelkader ,  Kent Wise

发明人： John Cooper ,  Mohamed F. Abdelkader ,  Kent Wise

IPC分类号： G01J3/44

CPC分类号： G01J3/44 ,  G01J3/0208 ,  G01J3/0213 ,  G01J3/10 ,  G01J3/1838 ,  G01J2003/282 ,  G01J2003/4424 ,  G01N21/39 ,  G01N21/65 ,  G01N2021/399

摘要： One embodiment of a Raman spectrometer having a temperature controlled diode laser with Bragg grating optical feedback 100 which provides a means for the acquisition of Raman spectra using sequentially shifted excitations and provides a means for spectral processing to obtain a Raman spectrum which is free from background interference such as fluorescence.

摘要翻译： 具有布拉格光栅反馈100的温度控制二极管激光器的拉曼光谱仪的一个实施例，其提供使用顺序移位激发来获取拉曼光谱的手段，并且提供用于获得无背景干扰的拉曼光谱的光谱处理的手段 如荧光。

公开(公告)号：US20150226607A1

公开(公告)日：2015-08-13

申请号：US14179200

申请日：2014-02-12

申请人： Bruker Optics, Inc.

发明人： John B. Cooper ,  Mohamed F. Abdelkader ,  Kent L. Wise

IPC分类号： G01J3/10 ,  G01N21/65 ,  G01J3/12 ,  G01J3/44

CPC分类号： G01J3/10 ,  G01J3/027 ,  G01J3/44 ,  G01N21/65

摘要： A spectrometer is provided for acquiring a Raman spectrum from a sample. The spectrometer includes a first laser, a second laser, a detector and a processing device. The first laser is adapted to produce a first laser beam for generating first Raman spectra from the sample. The second laser is adapted to produce a second laser beam for generating second Raman spectra from the sample. The detector is adapted to collect the first Raman spectra and the second Raman spectra. The processing device is adapted to process the collected first and second Raman spectra to provide the Raman spectrum.

摘要翻译： 提供了一种用于从样品中获取拉曼光谱的光谱仪。 光谱仪包括第一激光器，第二激光器，检测器和处理装置。 第一激光器适于产生用于从样品产生第一拉曼光谱的第一激光束。 第二激光器适于产生用于从样品产生第二拉曼光谱的第二激光束。 检测器适于收集第一拉曼光谱和第二拉曼光谱。 处理装置适于处理所收集的第一和第二拉曼光谱以提供拉曼光谱。

公开(公告)号：US20100291599A1

公开(公告)日：2010-11-18

申请号：US12467440

申请日：2009-05-18

申请人： Thomas J. Tague, JR. ,  William Kopaciewicz ,  Vincent J. Davisson ,  Elena Chernokalskaya ,  Timothy S. Rider ,  Cruz A.D. Hinojos ,  Jun Zhao

发明人： Thomas J. Tague, JR. ,  William Kopaciewicz ,  Vincent J. Davisson ,  Elena Chernokalskaya ,  Timothy S. Rider ,  Cruz A.D. Hinojos ,  Jun Zhao

IPC分类号： G01N33/53 ,  G01N21/65 ,  G01J3/44

CPC分类号： G01N21/658 ,  G01J3/44 ,  G01N21/65 ,  G01N33/54373

摘要： Raman spectra of protein immunoblots or enzyme linked immunosorbant assay procedures are acquired with a scanning Raman spectrometer. The sensitivity of the measurement is increased by conjugating secondary antibodies used in the Western blot and ELISA methods to surface enhanced Raman Scattering (SERS) labels. The resulting blot or well plate is analyzed with a Raman system that has forms a pixel map of the sample. More specifically, the Raman system generates an effectively line-shaped illumination pattern and scans the sample in the direction perpendicular to the line while the signal is accumulating on the detector. Each pixel is therefore a rectangle defined by the length of the illumination and the distance traveled by the sample within the duration of signal accumulation on the detector. The pixels are sequentially acquired to generate a map of the sample.

摘要翻译： 使用扫描拉曼光谱仪获得蛋白免疫印迹或酶联免疫吸附测定程序的拉曼光谱。 通过将Western印迹和ELISA方法中使用的二次抗体与表面增强的拉曼散射（SERS）标记缀合，来增加测量的灵敏度。 用形成样品的像素图的拉曼系统分析所得到的印迹或孔板。 更具体地，拉曼系统产生有效的线状照明图案，并且在信号积聚在检测器上的同时沿垂直于线的方向扫描样品。 因此，每个像素是由照明长度和样本在检测器上的信号累积持续时间内行进的距离所定义的矩形。 依次获取像素以生成样本的图。