公开(公告)号：US12289332B2

公开(公告)日：2025-04-29

申请号：US17983048

申请日：2022-11-08

Applicant: CFD Research Corporation

Inventor： Brian Gene Palmer

IPC: H04L9/40

Abstract: The present invention includes systems and methods for providing cybersecurity to web-enabled applications for protection of critical software and host systems. The present invention is operable to build a Hidden Markov model of an application using automated analysis of code and documentation in order to characterize potential state and state transitions. The present invention is also operable to use additional data such as timing and proximity to assess incoming data. Incoming messages are then assigned a trust score based on Bayesian calculations.

公开(公告)号：US12121889B2

公开(公告)日：2024-10-22

申请号：US17502517

申请日：2021-10-15

Applicant: CFD RESEARCH CORPORATION ,  Garry Lynn Freeman, Jr.

Inventor： Joseph Roger Herdy, Jr. ,  Garry Lynn Freeman, Jr.

IPC: G01M9/04 ,  B01J4/00 ,  B01J6/00 ,  C01B13/02 ,  C01B21/02

CPC classification number: B01J4/002 ,  B01J6/00 ,  C01B13/0203 ,  C01B21/02 ,  G01M9/04 ,  B01J2204/007

Abstract: A variable 3D CD nozzle includes: a flexible body defining a flow path having an inlet extending through a narrowed throat to an expanded outlet, wherein the flexible body comprises a plurality of flexible members movably interconnected together; and at least one means for changing a shape of the flexible body to change a dimension or location of the throat plane relative to at least one of the inlet plane or outlet plane. A method of changing airflow in a nozzle includes operating at least one means for changing the shape of the flexible nozzle body to change the dimension or the location of the throat plane. A method of testing an object includes placing a test object in the test region of the test cell and passing a test gas from the outlet opening of the nozzle onto the test object.

公开(公告)号：US20210338664A1

公开(公告)日：2021-11-04

申请号：US16862500

申请日：2020-04-29

Applicant: CFD Research Corporation

Inventor： Narender Singh

IPC: A61K31/497 ,  A61P1/16

Abstract: A method for providing a therapy to a subject that has been exposed to an Aflatoxin B1 can include administering a compound having a structure of Formula 1 to the subject after exposure to the Aflatoxin B1: wherein: R1, R2, R3, R4, R5 and/or R6 are each individually a chemical moiety and n is 1, 2, 3, 4, or 5. The compound can be Amprenavir or a derivative thereof, prodrug thereof, salt thereof, or stereoisomer thereof, or having any chirality at any chiral center, or tautomer, polymorph, solvate, or combination thereof. The prodrug can be Amprenavir phosphate.

公开(公告)号：US20210280088A1

公开(公告)日：2021-09-09

申请号：US16696997

申请日：2019-11-26

Applicant: CFD Research Corporation

Inventor： David Keith Sedberry ,  Vincent J. Harrand ,  Phillip E. Whitley ,  Andrzej Przekwas

IPC: G09B23/34 ,  G01N33/00

Abstract: A modular surrogate can include: a body having an external body surface with an anatomical shape, wherein the body includes an internal chamber with at least one port formed in the body extending inwardly; at least one anatomical module having an external module portion and a module stem coupled thereto, the module stem being received into a corresponding module port of the at least one port, the external module portion having an external module surface with an anatomical shape, the external body surface matches with the external module surface to provide a continuous anatomical shape; at least one sensor located in the at least one anatomical module; and at least one controller, wherein when the at least one anatomical module is coupled with the body, the at least one sensor is capable of being operably coupled with the at least one controller.

公开(公告)号：US20210269868A1

公开(公告)日：2021-09-02

申请号：US17187267

申请日：2021-02-26

Applicant: CFD Research Corporation

Inventor： David Edwin Gaddes, III ,  Ketan Harendrakumar Bhatt ,  Balabhaskar Prabhakarpandian

IPC: C12Q1/6853 ,  C12Q1/6832 ,  C12Q1/6816

Abstract: A primer composition for amplifying a target nucleic acid of a plurality of target organisms can include: a first primer having in order: 3′-a first target specific sequence; a melt key region; and a first super primer region, wherein the first target specific sequence includes a nucleic acid sequence that specifically hybridizes with a first unique nucleic acid sequence of a first target organism over nucleic acid sequences of other organisms, the melt key region includes a nucleic acid sequence that has less than full identity with a melt key probe and a complement of the melt key region hybridizes with the melt key probe with at least one nucleotide mismatch with the melt key probe, and the first super primer region includes a nucleic acid sequence that is common to the plurality of target organisms.

公开(公告)号：US20210187332A1

公开(公告)日：2021-06-24

申请号：US17119621

申请日：2020-12-11

Applicant: CFD Research Corporation

Inventor： Zachary William Wright ,  William Christopher Krolick ,  Wyatt Gilbert Ramos

IPC: A62B3/00

Abstract: A door breach device can include: an elongate shaft having a first end and an opposite second end; a pivot mechanism at the first end of the shaft; a spearhead rotatably coupled with the pivot mechanism and having a tip on a tip-side of the pivot mechanism and having a shaft cavity on a shaft-side, where the shaft cavity is adapted to receive the shaft therein; a restraint slidably received on the shaft-side of the spearhead and on the shaft; a handle protruding from the shaft; and a hitch at the second end of the shaft. A method of breaching a door can include: forcing the spearhead through a door until the restraint releases the spearhead and the spearhead rotates by the pivot mechanism so as to form an angle with the shaft; and pulling the spearhead against the door until the door is breached.

公开(公告)号：US20210116338A1

公开(公告)日：2021-04-22

申请号：US17074007

申请日：2020-10-19

Applicant: CFD RESEARCH CORPORATION

Inventor： David Edwin Gaddes, III ,  Balabhaskar Prabhakarpandian ,  Ketan Harendrakumar Bhatt

IPC: G01N1/40 ,  B01L3/00

Abstract: A fluidic device can include: a plurality of fluid conduits, each fluid conduit including a first conduit portion separated from a second conduit portion; and at least one transport body that is movably positioned between the first conduit portion and the second conduit portion of each fluid conduit. The at least one transport body can include: at least one port adapted to be aligned with a first conduit portion and a second conduit portion of at least one first conduit so as to fluidly couple the first conduit portion with the second conduit portion; and at least one blocking body portion adapted to be aligned with a first conduit portion and a second conduit portion of at least one second conduit so as to fluidly isolate the first conduit portion from the second conduit portion of the at least one second conduit.

公开(公告)号：US20200083543A1

公开(公告)日：2020-03-12

申请号：US16503261

申请日：2019-07-03

Applicant: CFD Research Corporation

Inventor： Pyoungho CHOI ,  Sameer Singhal ,  Joe Don Edington

IPC: H01M6/36 ,  H01M4/06

Abstract: A thermal battery can include: an anode of lithium alloy; a metal-fluoride cathode having Ni; and an electrolyte composition in contact with the anode and cathode. The electrolyte composition can be a tertiary electrolyte composition of LiF—LiCl—Li2SO4. A thermal battery can also include: an anode of lithium alloy; a metal-fluoride cathode having an oxide selected from V2O5 or LiVO3; and an electrolyte composition in contact with the anode and cathode. In one aspect, a metal of the metal fluoride cathode includes Ni, Fe, V, Cr, Mn, Co, or mixture thereof. In one aspect, the metal-fluoride cathode includes NiF2, FeF3, VF3, CrF3, MnF3, CoF3, or a mixture thereof. A method of providing electricity can include: providing an electronic device having a thermal battery with a metal-fluoride cathode having Ni and/or having an oxide selected from V2O5 or LiVO3; and discharging the thermal battery to provide electricity.

公开(公告)号：US10012640B2

公开(公告)日：2018-07-03

申请号：US14768154

申请日：2014-02-14

Applicant: CFD Research Corporation

Inventor： Kapil Pant ,  Balabhaskar Prabhakarpandian

IPC: C12M1/00 ,  C12M3/00 ,  B01L3/00 ,  G01N33/50 ,  C12M3/06 ,  C12M1/12 ,  C12M1/34 ,  C12M1/36 ,  C12M1/42

CPC classification number: G01N33/5008 ,  B01L3/5025 ,  B01L3/502715 ,  B01L2300/0829 ,  B01L2300/0861 ,  B01L2300/0874 ,  B01L2400/0487 ,  C12M23/16 ,  C12M23/34 ,  C12M25/14 ,  C12M29/00 ,  C12M29/04 ,  C12M35/08 ,  C12M41/00 ,  C12M41/48

Abstract: A cell culture assay device can include: a substrate having a plurality of discrete microfluidic networks and a plurality of wells over the discrete microfluidic networks, each discrete microfluidic network having one or more wells fluidly coupled thereto, the wells extending upward from the discrete microfluidic networks; and a manifold body coupled with the substrate and having at least one fluid conduit pair for each microfluidic network and/or each well, each fluid conduit pair including a fluid inlet conduit and a fluid outlet conduit fluidly coupled to a corresponding microfluidic network and/or well. The substrate can be formed from a substrate base having the microfluidic networks coupled to a well plate having the wells associated with the microfluidic networks.

公开(公告)号：US20140255970A1

公开(公告)日：2014-09-11

申请号：US14202491

申请日：2014-03-10

Applicant: CFD Research Corporation

Inventor： Balabhaskar Prabhakarpandian ,  Kapil Pant

IPC: G01N33/50

CPC classification number: G01N33/5029 ,  B01L3/5027 ,  G01N33/5005 ,  G01N33/5011 ,  G01N33/5061 ,  G01N33/5088 ,  G01N33/86 ,  G01N2333/4703 ,  G01N2333/70525

Abstract: A cell culture device can include: an internal chamber configured for an internal cell culture that has at least one port coupled to a perfusion modulating device capable of modulating perfusion in the internal chamber; at least one fluid channel bordering the internal chamber that is configured for a channel cell culture that has at least one port coupled to a perfusion modulating device capable of modulating perfusion in the fluid channel; and a wall separating the internal chamber and at least one fluid channel having gaps that fluidly couple the internal chamber with the at least one fluid channel, wherein the perfusion modulating device causes reduced fluid flow. The internal chamber can include a first cell type and the at least one fluid channel includes a second cell type. The first cell type has an ischemic zone in the middle, a non-ischemic zone adjacent with the at least one fluid channel, and a border zone between the ischemic zone and non-ischemic zone. In one aspect, the internal chamber and at least one fluid channel are modeled from physiological features. In one aspect, the internal chamber and at least one fluid channel are modeled from idealized features.

Abstract translation: 细胞培养装置可以包括：配置用于内部细胞培养物的内部室，其具有耦合到能够调节内部腔室灌注的灌注调节装置的至少一个端口; 至少一个与所述内室邻接的流体通道，其构造成用于通道细胞培养，所述通道细胞培养物具有至少一个端口，所述至少一个端口耦合到能够调节所述流体通道中的灌注的灌注调节装置; 以及分隔内室和至少一个流体通道的壁，所述至少一个流体通道具有使内室与至少一个流体通道流体连接的间隙，其中灌注调节装置引起减少的流体流动。 内部腔室可以包括第一细胞类型，并且所述至少一个流体通道包括第二细胞类型。 第一细胞类型在中间具有缺血区，与至少​​一个流体通道相邻的非缺血区，以及缺血区与非缺血区之间的边界区。 在一个方面，内部室和至少一个流体通道由生理特征建模。 在一个方面，内部室和至少一个流体通道由理想特征建模。