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1.发明授权公开(公告)号：US08028566B2
公开(公告)日：2011-10-04
申请号：US11815884
申请日：2006-02-10
Applicant: Ulrik Darling Larsen
Inventor： Ulrik Darling Larsen
IPC: G01N15/06
Abstract: The present invention relates to an apparatus for characterizing particles suspended in a liquid, especially a self-contained disposable cartridge for single-use analysis, such as for single-use analysis of a small quantity of whole blood. Furthermore, the present invention relates to a method for characterizing particles in liquid and a device for sampling a small and accurate volume of liquid. The apparatus comprises a housing having a mixing chamber and a collection chamber separated by a wall containing an opening, a first bore in the outer surface of the housing for entrance of a liquid sample, a first cavity for receiving and holding a first liquid sample, and a second cavity for receiving and holding a second liquid sample.
Abstract translation: 本发明涉及用于表征悬浮在液体中的颗粒的装置，特别是用于一次使用分析的独立一次性盒，例如用于少量全血的一次性分析。 此外，本发明涉及用于表征液体中的颗粒的方法以及用于对小量和精确体积的液体进行取样的装置。 该装置包括具有混合室和由包含开口的壁分离的收集室的壳体，用于引入液体样品的壳体外表面中的第一孔，用于接收和保持第一液体样品的第一腔， 以及用于接收和保持第二液体样品的第二腔。
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公开(公告)号：US20110318774A1
公开(公告)日：2011-12-29
申请号：US13226683
申请日：2011-09-07
Applicant: Ulrik Darling Larsen
Inventor： Ulrik Darling Larsen
IPC: C12Q1/02
CPC classification number: G01N15/12 , B01L3/502715 , B01L3/502738 , B01L2200/0605 , B01L2300/0645 , B01L2300/0809 , B01L2300/0867 , B01L2300/087 , B01L2400/0406 , B01L2400/0487 , B01L2400/0622 , B01L2400/0644 , G01N1/38 , G01N35/1097 , G01N2015/0073 , G01N2015/008 , G01N2015/0084 , G01N2015/1062
Abstract: The present invention relates to an apparatus for characterizing particles suspended in a liquid, especially a self-contained disposable cartridge for single-use analysis, such as for single-use analysis of a small quantity of whole blood. Furthermore, the present invention relates to a method for characterizing particles in liquid and a device for sampling a small and accurate volume of liquid. The apparatus comprises a housing having a mixing chamber and a collection chamber separated by a wall containing an opening, a first bore in the outer surface of the housing for entrance of a liquid sample, a first cavity for receiving and holding a first liquid sample, and a second cavity for receiving and holding a second liquid sample.
Abstract translation: 本发明涉及用于表征悬浮在液体中的颗粒的装置，特别是用于一次使用分析的独立一次性盒，例如用于少量全血的一次性分析。 此外，本发明涉及用于表征液体中的颗粒的方法以及用于对小量和精确体积的液体进行取样的装置。 该装置包括具有混合室和由包含开口的壁分离的收集室的壳体，用于引入液体样品的壳体外表面中的第一孔，用于接收和保持第一液体样品的第一腔， 以及用于接收和保持第二液体样品的第二腔。
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公开(公告)号：US07928718B2
公开(公告)日：2011-04-19
申请号：US11664170
申请日：2005-09-30
Applicant: Ulrik Darling Larsen
Inventor： Ulrik Darling Larsen
CPC classification number: G01N15/1227
Abstract: A method of calibration of a particle characterization apparatus, and a particle characterization apparatus, in which particles suspended in a liquid are passed through an orifice one by one for characterization of the particles, for instance by Coulter counting. The calibration does not require utilization of special calibration particles or liquids. A priori knowledge of the shape of a typical size distribution of a blood sample is utilized to adjust the apparatus based on an initial relatively short counting period of the sample in question. The initially determined size distribution is compared to the corresponding known typical size distribution and the apparatus is subsequently adjusted to counteract possible differences. Upon adjustment of the apparatus, the remaining part of the sample is passed through the orifice for determination of the actual particle size distribution of the remaining sample.
Abstract translation: 颗粒表征装置的校准方法和颗粒表征装置，其中悬浮在液体中的颗粒逐个通过孔口，用于表征颗粒，例如通过库尔特计数。 校准不需要使用特殊的校准颗粒或液体。 利用血液样本的典型尺寸分布的形状的先验知识来基于所讨论的样品的初始相对较短的计数周期来调节装置。 将初始确定的尺寸分布与相应的已知典型尺寸分布进行比较，随后调整该装置以抵消可能的差异。 在调节设备时，将剩余部分样品通过孔口，以确定剩余样品的实际粒度分布。
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公开(公告)号：US07968052B2
公开(公告)日：2011-06-28
申请号：US12067065
申请日：2006-09-19
Applicant: Rune Funder Mikkelsen , Ulrik Darling Larsen
Inventor： Rune Funder Mikkelsen , Ulrik Darling Larsen
IPC: G01N15/12
CPC classification number: G01N15/1227 , G01N2015/1281
Abstract: An apparatus which enables characterization of particles suspended in a liquid includes a housing with a mixing chamber and a collection chamber separated by a wall containing an aperture for passage of particles between, the mixing chamber and the collection chamber, the mixing chamber further containing a mixing member, a first electrode in the mixing chamber and a second electrode in the collection chamber for conduction of an electrical current through the aperture, a processor that is adapted for controlling the measurement sequence of the apparatus and detecting possible blockage of the aperture by detecting extended duration of the electrical pulse caused by the blocking particle, and upon detection of a blockage, reversing the liquid flow while mixing in the mixing chamber for removal of the blocking particle, and restarting particle counting.
Abstract translation: 能够表征悬浮在液体中的颗粒的装置包括具有混合室的壳体和由包含用于在混合室和收集室之间通过颗粒的孔的壁隔开的收集室，混合室还包含混合 构件，混合室中的第一电极和用于传导电流通过孔的收集室中的第二电极，适于控制装置的测量顺序并通过检测延伸的孔来检测孔的可能阻塞的处理器 由阻塞颗粒引起的电脉冲的持续时间，并且在检测到阻塞时，在混合室中混合时反转液体流动以除去阻塞颗粒，并重新开始颗粒计数。
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5.发明授权公开(公告)号：US07771658B2
公开(公告)日：2010-08-10
申请号：US10517385
申请日：2003-06-11
Applicant: Ulrik Darling Larsen
Inventor： Ulrik Darling Larsen
CPC classification number: G01N15/12 , B01F13/0059 , B01F13/0222 , B01L3/502715 , B01L2200/027 , B01L2300/0645 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2400/0406 , B01L2400/0478 , B01L2400/0481 , G01N15/1218 , G01N21/03 , G01N21/35 , G01N21/359 , G01N33/5094 , G01N33/80 , G01N2015/1062 , G01N2015/1087 , G01N2021/0321 , Y10T436/107497 , Y10T436/117497 , Y10T436/25625 , Y10T436/2575
Abstract: A disposable cartridge for characterizing particles suspended in a liquid, especially a self-contained disposable cartridge for single-use analysis, such as for single-use analysis of a small quantity of whole blood. The self-contained disposable cartridge facilitates a straightforward testing procedure, which can be performed by most people without any particular education. Furthermore, the apparatus used to perform the test on the cartridge is simple, maintenance free, and portable.
Abstract translation: 用于表征悬浮在液体中的颗粒的一次性盒，特别是用于单次使用分析的独立一次性盒，例如用于少量全血的一次性分析。 独立的一次性盒式磁带有助于简单的测试程序，这可以由大多数人进行，无需特别的教育。 此外，用于对盒进行测试的设备简单，免维护，便于携带。
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Patent Agency Ranking
公开(公告)号：US20080314130A1
公开(公告)日：2008-12-25
申请号：US12067065
申请日：2006-09-19
Applicant: Rune Funder Mikkelsen , Ulrik Darling Larsen
Inventor： Rune Funder Mikkelsen , Ulrik Darling Larsen
IPC: G01N15/12
CPC classification number: G01N15/1227 , G01N2015/1281
Abstract: The present invention relates to a particle characterisation apparatus in which particles suspended in a liquid are passed through an aperture, in principle one by one, to enable characterisation of the particles, for instance by Coulter counting. In particular the present invention relates to an apparatus for characterizing particles suspended in a liquid sample, comprising a housing with a mixing chamber 3 and a collection chamber separated by a wall containing an aperture 59 for passage of particles between the mixing chamber 3 and the collection chamber 5, the mixing chamber 3 further containing a mixing member, a first electrode 34 in the mixing chamber 3 and a second electrode 35 in the collection chamber 5 for conduction of an electrical current through the aperture 59, a processor that is adapted for controlling the measurement sequence of the apparatus and detect possible blockage of the aperture by detecting extended duration of the electrical pulse caused by the blocking particle, and upon detection of a blockage, reverse the liquid flow while mixing in the mixing chamber for removal of the blocking particle, and restart particle counting. Experiments show that most particles blocking an aperture are removed in the apparatus according to the present invention. A 75% decrease of non-successful measurements was achieved.
Abstract translation: 本发明涉及一种颗粒表征装置，其中悬浮在液体中的颗粒原则上通过一个孔，以使得能够表征颗粒，例如通过库尔特计数。 特别地，本发明涉及一种用于表征悬浮在液体样品中的颗粒的装置，包括具有混合室3的壳体和由包含孔59分隔的收集室的收集室，用于在混合室3和收集器之间通过颗粒 腔室5，混合室3还包含混合构件，混合室3中的第一电极34和收集室5中的第二电极35，用于传导通过孔59的电流;处理器，适于控制 该装置的测量顺序，通过检测由阻塞颗粒引起的电脉冲延长的持续时间，以及在检测到阻塞时，检测可能的孔径阻塞，在混合室中混合时反转液体流动以除去阻塞颗粒 ，并重新开始粒子计数。 实验表明，在根据本发明的装置中除去大部分堵塞孔的颗粒。 实现非成功测量减少75％。
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公开(公告)号：US06959618B1
公开(公告)日：2005-11-01
申请号：US10048835
申请日：2000-08-03
Applicant: Ulrik Darling Larsen
Inventor： Ulrik Darling Larsen
CPC classification number: G01N15/1209
Abstract: An apparatus is provided for characterizing cells in a biological liquid sample and operating according to the Coulter principle. The apparatus has a disposable sensor unit and a docking station for removably receiving the sensor unit. The sensor unit housing contains electrodes in each of two chambers separated by a wall containing an orifice. The housing is adapted to contain and retain for disposal liquid pumped through the orifice during particle characterization operations.
Abstract translation: 提供了用于表征生物液体样品中的细胞并根据库尔特原理进行操作的装置。 该装置具有一次性传感器单元和用于可移除地接收传感器单元的对接站。 传感器单元壳体在两个室中的每一个中都包含电极，该电极由包含孔口的壁分隔开。 在颗粒表征操作期间，壳体适于容纳和保留用于泵送通过孔口的处理液体。
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公开(公告)号：US20110027825A1
公开(公告)日：2011-02-03
申请号：US12918860
申请日：2009-03-02
Applicant: Ulrik Darling Larsen
Inventor： Ulrik Darling Larsen
IPC: C12Q1/06
CPC classification number: G01N15/1227
Abstract: The present invention relates to a method of determining pulse height distribution by using an apparatus comprising: an analogue to digital pulses height categorisation unit comparing the pulse to analogue threshold voltages and counting each event within each pulse height category using a micro controller. The method may comprise the steps of i) selecting a first set of threshold voltages, ii) performing a first measurement using the first set of threshold voltages, iii) selecting a new set of threshold voltages different from the first set of threshold voltages, iv) performing a new measurement using the new set of threshold voltages, v) determining cell size distribution based on the first measurement and the new measurement. The present invention further relates to an apparatus comprising an analogue to digital pulses height categorisation unit comparing the pulse to analogue threshold voltages, a micro controller configured for counting each event within each pulse height category, the micro controller further configured for i) selecting a first set of threshold voltages, ii) performing a first measurement using the first set of threshold voltages, iii) selecting a new set of threshold voltages different from the first set of threshold voltages, iv) performing a new measurement using the new set of threshold voltages, v) determining cell size distribution based on the first measurement and the new measurement.
Abstract translation: 本发明涉及一种通过使用一种装置来确定脉冲高度分布的方法，该装置包括：模数 - 数字脉冲高度分类单元，用于使用微控制器对脉冲和模拟阈值电压进行比较并计数每个脉冲高度类别内的每个事件。 该方法可以包括以下步骤：i）选择第一组阈值电压，ii）使用第一组阈值电压执行第一测量，iii）选择不同于第一组阈值电压的新的阈值电压集合，iv ）使用新的一组阈值电压执行新的测量，v）基于第一测量和新测量来确定单元尺寸分布。 本发明还涉及一种包括比较脉冲与模拟阈值电压的模数 - 数字脉冲高度分类单元的装置，微控制器，被配置为对每个脉冲高度类别内的每个事件进行计数，微控制器进一步配置为：i）选择第一 一组阈值电压，ii）使用第一组阈值电压执行第一测量，iii）选择与第一组阈值电压不同的一组新的阈值电压，iv）使用新的阈值电压集执行新的测量 v）基于第一测量和新测量来确定单元尺寸分布。
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9.发明授权公开(公告)号：US07797990B2
公开(公告)日：2010-09-21
申请号：US10517382
申请日：2003-06-11
Applicant: Ulrik Darling Larsen , Preben Merrild Elkjær
Inventor： Ulrik Darling Larsen , Preben Merrild Elkjær
IPC: G01N15/06
CPC classification number: G01N15/12 , B01F13/0059 , B01F13/0222 , B01L3/502715 , B01L2200/027 , B01L2300/0645 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2400/0406 , B01L2400/0478 , B01L2400/0481 , G01N15/1218 , G01N21/03 , G01N21/35 , G01N21/359 , G01N33/5094 , G01N33/80 , G01N2015/1062 , G01N2015/1087 , G01N2021/0321 , Y10T436/107497 , Y10T436/117497 , Y10T436/25625 , Y10T436/2575
Abstract: A particle characterization apparatus in which particles suspended in a liquid pass through an orifice or aperture for detection and characterization of the particles utilizing impedance determination. In particular, the apparatus includes a membrane of a polymer as a base material for precision machining of a sub-millimeter orifice. Forming the orifice in a polymer membrane facilitates the construction of a single use cartridge for haematology analysis due to low material and production costs.
Abstract translation: 一种粒子表征装置，其中悬浮在液体中的颗粒通过孔或孔，用于利用阻抗确定来检测和表征颗粒。 特别地，该装置包括聚合物膜作为用于精密加工亚毫米孔的基材。 在聚合物膜中形成孔口由于材料和生产成本低而有助于构建用于血液学分析的单一使用盒。
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公开(公告)号：US07701193B2
公开(公告)日：2010-04-20
申请号：US10570150
申请日：2004-08-27
Applicant: Freddy Petersen , Rune Funder Mikkelsen , Morten Wilsbech
Inventor： Freddy Petersen , Rune Funder Mikkelsen , Morten Wilsbech
CPC classification number: G01N15/1227
Abstract: A pulse height analyzer for determination of the pulse height distribution of electronic pulses includes a set of comparators with a common input for analogue to digital conversion of the electronic pulses, a set of latches wherein the inputs of the latches are connected to the outputs of respective comparators for recording passage of the corresponding threshold voltages by the rising edge of a pulse, a priority encoder connected to the latch outputs for determination of a pulse height category consisting of pulses with a pulse height within a pulse height interval defined by respective threshold voltages, and a micro controller that is adapted to count the number of pulses within each pulse height category.
Abstract translation: 用于确定电子脉冲的脉冲高度分布的脉冲高度分析器包括具有用于电子脉冲的模数转换的公共输入的一组比较器，一组锁存器，其中锁存器的输入连接到相应的输出 比较器，用于通过脉冲的上升沿记录相应的阈值电压的通过，连接到锁存器输出的优先级编码器，用于确定脉冲高度类别，该脉冲高度类别由脉冲高度在由相应的阈值电压所限定的脉冲高度间隔内， 以及适于对每个脉冲高度类别内的脉冲数进行计数的微控制器。
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