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    Non-mechanical multi-mode MCF/CF
    2.
    发明授权
    Non-mechanical multi-mode MCF/CF 有权

    公开(公告)号：US11719985B2

    公开(公告)日：2023-08-08

    申请号：US17813392

    申请日：2022-07-19

    申请人： ChemImage Corporation

    发明人： Lei Shi ,  George Ventouris

    IPC分类号： G02F1/1347 ,  G02B5/20

    CPC分类号： G02F1/13471 ,  G02B5/208

    摘要： A non-mechanical liquid crystal tunable filter (LCTF) assembly capable of switching between a multi-conjugate filter mode and a conformal filter mode is described. The non-mechanical LCTF architecture can include a plurality of LCTF components that each comprises a first optical filter comprising a first optical axis, a second optical filter comprising a second optical axis, wherein the second optical axis is rotated 90° relative to the first optical axis, and a first twisted nematic cell positioned between the first optical filter and the second optical filter, the first twisted nematic cell configured to polarize received light by 90° when a voltage is not applied and not polarize the received light when the voltage is applied. The non-mechanical LCTF assembly is configured to switch between a conformal filter mode and a multi-conjugate filter mode based on whether the voltage is applied to each of the plurality of LCTF components.

    NON-MECHANICAL MULTI-MODE MCF/CF
    4.
    发明申请
    NON-MECHANICAL MULTI-MODE MCF/CF 有权

    公开(公告)号：US20230036774A1

    公开(公告)日：2023-02-02

    申请号：US17813392

    申请日：2022-07-19

    申请人： ChemImage Corporation

    发明人： Lei SHI ,  George VENTOURIS

    IPC分类号： G02F1/1347 ,  G02B5/20

    摘要： A non-mechanical liquid crystal tunable filter (LCTF) assembly capable of switching between a multi-conjugate filter mode and a conformal filter mode is described. The non-mechanical LCTF architecture can include a plurality of LCTF components that each comprises a first optical filter comprising a first optical axis, a second optical filter comprising a second optical axis, wherein the second optical axis is rotated 90° relative to the first optical axis, and a first twisted nematic cell positioned between the first optical filter and the second optical filter, the first twisted nematic cell configured to polarize received light by 90° when a voltage is not applied and not polarize the received light when the voltage is applied. The non-mechanical LCTF assembly is configured to switch between a conformal filter mode and a multi-conjugate filter mode based on whether the voltage is applied to each of the plurality of LCTF components.

    SYSTEMS AND METHODS FOR SPECTRAL PROCESSING IMPROVEMENTS IN SPATIAL HETERODYNE SPECTROSCOPY
    5.
    发明申请
    SYSTEMS AND METHODS FOR SPECTRAL PROCESSING IMPROVEMENTS IN SPATIAL HETERODYNE SPECTROSCOPY 有权

    公开(公告)号：US20220018714A1

    公开(公告)日：2022-01-20

    申请号：US17379616

    申请日：2021-07-19

    申请人： CHEMIMAGE CORPORATION

    发明人： Nathaniel GOMER ,  Heather E. GOMER

    IPC分类号： G01J3/44 ,  G01J3/28

    摘要： Raman spectroscopy data is collected using a Spatial Heterodyne Spectrometer and processed in order to reduce signal noise. The processing of the Raman spectroscopy data includes segmenting generating an interferogram from the Raman spectroscopy data, segmenting the interferogram, determining an estimate of power spectrum density, and averaging the estimates of power spectrum density for each segment to provide an output spectrum. The output spectrum has greatly reduced variance of the individual power measurements, and allows the length of segments to be optimized to balance noise reduction operations and the loss of frequency resolution.

    SYSTEMS AND METHODS FOR DETECTING ORAL CANCER USING MOLECULAR CHEMICAL IMAGING
    6.
    发明申请
    SYSTEMS AND METHODS FOR DETECTING ORAL CANCER USING MOLECULAR CHEMICAL IMAGING 有权

    公开(公告)号：US20210353225A1

    公开(公告)日：2021-11-18

    申请号：US17323462

    申请日：2021-05-18

    申请人： CHEMIMAGE CORPORATION

    发明人： Shona STEWART ,  Aaron SMITH ,  Patrick J. TREADO

    IPC分类号： A61B5/00 ,  A61B1/07 ,  A61B1/06 ,  A61B1/05 ,  A61B1/04 ,  A61B1/24

    摘要： Methods and systems of identifying oral cancer in vivo are disclosed. An oral cavity of a patient is illuminated with a plurality of illuminating photons. A plurality of interacted photos are received from the oral cavity. The interacted photons may have been absorbed, reflected, scattered or emitted by the oral cavity. The interacted photons are filtered into first and second polarized multi-passband wavelengths using first and second tunable conformal filters, respectively. A detector captures the first and second polarized multi-passband wavelengths. A processor automatically discriminates between cancerous tissue and non-cancerous tissue in an image resolved from the first and second polarized multi-passband wavelengths.

    System and Method for Drug Detection Using SWIR
    8.
    发明申请
    System and Method for Drug Detection Using SWIR 审中-公开
    使用SWIR进行药物检测的系统和方法

    公开(公告)号：US20140043488A1

    公开(公告)日：2014-02-13

    申请号：US14055509

    申请日：2013-10-16

    申请人： ChemImage Corporation

    发明人： Patrick Treado ,  Matthew Nelson ,  Charles Gardner

    IPC分类号： G01N33/15

    CPC分类号： G01N33/15 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/027 ,  G01J3/0278 ,  G01J3/44 ,  G01N21/359 ,  G01N33/0057

    摘要： A method for detecting unknown materials, such as drugs. A first location is surveyed using a video capture device to identify a second location comprising an unknown material. The second location is interrogated using SWIR spectroscopic and/or imaging methods to generate a SWIR hyperspectral image. The SWIR hyperspectral image is analyzed to associate the unknown material with a known drug material. A system for detecting unknown materials, such as drugs comprising a first collection lens for collecting interacted photons from a first location and a visible imaging device for generating a visible image. A second collection lens may collect a plurality of interacted photons from a second location and a tunable filter may filter the interacted photons. A spectroscopic imaging device may detect the interacted photons and generate a SWIR hyperspectral image. A processor may analyze the SWIR hypespectral image to associate an unknown material with a known material.

    摘要翻译： 检测未知物质如药物的方法。 使用视频捕获设备来测量第一位置以识别包括未知材料的第二位置。 使用SWIR光谱和/或成像方法询问第二个位置以产生SWIR高光谱图像。 分析SWIR高光谱图像以将未知材料与已知药物材料相关联。 一种用于检测未知材料的系统，例如药物，其包括用于从第一位置收集相互作用的光子的第一收集透镜和用于产生可见图像的可见成像装置。 第二采集透镜可以从第二位置收集多个相互作用的光子，并且可调谐滤光器可以过滤相互作用的光子。 光谱成像装置可以检测相互作用的光子并产生SWIR高光谱图像。 处理器可以分析SWIR超光谱图像以将未知材料与已知材料相关联。

    Method and apparatus for automated spectral calibration
    9.
    发明授权
    Method and apparatus for automated spectral calibration 有权
    用于自动光谱校准的方法和装置

    公开(公告)号：US08440959B2

    公开(公告)日：2013-05-14

    申请号：US12897376

    申请日：2010-10-04

    申请人： Matthew Nelson ,  Patrick Treado

    发明人： Matthew Nelson ,  Patrick Treado

    IPC分类号： G01D18/00

    CPC分类号： A61B5/0059 ,  A61B2560/0223 ,  G01J3/28 ,  G01J3/42

    摘要： A method and apparatus for automated spectral calibration of a spectroscopy device. A method for simultaneous calibration and spectral imaging of a sample by: simultaneously illuminating the sample and a calibrant with a plurality of illuminating photons; receiving, at the spectrometer, a first plurality of photons collected from the sample and a second plurality of photons collected from the calibrant; forming a calibrant spectrum from the first plurality of collected photons and a sample spectrum from the second plurality of collected photons; comparing the calibrant spectrum with a reference spectrum of the calibrant to determine a wavelength-shift in the calibrant spectrum; applying the wavelength-shift to the sample spectrum to obtain a calibrated sample spectrum.

    摘要翻译： 一种用于光谱装置的自动光谱校准的方法和装置。 一种通过以下步骤同时校准和光谱成像的方法：同时用多个照明光子照射样品和校准物; 在光谱仪处接收从样品收集的第一组多个光子和从校准物收集的第二组多个光子; 从所述第一多个收集的光子形成校准谱，以及来自所述第二多个收集的光子的样品光谱; 将校准谱与校准物的参考光谱进行比较，以确定校准谱中的波长漂移; 将波长偏移应用于样本光谱以获得校准的样本光谱。

    Raman chemical imaging of implantable drug delivery devices
    10.
    发明授权
    Raman chemical imaging of implantable drug delivery devices 有权
    可植入药物递送装置的拉曼化学成像

    公开(公告)号：US08416405B2

    公开(公告)日：2013-04-09

    申请号：US12537671

    申请日：2009-08-07

    申请人： Janice Panza ,  John Maier

    发明人： Janice Panza ,  John Maier

    IPC分类号： G01J3/44

    CPC分类号： G01J3/44 ,  G01N21/65 ,  G01N2201/129

    摘要： A system and method of determining an attribute of a biological tissue sample or a drug delivery device. A sample is illuminated with substantially monochromatic light to thereby generate Raman scattered photons. The Raman scattered photons are assessed to thereby generate a spectroscopic data set wherein said spectroscopic data set comprises at least one of: a Raman spectra and a spatially accurate wavelength resolved image. The spectroscopic data set is evaluated to determine at least one of: an attribute of a biological tissue sample and a drug delivery device. In one embodiment, the biological tissue comprises arterial tissue. In another embodiment, the drug delivery device is a drug-eluting stent. In another embodiment, Raman chemical imaging can be used to evaluate a sample and identify at least one of: the tissue, a drug, a drug delivery device, and a matrix associated with a drug delivery device.

    摘要翻译： 一种确定生物组织样品或药物递送装置的属性的系统和方法。 用基本单色光照射样品，从而产生拉曼散射光子。 评估拉曼散射光子，从而产生光谱数据集，其中所述光谱数据集包括拉曼光谱和空间上准确的波长分辨图像中的至少一个。 评估光谱数据集以确定生物组织样品和药物递送装置的属性中的至少一个。 在一个实施方案中，生物组织包含动脉组织。 在另一个实施方案中，药物递送装置是药物洗脱支架。 在另一个实施方案中，拉曼化学成像可用于评估样品并鉴定组织，药物，药物递送装置和与药物递送装置相关联的基质中的至少一种。