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公开(公告)号：US20180214467A1
公开(公告)日：2018-08-02
申请号：US15747827
申请日：2016-07-29
申请人： EDUCATIONAL FOUNDATION JICHI MEDICAL UNIVERSITY , NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY , Matsutani Chemical Industry Co., Ltd.
发明人： Toshihiko YADA , Yusaku IWASAKI , Hiroshi HARA , Tohru HIRA , Yuka KISHIMOTO , Machiko MINAMI
IPC分类号： A61K31/7004
CPC分类号： A61K31/7004 , A61K31/715
摘要： An object of the present invention is to provide a GLP-1 secretagogue which is an incretin hormone-related drug relatively inexpensive, excellent in safety, and capable of promoting GLP-1 secretion without containing sucrose as an essential constituent. The object is achieved by a GLP-1 secretagogue characterized by containing D-psicose as an active ingredient.
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公开(公告)号：US09244079B2
公开(公告)日：2016-01-26
申请号：US13825445
申请日：2011-05-12
IPC分类号： G01N33/53 , G01N33/68 , G01N33/564
CPC分类号： G01N33/6854 , G01N33/564 , G01N2800/328
摘要： [Problem] The present invention provides a novel pathological marker of angiitis which serves as an alternative to MPO-ANCAs.[Means for Solution] According to one embodiment of the present invention, a method for testing angiitis which includes a step of detecting an antibody specifically recognizing a moesin in a biological sample is provided. In addition, according to another embodiment of the present invention, a reagent for testing angiitis which contains a substance that detects an antibody specifically recognizing a moesin in a biological sample is provided.
摘要翻译： [问题]本发明提供了作为MPO-ANCA的替代物的血管炎的新型病理学标志物。 [解决方案]根据本发明的一个实施方案，提供了一种检测血管炎的方法，其包括检测特异性识别生物样品中的moesin的抗体的步骤。 此外，根据本发明的另一个实施方案，提供了一种用于测试血管炎的试剂，其包含检测特异性识别生物样品中的moesin的抗体的物质。
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公开(公告)号：US20120004186A1
公开(公告)日：2012-01-05
申请号：US13215004
申请日：2011-08-22
申请人： Shigeto YOSHIDA , Toshiki SUDO
发明人： Shigeto YOSHIDA , Toshiki SUDO
IPC分类号： A61K38/16 , A61P7/02 , G01N33/86 , C07K14/435 , C12Q1/02
CPC分类号： C07K14/43563 , A61K38/17 , G01N33/5088
摘要： The invention provides a pharmaceutical composition comprising at least one polypeptide of the following (a) to (d):(a) a polypeptide comprising the amino acid sequence of SEQ ID NO:1; (b) a polypeptide comprising an amino acid sequence comprising one or more amino acid deletions, insertions, substitutions or additions in the amino acid sequence of the above (a) and having a platelet aggregation inhibitory activity and/or a platelet adhesion inhibitory activity; (c) a polypeptide comprising the amino acid sequence of SEQ ID NO:3; and (d) a polypeptide comprising an amino acid sequence comprising one or more amino acid deletions, insertions, substitutions or additions in the amino acid sequence of the above (c) and having a platelet aggregation inhibitory activity and/or a platelet adhesion inhibitory activity, as an active component.
摘要翻译： 本发明提供了包含以下（a）至（d）的至少一种多肽的药物组合物：（a）包含SEQ ID NO：1的氨基酸序列的多肽; （b）包含在上述（a）的氨基酸序列中包含一个或多个氨基酸缺失，插入，取代或添加并具有血小板聚集抑制活性和/或血小板粘附抑制活性的氨基酸序列的多肽; （c）包含SEQ ID NO：3的氨基酸序列的多肽; 和（d）包含在上述（c）的氨基酸序列中包含一个或多个氨基酸缺失，插入，取代或添加并具有血小板聚集抑制活性和/或血小板粘附抑制活性的氨基酸序列的多肽 ，作为活性成分。
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公开(公告)号：US20130102006A1
公开(公告)日：2013-04-25
申请号：US13805513
申请日：2011-06-22
申请人： Kengo Takeuchi , Yuichi Ishikawa , Hiroyuki Mano , Manabu Soda , Eirin Sai
发明人： Kengo Takeuchi , Yuichi Ishikawa , Hiroyuki Mano , Manabu Soda , Eirin Sai
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12P19/34 , C12Q1/68 , C12Q2600/156 , G01N33/57484
摘要： Polynucleotides which are novel causative genes for cancer are elucidated, and a detection method of the polynucleotides or polypeptides encoded by the polynucleotides, and a kit and a primer set for detection are provided, based on the knowledge gained by the elucidation. In the detection method, a fusion gene comprising part of an SDC4, CD74, EZR, SLC34A2, LRIG3, or TPM3 gene and part of a ROS1 gene, or a fusion protein encoded by the fusion gene is detected. The primer set or the detection kit comprises a sense primer designed based on a portion encoding SDC4, CD74, EZR, SLC34A2, LRIG3, or TPM3 and an antisense primer designed based on a portion encoding ROS1.
摘要翻译： 阐明了作为癌症的新型致病基因的多核苷酸，并且基于通过阐明获得的知识，提供了由多核苷酸编码的多核苷酸或多肽的检测方法以及用于检测的试剂盒和引物组。 在检测方法中，检测包含SDC4，CD74，EZR，SLC34A2，LRIG3或TPM3基因和部分ROS1基因的融合基因或融合基因编码的融合蛋白。 引物组或检测试剂盒包括基于编码SDC4，CD74，EZR，SLC34A2，LRIG3或TPM3的部分设计的有义引物和基于编码ROS1的部分设计的反义引物。
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公开(公告)号：US09109259B2
公开(公告)日：2015-08-18
申请号：US13805513
申请日：2011-06-22
申请人： Kengo Takeuchi , Yuichi Ishikawa , Hiroyuki Mano , Manabu Soda , Eirin Sai
发明人： Kengo Takeuchi , Yuichi Ishikawa , Hiroyuki Mano , Manabu Soda , Eirin Sai
IPC分类号： C12Q1/68 , C12P19/34 , G01N33/574
CPC分类号： C12Q1/6886 , C12P19/34 , C12Q1/68 , C12Q2600/156 , G01N33/57484
摘要： Polynucleotides which are novel causative genes for cancer are elucidated, and a detection method of the polynucleotides or polypeptides encoded by the polynucleotides, and a kit and a primer set for detection are provided, based on the knowledge gained by the elucidation. In the detection method, a fusion gene comprising part of an SDC4, CD74, EZR, SLC34A2, LRIG3, or TPM3 gene and part of a ROS1 gene, or a fusion protein encoded by the fusion gene is detected. The primer set or the detection kit comprises a sense primer designed based on a portion encoding SDC4, CD74, EZR, SLC34A2, LRIG3, or TPM3 and an antisense primer designed based on a portion encoding ROS1.
摘要翻译： 阐明了作为癌症的新型致病基因的多核苷酸，并且基于通过阐明获得的知识，提供了由多核苷酸编码的多核苷酸或多肽的检测方法以及用于检测的试剂盒和引物组。 在检测方法中，检测包含SDC4，CD74，EZR，SLC34A2，LRIG3或TPM3基因和部分ROS1基因的融合基因或融合基因编码的融合蛋白。 引物组或检测试剂盒包括基于编码SDC4，CD74，EZR，SLC34A2，LRIG3或TPM3的部分设计的有义引物和基于编码ROS1的部分设计的反义引物。
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公开(公告)号：US09023365B2
公开(公告)日：2015-05-05
申请号：US12278916
申请日：2007-02-08
申请人： Shigeto Yoshida , Yoshio Ohba , Norimitsu Hariguchi , Masami Mizukoshi , Masanori Kawasaki , Makoto Matsumoto , Yoshihiro Goto
发明人： Shigeto Yoshida , Yoshio Ohba , Norimitsu Hariguchi , Masami Mizukoshi , Masanori Kawasaki , Makoto Matsumoto , Yoshihiro Goto
IPC分类号： C12N15/62 , C12N15/866 , A61K39/015 , C12N15/86 , A61K39/04 , A61K39/145 , C07K14/005 , A61K39/00
CPC分类号： C12N15/86 , A61K39/00 , A61K39/015 , A61K39/04 , A61K39/12 , A61K39/145 , A61K2039/525 , A61K2039/5256 , A61K2039/543 , A61K2039/544 , C07K14/005 , C07K2319/02 , C07K2319/43 , C12N2710/14143 , C12N2760/16134 , C12N2830/205 , Y02A50/386 , Y02A50/394 , Y02A50/41 , Y02A50/412
摘要： A recombinant transfer vector capable of expressing a foreign gene fused to a viral gene under the control of dual promoters and a recombinant baculovirus, and methods for production thereof, as well as pharmaceuticals comprising the recombinant baculovirus as an active ingredient.
摘要翻译： 能够在双重启动子和重组杆状病毒的控制下表达与病毒基因融合的外源基因的重组转移载体及其制备方法，以及包含重组杆状病毒作为活性成分的药物。
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公开(公告)号：US09023067B2
公开(公告)日：2015-05-05
申请号：US13381436
申请日：2010-07-12
申请人： Takeshi Ohdaira
发明人： Takeshi Ohdaira
IPC分类号： A61B17/04 , A61B17/068 , A61B17/00 , A61B17/064
CPC分类号： A61B17/0401 , A61B17/0469 , A61B17/0482 , A61B17/0487 , A61B17/068 , A61B2017/00544 , A61B2017/0409 , A61B2017/0414 , A61B2017/0417 , A61B2017/0427 , A61B2017/0464 , A61B2017/047 , A61B2017/0472 , A61B2017/0496 , A61B2017/0647
摘要： A surgical system for small-pit closure in hollow organs is provided. The surgical system is provided with a surgical device for small-pit closure in hollow organs, with the surgical device including the following components: a suture-member cartridge in which a pair of parallel tubular members that accommodate respective suture members are feedably connected to the rear ends of a pair of arrow-shaped members that latch into tissue in a hollow organ; an auxiliary shooting unit having plungers respectively provided in a pair of cylinders open at both ends; a hollow-organ-insertable unit configured of a pair of flexible air tubes; and a gas shooter that sequentially discharges compressed air or high-pressure gas into the open-ended cylinders in response to operations of a trigger, for sequentially ejecting the arrow-shaped members and driving the same into tissue in the hollow organ on both sides of a small pit site.
摘要翻译： 提供了一种用于空心器官中小坑闭合的手术系统。 手术系统设置有用于在中空器官中小坑封闭的手术装置，手术装置包括以下部件：缝合构件筒，其中一对平行的管状构件适应各自的缝合构件，其可馈送地连接到 一对箭头状构件的后端，其卡入中空器官中的组织; 辅助拍摄单元，其具有分别设置在两端敞开的一对气缸中的柱塞; 空心器官可插入单元，由一对柔性空气管构成; 以及气体喷射器，其响应于触发器的操作而顺序地将压缩空气或高压气体排放到开放式气缸中，以顺序地将箭头状部件排出并将其驱动到中空器官的两侧的组织中 一个小坑遗址。
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8.发明授权Surgical system and surgical method for natural orifice transluminal endoscopic surgery (NOTES) 有权自然孔腔内窥镜手术的手术系统和手术方法（NOTES）公开(公告)号：US08640940B2
公开(公告)日：2014-02-04
申请号：US12989730
申请日：2009-04-28
申请人： Takeshi Ohdaira
发明人： Takeshi Ohdaira
IPC分类号： A61B17/115 , A61B18/00
CPC分类号： A61B17/07207 , A61B17/115
摘要： A system and method for use in NOTES is provided for reducing surgical invasiveness. An insertion body that is connected by an anvil assembly and joined to a thin wire guide or electric guide wire, is inserted via a natural orifice into a hollow organ so as to incise and remove a diseased or defective site from the hollow organ by using a pair of or front-end/rear-end linear cutters of a linear cutting/stapling device or linear stapler, after which the two cut ends of the tract are anastomosed and recovered by a circular anastomosis surgical stapler that is provided with the system.
摘要翻译： 提供了一种用于NOTES的系统和方法，用于减少手术侵袭性。 通过砧组件连接并连接到细线导向器或电导线的插入体经由天然孔插入中空器官中，以便通过使用中空器官切割和去除中空器官的病变或缺陷部位 线性切割/吻合装置或线性吻合器的一对或前端/后端线性切割器，之后，通过设置有该系统的圆形吻合手术吻合器将道的两个切割端吻合并回收。
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公开(公告)号：US20130244259A1
公开(公告)日：2013-09-19
申请号：US13825445
申请日：2011-05-12
IPC分类号： G01N33/68
CPC分类号： G01N33/6854 , G01N33/564 , G01N2800/328
摘要： [Problem] The present invention provides a novel pathological marker of angiitis which serves as an alternative to MPO-ANCAs.[Means for Solution]According to one embodiment of the present invention, a method for testing angiitis which includes a step of detecting an antibody specifically recognizing a moesin in a biological sample is provided. In addition, according to another embodiment of the present invention, a reagent for testing angiitis which contains a substance that detects an antibody specifically recognizing a moesin in a biological sample is provided.
摘要翻译： [问题]本发明提供了作为MPO-ANCA的替代物的血管炎的新型病理学标志物。 [解决方案]根据本发明的一个实施方案，提供了一种检测血管炎的方法，其包括检测特异性识别生物样品中的moesin的抗体的步骤。 此外，根据本发明的另一个实施方案，提供了一种用于测试血管炎的试剂，其包含检测特异性识别生物样品中的moesin的抗体的物质。
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公开(公告)号：US08034763B2
公开(公告)日：2011-10-11
申请号：US12065701
申请日：2006-11-02
申请人： Shigeto Yoshida , Toshiki Sudo
发明人： Shigeto Yoshida , Toshiki Sudo
CPC分类号： C07K14/43563 , A61K38/17 , G01N33/5088
摘要： The invention provides a pharmaceutical composition comprising at least one polypeptide of the following (a) to (d): (a) a polypeptide comprising the amino acid sequence of SEQ ID NO:1; (b) a polypeptide comprising an amino acid sequence comprising one or more amino acid deletions, insertions, substitutions or additions in the amino acid sequence of the above (a) and having a platelet aggregation inhibitory activity and/or a platelet adhesion inhibitory activity; (c) a polypeptide comprising the amino acid sequence of SEQ ID NO:3; and (d) a polypeptide comprising an amino acid sequence comprising one or more amino acid deletions, insertions, substitutions or additions in the amino acid sequence of the above (c) and having a platelet aggregation inhibitory activity and/or a platelet adhesion inhibitory activity, as an active component.
摘要翻译： 本发明提供了包含以下（a）至（d）的至少一种多肽的药物组合物：（a）包含SEQ ID NO：1的氨基酸序列的多肽; （b）包含在上述（a）的氨基酸序列中包含一个或多个氨基酸缺失，插入，取代或添加并具有血小板聚集抑制活性和/或血小板粘附抑制活性的氨基酸序列的多肽; （c）包含SEQ ID NO：3的氨基酸序列的多肽; 和（d）包含在上述（c）的氨基酸序列中包含一个或多个氨基酸缺失，插入，取代或添加并具有血小板聚集抑制活性和/或血小板粘附抑制活性的氨基酸序列的多肽 ，作为活性成分。
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