公开(公告)号：US20130018260A1

公开(公告)日：2013-01-17

申请号：US13571644

申请日：2012-08-10

申请人： Narendra T. Sanghvi ,  Chandan Guha ,  Russell James Fedewa ,  Roy Francis Carlson ,  Ralf Seip ,  Wo-Hsing Chen

发明人： Narendra T. Sanghvi ,  Chandan Guha ,  Russell James Fedewa ,  Roy Francis Carlson ,  Ralf Seip ,  Wo-Hsing Chen

IPC分类号： A61B8/00

CPC分类号： A61N7/02 ,  A61B8/08 ,  A61B8/0833 ,  A61B10/0051 ,  A61B10/007 ,  A61B18/04 ,  A61B2017/2253 ,  A61N2007/0004 ,  A61N2007/0073 ,  A61N2007/0082

摘要： A method of diagnosis and treatment of tumors using High Intensity Focused Ultrasound is provided. The method of diagnosing the presence of a tumor in a patient comprises the steps of subjecting a tumor to high intensity focused ultrasound (HIFU) to cause the tumor cells to release cellular material and evaluating the cellular material for a tumor marker. The method of treating a tumor in a patient can also comprise the step of subjecting a tumor to high intensity focused ultrasound (HIFU) to provoke an immune response.

摘要翻译： 提供了使用高强度聚焦超声诊断和治疗肿瘤的方法。 诊断患者肿瘤存在的方法包括以下步骤：使肿瘤进行高强度聚焦超声（HIFU）以使肿瘤细胞释放细胞物质并评估肿瘤标志物的细胞材料。 治疗患者肿瘤的方法还可以包括使肿瘤进行高强度聚焦超声（HIFU）以引起免疫应答的步骤。

公开(公告)号：US07559905B2

公开(公告)日：2009-07-14

申请号：US11524864

申请日：2006-09-21

申请人： Shuhei Kagosaki ,  Yutaka Shimazaki ,  Kenji Yamashita ,  Bernard J. Esarey ,  Artur P. Katny ,  Ralf Seip ,  Narendra T. Sanghvi

发明人： Shuhei Kagosaki ,  Yutaka Shimazaki ,  Kenji Yamashita ,  Bernard J. Esarey ,  Artur P. Katny ,  Ralf Seip ,  Narendra T. Sanghvi

IPC分类号： A61N7/00

CPC分类号： A61B8/00 ,  A61B2017/2253 ,  A61B2018/00023 ,  A61B2090/378 ,  A61N7/02

摘要： A HIFU system is disclosed including a fluid circulation system including a degasser.

摘要翻译： 公开了一种HIFU系统，包括包括脱气器的流体循环系统。

公开(公告)号：US20120035473A1

公开(公告)日：2012-02-09

申请号：US12981076

申请日：2010-12-29

申请人： Narendra T. Sanghvi ,  Ralf Seip ,  Russell J. Fedewa ,  Roy F. Carlson ,  Wo-Hsing Chen ,  Artur P. Katny

发明人： Narendra T. Sanghvi ,  Ralf Seip ,  Russell J. Fedewa ,  Roy F. Carlson ,  Wo-Hsing Chen ,  Artur P. Katny

IPC分类号： A61N7/00 ,  A61B8/14

CPC分类号： A61N7/022 ,  A61B8/12 ,  A61B8/4281 ,  A61B8/481 ,  A61B17/2251 ,  A61B2017/2253 ,  A61B2090/378 ,  A61N2007/0052 ,  A61N2007/0065 ,  A61N2007/0091

摘要： A high-intensity focused ultrasound ablation of tissue using minimally invasive medical procedures is provided.

摘要翻译： 提供了使用微创医疗程序的高强度聚焦超声消融组织。

公开(公告)号：US07662114B2

公开(公告)日：2010-02-16

申请号：US11070371

申请日：2005-03-02

申请人： Ralf Seip ,  Wo-Hsing Chen ,  Narendra T. Sanghvi

发明人： Ralf Seip ,  Wo-Hsing Chen ,  Narendra T. Sanghvi

IPC分类号： A61N7/00 ,  A61B8/00

CPC分类号： A61N7/02 ,  A61N2007/0052 ,  A61N2007/0065 ,  A61N2007/0078 ,  A61N2007/0095 ,  A61N2007/027

摘要： Ultrasound transducers are disclosed which focus acoustic energy at various focal locations while minimizing focal spot degradation and the generation of unwanted on-axis or off-axis energy concentrations through using a generally constant f-number at the various focal locations.

摘要翻译： 公开了超声换能器，其将各种焦点位置处的声能集中，同时通过在各种焦点位置使用通常恒定的f数来最小化焦点劣化和产生不期望的轴上或离轴能量浓度。

公开(公告)号：US20080091123A1

公开(公告)日：2008-04-17

申请号：US11877338

申请日：2007-10-23

申请人： Russell Fedewa ,  Toyoaki Uchida ,  Narendra Sanghvi ,  Roy Carlson

发明人： Russell Fedewa ,  Toyoaki Uchida ,  Narendra Sanghvi ,  Roy Carlson

IPC分类号： A61N7/00

CPC分类号： A61N7/00 ,  A61B34/10 ,  A61B2090/378 ,  A61N7/02 ,  A61N2007/0052 ,  A61N2007/0082

摘要： A method and apparatus is disclosed for determining the success of a proposed HIFU Treatment, of an ongoing HIFU Treatment, and/or of a completed HIFU Treatment. An energy density of a given HIFU Treatment may be used as a comparison factor between the given HIFU Treatment and other HIFU Treatments and as a predictor of the success of the given HIFU Treatment. One exemplary energy density is the amount of energy deposited in the treatment region divided by the volume of the treatment region. Another exemplary energy density is the amount of energy deposited in the treatment region divided by the pre-treatment mass of the treatment region. A method and apparatus is disclosed to detect the presence of focal hyperechoic features and non-focal hyperechoic features. A method and apparatus is disclosed to detect the presence of an acoustic obstruction.

公开(公告)号：US5520188A

公开(公告)日：1996-05-28

申请号：US333471

申请日：1994-11-02

申请人： Carl W. Hennige ,  Stan DeMarta ,  Claudio I. Zanelli

发明人： Carl W. Hennige ,  Stan DeMarta ,  Claudio I. Zanelli

IPC分类号： A61B8/08 ,  A61B17/22 ,  A61N7/02 ,  B06B1/06 ,  G01S15/89 ,  G10K11/34 ,  A61B8/00

CPC分类号： A61B8/4483 ,  A61B8/0833 ,  A61N7/02 ,  B06B1/0625 ,  G01S15/8922 ,  G10K11/346 ,  A61B2017/22028 ,  A61B2090/378 ,  A61N2007/0052

摘要： A transducer for use in a localization and therapeutic ultrasound system. The transducer of the present invention includes multiple elements that are driven separately. The elements operate together to focus a continuous wave ultrasound beam at a focal zone that is at a variable distance from the elements. The transducer includes a mechanism to adjust the focal distance so that the focal zone may be moved to multiple depths.

摘要翻译： 用于定位和治疗超声系统的换能器。 本发明的换能器包括分开驱动的多个元件。 这些元件一起操作以将连续波超声波束聚焦在距离元件可变距离的聚焦区域。 换能器包括调节焦距的机构，使得焦点区域可以移动到多个深度。

公开(公告)号：US20120150035A1

公开(公告)日：2012-06-14

申请号：US13397283

申请日：2012-02-15

申请人： Ralf Seip ,  Wo-Hsing Chen ,  Roy F. Carlson ,  Narendra T. Sanghvi ,  Kris A. Dines ,  Michael A. Penna ,  Richard Pfile

发明人： Ralf Seip ,  Wo-Hsing Chen ,  Roy F. Carlson ,  Narendra T. Sanghvi ,  Kris A. Dines ,  Michael A. Penna ,  Richard Pfile

IPC分类号： A61B8/06 ,  A61N7/00 ,  A61B8/00

CPC分类号： A61B8/06 ,  A61B8/12 ,  A61B8/483 ,  A61B34/10 ,  A61B2017/00274 ,  A61B2018/00547 ,  A61B2090/378 ,  A61N7/02 ,  A61N7/022

摘要： A HIFU System (100) is disclosed which may automatically generate a proposed treatment plan for treating a tissue treatment area (10) with HIFU Therapy. In one example, the proposed treatment plan includes a plurality of treatment sites selected based on a three-dimensional model generated from ultrasound data. In another example, the proposed treatment plan excludes portions of the tissue treatment area (10) corresponding to blood flow, such as the neuro-vascular bundles (20) when treating the prostate (11).

摘要翻译： 公开了一种HIFU系统（100），其可以自动产生用HIFU治疗来治疗组织治疗区域（10）的建议治疗计划。 在一个示例中，所提出的治疗计划包括基于从超声数据生成的三维模型选择的多个治疗部位。 在另一个例子中，所提出的治疗方案排除了在治疗前列腺时，诸如神经 - 维管束（20）的对应于血流的组织治疗区域（10）的部分（11）。

公开(公告)号：US20090069677A1

公开(公告)日：2009-03-12

申请号：US11853191

申请日：2007-09-11

申请人： WO-HSING CHEN ,  ROY CARLSON ,  CLINT C. WEIS ,  RALF SEIP ,  NARENDRA T. SANGHVI

发明人： WO-HSING CHEN ,  ROY CARLSON ,  CLINT C. WEIS ,  RALF SEIP ,  NARENDRA T. SANGHVI

IPC分类号： A61N7/00

CPC分类号： A61N7/02 ,  A61B2090/378

摘要： A method and apparatus is disclosed for determining the presence of tissue change due to exposure to HIFU Therapy.

摘要翻译： 公开了一种用于确定由于暴露于HIFU治疗而导致的组织变化的存在的方法和装置。

公开(公告)号：US20080091124A1

公开(公告)日：2008-04-17

申请号：US11877348

申请日：2007-10-23

申请人： Russell Fedewa ,  Toyoaki Uchida ,  Narendra Sanghvi ,  Roy Carlson

发明人： Russell Fedewa ,  Toyoaki Uchida ,  Narendra Sanghvi ,  Roy Carlson

IPC分类号： A61N7/00

CPC分类号： A61N7/00 ,  A61B34/10 ,  A61B2090/378 ,  A61N7/02 ,  A61N2007/0052 ,  A61N2007/0082

摘要： A method and apparatus is disclosed for determining the success of a proposed HIFU Treatment, of an ongoing HIFU Treatment, and/or of a completed HIFU Treatment. An energy density of a given HIFU Treatment may be used as a comparison factor between the given HIFU Treatment and other HIFU Treatments and as a predictor of the success of the given HIFU Treatment. One exemplary energy density is the amount of energy deposited in the treatment region divided by the volume of the treatment region. Another exemplary energy density is the amount of energy deposited in the treatment region divided by the pre-treatment mass of the treatment region. A method and apparatus is disclosed to detect the presence of focal hyperechoic features and non-focal hyperechoic features. A method and apparatus is disclosed to detect the presence of an acoustic obstruction.

摘要翻译： 公开了一种用于确定所提出的HIFU治疗，正在进行的HIFU治疗和/或完成的HIFU治疗的成功的方法和装置。 给定HIFU治疗的能量密度可用作给定HIFU治疗与其他HIFU治疗之间的比较因子，并且作为给定HIFU治疗成功的预测因子。 一个示例性能量密度是在处理区域中沉积的能量的量除以处理区域的体积。 另一个示例性能量密度是处理区域中所沉积的能量除以处理区域的预处理质量。 公开了一种检测局灶性高回声特征和非局灶性高回声特征的存在的方法和装置。 公开了一种检测声阻塞的存在的方法和装置。

公开(公告)号：US5873902A

公开(公告)日：1999-02-23

申请号：US893130

申请日：1997-07-15

申请人： Narendra T. Sanghvi ,  Francis J. Fry ,  Carl W. Hennige ,  Claudio I. Zanelli

发明人： Narendra T. Sanghvi ,  Francis J. Fry ,  Carl W. Hennige ,  Claudio I. Zanelli

IPC分类号： A61B17/00 ,  A61N7/02 ,  G01H1/16 ,  A61F7/00

CPC分类号： G01H1/16 ,  A61N7/022 ,  A61B2017/00274 ,  A61B2018/00547

摘要： A method of treatment by ultrasound comprises providing a first, ultrasound field intensity-to-voltage transducer sized for insertion into the vicinity of a treatment site and a second ultrasound treatment transducer. The free field intensities created by the second transducer in response to various second transducer exciting signal levels are determined. The first transducer outputs in the free field in response to various second transducer exciting signal levels are also determined. The first transducer is inserted into the vicinity of the treatment site, and the second transducer is positioned to create an ultrasound field at the treatment site. The distance from the second transducer to the first transducer is determined. An exciting signal is applied to the second transducer. The output of the first transducer is determined. The level of the exciting signal applied to the second transducer, the determined distance and the first transducer output are employed to determine the attenuation coefficient of the tissues between the second transducer and the first transducer.