公开(公告)号：US20100260767A1

公开(公告)日：2010-10-14

申请号：US12687981

申请日：2010-01-15

申请人： Kenneth Jacobs ,  Debra D. Pittman ,  Lynette Fouser ,  Vikki Spaulding ,  Dejun Xuan

发明人： Kenneth Jacobs ,  Debra D. Pittman ,  Lynette Fouser ,  Vikki Spaulding ,  Dejun Xuan

IPC分类号： A61K39/395 ,  C07K16/24 ,  A61P37/00 ,  A61P29/00

CPC分类号： C07K16/244 ,  A61K38/20 ,  A61K2039/505 ,  C07K14/54 ,  C07K14/5428 ,  C07K2317/76 ,  C12N2799/022 ,  A61K2300/00

摘要： Inhibitors of IL-22 are disclosed as well as pharmaceutical compositions and methods of using same. The inhibitors include IL-22 antibodies and are useful for treating inflammatory disorders.

摘要翻译： 公开了IL-22的抑制剂以及药物组合物及其使用方法。 抑制剂包括IL-22抗体，可用于治疗炎症性疾病。

公开(公告)号：US20090148427A1

公开(公告)日：2009-06-11

申请号：US12254940

申请日：2008-10-21

申请人： Gray D. Shaw ,  Dianne S. Sako ,  Ravindra Kumar ,  Francis Sullivan ,  Tom McDonagh

发明人： Gray D. Shaw ,  Dianne S. Sako ,  Ravindra Kumar ,  Francis Sullivan ,  Tom McDonagh

IPC分类号： A61K38/43 ,  A61K38/16

CPC分类号： C07K14/705 ,  A61K38/1709 ,  C07K2319/00

摘要： The present invention provides compositions and methods for treating or preventing vascular-associated disorders.

摘要翻译： 本发明提供了用于治疗或预防血管相关疾病的组合物和方法。

公开(公告)号：US07252820B2

公开(公告)日：2007-08-07

申请号：US11066236

申请日：2005-02-25

申请人： Amechand Boodhoo ,  Jasbir S. Seehra ,  Gray Shaw ,  Dianne Sako

发明人： Amechand Boodhoo ,  Jasbir S. Seehra ,  Gray Shaw ,  Dianne Sako

IPC分类号： A61K38/48 ,  C12N9/64 ,  C12N15/57

CPC分类号： A61K38/4886 ,  C12N9/6418

摘要： Methods and compositions for treating a wide range of inflammatory diseases and disorders, and for inhibiting selectin-mediated binding by administering a mocarhagin protein, or fragments thereof with mocarhagin protein activity are provided. The mocarhagin protein may be administered alone, or in combination with a cytokine, lymphokine, or hematopoietic factor.

摘要翻译： 提供了用于治疗多种炎性疾病和病症的方法和组合物，并且通过施用莫卡海明蛋白或其片段具有莫卡宾蛋白活性来抑制选择素介导的结合。 莫卡海明蛋白可以单独施用或与细胞因子，淋巴因子或造血因子组合施用。

公开(公告)号：US07235367B2

公开(公告)日：2007-06-26

申请号：US09903876

申请日：2001-07-11

申请人： William S. Somers ,  Zhang-Bao Xu ,  Tatos N. Akopian ,  Chu-Lai Hsiao ,  Rayomand Unwalla

发明人： William S. Somers ,  Zhang-Bao Xu ,  Tatos N. Akopian ,  Chu-Lai Hsiao ,  Rayomand Unwalla

IPC分类号： G01N23/20 ,  G01N33/53

CPC分类号： C07K14/70567 ,  C07K2299/00

摘要： This invention is directed to the crystal structure of Estrogen Receptor-β (ER-β) complexed with genistein, and to the use of this structure in rational drug design methods to identify agents that may interact with active sites of ER-β, which may be useful as novel chemotherapeutic agents.

摘要翻译： 本发明涉及与染料木黄酮复合的雌激素受体-β（ER-β）的晶体结构，以及在合理药物设计方法中使用该结构来鉴定可与ER-β的活性位点相互作用的药剂 作为新型化学治疗剂有用。

公开(公告)号：US07223848B2

公开(公告)日：2007-05-29

申请号：US10163853

申请日：2002-06-05

申请人： Jonathan L. Coffman ,  William B. Foster ,  Shujun Sun

发明人： Jonathan L. Coffman ,  William B. Foster ,  Shujun Sun

IPC分类号： C07K1/18 ,  C07K1/20 ,  C07K1/22

CPC分类号： C07K1/36 ,  B01D15/20 ,  B01D15/327 ,  C07K1/22 ,  C07K14/31 ,  C07K2319/30 ,  Y10S436/828

摘要： The present invention provides a process for dissociating Fc-containing molecules from complexes of Protein A/Fc-containing molecules or mixtures containing Fc-containing molecules and Protein A. The association, e.g., by hydrophobic interactions, between the Fc-containing molecules and Protein A can be reduced or inhibited by raising the pH of dissociation. The pH of dissociation can be raised by addition of agents capable of inhibiting hydrophobic interactions, including buffers containing arginine and/or ethylene glycol, to the mixture, either prior to adding the mixture to the column chromatography substrate, after adding the mixture to the column chromatography substrate, or both prior to and after adding the mixture to the column chromatography substrate. Separation of Fc-containing molecules from Protein A can be performed on a number of different column chromatographic substrates, including column chromatographic substrates contained in Q columns (Q column chromatography substrate), HIC columns (hydrophobic interaction column chromatography substrate), and IMAC columns (metal chelate column chromatography substrate).

摘要翻译： 本发明提供了一种从包含含蛋白A / Fc的分子或含有Fc分子和蛋白质A的混合物的复合物中解离含Fc分子的方法。在含Fc分子和蛋白质之间的关联，例如通过疏水相互作用 可以通过提高解离的pH来降低或抑制A。 在将混合物加入到柱中之前，可以通过加入能够抑制疏水相互作用的试剂（包括含有精氨酸和/或乙二醇的缓冲液）到混合物中来提高解离的pH值。 色谱底物，或在将混合物加入柱色谱底物之前和之后两者。 含有Fc的分子与蛋白A的分离可以在许多不同的色谱层析基质上进行，包括Q柱（Q柱色谱底物），HIC柱（疏水相互作用柱色谱底物）和IMAC色谱柱 金属螯合柱色谱法）。

公开(公告)号：US20070053897A1

公开(公告)日：2007-03-08

申请号：US11483146

申请日：2006-07-06

申请人： Simon Jones ,  Jin Tang

发明人： Simon Jones ,  Jin Tang

IPC分类号： A61K39/395 ,  A61K38/46 ,  C12P21/06 ,  C12N9/20

CPC分类号： C12N9/18 ,  A61K38/00 ,  C12N9/20

摘要： The invention provides a novel calcium-independent cytosolic phospholipase A2/B enzyme, polynucleotides encoding such enzyme and methods for screening unknown compounds for anti-inflammatory activity mediated by the arachidonic acid cascade.

摘要翻译： 本发明提供了一种新的不依赖钙的胞质磷脂酶A 2 / B酶，编码这种酶的多核苷酸以及用于筛选未知化合物用于由花生四烯酸级联介导的抗炎活性的方法。

公开(公告)号：US07094402B2

公开(公告)日：2006-08-22

申请号：US09924338

申请日：2001-08-07

申请人： James Tobin

发明人： James Tobin

IPC分类号： A61K39/395 ,  C07K16/24

CPC分类号： C07K14/7155 ,  A61K38/00 ,  C07K2319/30 ,  Y10S514/885

摘要： Polynucleotides encoding the human IL-11 receptor and fragments thereof are disclosed. IL-11 receptor proteins, methods for their production, antibodies to human IL-11 receptor, inhibitors of binding of human IL-11 and its receptor and methods for identification of their receptor are also disclosed.

摘要翻译： 公开了编码人IL-11受体的多核苷酸及其片段。 还公开了IL-11受体蛋白质，其生产方法，人IL-11受体的抗体，人IL-11及其受体结合的抑制剂及其受体鉴定方法。

公开(公告)号：US20060165706A1

公开(公告)日：2006-07-27

申请号：US11321444

申请日：2005-12-29

申请人： Beatriz Carreno ,  Clive Wood ,  Katherine Turner ,  Mary Collins ,  Gary Gray ,  Donna Morris ,  Denise O'Hara ,  Paul Hinton ,  Naoya Tsurushita

发明人： Beatriz Carreno ,  Clive Wood ,  Katherine Turner ,  Mary Collins ,  Gary Gray ,  Donna Morris ,  Denise O'Hara ,  Paul Hinton ,  Naoya Tsurushita

IPC分类号： A61K39/395 ,  C07K16/46

CPC分类号： A61K51/1027 ,  A61K47/6827 ,  A61K47/6829 ,  A61K47/6849 ,  A61K2039/505 ,  C07K16/2818 ,  C07K2317/24 ,  C07K2317/34

摘要： The invention provides an antibody-toxic moiety conjugates comprising an antibody that specifically recognizes a molecule expressed on the surface of a T cell which is expressed only on T cells and is only expressed transiently on T cells upon T cell activation. Preferably, the T cell molecule is CTLA4. The invention further provides anti-CTLA4 antibodies and humanized forms thereof.

公开(公告)号：US20060140919A1

公开(公告)日：2006-06-29

申请号：US11366331

申请日：2006-03-02

申请人： Carl June ,  Craig Thompson ,  Gary Nabel ,  Gary Gray ,  Paul Rennert

发明人： Carl June ,  Craig Thompson ,  Gary Nabel ,  Gary Gray ,  Paul Rennert

IPC分类号： A61K39/395 ,  A61K35/14

CPC分类号： C07K14/705 ,  A61K2039/5158 ,  C07K16/2806 ,  C07K16/2809 ,  C07K16/2818 ,  C07K16/2896 ,  C07K2317/34 ,  C12N5/0636 ,  C12N2501/51 ,  C12N2501/515 ,  C12N2501/599

摘要： Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the absence of exogenous growth factors or accessory cells. T cell activation is accomplished by stimulating the T cell receptor (TCR)/CD3 complex or the CD2 surface protein. To induce proliferation of an activated population T cells, an accessory molecule on the surface of the T cells, such as CD28, is stimulated with a ligand which binds the accessory molecule. The T cell population expanded by the method of the invention can be genetically transduced and used for immunotherapy or can be used in methods of diagnosis.

公开(公告)号：US20060099177A1

公开(公告)日：2006-05-11

申请号：US11326148

申请日：2006-01-05

申请人： Carl June ,  Craig Thompson ,  Gary Nabel ,  Gary Gray ,  Paul Rennert

发明人： Carl June ,  Craig Thompson ,  Gary Nabel ,  Gary Gray ,  Paul Rennert

IPC分类号： A61K35/14 ,  C12N5/08

CPC分类号： C07K16/2809 ,  A61K35/17 ,  A61K2039/507 ,  C07K16/2806 ,  C07K16/2818 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/74 ,  C07K2319/30 ,  C12N2740/16011

摘要： Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the absence of exogenous growth factors or accessory cells. T cell activation is accomplished by stimulating the T cell receptor (TCR)/CD3 complex or the CD2 surface protein. To induce proliferation of an activated population T cells, an accessory molecule on the surface of the T cells, such as CD28, is stimulated with a ligand which binds the accessory molecule. The T cell population expanded by the method of the invention can be genetically transduced and used for immunotherapy or can be used in methods of diagnosis.