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    α-1,3 fucosyltransferases and expression systems for making and expressing them
    3.
    发明授权
    α-1,3 fucosyltransferases and expression systems for making and expressing them 失效
    α-1,3岩藻糖基转移酶和用于制备和表达它们的表达系统

    公开(公告)号：US06962806B2

    公开(公告)日：2005-11-08

    申请号：US10189977

    申请日：2002-07-03

    申请人： Diane E. Taylor ,  Zhongming Ge

    发明人： Diane E. Taylor ,  Zhongming Ge

    IPC分类号： C12N1/21 ,  C12N9/10 ,  C12N15/54 ,  C12Q1/68

    CPC分类号： C12N9/1051 ,  C07K2319/00 ,  C12Q1/6886

    摘要： A bacterial α1,3-fucosyltransferase gene and deduced amino acid sequence is provided. The gene is useful for preparing α1,3-fucosyltransferase polypeptide, and active fragment thereof, which can be used in the production of oligosaccharides such as Lewis X, Lewis Y, and siayl Lewis X, which are structurally similar to certain tumor-associated carbohydrate antigens found in mammals. These product glycoconjugates also have research and diagnostic utility in the development of assays to detect mammalian tumors. In addition the polypeptide of the invention can be used to develop diagnostic and research assays to determine the presence of H. pylori in human specimens.

    摘要翻译： 提供细菌α1,3-岩藻糖基转移酶基因和推导的氨基酸序列。 该基因可用于制备α1,3-岩藻糖基转移酶多肽及其活性片段，其可用于生产低聚糖例如Lewis X，Lewis Y和siayl Lewis X，其结构上类似于某些肿瘤相关碳水化合物 在哺乳动物中发现的抗原。 这些产品糖缀合物在开发检测哺乳动物肿瘤的检测中也具有研究和诊断效用。 此外，本发明的多肽可用于开发诊断和研究测定以确定幽门螺杆菌在人标本中的存在。

    Nucleic acids encoding alpha-1,3 fucosyltransferases and expression systems for making and expressing them
    4.
    发明申请
    Nucleic acids encoding alpha-1,3 fucosyltransferases and expression systems for making and expressing them 有权
    编码α-1,3岩藻糖基转移酶的核酸和用于制备和表达它们的表达系统

    公开(公告)号：US20020068347A1

    公开(公告)日：2002-06-06

    申请号：US09733524

    申请日：2000-12-07

    申请人： The Governers of the University of Alberta, a Canada corporation

    发明人： Diane E. Taylor ,  Zhongming Ge

    IPC分类号： C12N009/10 ,  C12Q001/68 ,  G01N033/543 ,  C07H021/04 ,  C12P021/02

    CPC分类号： C12N9/1051 ,  C07K2319/00 ,  C12Q1/6886

    摘要： A bacterial null1,3-fucosyltransferase gene and deduced amino acid sequence is provided. The gene is useful for preparing null1,3-fucosyltransferase polypeptide, and active fragment thereof, which can be used in the production of oligosaccharides such as Lewis X, Lewis Y, and siayl Lewis X, which are structurally similar to certain tumor-associated carbohydrate antigens found in mammals. These product glycoconjugates also have research and diagnostic utility in the development of assays to detect mammalian tumors. In addition the polypeptide of the invention can be used to develop diagnostic and research assays to determine the presence of H. pylori in human specimens.

    摘要翻译： 提供细菌α1,3-岩藻糖基转移酶基因和推导的氨基酸序列。 该基因可用于制备α1,3-岩藻糖基转移酶多肽及其活性片段，其可用于生产低聚糖例如Lewis X，Lewis Y和siayl Lewis X，其结构上类似于某些肿瘤相关碳水化合物 在哺乳动物中发现的抗原。 这些产品糖缀合物在开发检测哺乳动物肿瘤的检测中也具有研究和诊断效用。 此外，本发明的多肽可用于开发诊断和研究测定以确定幽门螺杆菌在人标本中的存在。

    Lean premixed fuel burner
    6.
    发明授权
    Lean premixed fuel burner 失效
    精益燃料预燃燃烧器

    公开(公告)号：US5588825A

    公开(公告)日：1996-12-31

    申请号：US572269

    申请日：1995-12-13

    申请人： Larry W. Kostiuk ,  Matthew R. Johnson

    发明人： Larry W. Kostiuk ,  Matthew R. Johnson

    IPC分类号： F23D14/58 ,  F23D14/74

    CPC分类号： F23D14/58 ,  F23D14/74 ,  F23D2900/14002

    摘要： A lean premixed fuel burner includes a peripheral ring stabilizer which divides the flow into a primary gas flow and a secondary gas flow and generates a secondary flame substantially surrounding the main flame formed by the main gas flow. Further stabilizers are provided in the area of the primary gas flow on the inside of the peripheral stabilizer. These stabilizers divide the main gas flow into a plurality of subsidiary flows whereby the primary flame is formed by a plurality of discrete flame formed in the spaces between the secondary stabilizers thereby to provide a main flame significantly shorter in the direction of gas flow than if a single primary flame is used.

    摘要翻译： 贫预混合燃料燃烧器包括外围环稳定器，其将流分成主气流和二次气流，并产生基本上围绕由主气流形成的主火焰的二次火焰。 在外围稳定器内部的主要气流区域中提供了进一步的稳定剂。 这些稳定剂将主气流分成多个辅助流，由此一次火焰由形成在二次稳定器之间的空间中的多个分立的火焰形成，从而在气流方向上提供显着短于气流方向的主火焰，如 使用单一主火焰。

    Electrostatically regulated atomic scale electroconductivity device
    8.
    发明授权
    Electrostatically regulated atomic scale electroconductivity device 有权
    静电原子尺度导电装置

    公开(公告)号：US08076668B2

    公开(公告)日：2011-12-13

    申请号：US11908181

    申请日：2006-03-08

    申请人： Robert A. Wolkow ,  Paul G. Piva ,  Jason L. Pitters ,  Gino A. Dilabio

    发明人： Robert A. Wolkow ,  Paul G. Piva ,  Jason L. Pitters ,  Gino A. Dilabio

    IPC分类号： G01R27/02

    CPC分类号： H01L51/0595 ,  B82Y10/00 ,  B82Y15/00 ,  B82Y30/00 ,  H01L51/0508

    摘要： An atomic scale electroconductivity device with electrostatic regulation is provided that includes a perturbing species having a localized electronic charge ol a dangling bond. A sensing species having an electronic conductivity is placed in proximity to the perturbing species at a distance sufficient to induce a change in the electronic conductivity associated with the localized electronic charge. Electronics are provided to measure the conductivity via the sensing species. The dangling bond functions as a single atom gate electrode.

    摘要翻译： 提供了具有静电调节的原子级电导率装置，其包括具有悬挂键的局部电荷的扰动物质。 具有电子传导性的感测物质被放置在扰动物质附近，距离足以引起与局部电子电荷相关的电子传导性的变化。 电子设备用于通过感测物种测量电导率。 悬挂键用作单个原子栅电极。

    Continuous biochemical reactor for analysis of sub-picomole quantities of complex organic molecules
    9.
    发明授权
    Continuous biochemical reactor for analysis of sub-picomole quantities of complex organic molecules 失效
    用于分析亚皮摩尔量的复杂有机分子的连续生化反应器

    公开(公告)号：US5415841A

    公开(公告)日：1995-05-16

    申请号：US292605

    申请日：1994-08-18

    申请人： Norman J. Dovichi ,  Karen C. Waldron

    发明人： Norman J. Dovichi ,  Karen C. Waldron

    IPC分类号： B01J19/00 ,  G01N33/68

    CPC分类号： G01N33/6824 ,  B01J19/0093 ,  Y10T436/143333 ,  Y10T436/25375 ,  Y10T436/255

    摘要： A novel reactor for reacting and subsequently analyzing sub-picomole quantities of a sample organic molecule. The reactor includes a continuous capillary connected between two valves that control fluid flow in the capillary. One part of the capillary forms a reaction chamber where the sample may be immobilized for subsequent reaction with reagents supplied through the valves. Another part of the capillary passes through or terminates in the detector portion of an analyzer such as an electrophoresis apparatus, liquid chromatographic apparatus or mass spectrometer. The apparatus may form a peptide or protein sequencer for carrying out the Edman degradation reaction and analyzing the reaction product produced by the reaction. The protein or peptide sequencer includes a reaction chamber for carrying out coupling and cleavage on a peptide or protein to produced derivatized amino acid residue, a conversion chamber for carrying out conversion and producing a converted amino acid residue and an analyzer for identifying the converted amino acid residue. The reaction chamber may be contained within one arm of a capillary and the conversion chamber is located in another arm of the capillary. An electrophoresis length of capillary is directly capillary coupled to the conversion chamber to allow electrophoresis separation of the converted amino acid residue as it leaves the conversion chamber. Identification of the converted amino acid residue takes place at one end of the electrophoresis length of the capillary.

    摘要翻译： 一种用于反应并随后分析亚微微摩尔量的样品有机分子的新型反应器。 反应器包括连接在控制毛细管中的流体流动的两个阀之间的连续毛细管。 毛细管的一部分形成反应室，其中样品可以被固定以便随后通过阀提供的试剂反应。 毛细管的另一部分通过或终止于分析仪的检测器部分，例如电泳装置，液相色谱装置或质谱仪。 该装置可以形成用于进行埃德曼降解反应并分析由反应产生的反应产物的肽或蛋白测序仪。 蛋白质或肽测序仪包括用于在肽或蛋白质上进行偶联和切割以产生衍生的氨基酸残基的反应室，用于进行转化并产生转化的氨基酸残基的转化室和用于鉴定转化的氨基酸的分析仪 残留物 反应室可以包含在毛细管的一个臂内，并且转化室位于毛细管的另一个臂中。 毛细管的电泳长度直接毛细耦合到转化室，以便在转化的氨基酸残基离开转化室时电泳分离转化的氨基酸残基。 转化的氨基酸残基的鉴定发生在毛细管的电泳长度的一端。