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1.发明授权公开(公告)号：US11834524B2
公开(公告)日：2023-12-05
申请号：US17828152
申请日：2022-05-31
发明人： Jue Wang , Yaru Wu , Meiqin Zhu
CPC分类号： C08B37/003 , A61K8/73 , A61K47/36
摘要： The application discloses a method for preparing chitin highly dispersible in aqueous phase and prepared chitin. After chitin is ground, dissolved, modified with glycidol and purified, a final product glycidol chitin is obtained. The glycidol chitin prepared according to this method has good solubility in purified water, and the concentration can reach 100 mg/mL, which is obviously different from common insoluble or poorly soluble chitin derivatives. Glycidol chitin may have a wide range of application prospects in biomedicine, cosmetics, absorbable materials, and other related aspects.
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公开(公告)号：US20220081492A1
公开(公告)日：2022-03-17
申请号：US17106194
申请日：2020-11-30
摘要： Provided are a chitin whisker-enhanced hyaluronic acid cell scaffold and a preparation method thereof. Components of the cell scaffold include chitin whiskers and cross-linked hyaluronic acid. The chitin whisker-enhanced hyaluronic acid cell scaffold is obtained by dispersing chitin whiskers into deionized water using ultrasound, followed by addition of hyaluronic acid and uniform mixing to obtain an aqueous solution, adjusting a pH value of the aqueous solution to be in a range of 4.0 to 6.0, subjecting the aqueous solution to a cross-linking reaction, dialyzing a reaction product in a phosphate buffer solution, and freeze drying a resulting product. The chitin whisker-enhanced hyaluronic acid cell scaffold and the preparation method thereof can increase a mechanical property and a resistance to degradation of a scaffold material and expand an application scope of hyaluronic acid cell scaffolds.
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3.发明公开公开(公告)号：US20240238479A1
公开(公告)日：2024-07-18
申请号：US18135733
申请日：2023-04-17
发明人： Qingzhi Deng , Zhihong Zhang , Yufei Xiong , Wei Huang , Quan Zhang , Bair Zu
IPC分类号： A61L27/26
CPC分类号： A61L27/26 , A61L2400/06 , A61L2430/34
摘要： The present disclosure provides a collagen and sodium hyaluronate cross-linked composite filler for injection and a preparation method thereof. The collagen and sodium hyaluronate cross-linked composite filler is obtained by a cross-linking reaction of collagen and sodium hyaluronate with a 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride/N-hydroxysuccinimide (EDC/NHS) cross-linking system. As the EDC/NHS is used as a cross-linking agent in the present disclosure, the resulting product has no biological toxicity, so that the injury caused by a final product to an injection site and the human body is reduced. Meanwhile, due to intramolecular and intermolecular cross-linking, the degradation rate of the collagen and the sodium hyaluronate is reduced, and the retention time of the two in the body is prolonged. Therefore, the collagen and sodium hyaluronate cross-linked composite filler for injection in the present disclosure can be used in plastic surgery in the medical industry.
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4.发明公开公开(公告)号：US20230312763A1
公开(公告)日：2023-10-05
申请号：US17828152
申请日：2022-05-31
发明人： Jue Wang , Yaru Wu , Meiqin Zhu
CPC分类号： C08B37/003 , A61K47/36 , A61K8/73
摘要： The application discloses a method for preparing chitin highly dispersible in aqueous phase and prepared chitin. After chitin is ground, dissolved, modified with glycidol and purified, a final product glycidol chitin is obtained. The glycidol chitin prepared according to this method has good solubility in purified water, and the concentration can reach 100 mg/mL, which is obviously different from common insoluble or poorly soluble chitin derivatives. Glycidol chitin may have a wide range of application prospects in biomedicine, cosmetics, absorbable materials, and other related aspects.
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公开(公告)号：US20220064436A1
公开(公告)日：2022-03-03
申请号：US17197022
申请日：2021-03-09
IPC分类号： C08L67/04
摘要： Provided is a gradient injection containing a mixture of polymer microspheres. The injection is a freeze-dried powder composed of a filler, cross-linked sodium hyaluronate microspheres, poly-L-lactic acid (PLLA) microspheres, and an excipient. The powder can be mixed with sterile water and then used for injection cosmetology. A triple gradient effectiveness is provided by mixing the filler, the cross-linked sodium hyaluronate microspheres, and the PLLA microspheres to improve the subcutaneous capacity of human skin and repair skin wrinkles, folds, scars, and aging. The gradient injection is also suitable for repairing large-volume facial fat loss without adverse reactions such as nodules and granulomas.
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公开(公告)号：US20230383099A1
公开(公告)日：2023-11-30
申请号：US18147703
申请日：2022-12-29
发明人： Jue Wang , Jie Zheng , Xingyu Liu , Meiqin Zhu , Qianqian Jia
CPC分类号： C08L5/08 , C08B37/003 , C08J3/075 , C12N5/0018 , A61L27/52 , A61L27/54 , A61L27/20 , C08J2305/08 , C12N2500/34 , A61L2430/34
摘要： Disclosed in the present disclosure are a hydroxybutyl chitin, a hydroxybutyl chitin hydrogel and a preparation method thereof. Chitin is subjected to pulverization, dissolution, modification with epoxybutane, and purification to obtain a final product, namely the hydroxybutyl chitin. The hydroxybutyl chitin prepared by the method has good solubility in purified water, and a hydrogel with a low solid content can be formed. The hydroxybutyl chitin hydrogel will have a wide application aspect in biomedicine, absorbable materials, and other fields.
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公开(公告)号：US20230067215A1
公开(公告)日：2023-03-02
申请号：US17539154
申请日：2021-11-30
发明人： Jie Li , Yang Fu , Cuiying Zhou , Feifei Wu , Shitu Ma
摘要： The present invention provides a gel for injection containing controlled degradation polyester microspheres. The gel for injection consists of crosslinked sodium hyaluronate gel, non-crosslinked sodium hyaluronate gel, polyester microspheres wrapped with hard fat and a balanced salt solution. The polyester microspheres are separated from water by means of wrapping and hydrophobic effect of the hard fat, and accordingly the present invention solve the problem that polyester materials are prone to degradation in gel. In the meantime, the hard fat has the characteristic of low melting point (melting point being 33° C.-39° C.), after the product is injected into human body, the hard fat is molten and separated under the action of human body temperature, and the wrapped polyester microspheres are released so that the microspheres can be degraded in the human body to achieve controlled degradation.
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公开(公告)号：US11098168B2
公开(公告)日：2021-08-24
申请号：US16454089
申请日：2019-06-27
发明人： Jin Zeng , Weiwei Wang , Weiqing Sun
摘要： Related to is the field of polymer materials, and particularly related to are a method for preparing cross-linked hyaluronic acid gel and a cross-linked hyaluronic acid gel prepared by the method. Under an alkaline condition, a disulfide cross-linking agent is dropwise added into an alkaline solution of hyaluronic acid for cross-linking reaction, and after the reaction is completed, dialysis and freeze drying are carried out to obtain the cross-linked hyaluronic acid gel. A new disulfide cross-linking agent N,N-bis(acroloyl)cystamine is introduced, and it effectively solves degradation regulating problems of cross-linked hyaluronic acid; the disulfide bond ratio is controllable, which can effectively improve a cross-linking modification degree ratio in the cross-linked hyaluronic acid, thereby solving the problem of difficult degradation of highly cross-linked hyaluronic acid gel in the past. The cross-linked material has potential applications in aspects of drug carriers and tissue engineering scaffolds.
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公开(公告)号：US09861722B2
公开(公告)日：2018-01-09
申请号：US15201597
申请日：2016-07-04
发明人： Zhiguo Zhang , Yange Suo , Wei Huang , Weiqing Sun
CPC分类号： A61L24/0036 , A61L24/08 , A61L2400/04 , C08B15/04 , C08L1/04
摘要： Disclosed is a method for preparing an oxidized cellulose hemostatic product, including using a sodium hydroxide solution with the concentration of 1 to 5% to pre-process a cellulose product; after removing lignins or impurities on the fiber surface, using an alkaline solution to activate the fiber surface further; after the activating treatment, using demin-water for washing until it is neutral and drying the obtained cellulose product in air to obtain a raw material; using a sodium hydroxide solution with the concentration of 5 to 20% as a solvent; adding the cellulose product, carbamide and ZnO that are 3 to 10%, 2% and 2% of the sodium hydroxide solution respectively.
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公开(公告)号：US12121907B1
公开(公告)日：2024-10-22
申请号：US18523848
申请日：2023-11-29
发明人： Yang Fu , Lingling Lyu , Jue Wang , Wei Huang
摘要： A cyclical and continuous device and method for wet sieving of polysaccharide granules are provided. The device includes a first dosing tank, a second dosing tank connected to the first dosing tank by a first circulation pump, a first suction filtration tank connected to the second dosing tank by a second circulation pump, and a second suction filtration tank connected to the first dosing tank by a third circulation pump. An overflow port provided on a side wall of the second dosing tank is higher than a feed port of the first dosing tank. A sieve of a mesh filter for coarse powder is disposed in the first dosing tank. A sieve of a mesh filter for fine powder is disposed in the second dosing tank. A stirring device is disposed in both the first dosing tank and the second dosing tank.
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