公开(公告)号：US12033729B2

公开(公告)日：2024-07-09

申请号：US16330674

申请日：2017-09-06

申请人： Indiana University Research and Technology Corporation

发明人： Titus Karl Ludwig Schleyer ,  Xia Ning

IPC分类号： G16H10/20 ,  G06F16/335 ,  G06Q10/10 ,  G06Q50/10 ,  G06Q50/22 ,  G16H10/60 ,  G16H80/00

CPC分类号： G16H10/20 ,  G06F16/335 ,  G06Q10/10 ,  G06Q50/10 ,  G06Q50/22 ,  G16H10/60 ,  G16H80/00

摘要： Methods for generating a health management template for a patient condition including retrieving a healthcare template It corresponding to a patient condition, the healthcare template comprising a plurality of data fields, populating the data fields with patient data; and generating an updated healthcare template based on a user input, wherein the user input comprises at least one of a search request or a data option selection are disclosed. Systems are also disclosed.

公开(公告)号：US20240199591A1

公开(公告)日：2024-06-20

申请号：US18392203

申请日：2023-12-21

申请人： Northeastern University ,  Indiana University Research and Technology Corporation

发明人： Ganeshsingh A. THAKUR ,  Diomedes E. LOGOTHETIS ,  Lucas CANTWELL ,  Yu XU ,  Anantha SHEKHAR

IPC分类号： C07D409/12 ,  A61K31/415 ,  A61P25/22 ,  C07D231/40 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12

CPC分类号： C07D409/12 ,  A61K31/415 ,  A61P25/22 ,  C07D231/40 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12

摘要： Selective small molecule regulators of GIRK potassium channels are provided, which are effective in treatment of post-traumatic stress disorder and other medical conditions.

公开(公告)号：US11957115B2

公开(公告)日：2024-04-16

申请号：US16496261

申请日：2018-03-21

申请人： The Jackson Laboratory ,  Indiana University Research and Technology Corporation

发明人： Gareth Howell ,  Michael Sasner ,  Gregory Carter ,  Bruce Lamb

IPC分类号： A01K67/0278 ,  C07K14/705 ,  C07K14/775 ,  G01N33/68

CPC分类号： A01K67/0278 ,  C07K14/70503 ,  C07K14/775 ,  G01N33/6896 ,  A01K2217/056 ,  A01K2217/072 ,  A01K2217/15 ,  A01K2227/105 ,  A01K2267/0312 ,  G01N2500/00

摘要： Genetically modified mice characterized by one or more symptoms or signs associated with expression of human APOE4p and mouse Trem2p and relevant to non-familial late-onset Alzheimer's disease are provided wherein the genome of the mouse includes: 1) a DNA sequence encoding a human APOE4 protein (APOE4p) operably linked to a promoter; and 2) a DNA sequence encoding a mouse Trem2 protein having a mutation p,R47H (Trem2p) operably linked to a promoter, such that the mouse expresses human APOE4p and mouse Trem2p. Methods ace provided for screening for a compound for use in the treatment of Alzheimer's disease using such genetically modified mice.

公开(公告)号：US20240116998A1

公开(公告)日：2024-04-11

申请号：US18264157

申请日：2022-02-15

申请人： INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION

发明人： Richard D. DIMARCHI ,  Piotr Andrzej MROZ ,  Kishore THALLURI

IPC分类号： C07K14/605 ,  A61P3/08

CPC分类号： C07K14/605 ,  A61P3/08 ,  A61K38/00

摘要： Provided herein are GLP-1 receptor antagonists peptides and pharmaceutical compositions for the treatment of hypoglycemia. Further provided herein are methods of treating atypical hypoglycemia in patients that have become hyperinsulinemic, including those who become hyperinsulinemic after bariatric surgery.

公开(公告)号：US11952370B2

公开(公告)日：2024-04-09

申请号：US17053458

申请日：2019-06-11

申请人： Northeastern University ,  Indiana University Research and Technology Corporation

发明人： Ganeshsingh A. Thakur ,  Diomedes E. Logothetis ,  Lucas Cantwell ,  Yu Xu ,  Anantha Shekhar

IPC分类号： A61K31/415 ,  A61P25/22 ,  C07D231/40 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

CPC分类号： C07D409/12 ,  A61K31/415 ,  A61P25/22 ,  C07D231/40 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12

摘要： Selective small molecule regulators of GIRK potassium channels are provided, which are effective in treatment of post-traumatic stress disorder and other medical conditions.

公开(公告)号：US11944626B2

公开(公告)日：2024-04-02

申请号：US16311533

申请日：2017-06-20

申请人： The Regents of the University of Michigan ,  Indiana University Research and Technology Corporation

发明人： Scott D. Larsen ,  Brandt C. Huddle ,  Kun Yang ,  Ronald Buckanovich ,  Thomas Hurley

IPC分类号： A61K31/519 ,  A61K31/337 ,  A61K31/4745 ,  A61K31/522 ,  A61K31/555 ,  A61K31/7068 ,  A61K39/395 ,  A61K45/06 ,  A61P31/00 ,  A61P35/00 ,  C07D487/04

CPC分类号： A61K31/519 ,  A61K31/337 ,  A61K31/4745 ,  A61K31/522 ,  A61K31/555 ,  A61K31/7068 ,  A61K39/395 ,  A61K45/06 ,  A61P31/00 ,  A61P35/00 ,  C07D487/04 ,  A61K31/522 ,  A61K2300/00 ,  A61K31/555 ,  A61K2300/00 ,  A61K31/337 ,  A61K2300/00 ,  A61K31/4745 ,  A61K2300/00 ,  A61K31/7068 ,  A61K2300/00

摘要： This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a thiopyrimidinone structure which function as inhibitors of ALDH protein, and their use as therapeutics for the treatment of cancer and other diseases.

公开(公告)号：US20240058422A1

公开(公告)日：2024-02-22

申请号：US18365081

申请日：2023-08-03

申请人： INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION

发明人： Richard D. DiMARCHI ,  Piotr Andrzej MROZ ,  Kishore THALLURI

IPC分类号： A61K38/26

CPC分类号： A61K38/26

摘要： Provided herein are GLP-1 receptor antagonists peptides and pharmaceutical compositions for the treatment of hypoglycemia. Further provided herein are methods of treating atypical hypoglycemia in patients that have become hyperinsulinemic, including those who become hyperinsulinemic after bariatric surgery.

公开(公告)号：US20230382966A1

公开(公告)日：2023-11-30

申请号：US18032479

申请日：2021-10-26

申请人： INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION

发明人： Richard D. DIMARCHI ,  Archita S. AGRAWAL

IPC分类号： C07K14/50

CPC分类号： C07K14/50 ,  A61K38/00

摘要： Compositions comprising novel peptides and dimers that exhibit antagonist activity against FGF23 binding to Klotho are disclosed. Such peptides can be used to treat hypoparathyroidism and osteoporosis.

公开(公告)号：US11581175B2

公开(公告)日：2023-02-14

申请号：US16334329

申请日：2017-09-19

申请人： Indiana University Research and Technology Corporation

发明人： Nicholas Manicke ,  Chengsen Zhang

IPC分类号： H01J49/04 ,  H01J49/16

摘要： Mass spectrometry cartridge including a base in mechanical communication with a spray substrate holder, an absorbent pad between the base and the spray substrate holder, a translatable sample well holder interposed between the spray substrate holder and a top cover, the top cover configured to house a conductive element, wherein when the translatable sample well holder is in a first position, the translatable well holder is vertically above the absorbent pad, when the translatable sample well holder is in a second position, the translatable well holder is vertically above a spray substrate are disclosed. Methods of analyzing a sample are also disclosed.

公开(公告)号：US11460861B2

公开(公告)日：2022-10-04

申请号：US16486104

申请日：2018-02-16

申请人： Indiana University Research and Technology Corporation

发明人： Geoffrey C. Fox ,  Supun M. Kamburugamuve Loku Acharige

IPC分类号： G05D1/02 ,  B60W60/00 ,  G05D1/00 ,  H04L67/1001 ,  H04L67/125 ,  H04L67/562 ,  H04L67/565

摘要： A method of controlling an operation of a robot (102) is provided using a cluster of nodes (104) in a network (106). The method includes receiving, using a gateway cloud driver (108), robot state information from the robot (102) via the network (106), and converting, using the gateway cloud driver (108), the robot state information into at least one message. The method further includes transmitting, using a message broker (110), the at least one message to the cluster of nodes (104) via the network (106). The method further includes processing, using the cluster of nodes (104) in the network (106), the at least one message by parallel computing, and generating, using the cluster of nodes (104) in the network (106), a robot command to control the operation of the robot (102).