公开(公告)号：US10370901B2

公开(公告)日：2019-08-06

申请号：US14427205

申请日：2013-09-11

申请人： ITI Scotland Limited

发明人： Marian Wiercigroch

IPC分类号： E21B7/06 ,  E21B7/04 ,  E21B7/24 ,  E21B3/00

摘要： Provided is an apparatus for use in directional drilling, which apparatus comprises: (a) a drill bit; (b) at least one steering actuator capable of exerting a longitudinal force on the drill bit, so as to change the direction of drilling; and/or (c) at least one drill bit steering insert, capable of extending and retracting so as to change the cutting characteristics of the drill bit and thereby change the direction of drilling. Further provided is a method of directional drilling, employing the apparatus of the invention.

公开(公告)号：US10067143B2

公开(公告)日：2018-09-04

申请号：US13695271

申请日：2011-04-28

申请人： Jonathan Peter Clark

发明人： Jonathan Peter Clark

IPC分类号： G01N33/68 ,  C12Q1/37 ,  G01N33/542

CPC分类号： G01N33/6872 ,  C12Q1/37 ,  G01N33/542 ,  G01N33/6842 ,  G01N33/6845 ,  G01N2500/00

摘要： The present application relates to a method of assaying ubiquitination in a sample by combining ubiquitin together with a substrate in a sample containing UBE1, UbcH3, Skp2-isoform 1, Skp1, Cull, Rbx1, Cks1, CDK2 and Cyclin E1 under conditions suitable for ubiquitination to take place, exposing the sample to a labelled binding partner which is specific for the ubiquitin, and measuring the amount of ubiquitin bound to the substrate.

公开(公告)号：US08809619B2

公开(公告)日：2014-08-19

申请号：US12679570

申请日：2008-10-17

申请人： Nico Scheer ,  Charles Roland Wolf

发明人： Nico Scheer ,  Charles Roland Wolf

IPC分类号： A01K67/027

CPC分类号： C12N15/8509 ,  A01K67/0276 ,  A01K2217/05 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/03

摘要： The invention relates to the generation of mouse models of drug metabolism in which clusters of genes that are involved in drug metabolism have been knocked out. The development of new drugs and chemicals for therapeutic use or for other purposes is extremely complex. Of particular importance is the understanding of how these chemical agents are handled in the body, whether they have appropriate pharmacokinetics and whether, as a consequence of metabolism, any safety issues arise. Many of the proteins that are involved in the metabolism, disposition and elimination of drugs are members of multigene families that exhibit very marked species differences in gene number, function and regulation. For these reasons, experiments carried out in laboratory animals to establish routes of metabolism or toxicity can be severely compromised and, as a consequence, do not faithfully represent the human situation. One example of this complexity is reflected in the mammalian cytochrome P450 system, where the sizes of multigene families of proteins which carry out particular metabolic functions vary enormously between species.

摘要翻译： 本发明涉及药物代谢小鼠模型的产生，其中参与药物代谢的基因簇已被淘汰。 用于治疗用途或用于其他目的的新药和化学品的开发是非常复杂的。 特别重要的是了解这些化学试剂如何在体内被处理，是否具有适当的药代动力学，以及作为新陈代谢的结果，是否出现任何安全问题。 涉及药物的代谢，处置和消除的许多蛋白质是多基因家族的成员，其在基因数目，功能和调控上表现出非常明显的物种差异。 由于这些原因，在实验动物中进行的实验动物建立新陈代谢或毒性的路线可能会受到严重的损害，因此不能忠实地代表人的情况。 这种复杂性的一个例子反映在哺乳动物细胞色素P450系统中，其中进行特定代谢功能的多基因家族蛋白质的大小在物种之间变化很大。

公开(公告)号：US08624079B2

公开(公告)日：2014-01-07

申请号：US12602723

申请日：2008-06-04

申请人： Charles Roland Wolf ,  Nico Scheer

发明人： Charles Roland Wolf ,  Nico Scheer

IPC分类号： A01K67/027 ,  A01K67/00 ,  A01K67/033 ,  G01N33/00 ,  C12N5/00

CPC分类号： A01K67/0276 ,  A01K67/0278 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/03 ,  A01K2267/0393 ,  C07K14/721 ,  C07K14/80 ,  C12N15/8509

摘要： The present invention relates to transgenic non-human animals, tissues or cells derived therefrom and methods of producing them. The transgenic non-human animals or tissues or cells derived therefrom provide a system capable of expressing human proteins responsible for drug metabolism in place of the homologous endogenous non-human animal proteins and for the controlled expression of human genes introduced into the animal so that the expression of the human genes is regulated in a manner more closely analogous to that seen in vivo in humans. One aspect of the invention relates to the use of a human DNA sequence comprising at least part of introns 6 and/or 7 of the human PXR gene.

摘要翻译： 本发明涉及转基因非人动物，由其衍生的组织或细胞及其生产方法。 从其衍生的转基因非人动物或组织或细胞提供能够表达负责药物代谢的人蛋白来代替同源的内源性非人动物蛋白的系统，以及引入动物的人基因的受控表达，使得 人类基因的表达以与人类体内更为类似的方式调节。 本发明的一个方面涉及包含人PXR基因的至少部分内含子6和/或7的人DNA序列的用途。

公开(公告)号：US08495042B2

公开(公告)日：2013-07-23

申请号：US12682648

申请日：2008-10-10

申请人： Beatrice Symington

发明人： Beatrice Symington

IPC分类号： G06F17/30

CPC分类号： G06F17/30716

摘要： Automatic information extraction apparatus for extracting data for review by a human curator from digital representations of documents comprising natural language text, the automatic information extraction apparatus having a plurality of selectable operating modes in which the automatic information extraction apparatus is operable to extract different data for review by a human curator. In the different operating modes, the information extraction apparatus may extract data with a different balance between recall and precision.

摘要翻译： 自动信息提取装置，用于从包括自然语言文本的文件的数字表示中提取数据以供人类策展人审查，所述自动信息提取装置具有多个可选择的操作模式，其中所述自动信息提取装置可操作以提取不同的数据以供审查 由一个人的策展人。 在不同的操作模式中，信息提取装置可以在回调和精度之间以不同的平衡提取数据。

公开(公告)号：US08468979B2

公开(公告)日：2013-06-25

申请号：US12528915

申请日：2008-02-28

申请人： Toby Mottram ,  Neil Telfer

发明人： Toby Mottram ,  Neil Telfer

IPC分类号： A01K15/00

CPC分类号： A01K11/00 ,  A01K11/006 ,  A01K27/009 ,  A01K29/005 ,  A61D17/002

摘要： A collar (1000) for an animal comprising an elongate strap member (1001) and at least a first and second housings (1011, 1013) at each end of said elongate strap member (1001), each of said first and second housings (1011, 1013) comprising interlocking means (1021, 1023) such that said first housing (1011) releasably engages said second housing (1013) in the proximity of the underside of an animal's neck when the collar (1000) is fitted around said animal's neck.

摘要翻译： 一种用于动物的套环（1000），包括细长带构件（1001）和在所述细长带构件（1001）的每个端部处的至少第一和第二壳体（1011,1013），所述第一和第二壳体（1011） ，1013）包括互锁装置（1021,1023），使得当所述套环（1000）围绕所述动物的颈部安装时，所述第一壳体（1011）在动物颈部的下侧附近可释放地接合所述第二壳体（1013）。

公开(公告)号：US20120276574A1

公开(公告)日：2012-11-01

申请号：US13501737

申请日：2010-10-11

申请人： Nicol Low ,  David Thomson ,  Jonathan Salmon

发明人： Nicol Low ,  David Thomson ,  Jonathan Salmon

IPC分类号： B01L3/00 ,  G01N33/68 ,  B23P11/00 ,  G01N1/28 ,  G01N21/00 ,  C12Q1/02 ,  G01N33/50

CPC分类号： B01L3/502715 ,  B01F7/1605 ,  B01F11/0258 ,  B01F13/0059 ,  B01F13/0827 ,  B01F15/00006 ,  B01F2215/0431 ,  B01L3/5027 ,  B01L2300/0832 ,  Y10T137/0402 ,  Y10T436/143333 ,  Y10T436/25

摘要： Provided is a microfluidic or nanofluidic apparatus which comprises:(a) a reservoir for one or more fluids;(b) a mixing device configured to mix the one or more fluids within the reservoir; and(c) a microfluidic or nanofluidic device in fluid connection with the reservoir;wherein the reservoir is suitable for containing a total volume of fluid of from 100 microliters to 100 milliliters. Also provided is a method of manufacturing the apparatus and the use of the apparatus to detect an analyte in a fluid.

摘要翻译： 提供了一种微流体或纳流体装置，其包括：（a）用于一种或多种流体的储存器; （b）混合装置，其被配置为混合储存器内的一种或多种流体; 和（c）与储存器流体连接的微流体或纳流体装置; 其中所述储存器适于容纳从100微升到100毫升的总体积的流体。 还提供了一种制造该装置的方法以及该装置用于检测流体中的分析物的用途。

公开(公告)号：US20120271578A1

公开(公告)日：2012-10-25

申请号：US13542559

申请日：2012-07-05

申请人： Helge Nareid

发明人： Helge Nareid

IPC分类号： G01R31/36 ,  G06F19/00

CPC分类号： G01R31/3648 ,  G01R31/392

摘要： A battery management system includes a neural network, for estimating an amount of charge stored in a battery following a recharging operation. Then, an amount of charge drawn during a discharging operation is subtracted from this estimated amount of charge to derive an estimate for the state of charge of the battery at a present time. A parameter representing the state of health of the battery may be provided as an input to the neural network, and the parameter representing the state of health of the battery may be generated by a second neural network.

摘要翻译： 电池管理系统包括神经网络，用于估计在充电操作之后存储在电池中的电量。 然后，从该估计的电荷量中减去在放电操作期间拉出的电荷量，以导出当前电池的充电状态的估计。 可以提供表示电池的健康状态的参数作为神经网络的输入，并且可以由第二神经网络生成表示电池的健康状态的参数。

公开(公告)号：US20120011428A1

公开(公告)日：2012-01-12

申请号：US12738751

申请日：2008-10-17

申请人： Alastair Chisholm

发明人： Alastair Chisholm

IPC分类号： G06F17/24

CPC分类号： G06F17/241 ,  G06F17/30525 ,  G06F17/30616 ,  G06F19/26

摘要： Disclosed is a computer-implemented method of presenting data which has been automatically extracted from a digital representation of a document to a curator for review, the extracted data comprising annotation entity data concerning one or more instances of entities which have been identified in the digital representation of a document, the annotation entity data comprising data specifying the location of the identified instances of entities within the digital representation of a document, the method comprising the steps of (i) displaying in a first region of a display screen a user selectable portion of the digital representation of a document with said instances of entities which are specified by the annotation entity data as being located within the displayed portion of the digital representation of a document highlighted at the location specified by the annotation entity data; (ii) displaying in a second region of the display screen a list of a plurality of instances of entities which have been identified in the digital representation of a document, at least one of the listed instances of an entity having a user selectable user interface element associated therewith; and (iii) responsive to a user selecting the user selectable user interface element associated with an instance of an entity, adjusting the portion of the digital representation of a document which is displayed in the first region to include the location within the digital representation of a document where the instance of an entity associated with the selected user interface element is located.

摘要翻译： 公开了一种计算机实现的方法，其将已经从文档的数字表示自动提取的数据呈现给策展人以供审查，所提取的数据包括关于在数字表示中已经识别的实体的一个或多个实例的注释实体数据 所述注释实体数据包括指定文档的数字表示内的所识别的实体实例的位置的数据，所述方法包括以下步骤：（i）在显示屏幕的第一区域中显示用户可选择的部分 具有由注释实体数据指定为位于由注释实体数据指定的位置突出显示的文档的数字表示的显示部分内的所述实体实例的文档的数字表示; （ii）在显示屏幕的第二区域中显示已经在文档的数字表示中被识别的多个实体实例的列表，具有用户可选择的用户界面元素的实体的列出的实例中的至少一个 相关联 以及（iii）响应于用户选择与实体的实例相关联的用户可选择的用户界面元素，调整在第一区域中显示的文档的数字表示的部分以包括数字表示中的位置 与所选择的用户界面元素相关联的实体的实例所在的文档。

公开(公告)号：US20110271730A1

公开(公告)日：2011-11-10

申请号：US13144826

申请日：2010-01-14

申请人： Richard Martin Curtis

发明人： Richard Martin Curtis

IPC分类号： B21C37/12 ,  B29C53/68 ,  B65H20/06 ,  B21C49/00

CPC分类号： B21C37/121 ,  B21C37/126 ,  B21C49/00 ,  B29C53/68 ,  B29C53/8016 ,  B65H20/26 ,  B65H2301/414321 ,  B65H2701/173

摘要： A winding apparatus for and method of manufacturing helically wound structures (116) includes a rotating faceplate (74) upon which are mounted a forming station for forming a supply of strip material before it is wound into a desired structure, a plurality of inner supports in the form of rollers (110) mounted for rotation about an axis and with said faceplate and a plurality of outer driven rollers (92) provided on an outer faceplate (118). In operation, the inner rollers act to support an inner portion S1 of strip material wound thereon whilst allowing it to be supplied from an inner diameter thereof to said forming station and the outer rollers (92) act to support an outer portion S2 of said strip. Said outer rollers are driven as and when necessary to transfer material to the inner portion S1.

摘要翻译： 用于制造螺旋缠绕结构（116）的缠绕设备和方法包括旋转面板（74），在其上安装有用于在被卷绕成所需结构之前形成条带材料供应的成形站，多个内部支撑件 安装用于围绕轴线旋转并与所述面板一起旋转的辊子（110）和设置在外面板（118）上的多个外部从动辊（92）的形式。 在操作中，内辊用于支撑缠绕在其上的条带材料的内部部分S1，同时允许其从其内径供应到所述成形站，并且外辊（92）用于支撑所述条带的外部部分S2 。 所述外部辊子在必要时被驱动以将材料转移到内部部分S1。