公开(公告)号：US4485174A

公开(公告)日：1984-11-27

申请号：US427470

申请日：1982-09-29

申请人： Ching Chiang ,  Susan K. Bolton

发明人： Ching Chiang ,  Susan K. Bolton

IPC分类号： G01N33/49 ,  C12Q1/32 ,  G01N33/50 ,  G01N33/72 ,  G01N33/96

CPC分类号： C12Q1/32 ,  G01N33/721 ,  G01N33/96 ,  G01N2333/805 ,  G01N2496/70 ,  Y10T436/102499 ,  Y10T436/105831 ,  Y10T436/108331

摘要： Blood gas control containing hemoglobin, a pH buffering agent, and a reduced pyridine nucleotide capable of participating in a reaction which reduces methemoglobin to normal hemoglobin.

摘要翻译： 含有血红蛋白，pH缓冲剂和能够参与将血红蛋白降低至正常血红蛋白的反应的还原吡啶核苷酸的血气控制。

公开(公告)号：US4468608A

公开(公告)日：1984-08-28

申请号：US329747

申请日：1981-12-11

申请人： Norman F. Rolfe

发明人： Norman F. Rolfe

IPC分类号： G01N27/416 ,  G01R31/02 ,  G01R31/16

CPC分类号： G01N27/4165

摘要： An electrochemical sensor system includes a high impedance ion selective electrode and an electrode test circuit that has an isolation capacitor connected between the output signal lead from the ion selective electrode and a test voltage terminal, and a monitoring circuit connected to respond to the output signal from the electrode. The isolation capacitor is a high quality capacitor and provides a shunt impedance that is much higher than the maximum electrode impedance. A voltage transition at the test voltage terminal is coupled by the isolation capacitor to the output lead and the resulting decay rate of the voltage transition on the output lead is monitored to provide an indication of the quality of the electrode.

摘要翻译： 电化学传感器系统包括高阻抗离子选择电极和电极测试电路，其具有连接在离子选择性电极的输出信号引线与测试电压端子之间的隔离电容器，以及连接到响应于来自 电极。 隔离电容器是高质量的电容器，并提供比最大电极阻抗高得多的并联阻抗。 测试电压端子处的电压转换通过隔离电容器耦合到输出引线，并且监测在输出引线上产生的电压转变的衰减速率以提供电极质量的指示。

公开(公告)号：US4447544A

公开(公告)日：1984-05-08

申请号：US400686

申请日：1982-07-22

申请人： Bruce P. Neri ,  Stanley M. Liffmann

发明人： Bruce P. Neri ,  Stanley M. Liffmann

IPC分类号： G01N33/84 ,  G01N33/52 ,  G01N33/96

CPC分类号： G01N33/84 ,  Y10T436/109163 ,  Y10T436/166666 ,  Y10T436/25125

摘要： An aqueous reagent for determining inorganic phosphate in a protein-containing liquid biological sample comprises a molybdate salt, an acid capable of reacting with the molybdate salt to form molybdic acid for complexation with phosphate to form phosphomolybdate complexes, a ferric salt in an amount sufficient to inhibit turbidity in the sample, and a nonionic surfactant reagent in an amount sufficient to further inhibit turbidity in the sample, the molybdate salt and the acid being present in amounts sufficient to form an amount of molybdic acid sufficient to produce a detectible color change when complexed with phosphate in the sample.

摘要翻译： 用于测定含蛋白质的液体生物样品中的无机磷酸盐的水性试剂包括钼酸盐，能够与钼酸盐反应形成钼酸以与磷酸盐络合以形成磷钼酸盐络合物的酸， 抑制样品中的浊度，和非离子表面活性剂试剂，其量足以进一步抑制样品中的浊度，钼酸盐和酸以足以形成一定量的钼酸的量存在，以在复合时产生可检测的颜色变化 与样品中的磷酸盐。

公开(公告)号：US4410631A

公开(公告)日：1983-10-18

申请号：US271321

申请日：1981-06-15

申请人： John D. Czaban ,  Alan D. Cormier

发明人： John D. Czaban ,  Alan D. Cormier

IPC分类号： G01N27/416 ,  G01N27/26 ,  C09K3/00

CPC分类号： G01N27/4165 ,  G01N27/333 ,  G01N33/492 ,  Y10T436/10

摘要： A reference liquid system for use with a chemical analyzer that has a plurality of ion selective electrodes comprises a plurality of reference liquids, each of which has a first salt component such that ions of a first element to be measured are present in a predetermined concentration, a second salt component such that ions of a second element to be measured are present in a predetermined concentration, and an error compensation salt component present in a concentration effective to adjust(a) the activity coefficient factor and/or(b) the junction potential factorto reduce the error involved in use of the compensated reference liquid to less than fifty percent of the error involved in use of a corresponding uncompensated reference liquid.

摘要翻译： 一种与具有多个离子选择性电极的化学分析仪一起使用的参考液体系统包括多个参考液体，每个参比液体具有第一盐成分，使得待测量的第一元素的离子以预定浓度存在， 第二盐成分，使得待测量的第二元素的离子以预定浓度存在，以及有效调整（a）活性系数因子和/或（b）结电位的浓度存在的误差补偿盐成分 因素，以减少使用补偿参考液体所涉及的误差小于使用相应的未补偿参考液体所涉及的误差的百分之五十。

公开(公告)号：US4361540A

公开(公告)日：1982-11-30

申请号：US319314

申请日：1981-11-09

申请人： Melvin S. Weinberg ,  Alan D. Cormier

发明人： Melvin S. Weinberg ,  Alan D. Cormier

IPC分类号： G01N27/403 ,  G01N33/487 ,  G01N33/49 ,  G01N27/30

CPC分类号： G01N33/4915

摘要： An analysis system for measuring a plurality of parameters of a fluid sample comprises a housing, and a flow-through cell in the housing that has opposed surfaces with at least two ports in each surface. One of the ports is an inlet port, a second of the ports is an outlet port, and at least two of the ports are sensing ports. A sample flow path including a serpentine portion in the cell serially connects the ports and extends from a port in one surface to a port in the other surface and back to a port in the one surface, and a sensor is disposed in sealing engagement with each sensing port and forms a portion of the serpentine flow path so that sample fluid to be analyzed contacts a surface of each sensor.

摘要翻译： 用于测量流体样品的多个参数的分析系统包括壳体和壳体中的流通池，其具有在每个表面中具有至少两个端口的相对表面。 其中一个端口是入口端口，第二个端口是出口端口，并且至少两个端口是感测端口。 包括单元中的蛇形部分的样品流动路径串联地连接并且从一个表面中的端口延伸到另一表面中的端口并且返回到一个表面中的端口，并且传感器设置成与每个端口密封接合 感测端口并形成蛇形流动路径的一部分，使得待分析的样品流体接触每个传感器的表面。

公开(公告)号：US4299794A

公开(公告)日：1981-11-10

申请号：US161375

申请日：1980-06-20

申请人： Thomas F. Kelley ,  Dinesh I. Mody ,  Charles F. Mountain

发明人： Thomas F. Kelley ,  Dinesh I. Mody ,  Charles F. Mountain

IPC分类号： G01N7/18 ,  G01N7/14 ,  G01N33/483 ,  G01N33/84 ,  G01N33/50 ,  G01N1/10

CPC分类号： G01N33/84 ,  G01N7/14 ,  Y10T436/204998

摘要： A total carbon dioxide analyzer system has a reaction chamber that includes a tube and a piston mounted for sliding movement in the tube to change the volume of the chamber. A valve coupled to the chamber has a sample inlet port and a reagent inlet port, and is movable between a first state in which the sample inlet port is connected to the chamber, a second state in which the reagent inlet port is connected to the chamber, and a third state in which the reaction chamber is sealed. A system controller coordinately operates the valve and moves the piston to increase the volume of said chamber to draw sample into the chamber for mixing with an acid reagent in the chamber, and then seals the chamber and increases the volume of the chamber to facilitate the release of carbon dioxide. A transducer then senses the pressure of carbon dioxide in the reaction chamber.

摘要翻译： 总的二氧化碳分析仪系统具有包括管和活塞的反应室，该活塞安装成用于在管中滑动以改变腔的体积。 联接到所述室的阀具有样品入口和试剂入口，并且可以在样品入口与腔室连接的第一状态和第二状态之间移动，其中试剂入口连接到腔室 和第三状态，其中反应室被密封。 系统控制器协调地操作阀并移动活塞以增加所述室的体积以将样品抽入室中以与室中的酸试剂混合，然后密封室并增加室的体积以便于释放 的二氧化碳。 传感器然后感测反应室中二氧化碳的压力。

公开(公告)号：US4245509A

公开(公告)日：1981-01-20

申请号：US21069

申请日：1979-03-16

申请人： Dinesh I. Mody ,  Carolyn Bergkvist ,  Gustav H. Dreier

发明人： Dinesh I. Mody ,  Carolyn Bergkvist ,  Gustav H. Dreier

IPC分类号： G01N1/00 ,  G01N1/38 ,  G01N1/14

CPC分类号： G01N35/1097 ,  G01N1/38 ,  G01N2001/382

摘要： Sampling apparatus designed for aspirating, diluting and mixing a small sample of fluid in precise amounts and delivering the mixture to a scientific apparatus at a place remote from the place of aspiration. Operation of the device may be manual but is preferably automatic. The apparatus is designed to process a plurality of sample fluids with no cross-contamination between samples. In essence, the apparatus is a fluid handling system including a sample pick-up assembly in fluid communication with an automatic valve assembly having two operative positions. The automatic valve assembly is in fluid communication with a dilutor assembly having a sample pump and a diluent pump operable by a common means. A mixing and delivery assembly is also in fluid communication with the automatic valve assembly and includes a cup designed for bidirectional rotation with an annular space about the cup. A dispensing probe dispenses into the cup precise amounts of sample and diluent in a predetermined ratio to each other and, following rotation of the cup to achieve the mixture of sample and diluent, an aspirator probe enters the mixture and delivers an amount thereof to an adjacent scientific instrument. The apparatus further includes a means for expelling the remainder of the mixture from the cup into the annular space surrounding the cup, and from there through a valve, to waste.

摘要翻译： 采样设备设计用于精确量吸入，稀释和混合小样本的流体，并将混合物输送到远离抽吸位置的地方的科学仪器。 设备的操作可以是手动的，但是优选是自动的。 该设备被设计成在样品之间没有交叉污染的情况下处理多个样品流体。 实质上，该装置是一种流体处理系统，其包括与具有两个操作位置的自动阀组件流体连通的样品拾取组件。 自动阀组件与具有可由常用装置操作的样品泵和稀释剂泵的稀释器组件流体连通。 混合和输送组件还与自动阀组件流体连通，并且包括设计成用于围绕杯的环形空间进行双向旋转的杯。 分配探针以预定的比例将精确量的样品和稀释剂分配到杯中，并且在杯的旋转以实现样品和稀释剂的混合物之后，吸气探针进入混合物并将其量递送到相邻的 科学仪器。 该装置还包括将混合物的剩余部分从杯子排出到围绕杯子的环形空间中并从那里通过阀排出的装置，以浪费。

公开(公告)号：US4195665A

公开(公告)日：1980-04-01

申请号：US881000

申请日：1978-02-24

申请人： Gaillard R. Nolan ,  William E. Flynn

发明人： Gaillard R. Nolan ,  William E. Flynn

IPC分类号： F16K11/02 ,  G01N1/00

CPC分类号： G01N35/1097 ,  F16K11/027 ,  Y10T137/86445 ,  Y10T137/86501 ,  Y10T137/86911 ,  Y10T137/8782

摘要： The fluid valve essentially comprises a support structure designed rotatably to support an inlet within a certain oscillatory ambit and stationarily supporting a plurality of outlets within the oscillatory ambit, and operative means for effecting fluid-tight communication seriatim between the inlet and one of the outlets. The inlet is preferably a blunt needle provided with a side port and each of the outlets comprises an inverted "Y"-shaped member formed of an entrance portion and a pair of leg portions. The needle is designed to be thrust into the entrance portion, so that its side port establishes fluid-tight communication with one of the leg portions. Means are provided, including a pneumatic cylinder, for effecting relative motion between the inlet and the outlets. There is also a means for normally closing off all the entrance portions of the outlets except the selected one, and only during the entry of the blunt needle therein. Such means includes a plurality of pinch rods and a cylindrical cam mounted about the pneumatic cylinder and provided with a channel to cooperate with one end of the pinch rods so as to open the selected outlet when the needle is thrust therein. Means are also provided for selectively indexing the needle within the oscillatory ambit which comprises both electrical and mechanical parts.

摘要翻译： 流体阀基本上包括支撑结构，该支撑结构可旋转地设计成支撑一定振荡范围内的入口，并且在振荡范围内固定地支撑多个出口，以及用于在入口和一个出口之间进行流体密封通信的操作装置。 入口优选是设置有侧端口的钝针，并且每个出口包括由入口部分和一对腿部部分形成的倒置的“Y”形构件。 针被设计成被推入入口部分，使得其侧面与腿部之一建立流体密封连通。 提供了包括用于在入口和出口之间进行相对运动的气缸的装置。 还有一种用于通常关闭出口除了所选择的出口的所有入口部分，并且仅在钝针入口期间的装置。 这种装置包括多个夹紧杆和围绕气缸安装的圆柱形凸轮，并且设置有与夹紧杆的一端配合的通道，以便当针被推入时打开所选择的出口。 还提供了用于在包括电气和机械部件的振荡范围内选择性地分度针的装置。

公开(公告)号：US3973915A

公开(公告)日：1976-08-10

申请号：US497256

申请日：1974-08-14

申请人： Italo Raffaele ,  Luigi Rossi

发明人： Italo Raffaele ,  Luigi Rossi

IPC分类号： B01L99/00 ,  G01N33/487 ,  B01L11/00 ,  G01N31/00 ,  G01N33/16

CPC分类号： B01L99/00 ,  G01N33/4925

摘要： Equilibrator device for use in determination of the acid-base status, the oxygen dissociation curve of blood and other properties of physiological interest. The device comprises, within a confined and thermostatically controlled environment, a cuvette for accommodating a sample of blood or other liquid to be equilibrated with a gas phase, means for controlledly rotating such cuvette and means for promoting passage of a gaseous flow firstly through a humidifying ambient and then into the presence of said sample.

摘要翻译： 用于测定酸碱状态，血液氧分解曲线和其他生理兴趣性质的平衡仪。 该设备在受限和恒温控制的环境中包括用于容纳要用气相平衡的血液或其他液体样品的比色皿，用于可控地旋转这种比色杯的装置和用于促进气流首先通过加湿的装置 然后进入所述样品的存在。

公开(公告)号：US3963440A

公开(公告)日：1976-06-15

申请号：US483610

申请日：1974-06-27

申请人： Bernard Stein ,  Philip Spergel

发明人： Bernard Stein ,  Philip Spergel

IPC分类号： G01N33/49 ,  G01N27/38 ,  G01N27/416 ,  G01N33/483 ,  G01N33/487 ,  G01N35/00 ,  G01N27/00 ,  G01N31/00 ,  G01N33/16

CPC分类号： G01N35/00594 ,  G01N33/4925 ,  G01N2035/00435 ,  G01N35/00693

摘要： A blood analysis system comprises a tempering chamber in which a plurality of flow through measuring cells are disposed. A sensor electrode is associated with each cell. A sample flow path extends from an entrance port through a heater element, a first measuring cell, a control valve, a second measuring cell, a reference electrode interface, to a positive displacement pump. In standby condition, the entrance port is immersed in flush fluid and operation of the pump in such condition flows flush fluid through the entire sample path. Fluid access to either measuring cell is obtainable through the entrance port, auxiliary valve ports, or disconnectable conduits connected to the valve. The control valve is connected in the flow path between the two measuring cells, and in a first condition that control valve places the measuring cells in series fluid communication with the inlet port, and in a second condition isolates the measuring cells from one another so that the electrode systems associated with the two measuring cells may be calibrated concurrently and independently of one another.

摘要翻译： 血液分析系统包括其中设置有多个流过测量单元的回火室。 传感器电极与每个电池相关联。 样品流路从入口通过加热元件，第一测量单元，控制阀，第二测量单元，参考电极接口延伸到正排量泵。 在待机状态下，入口浸没在冲洗流体中，泵在这种状态下的运行通过整个采样路径冲洗流体。 可以通过入口，辅助阀口或连接到阀门的可断开的导管获得流体到任一个测量池的通路。 控制阀连接在两个测量单元之间的流路中，并且在控制阀将测量单元与入口串联流体连通的第一状态下，并且在第二状态下将测量单元彼此隔离使得 与两个测量单元相关联的电极系统可以彼此同时且独立地校准。