公开(公告)号：US08546321B2

公开(公告)日：2013-10-01

申请号：US13127574

申请日：2009-11-17

申请人： Elisabeth Bock ,  Vladimir Berezin

发明人： Elisabeth Bock ,  Vladimir Berezin

IPC分类号： A61K38/00 ,  A61K38/03

CPC分类号： C07K14/5406 ,  A61K38/00 ,  Y02A50/414

摘要： The present invention relates to small peptides derived from a cytokine, interleukin-4 (IL-4), capable of binding to the IL-4 receptors and inhibiting macrophage activation, and thereby preventing the onset of inflammatory response. The invention further relates to use of said peptides for the production of a medicament for the treatment of different pathological conditions, wherein IL-4 plays a prominent role.

摘要翻译： 本发明涉及能够结合IL-4受体并抑制巨噬细胞活化的细胞因子，白细胞介素-4（IL-4）的小肽，从而防止炎性反应的发生。 本发明还涉及所述肽用于生产用于治疗不同病理状况的药物的用途，其中IL-4起突出作用。

公开(公告)号：US20130203113A1

公开(公告)日：2013-08-08

申请号：US13696885

申请日：2011-05-05

申请人： Steen Pedersen ,  Kim Sneppen ,  Margit Pedersen ,  Sine Lo Svenningsen ,  Namiko Mitarai

发明人： Steen Pedersen ,  Kim Sneppen ,  Margit Pedersen ,  Sine Lo Svenningsen ,  Namiko Mitarai

IPC分类号： C12N15/67 ,  C12P21/00

CPC分类号： C12N15/67 ,  C07K14/43595 ,  C12N15/75 ,  C12P21/00

摘要： There is provided a method to increase the production of a desired protein in a microorganism by introduction of slowly translated codons in the encoding DNA gene sequence capable of slowing down the translation speed of the ribosomes moving along the mRNA, whereby the ribosomes protect the mRNA from being enzymatically degraded. This increases the stability of the mRNA transcript and thus results in an increased production of the desired protein. Moreover, there is provided a method of decreasing the half-life of a mRNA transcript from a gene encoding a peptide.

摘要翻译： 提供了一种通过在能够减慢沿着mRNA移动的核糖体的翻译速度的编码DNA基因序列中引入缓慢翻译的密码子来增加微生物中期望的蛋白质的产生的方法，由此核糖体保护mRNA免受 被酶降解。 这增加了mRNA转录物的稳定性，从而导致所需蛋白质的产生增加。 此外，提供了从编码肽的基因降低mRNA转录物的半衰期的方法。

公开(公告)号：US08288143B2

公开(公告)日：2012-10-16

申请号：US13148853

申请日：2010-02-09

申请人： Peter Stougaard ,  Mariane Schmidt

发明人： Peter Stougaard ,  Mariane Schmidt

IPC分类号： C07K1/00 ,  C12N9/38 ,  C07H21/04 ,  C12N15/00 ,  C12N1/20

CPC分类号： A23C9/1206 ,  A23C9/123 ,  A23C19/032 ,  C12N9/2471 ,  C12Y302/01023

摘要： A novel cold-active beta-galactosidase is enzyme specific for lactose. The enzyme is thus useful in e.g. the food industry for catalyzing at low temperatures the hydrolysis of lactose disaccharide into its constituent monosaccharides, glucose and galactose. A method produces the cold-active beta-galactosidase by recombinant DNA technology.

摘要翻译： 一种新型的冷活性β-半乳糖苷酶是对乳糖特异的酶。 因此，该酶可用于例如。 食品工业在低温下催化乳糖二糖水解成其组成单糖，葡萄糖和半乳糖。 一种方法通过重组DNA技术产生冷活性β-半乳糖苷酶。

公开(公告)号：US20120128770A1

公开(公告)日：2012-05-24

申请号：US13380086

申请日：2010-06-24

申请人： Harald S. Hansen ,  Thi Ai Diep ,  Jens Juul Holst ,  Mette Marie Rosenkilde ,  Niels Wellner Andersen

发明人： Harald S. Hansen ,  Thi Ai Diep ,  Jens Juul Holst ,  Mette Marie Rosenkilde ,  Niels Wellner Andersen

IPC分类号： A61K31/231 ,  A61K9/48 ,  C12N5/02 ,  A61K9/52 ,  C07C69/58 ,  A61P3/10 ,  A61K31/22 ,  A61K9/64

CPC分类号： A61K31/23 ,  A61K31/045 ,  A61K31/231 ,  A61K31/232

摘要： The present invention relates to 1 or 2 C16-C18 acyl glycerol based compounds which are capable of activating G-protein coupled receptor 119 and thereby stimulate GLP-1 release. Compounds of the present invention are useful in the prophylaxis and/or treatment of metabolic disorders and complications thereof, such as, type 2 diabetes mellitus (T2DM), obesity, insulin resistance, and cardiovascular disease.

摘要翻译： 本发明涉及能够激活G蛋白偶联受体119从而刺激GLP-1释放的1或2种C16-C18酰基甘油基化合物。 本发明的化合物可用于预防和/或治疗代谢紊乱及其并发症，例如2型糖尿病（T2DM），肥胖症，胰岛素抵抗和心血管疾病。

公开(公告)号：US20120101004A1

公开(公告)日：2012-04-26

申请号：US13377121

申请日：2010-06-09

申请人： Peter Garred ,  Christian Honoré

发明人： Peter Garred ,  Christian Honoré

IPC分类号： C40B30/04 ,  G01N33/566

CPC分类号： G01N33/564 ,  G01N2333/4716

摘要： The present invention relates to methods for detecting Ficolin-3 dependent activation of the lectin pathway of complement, methods for identifying abnormalities in Ficolin-3, and methods for screening for deficiencies/and or identifying abnormalities in any downstream components of the Ficolin-3 dependent activation of the lectin pathway of 5 complement using an acetylated Ficolin-3 ligand, said methods generally comprising the steps of: (a) providing a sample of blood, serum, plasma, another body fluid or an extract thereof; (b) (optionally) preventing in the sample activation of the classical pathway and/or the alternative pathway and/or any non-Ficolin-3 mediated activation of the lectin pathway; (c) acetylating a molecule; (d) contacting said acetylated molecule 10 with said sample, in conditions that permit specific binding of Ficolin-3 to said acetylated molecule, and, (e) detecting and quantifying specific binding of the Ficolin-3 to said acetylated molecule, (f) determining in the sample complement activation and/or deposition by the detection of a C2, C3, C4 and/or a C5 cleavage product and/or by detecting any of the terminal complement complex components C6, C7, C8 or C9 or 15 the C5b-9 terminal complement complex as such. The present invention also provides assays and kits comprising the methods of the invention.

摘要翻译： 本发明涉及用于检测补体的凝集素途径的Ficolin-3依赖性活化的方法，用于鉴定Ficolin-3异常的方法，以及筛选Ficolin-3依赖性的任何下游组分的缺陷和/或鉴定异常的方法 所述方法通常包括以下步骤：（a）提供血液，血清，血浆，另一体液或其提取物的样品;（b）使用乙酰化的Ficolin-3配体激活5个补体的凝集素途径。 （b）（任选地）阻止样品激活经典途径和/或替代途径和/或任何非Ficolin-3介导的凝集素途径的活化; （c）乙酰化分子; （d）使所述乙酰化分子10与所述样品接触，条件是允许Ficolin-3与所述乙酰化分子的特异性结合，和（e）检测和定量Ficolin-3与所述乙酰化分子的特异性结合，（f） 通过检测C2，C3，C4和/或C5切割产物和/或通过检测任何终末互补复合物组分C6，C7，C8或C9或15来确定样品中补体活化和/或沉积C5b -9末端补体复合物。 本发明还提供包含本发明方法的测定和试剂盒。

公开(公告)号：US20100139759A1

公开(公告)日：2010-06-10

申请号：US12517512

申请日：2007-11-23

申请人： Martin Aagesen

发明人： Martin Aagesen

IPC分类号： H01L31/0236 ,  H01L31/0368 ,  H01L33/00 ,  H01L21/20

CPC分类号： H01L31/0352 ,  H01L31/0304 ,  H01L33/18 ,  Y02E10/544

摘要： The present invention relates to an optical device and to a method of fabricating the same. In embodiments, the invention relates to a photovoltaic device or solar cell. The optical device comprises a first electrode and a second electrode and an active element disposed between the first and second electrodes. The active element comprising a plurality of semiconducting structures extending in a lengthwise direction from the first electrode and being in contact with the first and second electrodes; the active element comprises an np-junction. For the semiconducting structures, at least a part of the structures is of a general plate or flake shape. In embodiments, the semiconducting structures have at least one characteristic dimension in the nanometer range.

摘要翻译： 本发明涉及一种光学器件及其制造方法。 在实施例中，本发明涉及光伏器件或太阳能电池。 光学器件包括第一电极和第二电极以及设置在第一和第二电极之间的有源元件。 所述有源元件包括从所述第一电极沿长度方向延伸并与所述第一和第二电极接触的多个半导体结构; 有源元件包括np结。 对于半导体结构，至少一部分结构具有一般板或片状。 在实施例中，半导体结构在纳米范围内具有至少一个特征尺寸。

公开(公告)号：US20090324628A1

公开(公告)日：2009-12-31

申请号：US10585027

申请日：2004-12-28

申请人： Thor Grundtvig Theander ,  Thomas Lavstsen ,  Lars Hviid ,  Morten A. Nielsen ,  Pamela A. Magistrado ,  Ali Salanti ,  Trine Staalso ,  Anja Tatiana Ramstedt Jensen ,  Louise Jorgensen

发明人： Thor Grundtvig Theander ,  Thomas Lavstsen ,  Lars Hviid ,  Morten A. Nielsen ,  Pamela A. Magistrado ,  Ali Salanti ,  Trine Staalso ,  Anja Tatiana Ramstedt Jensen ,  Louise Jorgensen

IPC分类号： A61K39/00 ,  A61P37/04

CPC分类号： C07K14/445 ,  A61K39/00 ,  Y02A50/412

摘要： The present invention relates to nucleic acid molecules related to the PFD1235w/MAL7P1.1, PF11_0008, and PF13_0003 gene families as well as amino acid sequences encoded by such nucleic acid molecules with respect to their role in mediating adhesion of infected red blood cells to endothelial cells, which is characteristic for the pathogenesis of severe malaria (SM). Accordingly, the invention provides pharmaceutical compositions and vaccines, hereunder nucleotide-based vaccines comprising compounds that are related to VAR4, VAR5, and/or VAR6 polypeptides and PFD1235w/MAL7P1.1 PF11_0008, and/or PF13_0003 nucleic acid molecules. The invention further relates to the use of these compounds as medicaments and for the manufacture of compositions, such as immunogenic compositions. In addition, the invention relates to methods of treatment and prevention of severe malaria wherein these methods are based on the nucleic acid molecules and polypeptides of the invention. As these compounds can also be used as biotechnological tools the invention provides in vitro diagnostic methods and kits comprising reagents and IgGs/antibodies designated to the use in such methods. The invention also relates to methods of identifying agents capable of modulating the VAR4, VAR5, and/or VAR6 dependent adhesion to endothelial cells and agent capable of interacting with VAR4, VAR5, and/or VAR6. Finally, a method for identifying polypeptides, which will induce a specific IgG/antibody response upon administration to a subject is provided by the invention.

摘要翻译： 本发明涉及与PFD1235w / MAL7P1.1，PF11_0008和PF13_0003基因家族相关的核酸分子以及由这些核酸分子编码的氨基酸序列，涉及它们介导感染的红细胞与内皮粘附的作用 细胞，这是严重疟疾（SM）发病机制的特征。 因此，本发明提供药物组合物和疫苗，以下基于核苷酸的疫苗包含与VAR4，VAR5和/或VAR6多肽和PFD1235w / MAL7P1.1 PF11_0008和/或PF13_0003核酸分子相关的化合物。 本发明还涉及这些化合物作为药物和制备组合物如免疫原性组合物的用途。 此外，本发明涉及治疗和预防严重疟疾的方法，其中这些方法基于本发明的核酸分子和多肽。 由于这些化合物也可用作生物技术工具，本发明提供了体外诊断方法和试剂盒，其中包括用于此类方法的试剂和IgG /抗体。 本发明还涉及鉴定能够调节VAR4，VAR5和/或VAR6对内皮细胞和能够与VAR4，VAR5和/或VAR6相互作用的试剂依赖性粘附的试剂的方法。 最后，本发明提供了鉴定多肽的方法，所述多肽在给予受试者时将诱导特异性IgG /抗体应答。

公开(公告)号：US20140234294A1

公开(公告)日：2014-08-21

申请号：US14140247

申请日：2013-12-24

申请人： Kobenhavns Universitet

发明人： Vladimir Berezin ,  Elisabeth Bock ,  Artur Kochoyan

IPC分类号： C07K16/42

CPC分类号： C07K16/42 ,  A61K38/179 ,  C07K2317/70

摘要： The present invention relates to the use of peptides that are capable of binding to, and modulating the activity of NCAM. The peptides are peptide fragments of FGFRs. They are derived from two distinct binding sites for binding of the immunoglobulin-like module 2 of FGFR to NCAM F3 modules 1-2. The invention further relates to use of said peptides for the production of a medicament for the treatment of different pathological conditions, wherein NCAM and/or FGFRs play a prominent role.

摘要翻译： 本发明涉及能够结合并调节NCAM活性的肽的用途。 肽是FGFR的肽片段。 它们衍生自用于结合FGFR的免疫球蛋白样模块2与NCAM F3模块1-2的两个不同的结合位点。 本发明还涉及所述肽在生产用于治疗不同病理状况的药物中的用途，其中NCAM和/或FGFRs起着重要作用。

公开(公告)号：US20140030421A1

公开(公告)日：2014-01-30

申请号：US14002604

申请日：2012-03-01

申请人： Keld Ejdrup Markedal ,  Jens Christian Sorensen ,  Hilmer Sorensen ,  Anne Dorthe Sorensen

发明人： Keld Ejdrup Markedal ,  Jens Christian Sorensen ,  Hilmer Sorensen ,  Anne Dorthe Sorensen

IPC分类号： A23L1/211

CPC分类号： A23J1/14 ,  A23L11/34 ,  A23L11/35 ,  A23L33/185 ,  A23V2002/00 ,  B01D15/362 ,  B01D15/363

摘要： The present invention relates to a process for the manufacture of a product from a plant material including the steps of providing a disrupted plant material including

摘要翻译： 本发明涉及从植物材料制造产品的方法，包括以下步骤：提供包含<10％（w / w）淀粉和<10％（w / w）油/脂质的破坏的植物材料; 将破碎的植物材料的pH调节至pH3.5或更低的值以提供酸性悬浮液; 将酸性悬浮液加热到约50℃至约80℃的温度范围内。 将产品与加热的酸性悬浮液分离。 该产物可以是蛋白质产物或非蛋白质产物。 特别地，本发明的方法提供具有降低的营养价值的非蛋白质成分含量降低的蛋白质产物。

公开(公告)号：US08577624B2

公开(公告)日：2013-11-05

申请号：US12747598

申请日：2008-12-12

申请人： Michael G. Palmgren ,  Morten Buch-Pedersen ,  Bjørn Pañella Pedersen ,  Poul Nissen

发明人： Michael G. Palmgren ,  Morten Buch-Pedersen ,  Bjørn Pañella Pedersen ,  Poul Nissen

IPC分类号： G01N31/00 ,  C12Q1/34

CPC分类号： C12N9/14 ,  C07K2299/00 ,  C12Y306/01003

摘要： The present invention relates to a crystal structure of a plasma membrane proton pump type ATPase. The invention further describes method for identification of modulators of ATPases as well as uses of such modulators. Based on the provided three dimensional structure of the ATPase, various method, such as computer implemented methods may be used for identification of modulators, such putative modulators may be further analysed using in vitro and in vivo experiments to confirm there functionality. Several modulator interaction regions are described as target of regulation by ATPase modulators.

摘要翻译： 本发明涉及质膜质子泵型ATP酶的晶体结构。 本发明还描述了鉴定ATP酶的调节剂的方法以及这种调节剂的用途。 基于提供的ATP酶的三维结构，可以使用各种方法，例如计算机实施的方法来鉴定调节剂，可以使用体外和体内实验进一步分析这些推定的调节剂以确认其功能。 多个调节剂相互作用区域被描述为通过ATP酶调节剂调节的靶标。